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Kenneth Brown

TitleProfessor
InstitutionUniversity of Houston
DepartmentComparative Cultural Studies
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-3789
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    Collapse Research 
    Collapse research activities and funding
    F33AG005423     (BROWN, KENNETH L)Mar 1, 1988
    NIH/NIA
    REGULATION OF CHOLINE ACETYLTRANSFERASE
    Role: Principal Investigator
    R15DK040212     (BROWN, KENNETH L)Sep 1, 1988 - Jun 30, 1991
    NIH/NIDDK
    INTERACTION OF COBALAMINS WITH CHICKEN SERUM HAPTOCORRIN
    Role: Principal Investigator
    R01GM048858     (BROWN, KENNETH L)Sep 1, 1992 - Nov 30, 2006
    NIH/NIGMS
    Mechanism of Enzyme Mediated Activation of Coenzyme B12
    Role: Principal Investigator
    S15GM052167     (BROWN, KENNETH L)Jun 1, 1994 - May 31, 1995
    NIH/NIGMS
    PROVIDE SMALL INSTRUMENTATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, Hook JM, Arndt C, van den Berg H, Brennan B, Brichard B, Brown KLB, Butterfass-Bahloul T, Calaminus G, Daldrup-Link HE, Eriksson M, Gebhardt MC, Gelderblom H, Gerss J, Goldsby R, Goorin A, Gorlick R, Grier HE, Hale JP, Hall KS, Hardes J, Hawkins DS, Helmke K, Hogendoorn PCW, Isakoff MS, Janeway KA, Jürgens H, Kager L, Kühne T, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Meyers PA, Mottl H, Nathrath M, Papai Z, Randall RL, Reichardt P, Renard M, Safwat AA, Schwartz CL, Stevens MCG, Strauss SJ, Teot L, Werner M, Sydes MR, Whelan JS. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol. 2016 Oct; 17(10):1396-1408. PMID: 27569442.
      View in: PubMed
    2. Oberlin O, Rey A, Brown KL, Bisogno G, Koscielniak E, Stevens MC, Hawkins DS, Meyer WH, La TH, Carli M, Anderson JR. Prognostic Factors for Outcome in Localized Extremity Rhabdomyosarcoma. Pooled Analysis from Four International Cooperative Groups. Pediatr Blood Cancer. 2015 Dec; 62(12):2125-31. PMID: 26257045; PMCID: PMC5002346.
      View in: PubMed, PubMed Central
    3. Conrad KS, Jordan CD, Brown KL, Brunold TC. Spectroscopic and computational studies of cobalamin species with variable lower axial ligation: implications for the mechanism of Co-C bond activation by class I cobalamin-dependent isomerases. Inorg Chem. 2015 Apr 20; 54(8):3736-47. PMID: 25839944.
      View in: PubMed
    4. Chemaly SM, Brown KL, Fernandes MA, Munro OQ, Grimmer C, Marques HM. Probing the nature of the Co(III) ion in corrins: the structural and electronic properties of dicyano- and aquacyanocobyrinic acid heptamethyl ester and a stable yellow dicyano- and aquacyanocobyrinic acid heptamethyl ester. Inorg Chem. 2011 Sep 19; 50(18):8700-18. PMID: 21851069.
      View in: PubMed
    5. Rodeberg DA, Garcia-Henriquez N, Lyden ER, Davicioni E, Parham DM, Skapek SX, Hayes-Jordan AA, Donaldson SS, Brown KL, Triche TJ, Meyer WH, Hawkins DS. Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2011 Apr 01; 29(10):1304-11. PMID: 21357792; PMCID: PMC3083998.
      View in: PubMed, PubMed Central
    6. Raney RB, Anderson JR, Brown KL, Huh WW, Maurer HM, Meyer WH, Parham DM, Rodeberg DA, Wolden SL, Donaldson SS. Treatment results for patients with localized, completely resected (Group I) alveolar rhabdomyosarcoma on Intergroup Rhabdomyosarcoma Study Group (IRSG) protocols III and IV, 1984-1997: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2010 Oct; 55(4):612-6. PMID: 20806360; PMCID: PMC3128801.
      View in: PubMed, PubMed Central
    7. La TH, Wolden SL, Rodeberg DA, Hawkins DS, Brown KL, Anderson JR, Donaldson SS. Regional nodal involvement and patterns of spread along in-transit pathways in children with rhabdomyosarcoma of the extremity: a report from the Children's Oncology Group. Int J Radiat Oncol Biol Phys. 2011 Jul 15; 80(4):1151-7. PMID: 20542386; PMCID: PMC3116031.
      View in: PubMed, PubMed Central
    8. Hassanin HA, Hannibal L, Jacobsen DW, Brown KL, Marques HM, Brasch NE. NMR spectroscopy and molecular modelling studies of nitrosylcobalamin: further evidence that the deprotonated, base-off form is important for nitrosylcobalamin in solution. Dalton Trans. 2009 Jan 21; (3):424-33. PMID: 19122899; PMCID: PMC2754767.
      View in: PubMed, PubMed Central
    9. Meyer JS, Nadel HR, Marina N, Womer RB, Brown KL, Eary JF, Gorlick R, Grier HE, Randall RL, Lawlor ER, Lessnick SL, Schomberg PJ, Kailo MD. Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee. Pediatr Blood Cancer. 2008 Aug; 51(2):163-70. PMID: 18454470.
      View in: PubMed
    10. Chandra T, Brown KL. Vitamin B(12) and alpha-Ribonucleosides. Tetrahedron. 2008 Jan 01; 64(1):9-38. PMID: 19122750.
      View in: PubMed
    11. Pichumani K, Zou X, Chandra T, Brown KL. Determination of the anomeric configuration in carbohydrates by longitudinal cross-correlated relaxation studies: application to mono- and disaccharides. Magn Reson Chem. 2007 Sep; 45(9):734-8. PMID: 17640033.
      View in: PubMed
    12. Chandra T, Brown KL. Chemoselective deprotection of alpha-indole and imidazole ribonucleosides. Nucleosides Nucleotides Nucleic Acids. 2007; 26(1):1-8. PMID: 17162582.
      View in: PubMed
    13. Brown KL, Li J, Zou X. NMR observations of 13C-enriched coenzyme B12 bound to the ribonucleotide reductase from Lactobacillus leichmannii. Inorg Chem. 2006 Nov 13; 45(23):9172-4. PMID: 17083212; PMCID: PMC2517903.
      View in: PubMed, PubMed Central
    14. Pinter JS, Brown KL, Deyoung PA, Peaslee GF. Amperometric detection of hydrazine by cyclic voltammetry and flow injection analysis using ruthenium modified glassy carbon electrodes. Talanta. 2007 Feb 28; 71(3):1219-25. PMID: 19071436.
      View in: PubMed
    15. Chandra T, Zou X, Valente EJ, Brown KL. Regio- and stereoselective glycosylation: synthesis of 5-haloimidazole alpha-ribonucleosides. J Org Chem. 2006 Jun 23; 71(13):5000-3. PMID: 16776534.
      View in: PubMed
    16. Brown KL. The enzymatic activation of coenzyme B12. Dalton Trans. 2006 Mar 07; (9):1123-33. PMID: 16482346.
      View in: PubMed
    17. Pichumani K, Chandra T, Zou X, Brown KL. Cross-correlated relaxation between H1' chemical shift anisotropy and H1'-H2' dipolar relaxation mechanisms in ribonucleosides: application to the characterization of their anomeric configuration. J Phys Chem B. 2006 Jan 12; 110(1):5-8. PMID: 16471486.
      View in: PubMed
    18. Brown KL. Chemistry and enzymology of vitamin B12. Chem Rev. 2005 Jun; 105(6):2075-149. PMID: 15941210.
      View in: PubMed
    19. Hamza MS, Zou X, Banka R, Brown KL, van Eldik R. Kinetic and thermodynamic studies on ligand substitution reactions and base-on/base-off equilibria of cyanoimidazolylcobamide, a vitamin B12 analog with an imidazole axial nucleoside. Dalton Trans. 2005 Feb 21; (4):782-7. PMID: 15702190.
      View in: PubMed
    20. Brown KL, Chandra T, Zou S, Valente EJ. Regioselective glycosylation: synthesis of alpha-indoline nucleosides. Nucleosides Nucleotides Nucleic Acids. 2005; 24(8):1147-65. PMID: 16270659; PMCID: PMC1383618.
      View in: PubMed, PubMed Central
    21. Brown KL, Zou X, Banka RR, Perry CB, Marques HM. Solution structure and thermolysis of Cobeta-5'-deoxyadenosylimidazolylcobamide, a coenzyme B12 analogue with an imidazole axial nucleoside. Inorg Chem. 2004 Dec 13; 43(25):8130-42. PMID: 15578853.
      View in: PubMed
    22. Brown KL, Zou X, Chen G, Xia Z, Marques HM. Solution structure, enzymatic, and non-enzymatic reactivity of 3-isoadenosylcobalamin, a structural isomer of coenzyme B12 with surprising coenzymic activity. J Inorg Biochem. 2004 Feb; 98(2):287-300. PMID: 14729309.
      View in: PubMed
    23. Fukuoka M, Yamada S, Miyoshi S, Yamashita K, Yamanishi M, Zou X, Brown KL, Toraya T. Functions of the D-ribosyl moiety and the lower axial ligand of the nucleotide loop of coenzyme B(12) in diol dehydratase and ethanolamine ammonia-lyase reactions. J Biochem. 2002 Dec; 132(6):935-43. PMID: 12473196.
      View in: PubMed
    24. Nahvi A, Sudarsan N, Ebert MS, Zou X, Brown KL, Breaker RR. Genetic control by a metabolite binding mRNA. Chem Biol. 2002 Sep; 9(9):1043. PMID: 12323379.
      View in: PubMed
    25. Brown KL, Cheng S, Zou X, Zubkowski JD, Valente EJ, Knapton L, Marques HM. Cis Effects in the Cobalt Corrins. 1. Crystal Structures of 10-Chloroaquacobalamin Perchlorate, 10-Chlorocyanocobalamin, and 10-Chloromethylcobalamin. Inorg Chem. 1997 Aug 13; 36(17):3666-3675. PMID: 11670058.
      View in: PubMed
    26. Brown KL, Zhao D, Cheng S, Zou X. Diastereomeric Control in the Formation of Carbon-Cobalt Bonds in Organocobalt Corrinoids: Reactions of Cobalt(II) Corrinoids with Organic Hydroperoxides(1). Inorg Chem. 1997 Apr 23; 36(9):1764-1771. PMID: 11669778.
      View in: PubMed
    27. Brown KL, Cheng S, Zubkowski JD, Valente EJ. Side Chain Entropy and the Activation of Organocobalamins for Carbon-Cobalt Bond Homolysis: Synthesis, Characterization, and Thermolysis of the Neopentyl Derivative of a Unique Cobalamin Analog Lacking a c Side Chain. Inorg Chem. 1997 Apr 23; 36(9):1772-1781. PMID: 11669779.
      View in: PubMed
    28. Brown KL, Cheng S, Zubkowski JD, Valente EJ. Synthesis and Characterization of a Novel Green Cobalt Corrinoid. Inorg Chem. 1996 Sep 11; 35(19):5752. PMID: 11666775.
      View in: PubMed
    29. Brown KL, Zhou L. Solvent Cage Effects in Organocobalt Corrinoid Chemistry: Thermal Homolysis of alpha- and beta-(Cyanomethyl)cobinamides(1). Inorg Chem. 1996 Aug 14; 35(17):5032-5039. PMID: 11666711.
      View in: PubMed
    30. Zou X, Zhao D, Brown KL. Organic Free Radical-Promoted Isomerization of alpha- and beta-Alkylcobinamides(1). Inorg Chem. 1996 Jun 19; 35(13):3815-3820. PMID: 11666569.
      View in: PubMed
    31. Brown KL, Cheng S, Zubkowski JD, Valente EJ. Synthesis and Characterization of a Novel Green Cobalt Corrinoid(1). Inorg Chem. 1996 May 22; 35(11):3442-3446. PMID: 11666553.
      View in: PubMed
    32. Brown KL, Evans DR, Zubkowski JD, Valente EJ. Heteronuclear NMR Studies of Cobalt Corrinoids. 18. Correlation of Structure and Magnetic Resonance Parameters in Base-On Cobalamins(1). Inorg Chem. 1996 Jan 17; 35(2):415-423. PMID: 11666223.
      View in: PubMed
    33. Brown KL, Evans DR, Cheng S, Jacobsen DW. Thermolysis of Neopentylcobalamin Analogs Complexed to Haptocorrin: Side Chain Entropy and Activation of Organocobalamins for Carbon-Cobalt Bond Homolysis. Inorg Chem. 1996 Jan 03; 35(1):217-222. PMID: 11666187.
      View in: PubMed
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