 Captopril
"Captopril" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
| Descriptor ID |
D002216
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| MeSH Number(s) |
D12.125.072.401.623.270
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| Concept/Terms |
Captopril- Captopril
- (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
SQ-14,534- SQ-14,534
- SQ 14,534
- SQ14,534
- SQ-14534
- SQ 14534
- SQ14534
SQ-14,225- SQ-14,225
- SQ 14,225
- SQ14,225
- SQ-14225
- SQ 14225
- SQ14225
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Below are MeSH descriptors whose meaning is more general than "Captopril".
Below are MeSH descriptors whose meaning is more specific than "Captopril".
This graph shows the total number of publications written about "Captopril" by people in this website by year, and whether "Captopril" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 1 | 0 | 1 | | 1981 | 0 | 1 | 1 | | 1983 | 1 | 0 | 1 | | 1984 | 1 | 0 | 1 | | 1991 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Captopril" by people in Profiles.
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Chitnis AS, Aparasu RR, Chen H, Johnson ML. Effect of certain angiotensin-converting enzyme inhibitors on mortality in heart failure: a multiple-propensity analysis. Res Social Adm Pharm. 2012 Mar-Apr; 8(2):145-56.
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Chow GK, Streem SB. Medical treatment of cystinuria: results of contemporary clinical practice. J Urol. 1996 Nov; 156(5):1576-8.
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Chen CJ, Apparsundaram S, Lokhandwala MF. Intrarenally produced angiotensin II opposes the natriuretic action of the dopamine-1 receptor agonist fenoldopam in rats. J Pharmacol Exp Ther. 1991 Feb; 256(2):486-91.
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Eikenburg DC. Effects of captopril on vascular noradrenergic transmission in SHR. Hypertension. 1984 Sep-Oct; 6(5):660-5.
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Eikenburg DC, Lokhandwala MF. Effects of captopril on vascular noradrenergic transmission during the development of two-kidney, one clip Goldblatt hypertension in rats. J Hypertens. 1983 Aug; 1(2):115-22.
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Ljung B, Jandhyala B, Kjellstedt A. Angiotensin I converting enzyme activity in portal vein studied in normotensive rats and in models of primary and secondary hypertension. Acta Physiol Scand. 1981 Apr; 111(4):409-16.
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Hamed AT, Lokhandwala MF, Buckley JP, Jandhyala BS. Relationship between plasma renin activity and hypotensive effect of captopril in dogs. Res Commun Chem Pathol Pharmacol. 1980 May; 28(2):195-204.
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Jandhyala BS, Nandiwada P, Buckley JP, Lokhandwala MF. Studies on the mechanism of the hypotensive action of SQ-14225, an angiotensin-converting enzyme inhibitor in anesthetized dogs. Res Commun Chem Pathol Pharmacol. 1979 Sep; 25(3):429-46.
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