Peter Vekilov
Title | Professor |
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Institution | University of Houston |
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Department | Chemical Engineering |
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Address | 4800 Calhoun Rd Houston TX 77004
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Phone | 713-743-4315 |
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vCard | Download vCard |
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Research R01HL058038 (VEKILOV, PETER G)Jan 1, 1998 - Dec 31, 2001 NIH/NHLBI CONTROL OF PROTEIN NUCLEATION AND CRYSTALLITE GROWTH Role: Principal Investigator |
| U01HL114476 (KARNIADAKIS, GEORGE)Sep 1, 2013 - May 31, 2018 NIH/NHLBI Multiscale Modeling of Sickle Cell Anemia: Methods and Validation Role: Co-Principal Investigator |
| R21AI126215 (VEKILOV, PETER G)Jun 16, 2016 - May 31, 2018 NIH/NIAID Hematin crystallization in Plasmodium parasites Role: Principal Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Safari MS, Byington MC, Conrad JC, Vekilov PG. Polymorphism of Lysozyme Condensates. J Phys Chem B. 2017 Sep 25. PMID: 28881129.
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Safari MS, Poling-Skutvik R, Vekilov PG, Conrad JC. Differential dynamic microscopy of bidisperse colloidal suspensions. NPJ Microgravity. 2017; 3:21. PMID: 28868354.
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Olafson KN, Nguyen TQ, Vekilov PG, Rimer JD. Deconstructing Quinoline-Class Antimalarials to Identify Fundamental Physicochemical Properties of Beta-Hematin Crystal Growth Inhibitors. Chemistry. 2017 Aug 21. PMID: 28833627.
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Yamazaki T, Kimura Y, Vekilov PG, Furukawa E, Shirai M, Matsumoto H, Van Driessche AE, Tsukamoto K. Two types of amorphous protein particles facilitate crystal nucleation. Proc Natl Acad Sci U S A. 2017 Feb 28; 114(9):2154-2159. PMID: 28193873.
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Vorontsova MA, Vekilov PG, Maes D. Characterization of the diffusive dynamics of particles with time-dependent asymmetric microscopy intensity profiles. Soft Matter. 2016 Aug 17; 12(33):6926-36. PMID: 27489111.
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Byington MC, Safari MS, Conrad JC, Vekilov PG. Protein Conformational Flexibility Enables the Formation of Dense Liquid Clusters: Tests Using Solution Shear. J Phys Chem Lett. 2016 Jul 07; 7(13):2339-45. PMID: 27267087.
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Rittikulsittichai S, Kolhatkar AG, Sarangi S, Vorontsova MA, Vekilov PG, Brazdeikis A, Randall Lee T. Multi-responsive hybrid particles: thermo-, pH-, photo-, and magneto-responsive magnetic hydrogel cores with gold nanorod optical triggers. Nanoscale. 2016 Jun 09; 8(23):11851-61. PMID: 27227963.
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Lu L, Li X, Vekilov PG, Karniadakis GE. Probing the Twisted Structure of Sickle Hemoglobin Fibers via Particle Simulations. Biophys J. 2016 May 10; 110(9):2085-93. PMID: 27166816; PMCID: PMC4940994 [Available on 05/10/17].
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Vorontsova MA, Chan HY, Lubchenko V, Vekilov PG. Lack of Dependence of the Sizes of the Mesoscopic Protein Clusters on Electrostatics. Biophys J. 2015 Nov 03; 109(9):1959-68. PMID: 26536272; PMCID: PMC4643268 [Available on 11/03/16].
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Safari MS, Vorontsova MA, Poling-Skutvik R, Vekilov PG, Conrad JC. Differential dynamic microscopy of weakly scattering and polydisperse protein-rich clusters. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Oct; 92(4):042712. PMID: 26565277.
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Aich A, Freundlich M, Vekilov PG. The free heme concentration in healthy human erythrocytes. Blood Cells Mol Dis. 2015 Dec; 55(4):402-9. PMID: 26460266; PMCID: PMC4860002.
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Maes D, Vorontsova MA, Potenza MA, Sanvito T, Sleutel M, Giglio M, Vekilov PG. Do protein crystals nucleate within dense liquid clusters? Acta Crystallogr F Struct Biol Commun. 2015 Jul; 71(Pt 7):815-22. PMID: 26144225; PMCID: PMC4498701.
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Sun CC, Sun W, Price S, Hughes C, Ter Horst J, Veesler S, Lewtas K, Myerson A, Pan H, Coquerel G, van den Ende J, Meekes H, Mazzotti M, Rosbottom I, Taulelle F, Black S, Mackenzie A, Janbon S, Vekilov P, Threlfall T, Turner T, Back K, Cuppen H, Toroz D, Sefcik J, Lovelock J, Hammond R, Candoni N, Simone E, Ward M, Bertran CA, Vetter T, Sear R, De Yoreo J, Davey R, Anwar J, Santiso E, Wu DT, Roberts K, Peters B, Schroeder S, Jones F, Rasmuson A, Cölfen H, Zeglinski J, Salvalaglio M. Solvent and additive interactions as determinants in the nucleation pathway: general discussion. Faraday Discuss. 2015; 179:383-420. PMID: 26083497.
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Price S, Rimez B, Sun W, Peters B, Christenson H, Hughes C, Sun CC, Veesler S, Pan H, Brandel C, Biscans B, Meekes H, Rosbottom I, Roth WJ, Seton L, Taulelle F, Black S, Threlfall T, Vekilov P, Poornachary S, Diemand J, Toroz D, Salvalaglio M, Tipduangta P, Sefcik J, Booth S, Rasmuson A, Janbon S, Ter Horst J, Simone E, Hammond R, Bertran CA, Vetter T, Sear R, De Yoreo J, Harris K, Ristic R, Kavanagh A, Roberts K, Breynaert E, Myerson A, Coquerel G, Wu D, Cölfen H, Cuppen H, Smets M, Wu DT. Nucleation in complex multi-component and multi-phase systems: general discussion. Faraday Discuss. 2015; 179:503-42. PMID: 26081969.
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Sun W, Booth S, Myerson A, Hughes C, Pan H, Coquerel G, Brandel C, Meekes H, Mazzotti M, Fabian L, Black S, Vekilov P, Back K, Toroz D, Lovelock J, Sefcik J, Rasmuson A, Breynaert E, Sear R, Hammond R, Ward M, Threlfall T, De Yoreo J, Davey R, Ristic R, Lewtas K, Roberts K, Hare A, Gich M, Cölfen H, Likhatskiy M, ter Horst J, Sommerdijk N. Time and space resolved methods: general discussion. Faraday Discuss. 2015; 179:247-67. PMID: 26077829.
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Price S, Veesler S, Pan H, Lewtas K, Smets M, Rimez B, Myerson A, Hughes C, Hare A, Zhang F, Meekes H, Mazzotti M, Rosbottom I, Khamar D, van den Ende J, Fabian L, Black S, Taulelle F, Gich M, Vekilov P, Toroz D, Bertran CA, Sefcik J, Schroeder S, Booth S, Rasmuson A, Breynaert E, Simone E, Hammond R, Sear R, de Yoreo J, Davey R, Anwar J, Ristic R, Camacho Corzo DM, Roberts K, Harris K, Colfen H, Turner T. Molecular self-assembly and clustering in nucleation processes: general discussion. Faraday Discuss. 2015; 179:155-97. PMID: 26075634.
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Vorontsova MA, Maes D, Vekilov PG. Recent advances in the understanding of two-step nucleation of protein crystals. Faraday Discuss. 2015; 179:27-40. PMID: 25859918.
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Olafson KN, Ketchum MA, Rimer JD, Vekilov PG. Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):4946-51. PMID: 25831526; PMCID: PMC4413305.
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Olafson KN, Rimer JD, Vekilov PG. Growth of Large Hematin Crystals in Biomimetic Solutions. Cryst Growth Des. 2014 May 07; 14(5):2123-2127. PMID: 24839403.
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Vekilov PG, Vorontsova MA. Nucleation precursors in protein crystallization. Acta Crystallogr F Struct Biol Commun. 2014 Mar; 70(Pt 3):271-82. PMID: 24598910; PMCID: PMC3944685.
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Ketchum MA, Olafson KN, Petrova EV, Rimer JD, Vekilov PG. Hematin crystallization from aqueous and organic solvents. J Chem Phys. 2013 Sep 28; 139(12):121911. PMID: 24089723.
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Vekilov PG. Crystal nucleation: Nucleus in a droplet. Nat Mater. 2012 Oct; 11(10):838-40. PMID: 23001231.
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Li Y, Lubchenko V, Vorontsova MA, Filobelo L, Vekilov PG. Ostwald-like ripening of the anomalous mesoscopic clusters in protein solutions. J Phys Chem B. 2012 Sep 06; 116(35):10657-64. PMID: 22889282.
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Sleutel M, Van Driessche AE, Pan W, Reichel EK, Maes D, Vekilov PG. Does Solution Viscosity Scale the Rate of Aggregation of Folded Proteins? J Phys Chem Lett. 2012 May 17; 3(10):1258-63. PMID: 26286768.
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Chan HY, Lankevich V, Vekilov PG, Lubchenko V. Anisotropy of the Coulomb interaction between folded proteins: consequences for mesoscopic aggregation of lysozyme. Biophys J. 2012 Apr 18; 102(8):1934-43. PMID: 22768950; PMCID: PMC3328725.
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Vekilov PG. Phase diagrams and kinetics of phase transitions in protein solutions. J Phys Condens Matter. 2012 May 16; 24(19):193101. PMID: 22495288.
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Vekilov PG. Formation of Protein Condensed Phases: Nucleation Mechanisms. Protein Pept Lett. 2012 Apr 04. PMID: 22489787.
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Li Y, Lubchenko V, Vekilov PG. The use of dynamic light scattering and brownian microscopy to characterize protein aggregation. Rev Sci Instrum. 2011 May; 82(5):053106. PMID: 21639491.
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Vekilov PG. Gold nanoparticles: Grown in a crystal. Nat Nanotechnol. 2011 Feb; 6(2):82-3. PMID: 21293485.
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Vekilov PG. Nucleation. Cryst Growth Des. 2010 Nov 15; 10(12):5007-5019. PMID: 21132117.
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Vekilov PG. The two-step mechanism of nucleation of crystals in solution. Nanoscale. 2010 Nov; 2(11):2346-57. PMID: 20936214.
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Uzunova VV, Pan W, Galkin O, Vekilov PG. Free heme and the polymerization of sickle cell hemoglobin. Biophys J. 2010 Sep 22; 99(6):1976-85. PMID: 20858444; PMCID: PMC2941010.
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Pan W, Vekilov PG, Lubchenko V. Origin of anomalous mesoscopic phases in protein solutions. J Phys Chem B. 2010 Jun 10; 114(22):7620-30. PMID: 20423058.
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Qutub Y, Uzunova V, Galkin O, Vekilov PG. Interactions of hemin with model erythrocyte membranes. J Phys Chem B. 2010 Apr 08; 114(13):4529-35. PMID: 20235510.
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Pan W, Uzunova VV, Vekilov PG. Free heme in micromolar amounts enhances the attraction between sickle cell hemoglobin molecules. Biopolymers. 2009 Dec; 91(12):1108-16. PMID: 19322821.
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Shah M, Galkin O, Vekilov PG. Localized generation of attoliter protein solution droplets by electrofocused liquid-liquid separation. J Phys Chem B. 2009 May 21; 113(20):7340-6. PMID: 19397316.
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Vekilov PG. Metastable mesoscopic phases in concentrated protein solutions. Ann N Y Acad Sci. 2009 Apr; 1161:377-86. PMID: 19426331.
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Pan W, Filobelo L, Pham ND, Galkin O, Uzunova VV, Vekilov PG. Viscoelasticity in homogeneous protein solutions. Phys Rev Lett. 2009 Feb 06; 102(5):058101. PMID: 19257559.
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Canterino JE, Galkin O, Vekilov PG, Hirsch RE. Phase separation and crystallization of hemoglobin C in transgenic mouse and human erythrocytes. Biophys J. 2008 Oct; 95(8):4025-33. PMID: 18621841; PMCID: PMC2553125.
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Vekilov PG, Galkin O, Pettitt BM, Choudhury N, Nagel RL. Determination of the transition-state entropy for aggregation suggests how the growth of sickle cell hemoglobin polymers can be slowed. J Mol Biol. 2008 Mar 28; 377(3):882-8. PMID: 18280499; PMCID: PMC2596688.
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Vekilov PG. Sickle-cell haemoglobin polymerization: is it the primary pathogenic event of sickle-cell anaemia? Br J Haematol. 2007 Oct; 139(2):173-84. PMID: 17897293.
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Galkin O, Pan W, Filobelo L, Hirsch RE, Nagel RL, Vekilov PG. Two-step mechanism of homogeneous nucleation of sickle cell hemoglobin polymers. Biophys J. 2007 Aug 01; 93(3):902-13. PMID: 17449671; PMCID: PMC1913141.
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Gliko O, Pan W, Katsonis P, Neumaier N, Galkin O, Weinkauf S, Vekilov PG. Metastable liquid clusters in super- and undersaturated protein solutions. J Phys Chem B. 2007 Mar 29; 111(12):3106-14. PMID: 17388477.
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Pan W, Galkin O, Filobelo L, Nagel RL, Vekilov PG. Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin. Biophys J. 2007 Jan 01; 92(1):267-77. PMID: 17040989; PMCID: PMC1697867.
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Galkin O, Nagel RL, Vekilov PG. The kinetics of nucleation and growth of sickle cell hemoglobin fibers. J Mol Biol. 2007 Jan 12; 365(2):425-39. PMID: 17069853.
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Katsonis P, Brandon S, Vekilov PG. Corresponding-states laws for protein solutions. J Phys Chem B. 2006 Sep 07; 110(35):17638-44. PMID: 16942109.
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Penkova A, Pan W, Hodjaoglu F, Vekilov PG. Nucleation of protein crystals under the influence of solution shear flow. Ann N Y Acad Sci. 2006 Sep; 1077:214-31. PMID: 17124126.
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Brandon S, Katsonis P, Vekilov PG. Multiple extrema in the intermolecular potential and the phase diagram of protein solutions. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun; 73(6 Pt 1):061917. PMID: 16906874.
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Georgiou DK, Vekilov PG. A fast response mechanism for insulin storage in crystals may involve kink generation by association of 2D clusters. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1681-6. PMID: 16446456; PMCID: PMC1413625.
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Derewenda ZS, Vekilov PG. Entropy and surface engineering in protein crystallization. Acta Crystallogr D Biol Crystallogr. 2006 Jan; 62(Pt 1):116-24. PMID: 16369101.
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Filobelo LF, Galkin O, Vekilov PG. Spinodal for the solution-to-crystal phase transformation. J Chem Phys. 2005 Jul 01; 123(1):014904. PMID: 16035866.
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Kashchiev D, Vekilov PG, Kolomeisky AB. Kinetics of two-step nucleation of crystals. J Chem Phys. 2005 Jun 22; 122(24):244706. PMID: 16035792.
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Pan W, Kolomeisky AB, Vekilov PG. Nucleation of ordered solid phases of proteins via a disordered high-density state: phenomenological approach. J Chem Phys. 2005 May 01; 122(17):174905. PMID: 15910067.
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Gliko O, Neumaier N, Pan W, Haase I, Fischer M, Bacher A, Weinkauf S, Vekilov PG. A metastable prerequisite for the growth of lumazine synthase crystals. J Am Chem Soc. 2005 Mar 16; 127(10):3433-8. PMID: 15755162.
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Vekilov PG. Kinetics and mechanisms of protein crystallization at the molecular level. Methods Mol Biol. 2005; 300:15-52. PMID: 15657478.
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Qutub Y, Reviakine I, Maxwell C, Navarro J, Landau EM, Vekilov PG. Crystallization of transmembrane proteins in cubo: mechanisms of crystal growth and defect formation. J Mol Biol. 2004 Nov 05; 343(5):1243-54. PMID: 15491610.
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Shah M, Galkin O, Vekilov PG. Smooth transition from metastability to instability in phase separating protein solutions. J Chem Phys. 2004 Oct 15; 121(15):7505-12. PMID: 15473826.
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Feeling-Taylor AR, Yau ST, Petsev DN, Nagel RL, Hirsch RE, Vekilov PG. Crystallization mechanisms of hemoglobin C in the R state. Biophys J. 2004 Oct; 87(4):2621-9. PMID: 15454456; PMCID: PMC1304680.
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Chen Q, Vekilov PG, Nagel RL, Hirsch RE. Liquid-liquid phase separation in hemoglobins: distinct aggregation mechanisms of the beta6 mutants. Biophys J. 2004 Mar; 86(3):1702-12. PMID: 14990498; PMCID: PMC1304006.
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Galkin O, Vekilov PG. Mechanisms of homogeneous nucleation of polymers of sickle cell anemia hemoglobin in deoxy state. J Mol Biol. 2004 Feb 06; 336(1):43-59. PMID: 14741202.
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Booth NA, Chernov AA, Vekilov PG. Interplay of impurities and solution flow as determinants of step pattern dynamics. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jan; 69(1 Pt 1):011604. PMID: 14995630.
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Bergeron L, Filobelo LF, Galkin O, Vekilov PG. Thermodynamics of the hydrophobicity in crystallization of insulin. Biophys J. 2003 Dec; 85(6):3935-42. PMID: 14645082; PMCID: PMC1303694.
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Reviakine I, Georgiou DK, Vekilov PG. Capillarity effects on crystallization kinetics: insulin. J Am Chem Soc. 2003 Sep 24; 125(38):11684-93. PMID: 13129373.
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Gliko O, Reviakine I, Vekilov PG. Stable equidistant step trains during crystallization of insulin. Phys Rev Lett. 2003 Jun 06; 90(22):225503. PMID: 12857320.
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Lin H, Yau ST, Vekilov PG. Dissipating step bunches during crystallization under transport control. Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Mar; 67(3 Pt 1):031606. PMID: 12689079.
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Petsev DN, Chen K, Gliko O, Vekilov PG. Diffusion-limited kinetics of the solution-solid phase transition of molecular substances. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):792-6. PMID: 12552115; PMCID: PMC298680.
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Vekilov PG. Solvent entropy effects in the formation of protein solid phases. Methods Enzymol. 2003; 368:84-105. PMID: 14674270.
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Vekilov PG, Feeling-Taylor A, Hirsch RE. Nucleation and crystal growth of hemoglobins. The case of HbC. Methods Mol Med. 2003; 82:155-76. PMID: 12669643.
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Vekilov PG. Molecular mechanisms of defect formation. Methods Enzymol. 2003; 368:170-88. PMID: 14674274.
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Gliko O, Booth NA, Vekilov PG. Step bunching in a diffusion-controlled system: phase-shifting interferometry investigation of ferritin. Acta Crystallogr D Biol Crystallogr. 2002 Oct; 58(Pt 10 Pt 1):1622-7. PMID: 12351874.
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Vekilov PG, Feeling-Taylor AR, Yau ST, Petsev D. Solvent entropy contribution to the free energy of protein crystallization. Acta Crystallogr D Biol Crystallogr. 2002 Oct; 58(Pt 10 Pt 1):1611-6. PMID: 12351872.
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Chen K, Vekilov PG. Evidence for the surface-diffusion mechanism of solution crystallization from molecular-level observations with ferritin. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Aug; 66(2 Pt 1):021606. PMID: 12241188.
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Vekilov PG, Feeling-Taylor AR, Petsev DN, Galkin O, Nagel RL, Hirsch RE. Intermolecular interactions, nucleation, and thermodynamics of crystallization of hemoglobin C. Biophys J. 2002 Aug; 83(2):1147-56. PMID: 12124294; PMCID: PMC1302216.
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Galkin O, Chen K, Nagel RL, Hirsch RE, Vekilov PG. Liquid-liquid separation in solutions of normal and sickle cell hemoglobin. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8479-83. PMID: 12070342; PMCID: PMC124280.
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Yau ST, Thomas BR, Galkin O, Gliko O, Vekilov PG. Molecular mechanisms of microheterogeneity-induced defect formation in ferritin crystallization. Proteins. 2001 Jun 01; 43(4):343-52. PMID: 11340651.
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Yau ST, Vekilov PG. Direct observation of nucleus structure and nucleation pathways in apoferritin crystallization. J Am Chem Soc. 2001 Feb 14; 123(6):1080-9. PMID: 11456661.
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Hirsch RE, Samuel RE, Fataliev NA, Pollack MJ, Galkin O, Vekilov PG, Nagel RL. Differential pathways in oxy and deoxy HbC aggregation/crystallization. Proteins. 2001 Jan 01; 42(1):99-107. PMID: 11093264.
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Yau ST, Petsev DN, Thomas BR, Vekilov PG. Molecular-level thermodynamic and kinetic parameters for the self-assembly of apoferritin molecules into crystals. J Mol Biol. 2000 Nov 10; 303(5):667-78. PMID: 11061967.
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Yau ST, Vekilov PG. Quasi-planar nucleus structure in apoferritin crystallization. Nature. 2000 Aug 03; 406(6795):494-7. PMID: 10952306.
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Vekilov PG, Alexander JI. Dynamics of Layer Growth in Protein Crystallization. Chem Rev. 2000 Jun 14; 100(6):2061-2090. PMID: 11749284.
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Galkin O, Vekilov PG. Control of protein crystal nucleation around the metastable liquid-liquid phase boundary. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6277-81. PMID: 10823898; PMCID: PMC18593.
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Petsev DN, Thomas BR, Yau S, Vekilov PG. Interactions and aggregation of apoferritin molecules in solution: effects of added electrolytes. Biophys J. 2000 Apr; 78(4):2060-9. PMID: 10733984; PMCID: PMC1300798.
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Petsev DN, Vekilov PG. Evidence for non-DLVO hydration interactions in solutions of the protein apoferritin. Phys Rev Lett. 2000 Feb 07; 84(6):1339-42. PMID: 11017513.
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Wang M, Yin XB, Vekilov PG, Peng RW, Ming NB. Intrinsic instability of the concentration field in diffusion-limited growth and its effect on crystallization. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 Aug; 60(2 Pt B):1901-5. PMID: 11969979.
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Vekilov PG. Protein crystal growth--microgravity aspects. Adv Space Res. 1999; 24(10):1231-40. PMID: 11542664.
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Thomas BR, Vekilov PG, Rosenberger F. Effects of microheterogeneity in hen egg-white lysozyme crystallization. Acta Crystallogr D Biol Crystallogr. 1998 Mar 01; 54(Pt 2):226-36. PMID: 9761887.
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Stojanoff V, Siddons DP, Monaco LA, Vekilov P, Rosenberger F. X-ray topography of tetragonal lysozyme grown by the temperature-controlled technique. Acta Crystallogr D Biol Crystallogr. 1997 Sep 01; 53(Pt 5):588-95. PMID: 15299890.
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Thomas BR, Vekilov PG, Rosenberger F. Heterogeneity determination and purification of commercial hen egg-white lysozyme. Acta Crystallogr D Biol Crystallogr. 1996 Jul 01; 52(Pt 4):776-84. PMID: 15299642.
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Vekilov PG, Monaco BR, Thomas BR, Stojanoff V, Rosenberger F. Repartitioning of NaCl and protein impurities in lysozyme crystallization. Acta Crystallogr D Biol Crystallogr. 1996 Jul 01; 52(Pt 4):785-98. PMID: 15299643.
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Vekilov PG, Ataka M, Katsura T. Growth process of protein crystals revealed by laser Michelson interferometry investigation. Acta Crystallogr D Biol Crystallogr. 1995 Mar 01; 51(Pt 2):207-19. PMID: 15299322.
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1995 | 1 | 1996 | 2 | 1997 | 1 | 1998 | 1 | 1999 | 2 | 2000 | 6 | 2001 | 3 | 2002 | 5 | 2003 | 8 | 2004 | 6 | 2005 | 6 | 2006 | 6 | 2007 | 3 | 2008 | 2 | 2009 | 4 | 2010 | 5 | 2011 | 2 | 2012 | 6 | 2013 | 1 | 2014 | 2 | 2015 | 10 | 2016 | 4 | 2017 | 4 |
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