 Tacrolimus Binding Protein 1A
"Tacrolimus Binding Protein 1A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl cis/trans isomerase which is inhibited by both tacrolimus (commonly called FK506) and SIROLIMUS.
| Descriptor ID |
D022061
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| MeSH Number(s) |
D08.811.399.325.500.400.700.500 D12.776.543.750.705.400.700.500 D12.776.827.275.700.500
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| Concept/Terms |
Tacrolimus Binding Protein 1A- Tacrolimus Binding Protein 1A
- Macrophilin-12
- Macrophilin 12
- FKBP-12
- FKBP 12
- FKBP12
- FK506-Binding Protein 1
- FK506 Binding Protein 1
- FK506-Binding Protein 1A
- FK506 Binding Protein 1A
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Below are MeSH descriptors whose meaning is more general than "Tacrolimus Binding Protein 1A".
Below are MeSH descriptors whose meaning is more specific than "Tacrolimus Binding Protein 1A".
This graph shows the total number of publications written about "Tacrolimus Binding Protein 1A" by people in this website by year, and whether "Tacrolimus Binding Protein 1A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 2 | 0 | 2 | | 2009 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tacrolimus Binding Protein 1A" by people in Profiles.
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Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. J Biol Chem. 2014 Sep 12; 289(37):25556-70.
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Shor B, Cavender D, Harris C. A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice. BMC Immunol. 2009 May 20; 10:28.
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Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E. Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron. 2008 Dec 10; 60(5):832-45.
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Shor B, Zhang WG, Toral-Barza L, Lucas J, Abraham RT, Gibbons JJ, Yu K. A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis. Cancer Res. 2008 Apr 15; 68(8):2934-43.
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