 Chlorpromazine
"Chlorpromazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
| Descriptor ID |
D002746
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| MeSH Number(s) |
D02.886.369.198 D03.494.741.198
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Chlorpromazine".
Below are MeSH descriptors whose meaning is more specific than "Chlorpromazine".
This graph shows the total number of publications written about "Chlorpromazine" by people in this website by year, and whether "Chlorpromazine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2011 | 0 | 2 | 2 |
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Below are the most recent publications written about "Chlorpromazine" by people in Profiles.
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Bola JR, Kao DT, Soydan H. Antipsychotic medication for early-episode schizophrenia. Schizophr Bull. 2012 Jan; 38(1):23-5.
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Bola J, Kao D, Soydan H. Antipsychotic medication for early episode schizophrenia. Cochrane Database Syst Rev. 2011 Jun 15; (6):CD006374.
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Koka S, Lang C, Boini KM, Bobbala D, Huber SM, Lang F. Influence of chlorpromazine on eryptosis, parasitemia and survival of Plasmodium berghe infected mice. Cell Physiol Biochem. 2008; 22(1-4):261-8.
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Hoo JJ, Noldt P, Beckermann WJ, Agarwal DP, Goedde HW. In vitro effect of haloperidol, chlorpromazine, imipramine and lithium on the erythrocyte catechol-O-methyltransferase. Arzneimittelforschung. 1982; 32(6):681-3.
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Jurtshuk P, May AK, Pope LM, Aston PR. Comparative studies on succinate and terminal oxidase activity in microbial and mammalian electron-transport systems. Can J Microbiol. 1969 Jul; 15(7):797-807.
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Jurtshuk P, Bednarz AJ, Zey P, Denton CH. L-malate oxidation by the electron transport fraction of Azotobacter vinelandii. J Bacteriol. 1969 Jun; 98(3):1120-7.
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Jurtshuk P, Harper L. Oxidation of D(minus) lactate by the electron transport fraction of Azotobacter vinelandii. J Bacteriol. 1968 Sep; 96(3):678-86.
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KOHL HH, BRUNE GG, HIMWICH HE. A COMPARATIVE STUDY OF CHLORPROMAZINE AND ITS DEMETHYLATED DERIVATIVES: POTENCY AND TISSUE DISTRIBUTION. Biochem Pharmacol. 1964 Mar; 13:539-41.
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BRUNE GG, KOHL HH, STEINER WG, HIMWICH HE. Relevance of the N,N-dimethyl configuration to the pharmacological action of chlorpromazine. Biochem Pharmacol. 1963 Jul; 12:679-85.
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