 Buthionine Sulfoximine
"Buthionine Sulfoximine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
| Descriptor ID |
D019328
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| MeSH Number(s) |
D02.886.030.676.620.125 D12.125.166.676.620.125
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Buthionine Sulfoximine".
Below are MeSH descriptors whose meaning is more specific than "Buthionine Sulfoximine".
This graph shows the total number of publications written about "Buthionine Sulfoximine" by people in this website by year, and whether "Buthionine Sulfoximine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Buthionine Sulfoximine" by people in Profiles.
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Bhatt SR, Lokhandwala MF, Banday AA. Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B. Clin Exp Hypertens. 2014; 36(6):367-73.
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Allam F, Dao AT, Chugh G, Bohat R, Jafri F, Patki G, Mowrey C, Asghar M, Alkadhi KA, Salim S. Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats. J Nutr. 2013 Jun; 143(6):835-42.
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Banday AA, Lokhandwala MF. Oxidative stress causes renal angiotensin II type 1 receptor upregulation, Na+/H+ exchanger 3 overstimulation, and hypertension. Hypertension. 2011 Mar; 57(3):452-9.
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Salim S, Sarraj N, Taneja M, Saha K, Tejada-Simon MV, Chugh G. Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats. Behav Brain Res. 2010 Apr 02; 208(2):545-52.
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Banday AA, Lokhandwala MF. Inhibition of natriuretic factors increases blood pressure in rats. Am J Physiol Renal Physiol. 2009 Aug; 297(2):F397-402.
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Banday AA, Lokhandwala MF. Loss of biphasic effect on Na/K-ATPase activity by angiotensin II involves defective angiotensin type 1 receptor-nitric oxide signaling. Hypertension. 2008 Dec; 52(6):1099-105.
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Banday AA, Lokhandwala MF. Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F698-706.
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Banday AA, Lau YS, Lokhandwala MF. Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley rats. Hypertension. 2008 Feb; 51(2):367-75.
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Banday AA, Fazili FR, Lokhandwala MF. Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C. J Am Soc Nephrol. 2007 May; 18(5):1446-57.
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