Phenytoin
"Phenytoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Descriptor ID |
D010672
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MeSH Number(s) |
D03.383.129.308.432.555.730
|
Concept/Terms |
Phenytoin- Phenytoin
- Diphenylhydantoin
- Fenitoin
- 5,5-Diphenylhydantoin
Phenytoin Sodium- Phenytoin Sodium
- Sodium Diphenylhydantoinate
- Diphenylhydantoinate, Sodium
Epamin- Epamin
- Phizer Brand of Phenytoin
- Phenytoin Phizer Brand
Epanutin- Epanutin
- Pfizer Brand of Phenytoin
- Phenytoin Pfizer Brand
Dilantin- Dilantin
- Park Davis brand of Phenytoin
|
Below are MeSH descriptors whose meaning is more general than "Phenytoin".
Below are MeSH descriptors whose meaning is more specific than "Phenytoin".
This graph shows the total number of publications written about "Phenytoin" by people in this website by year, and whether "Phenytoin" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1980 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phenytoin" by people in Profiles.
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Wong GK, Poon WS. Use of phenytoin and other anticonvulsant prophylaxis in patients with aneurysmal subarachnoid hemorrhage. Stroke. 2005 Dec; 36(12):2532; author reply 2532.
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Otoom SA, Alkadhi KA. Epileptiform activity of veratridine model in rat brain slices: effects of antiepileptic drugs. Epilepsy Res. 2000 Feb; 38(2-3):161-70.
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Nautsch JP, Rolf LH, Brune GG. A rapid gas liquid chromatography method for simultaneous determination of various anticonvulsants. J Neurol. 1980; 223(3):219-23.
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Matz DR, Rolf LH, Brune GG. Serotonin metabolism with idiopathic grand mal seizures. J Neurol. 1978 Dec 22; 219(4):283-7.