 P-Glycoprotein
"P-Glycoprotein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
| Descriptor ID |
D020168
|
| MeSH Number(s) |
D12.776.157.530.100.652.500 D12.776.157.530.450.074.500.500.750 D12.776.395.550.020.610.610 D12.776.543.550.192.610.610 D12.776.543.585.100.610.500 D12.776.543.585.450.074.500.500.750
|
| Concept/Terms |
P-Glycoprotein- P-Glycoprotein
- P Glycoprotein
- PGY-1 Protein
- PGY 1 Protein
- Multidrug Resistance Protein 1
- ATP-Binding Cassette, Sub-Family B, Member 1
- P-gp
- MDR1 Protein
|
Below are MeSH descriptors whose meaning is more general than "P-Glycoprotein".
Below are MeSH descriptors whose meaning is more specific than "P-Glycoprotein".
This graph shows the total number of publications written about "P-Glycoprotein" by people in this website by year, and whether "P-Glycoprotein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "P-Glycoprotein" by people in Profiles.
-
Chai L, McLaren RP, Byrne A, Chuang WL, Huang Y, Dufault MR, Pacheco J, Madhiwalla S, Zhang X, Zhang M, Teicher BA, Carter K, Cheng SH, Leonard JP, Xiang Y, Vasconcelles M, Goldberg MA, Copeland DP, Klinger KW, Lillie J, Madden SL, Jiang YA. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int J Oncol. 2011 Mar; 38(3):701-11.
-
Lötsch J, Schmidt R, Vetter G, Schmidt H, Niederberger E, Geisslinger G, Tegeder I. Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein. J Neurochem. 2002 Oct; 83(2):241-8.
-
Nair RR, Rodgers JR, Schwarz LA. Enhancement of transgene expression by combining glucocorticoids and anti-mitotic agents during transient transfection using DNA-cationic liposomes. Mol Ther. 2002 Apr; 5(4):455-62.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|