 Cyclin-Dependent Kinase Inhibitor p27
"Cyclin-Dependent Kinase Inhibitor p27" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
| Descriptor ID |
D050760
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| MeSH Number(s) |
D12.644.360.225.600 D12.776.167.187.600 D12.776.476.225.600 D12.776.624.776.355.600
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| Concept/Terms |
Cyclin-Dependent Kinase Inhibitor p27- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin Dependent Kinase Inhibitor p27
- CDKN4 Protein
- p27 Kip1 Protein
- Kip1 Protein, p27
- Cyclin-Dependent Kinase Inhibitor 1B
- Cyclin Dependent Kinase Inhibitor 1B
- CDKN1B Protein
- p27Kip1 Protein
- CDK Inhibitor p27
- p27, CDK Inhibitor
- p27 CDK Inhibitor
- CDK Inhibitor, p27
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Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p27".
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This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p27" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor p27" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p27" by people in Profiles.
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Tang L, Wang Y, Strom A, Gustafsson JÅ, Guan X. Lapatinib induces p27(Kip1)-dependent G1 arrest through both transcriptional and post-translational mechanisms. Cell Cycle. 2013 Aug 15; 12(16):2665-74.
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Gray MC, Hewlett EL. Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Cell Microbiol. 2011 Jan; 13(1):123-34.
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DiMichele LA, Hakim ZS, Sayers RL, Rojas M, Schwartz RJ, Mack CP, Taylor JM. Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth. Circ Res. 2009 May 22; 104(10):1201-8.
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Kukoski R, Blonigen B, Macri E, Renshaw AA, Hoffman M, Loda M, Datta MW. p27 and cyclin E/D2 associations in testicular germ cell tumors: implications for tumorigenesis. Appl Immunohistochem Mol Morphol. 2003 Jun; 11(2):138-43.
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Chakravarthy MV, Fiorotto ML, Schwartz RJ, Booth FW. Long-term insulin-like growth factor-I expression in skeletal muscles attenuates the enhanced in vitro proliferation ability of the resident satellite cells in transgenic mice. Mech Ageing Dev. 2001 Sep; 122(12):1303-20.
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Chakravarthy MV, Abraha TW, Schwartz RJ, Fiorotto ML, Booth FW. Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway. J Biol Chem. 2000 Nov 17; 275(46):35942-52.
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