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William Widger

TitleProfessor
InstitutionUniversity of Houston
DepartmentBiology
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-8368
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    R01GM046297     (WIDGER, WILLIAM R)Jul 6, 1991 - Jun 30, 1995
    NIH/NIGMS
    GENOMIC ORGANIZATION OF PHOTOSYNTHETIC GENES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mali S, Mitchell M, Havis S, Bodunrin A, Rangel J, Olson G, Widger WR, Bark SJ. A Proteomic Signature of Dormancy in the Actinobacterium Micrococcus luteus. J Bacteriol. 2017 Jul 15; 199(14). PMID: 28484042.
      View in: PubMed
    2. Albayrak L, Khanipov K, Pimenova M, Golovko G, Rojas M, Pavlidis I, Chumakov S, Aguilar G, Chávez A, Widger WR, Fofanov Y. The ability of human nuclear DNA to cause false positive low-abundance heteroplasmy calls varies across the mitochondrial genome. BMC Genomics. 2016 Dec 12; 17(1):1017. PMID: 27955616.
      View in: PubMed
    3. Mali S, Moree WJ, Mitchell M, Widger W, Bark SJ. Observations on different resin strategies for affinity purification mass spectrometry of a tagged protein. Anal Biochem. 2016 Dec 15; 515:26-32. PMID: 27693234.
      View in: PubMed
    4. Redis RS, Vela LE, Lu W, Ferreira de Oliveira J, Ivan C, Rodriguez-Aguayo C, Adamoski D, Pasculli B, Taguchi A, Chen Y, Fernandez AF, Valledor L, Van Roosbroeck K, Chang S, Shah M, Kinnebrew G, Han L, Atlasi Y, Cheung LH, Huang GY, Monroig P, Ramirez MS, Catela Ivkovic T, Van L, Ling H, Gafà R, Kapitanovic S, Lanza G, Bankson JA, Huang P, Lai SY, Bast RC, Rosenblum MG, Radovich M, Ivan M, Bartholomeusz G, Liang H, Fraga MF, Widger WR, Hanash S, Berindan-Neagoe I, Lopez-Berestein G, Ambrosio ALB, Gomes Dias SM, Calin GA. Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2. Mol Cell. 2016 Feb 18; 61(4):640. PMID: 28934601.
      View in: PubMed
    5. Redis RS, Vela LE, Lu W, Ferreira de Oliveira J, Ivan C, Rodriguez-Aguayo C, Adamoski D, Pasculli B, Taguchi A, Chen Y, Fernandez AF, Valledor L, Van Roosbroeck K, Chang S, Shah M, Kinnebrew G, Han L, Atlasi Y, Cheung LH, Huang GY, Monroig P, Ramirez MS, Catela Ivkovic T, Van L, Ling H, Gafà R, Kapitanovic S, Lanza G, Bankson JA, Huang P, Lai SY, Bast RC, Rosenblum MG, Radovich M, Ivan M, Bartholomeusz G, Liang H, Fraga MF, Widger WR, Hanash S, Berindan-Neagoe I, Lopez-Berestein G, Ambrosio ALB, Gomes Dias SM, Calin GA. Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2. Mol Cell. 2016 Feb 18; 61(4):520-534. PMID: 26853146; PMCID: PMC4982398 [Available on 02/18/17].
      View in: PubMed, PubMed Central
    6. Miller AL, Geng C, Golovko G, Sharma M, Schwartz JR, Yan J, Sowers L, Widger WR, Fofanov Y, Vedeckis WV, Thompson EB. Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to glucocorticoids in dexamethasone-resistant human malignant lymphoid cells. Cancer Cell Int. 2014; 14:35. PMID: 24795534; PMCID: PMC4008436.
      View in: PubMed, PubMed Central
    7. Golovko G, Khanipov K, Rojas M, Martinez-Alcántara A, Howard JJ, Ballesteros E, Gupta S, Widger W, Fofanov Y. Slim-filter: an interactive Windows-based application for illumina genome analyzer data assessment and manipulation. BMC Bioinformatics. 2012 Jul 16; 13:166. PMID: 22800377; PMCID: PMC3505481.
      View in: PubMed, PubMed Central
    8. Zhou Y, Tozzi F, Chen J, Fan F, Xia L, Wang J, Gao G, Zhang A, Xia X, Brasher H, Widger W, Ellis LM, Weihua Z. Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. Cancer Res. 2012 Jan 01; 72(1):304-14. PMID: 22084398; PMCID: PMC3601736.
      View in: PubMed, PubMed Central
    9. Fang J, Palanisami A, Rajapakshe K, Widger WR, Miller JH. Nonlinear dielectric spectroscopy as an indirect probe of metabolic activity in thylakoid membrane. Biosensors (Basel). 2011 Jan 31; 1(1):13-22. PMID: 25586698; PMCID: PMC4264345.
      View in: PubMed, PubMed Central
    10. Bacsi A, Woodberry M, Widger W, Papaconstantinou J, Mitra S, Peterson JW, Boldogh I. Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells. Mitochondrion. 2006 Oct; 6(5):235-44. PMID: 17011837; PMCID: PMC3031911.
      View in: PubMed, PubMed Central
    11. Nawarathna D, Claycomb JR, Cardenas G, Gardner J, Warmflash D, Miller JH, Widger WR. Harmonic generation by yeast cells in response to low-frequency electric fields. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 May; 73(5 Pt 1):051914. PMID: 16802974.
      View in: PubMed
    12. Park BS, Widger W, Kohn H. Fluorine-substituted dihydrobicyclomycins: synthesis and biochemical and biological properties. Bioorg Med Chem. 2006 Jan 01; 14(1):41-61. PMID: 16185879.
      View in: PubMed
    13. Kohn H, Widger W. The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord. 2005 Sep; 5(3):273-95. PMID: 16181146.
      View in: PubMed
    14. Brogan AP, Widger WR, Bensadek D, Riba-Garcia I, Gaskell SJ, Kohn H. Development of a technique to determine bicyclomycin-rho binding and stoichiometry by isothermal titration calorimetry and mass spectrometry. J Am Chem Soc. 2005 Mar 02; 127(8):2741-51. PMID: 15725032.
      View in: PubMed
    15. Brogan AP, Verghese J, Widger WR, Kohn H. Bismuth-dithiol inhibition of the Escherichia coli rho transcription termination factor. J Inorg Biochem. 2005 Mar; 99(3):841-51. PMID: 15708806.
      View in: PubMed
    16. Ohnishi T, Johnson JE, Yano T, Lobrutto R, Widger WR. Thermodynamic and EPR studies of slowly relaxing ubisemiquinone species in the isolated bovine heart complex I. FEBS Lett. 2005 Jan 17; 579(2):500-6. PMID: 15642366.
      View in: PubMed
    17. Choksi KB, Boylston WH, Rabek JP, Widger WR, Papaconstantinou J. Oxidatively damaged proteins of heart mitochondrial electron transport complexes. Biochim Biophys Acta. 2004 Mar 02; 1688(2):95-101. PMID: 14990339.
      View in: PubMed
    18. Johnson JE, Choksi K, Widger WR. NADH-Ubiquinone oxidoreductase: substrate-dependent oxygen turnover to superoxide anion as a function of flavin mononucleotide. Mitochondrion. 2003 Oct; 3(2):97-110. PMID: 16120348.
      View in: PubMed
    19. Weber TP, Widger WR, Kohn H. Metal-1,4-dithio-2,3-dihydroxybutane chelates: novel inhibitors of the Rho transcription termination factor. Biochemistry. 2003 Aug 05; 42(30):9121-6. PMID: 12885245.
      View in: PubMed
    20. Brogan AP, Widger WR, Kohn H. Bicyclomycin fluorescent probes: synthesis and biochemical, biophysical, and biological properties. J Org Chem. 2003 Jul 11; 68(14):5575-87. PMID: 12839449.
      View in: PubMed
    21. Weber TP, Widger WR, Kohn H. Metal dependency for transcription factor rho activation. Biochemistry. 2003 Feb 18; 42(6):1652-9. PMID: 12578379.
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    22. Xu Y, Johnson J, Kohn H, Widger WR. ATP binding to Rho transcription termination factor. Mutant F355W ATP-induced fluorescence quenching reveals dynamic ATP binding. J Biol Chem. 2003 Apr 18; 278(16):13719-27. PMID: 12551938.
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    23. Martin KA, Siefert JL, Yerrapragada S, Lu Y, McNeill TZ, Moreno PA, Weinstock GM, Widger WR, Fox GE. Cyanobacterial signature genes. Photosynth Res. 2003; 75(3):211-21. PMID: 16228602.
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    24. Weber TP, Widger WR, Kohn H. The Mg2+ requirements for rho transcription termination factor: catalysis and bicyclomycin inhibition. Biochemistry. 2002 Oct 15; 41(41):12377-83. PMID: 12369827.
      View in: PubMed
    25. Xu Y, Kohn H, Widger WR. Mutations in the rho transcription termination factor that affect RNA tracking. J Biol Chem. 2002 Aug 16; 277(33):30023-30. PMID: 12034708.
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    26. Vincent F, Srinivasan J, Santillán A, Widger WR, Kohn H. C(5)-C(5a)-modified bicyclomycins: synthesis, structure, and biochemical and biological properties. J Org Chem. 2001 Apr 06; 66(7):2251-64. PMID: 11281764.
      View in: PubMed
    27. Vincent F, Widger WR, Openshaw M, Gaskell SJ, Kohn H. 5a-formylbicyclomycin: studies on the bicyclomycin-Rho interaction. Biochemistry. 2000 Aug 08; 39(31):9067-76. PMID: 10924099.
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    28. Vincent F, Openshaw M, Trautwein M, Gaskell SJ, Kohn H, Widger WR. Rho transcription factor: symmetry and binding of bicyclomycin. Biochemistry. 2000 Aug 08; 39(31):9077-83. PMID: 10924100.
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    29. Magyar A, Zhang X, Abdi F, Kohn H, Widger WR. Identifying the bicyclomycin binding domain through biochemical analysis of antibiotic-resistant rho proteins. J Biol Chem. 1999 Mar 12; 274(11):7316-24. PMID: 10066795.
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    30. Riba I, Gaskell SJ, Cho H, Widger WR, Kohn H. Evidence for the location of bicyclomycin binding to the Escherichia coli transcription termination factor Rho. J Biol Chem. 1998 Dec 18; 273(51):34033-41. PMID: 9852059.
      View in: PubMed
    31. Samartzidou H, Widger WR. Transcriptional and posttranscriptional control of mRNA from lrtA, a light-repressed transcript in Synechococcus sp. PCC 7002. Plant Physiol. 1998 May; 117(1):225-34. PMID: 9576792; PMCID: PMC35007.
      View in: PubMed, PubMed Central
    32. Santillán A, Zhang X, Hardesty J, Widger WR, Kohn H. Role of the C(6)-hydroxy group in bicyclomycin: synthesis, structure, and chemical, biochemical, and biological properties. J Med Chem. 1998 Mar 26; 41(7):1185-94. PMID: 9544218.
      View in: PubMed
    33. Siefert JL, Martin KA, Abdi F, Widger WR, Fox GE. Conserved gene clusters in bacterial genomes provide further support for the primacy of RNA. J Mol Evol. 1997 Nov; 45(5):467-72. PMID: 9342394.
      View in: PubMed
    34. Zhang Z, Zhang X, Widger WR, Kohn H. Role of the C(5)-C(5a) Exomethylene Group in Bicyclomycin: Synthesis, Structure, and Biochemical and Biological Properties. J Org Chem. 1996 Nov 01; 61(22):7764-7776. PMID: 11667732.
      View in: PubMed
    35. Zhang X, Widger WR, Kohn H. Role of the C(1) Triol Group in Bicyclomycin: Synthesis and Biochemical and Biological Properties. J Org Chem. 1996 Nov 01; 61(22):7750-7755. PMID: 11667730.
      View in: PubMed
    36. Santillán A, Zhang X, Lee OS, Widger WR, Kohn H. Role of the [4.2.2] Bicyclic Unit in Bicyclomycin: Synthesis, Structure, Chemical, Biochemical, and Biological Properties. J Org Chem. 1996 Nov 01; 61(22):7756-7763. PMID: 11667731.
      View in: PubMed
    37. Magyar A, Zhang X, Kohn H, Widger WR. The antibiotic bicyclomycin affects the secondary RNA binding site of Escherichia coli transcription termination factor Rho. J Biol Chem. 1996 Oct 11; 271(41):25369-74. PMID: 8810302.
      View in: PubMed
    38. Park HG, Zhang X, Moon HS, Zwiefka A, Cox K, Gaskell SJ, Widger WR, Kohn H. Bicyclomycin and dihydrobicyclomycin inhibition kinetics of Escherichia coli rho-dependent transcription termination factor ATPase activity. Arch Biochem Biophys. 1995 Nov 10; 323(2):447-54. PMID: 7487110.
      View in: PubMed
    39. Tan X, Varughese M, Widger WR. A light-repressed transcript found in Synechococcus PCC 7002 is similar to a chloroplast-specific small subunit ribosomal protein and to a transcription modulator protein associated with sigma 54. J Biol Chem. 1994 Aug 19; 269(33):20905-12. PMID: 8063707.
      View in: PubMed
    40. Chen X, Widger WR. Physical genome map of the unicellular cyanobacterium Synechococcus sp. strain PCC 7002. J Bacteriol. 1993 Aug; 175(16):5106-16. PMID: 8349551; PMCID: PMC204977.
      View in: PubMed, PubMed Central
    41. Zwiefka A, Kohn H, Widger WR. Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli. Biochemistry. 1993 Apr 13; 32(14):3564-70. PMID: 8466900.
      View in: PubMed
    42. Brand SN, Tan X, Widger WR. Cloning and sequencing of the petBD operon from the cyanobacterium Synechococcus sp. PCC 7002. Plant Mol Biol. 1992 Nov; 20(3):481-91. PMID: 1421151.
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    43. Widger WR. The cloning and sequencing of Synechococcus sp. PCC 7002 petCA operon: Implications for the cytochrome c-553 binding domain of cytochrome f. Photosynth Res. 1991 Dec; 30(2-3):71-84. PMID: 24415256.
      View in: PubMed
    44. Shiver JW, Peterson AA, Widger WR, Furbacher PN, Cramer WA. Prediction of bilayer spanning domains of hydrophobic and amphipathic membrane proteins: application to the cytochrome b and colicin families. Methods Enzymol. 1989; 172:439-61. PMID: 2747538.
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    45. Black MT, Meyer D, Widger WR, Cramer WA. Light-regulated methylation of chloroplast proteins. J Biol Chem. 1987 Jul 15; 262(20):9803-7. PMID: 3597439.
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    46. Black MT, Widger WR, Cramer WA. Large-scale purification of active cytochrome b6/f complex from spinach chloroplasts. Arch Biochem Biophys. 1987 Feb 01; 252(2):655-61. PMID: 3813555.
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    47. Cramer WA, Theg SM, Widger WR. On the structure and function of cytochrome b-559. Photosynth Res. 1986 Jan; 10(3):393-403. PMID: 24435387.
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    48. Babcock GT, Widger WR, Cramer WA, Oertling WA, Metz JG. Axial ligands of chloroplast cytochrome b-559: identification and requirement for a heme-cross-linked polypeptide structure. Biochemistry. 1985 Jul 02; 24(14):3638-45. PMID: 2994713.
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    49. Sahl HG, Grossgarten M, Widger WR, Cramer WA, Brandis H. Structural similarities of the staphylococcin-like peptide Pep-5 to the peptide antibiotic nisin. Antimicrob Agents Chemother. 1985 May; 27(5):836-40. PMID: 4015073; PMCID: PMC180162.
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    50. Westhoff P, Alt J, Widger WR, Cramer WA, Herrmann RG. Localization of the gene for apocytochromeb-559 on the plastid chromosome of spinach. Plant Mol Biol. 1985 Mar; 4(2-3):103-10. PMID: 24310746.
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    51. Widger WR, Farchaus JW, Cramer WA, Dilley RA. Studies on the relation of the Mr 9000 phosphoprotein to cytochrome b-559 in spinach thylakoid membranes. Arch Biochem Biophys. 1984 Aug 15; 233(1):72-9. PMID: 6465904.
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    52. Widger WR, Cramer WA, Hermodson M, Meyer D, Gullifor M. Purification and partial amino acid sequence of the chloroplast cytochrome b-559. J Biol Chem. 1984 Mar 25; 259(6):3870-6. PMID: 6706983.
      View in: PubMed
    53. Widger WR, Cramer WA, Herrmann RG, Trebst A. Sequence homology and structural similarity between cytochrome b of mitochondrial complex III and the chloroplast b6-f complex: position of the cytochrome b hemes in the membrane. Proc Natl Acad Sci U S A. 1984 Feb; 81(3):674-8. PMID: 6322162; PMCID: PMC344897.
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    54. Farchaus JW, Widger WR, Cramer WA, Dilley RA. Kinase-induced changes in electron transport rates of spinach chloroplasts. Arch Biochem Biophys. 1982 Aug; 217(1):362-7. PMID: 7125674.
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    55. Millner PA, Widger WR, Abbott MS, Cramer WA, Dilley RA. The effect of adenine nucleotides on inhibition of the thylakoid protein kinase by sulfhydryl-directed reagents. J Biol Chem. 1982 Feb 25; 257(4):1736-42. PMID: 7056741.
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    56. Ragan CI, Widger WR. The reconstitution of the mitochondrial energy-linked transhydrogenase. Biochem Biophys Res Commun. 1975 Feb 03; 62(3):744-9. PMID: 235261.
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    57. Ragan CI, Widger WR, King TE. Pyridine nucleotide transhydrogenase activity of soluble cardiac NADH dehydrogenase and particulate NADH-ubiquinone reductase. Biochem Biophys Res Commun. 1974 Oct 08; 60(3):894-900. PMID: 4154747.
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