 Survival of Motor Neuron 1 Protein
"Survival of Motor Neuron 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.
| Descriptor ID |
D055533
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| MeSH Number(s) |
D12.776.157.725.875.500 D12.776.580.922.500 D12.776.664.962.875.500
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| Concept/Terms |
Survival of Motor Neuron 1 Protein- Survival of Motor Neuron 1 Protein
- Survival Motor Neuron Protein 1
- Survival of Motor Neuron 1, Telomeric Protein
- SMN Protein (Spinal Muscular Atrophy)
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Below are MeSH descriptors whose meaning is more general than "Survival of Motor Neuron 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Survival of Motor Neuron 1 Protein".
This graph shows the total number of publications written about "Survival of Motor Neuron 1 Protein" by people in this website by year, and whether "Survival of Motor Neuron 1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Survival of Motor Neuron 1 Protein" by people in Profiles.
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Rietz A, Li H, Quist KM, Cherry JJ, Lorson CL, Burnett BG, Kern NL, Calder AN, Fritsche M, Lusic H, Boaler PJ, Choi S, Xing X, Glicksman MA, Cuny GD, Androphy EJ, Hodgetts KJ. Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2017 Jun 08; 60(11):4594-4610.
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Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. EMBO Mol Med. 2013 Jul; 5(7):1103-18.
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Cherry JJ, Evans MC, Ni J, Cuny GD, Glicksman MA, Androphy EJ. Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay. J Biomol Screen. 2012 Apr; 17(4):481-95.
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