Picrotoxin
"Picrotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
| Descriptor ID |
D010852
|
| MeSH Number(s) |
D02.455.426.392.368.367.800 D02.540.552
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Picrotoxin".
Below are MeSH descriptors whose meaning is more specific than "Picrotoxin".
This graph shows the total number of publications written about "Picrotoxin" by people in this website by year, and whether "Picrotoxin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Picrotoxin" by people in Profiles.
-
Birnbaum AD, Rohde SK, Qian H, Al-Ubaidi MR, Caldwell JH, Malchow RP. Cloning, immunolocalization, and functional expression of a GABA transporter from the retina of the skate. Vis Neurosci. 2005 Mar-Apr; 22(2):211-23.
-
Rangaswamy NV, Hood DC, Frishman LJ. Regional variations in local contributions to the primate photopic flash ERG: revealed using the slow-sequence mfERG. Invest Ophthalmol Vis Sci. 2003 Jul; 44(7):3233-47.
-
Frishman LJ, Linsenmeier RA. Effects of picrotoxin and strychnine on non-linear responses of Y-type cat retinal ganglion cells. J Physiol. 1982 Mar; 324:347-63.