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Richard Simpson

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentHealth & Human Performance
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-9270
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    Collapse Research 
    Collapse research activities and funding
    R21CA197527     (SIMPSON, RICHARD J)Sep 13, 2016 - Aug 31, 2018
    NIH/NCI
    CMV infection and NK-cell therapy for multiple myeloma
    Role: Principal Investigator
    R03AG052778     (LAVOY, EMILY)Sep 15, 2017 - Apr 30, 2019
    NIH/NIA
    Resistance Exercise to Improve Vaccine Outcomes in Older Adults
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kunz H, Quiriarte H, Simpson RJ, Ploutz-Snyder R, McMonigal K, Sams C, Crucian B. Alterations in hematologic indices during long-duration spaceflight. BMC Hematol. 2017; 17:12. PMID: 28904800.
      View in: PubMed
    2. Izumikawa K, Nobe Y, Yoshikawa H, Ishikawa H, Miura Y, Nakayama H, Nonaka T, Hasegawa M, Egawa N, Inoue H, Nishikawa K, Yamano K, Simpson RJ, Taoka M, Yamauchi Y, Isobe T, Takahashi N. TDP-43 stabilises the processing intermediates of mitochondrial transcripts. Sci Rep. 2017 Aug 09; 7(1):7709. PMID: 28794432.
      View in: PubMed
    3. Rawcliffe AJ, Graham SM, Simpson RJ, Moir GL, Martindale RJ, Psycharakis SG, Connaboy C. The Effects of British Army Footwear on Ground Reaction Force and Temporal Parameters of British Army Foot-Drill. J Strength Cond Res. 2017 Aug 09. PMID: 28800005.
      View in: PubMed
    4. Simpson RJ. Extracellular vesicles. Semin Cell Dev Biol. 2017 Jul; 67:1-2. PMID: 28648528.
      View in: PubMed
    5. Simpson RJ, Bigley AB, Agha N, Hanley PJ, Bollard CM. Mobilizing Immune Cells With Exercise for Cancer Immunotherapy. Exerc Sport Sci Rev. 2017 Jul; 45(3):163-172. PMID: 28418996.
      View in: PubMed
    6. Ishikawa H, Yoshikawa H, Izumikawa K, Miura Y, Taoka M, Nobe Y, Yamauchi Y, Nakayama H, Simpson RJ, Isobe T, Takahashi N. Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells. Nucleic Acids Res. 2017 Apr 07; 45(6):3437-3447. PMID: 27899605.
      View in: PubMed
    7. Hosseini AA, Simpson RJ, Altaf N, Bath PM, MacSweeney ST, Auer DP. Magnetic Resonance Imaging Plaque Hemorrhage for Risk Stratification in Carotid Artery Disease With Moderate Risk Under Current Medical Therapy. Stroke. 2017 Mar; 48(3):678-685. PMID: 28196937.
      View in: PubMed
    8. Rawcliffe AJ, Simpson RJ, Graham SM, Psycharakis SG, Moir GL, Connaboy C. Reliability of the Kinetics of British Army Foot Drill in Untrained Personnel. J Strength Cond Res. 2017 Feb; 31(2):435-444. PMID: 27442331.
      View in: PubMed
    9. LaVoy EC, Hussain M, Reed J, Kunz H, Pistillo M, Bigley AB, Simpson RJ. T-cell redeployment and intracellular cytokine expression following exercise: effects of exercise intensity and cytomegalovirus infection. Physiol Rep. 2017 Jan; 5(1). PMID: 28087817.
      View in: PubMed
    10. Sparrow RL, Simpson RJ, Greening DW. A Protocol for the Preparation of Cryoprecipitate and Cryo-depleted Plasma for Proteomic Studies. Methods Mol Biol. 2017; 1619:23-30. PMID: 28674874.
      View in: PubMed
    11. Greening DW, Simpson RJ. Characterization of the Low-Molecular-Weight Human Plasma Peptidome. Methods Mol Biol. 2017; 1619:63-79. PMID: 28674878.
      View in: PubMed
    12. Gopal SK, Greening DW, Rai A, Chen M, Xu R, Shafiq A, Mathias RA, Zhu HJ, Simpson RJ. Extracellular vesicles: their role in cancer biology and epithelial-mesenchymal transition. Biochem J. 2017 Jan 01; 474(1):21-45. PMID: 28008089.
      View in: PubMed
    13. Xu R, Simpson RJ, Greening DW. A Protocol for Isolation and Proteomic Characterization of Distinct Extracellular Vesicle Subtypes by Sequential Centrifugal Ultrafiltration. Methods Mol Biol. 2017; 1545:91-116. PMID: 27943209.
      View in: PubMed
    14. Greening DW, Simpson RJ, Sparrow RL. Preparation of Platelet Concentrates for Research and Transfusion Purposes. Methods Mol Biol. 2017; 1619:31-42. PMID: 28674875.
      View in: PubMed
    15. Belov L, Hallal S, Matic K, Zhou J, Wissmueller S, Ahmed N, Tanjil S, Mulligan SP, Best OG, Simpson RJ, Christopherson RI. Surface Profiling of Extracellular Vesicles from Plasma or Ascites Fluid Using DotScan Antibody Microarrays. Methods Mol Biol. 2017; 1619:263-301. PMID: 28674892.
      View in: PubMed
    16. Chen M, Xu R, Ji H, Greening DW, Rai A, Izumikawa K, Ishikawa H, Takahashi N, Simpson RJ. Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line. Sci Rep. 2016 Dec 05; 6:38397. PMID: 27917920.
      View in: PubMed
    17. Peake JM, Neubauer O, Walsh NP, Simpson RJ. Recovery of the immune system after exercise. J Appl Physiol (1985). 2017 May 01; 122(5):1077-1087. PMID: 27909225.
      View in: PubMed
    18. Greening DW, Xu R, Gopal SK, Rai A, Simpson RJ. Proteomic insights into extracellular vesicle biology - defining exosomes and shed microvesicles. Expert Rev Proteomics. 2017 Jan; 14(1):69-95. PMID: 27838931.
      View in: PubMed
    19. Giles CD, Brown LK, Adu MO, Mezeli MM, Sandral GA, Simpson RJ, Wendler R, Shand CA, Menezes-Blackburn D, Darch T, Stutter MI, Lumsdon DG, Zhang H, Blackwell MS, Wearing C, Cooper P, Haygarth PM, George TS. Response-based selection of barley cultivars and legume species for complementarity: Root morphology and exudation in relation to nutrient source. Plant Sci. 2017 Feb; 255:12-28. PMID: 28131338.
      View in: PubMed
    20. Izumikawa K, Yoshikawa H, Ishikawa H, Nobe Y, Yamauchi Y, Philipsen S, Simpson RJ, Isobe T, Takahashi N. Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA. Nucleic Acids Res. 2016 Nov 16; 44(20):9847-9859. PMID: 27683223.
      View in: PubMed
    21. Nguyen HP, Simpson RJ, Salamonsen LA, Greening DW. Extracellular Vesicles in the Intrauterine Environment: Challenges and Potential Functions. Biol Reprod. 2016 Nov; 95(5):109. PMID: 27655784.
      View in: PubMed
    22. Ross M, Tormey P, Ingram L, Simpson R, Malone E, Florida-James G. A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males. Exp Physiol. 2016 Oct 01; 101(10):1253-1264. PMID: 27427499.
      View in: PubMed
    23. Greening DW, Ji H, Chen M, Robinson BW, Dick IM, Creaney J, Simpson RJ. Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo. Sci Rep. 2016 Sep 08; 6:32643. PMID: 27605433; PMCID: PMC5015102.
      View in: PubMed, PubMed Central
    24. Meng D, Hosseini AA, Simpson RJ, Shaikh Q, Tench CR, Dineen RA, Auer DP. Lesion Topography and Microscopic White Matter Tract Damage Contribute to Cognitive Impairment in Symptomatic Carotid Artery Disease. Radiology. 2017 Feb; 282(2):502-515. PMID: 27598537.
      View in: PubMed
    25. Khondee P, Srisomsap C, Chokchaichamnankit D, Svasti J, Simpson RJ, Kingtong S. Histopathological effect and stress response of mantle proteome following TBT exposure in the Hooded oyster Saccostrea cucullata. Environ Pollut. 2016 Nov; 218:855-862. PMID: 27521293.
      View in: PubMed
    26. Gopal SK, Greening DW, Zhu HJ, Simpson RJ, Mathias RA. Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis. Sci Rep. 2016 Jun 21; 6:28321. PMID: 27324842; PMCID: PMC4914959.
      View in: PubMed, PubMed Central
    27. Greening DW, Lee ST, Ji H, Simpson RJ, Rigopoulos A, Murone C, Fang C, Gong S, O'Keefe G, Scott AM. Correction: Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways. Oncotarget. 2016 Jun 07; 7(23):35497. PMID: 27654651.
      View in: PubMed
    28. Greening DW, Nguyen HP, Evans J, Simpson RJ, Salamonsen LA. Modulating the endometrial epithelial proteome and secretome in preparation for pregnancy: The role of ovarian steroid and pregnancy hormones. J Proteomics. 2016 Jul 20; 144:99-112. PMID: 27262222.
      View in: PubMed
    29. Simpson RJ. Aging and inflammation: Directing traffic through physical activity. Brain Behav Immun. 2016 Aug; 56:10-1. PMID: 27223097.
      View in: PubMed
    30. Spielmann G, Bollard CM, Kunz H, Hanley PJ, Simpson RJ. A single exercise bout enhances the manufacture of viral-specific T-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy. Sci Rep. 2016 May 16; 6:25852. PMID: 27181409; PMCID: PMC4867645.
      View in: PubMed, PubMed Central
    31. Simpson RJ, Graham SM, Connaboy C, Clement R, Pollonini L, Florida-James GD. Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers. Appl Ergon. 2017 Jan; 58:566-572. PMID: 27154276.
      View in: PubMed
    32. Gopal SK, Greening DW, Hanssen EG, Zhu HJ, Simpson RJ, Mathias RA. Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells. Oncotarget. 2016 Apr 12; 7(15):19709-22. PMID: 26919098; PMCID: PMC4991413.
      View in: PubMed, PubMed Central
    33. Xu R, Greening DW, Zhu HJ, Takahashi N, Simpson RJ. Extracellular vesicle isolation and characterization: toward clinical application. J Clin Invest. 2016 Apr 01; 126(4):1152-62. PMID: 27035807; PMCID: PMC4811150 [Available on 04/01/17].
      View in: PubMed, PubMed Central
    34. Leach HJ, O'Connor DP, Simpson RJ, Rifai HS, Mama SK, Lee RE. An exploratory decision tree analysis to predict cardiovascular disease risk in African American women. Health Psychol. 2016 Apr; 35(4):397-402. PMID: 27018731.
      View in: PubMed
    35. Carrasco-Ramírez P, Greening DW, Andrés G, Gopal SK, Martín-Villar E, Renart J, Simpson RJ, Quintanilla M. Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation. Oncotarget. 2016 Mar 29; 7(13):16070-89. PMID: 26893367; PMCID: PMC4941298.
      View in: PubMed, PubMed Central
    36. Greening DW, Nguyen HP, Elgass K, Simpson RJ, Salamonsen LA. Human Endometrial Exosomes Contain Hormone-Specific Cargo Modulating Trophoblast Adhesive Capacity: Insights into Endometrial-Embryo Interactions. Biol Reprod. 2016 Feb; 94(2):38. PMID: 26764347.
      View in: PubMed
    37. Simpson RJ, Bigley AB, Spielmann G, LaVoy EC, Kunz H, Bollard CM. Human cytomegalovirus infection and the immune response to exercise. Exerc Immunol Rev. 2016; 22:8-27. PMID: 26853134.
      View in: PubMed
    38. Bigley AB, Spielmann G, Agha N, O'Connor DP, Simpson RJ. Dichotomous effects of latent CMV infection on the phenotype and functional properties of CD8+ T-cells and NK-cells. Cell Immunol. 2016 Feb; 300:26-32. PMID: 26651951.
      View in: PubMed
    39. Greening DW, Lee ST, Ji H, Simpson RJ, Rigopoulos A, Murone C, Fang C, Gong S, O'Keefe G, Scott AM. Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways. Oncotarget. 2015 Nov 10; 6(35):38166-80. PMID: 26517691; PMCID: PMC4741991.
      View in: PubMed, PubMed Central
    40. Sato S, Ishikawa H, Yoshikawa H, Izumikawa K, Simpson RJ, Takahashi N. Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5'-3' exoribonuclease) in the nucleoplasm. Nucleic Acids Res. 2015 Dec 02; 43(21):10397-410. PMID: 26531822; PMCID: PMC4666357.
      View in: PubMed, PubMed Central
    41. McLaren TI, Smernik RJ, McLaughlin MJ, McBeath TM, Kirby JK, Simpson RJ, Guppy CN, Doolette AL, Richardson AE. Complex Forms of Soil Organic Phosphorus-A Major Component of Soil Phosphorus. Environ Sci Technol. 2015 Nov 17; 49(22):13238-45. PMID: 26492192.
      View in: PubMed
    42. Bigley AB, Spielmann G, Agha N, Simpson RJ. The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man. Oxid Med Cell Longev. 2015; 2015:979645. PMID: 26583066; PMCID: PMC4637106.
      View in: PubMed, PubMed Central
    43. Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the Regulation of Immune Functions. Prog Mol Biol Transl Sci. 2015; 135:355-80. PMID: 26477922.
      View in: PubMed
    44. Pathan M, Keerthikumar S, Ang CS, Gangoda L, Quek CY, Williamson NA, Mouradov D, Sieber OM, Simpson RJ, Salim A, Bacic A, Hill AF, Stroud DA, Ryan MT, Agbinya JI, Mariadason JM, Burgess AW, Mathivanan S. FunRich: An open access standalone functional enrichment and interaction network analysis tool. Proteomics. 2015 Aug; 15(15):2597-601. PMID: 25921073.
      View in: PubMed
    45. Warren Olanow C, Bartus RT, Baumann TL, Factor S, Boulis N, Stacy M, Turner DA, Marks W, Larson P, Starr PA, Jankovic J, Simpson R, Watts R, Guthrie B, Poston K, Henderson JM, Stern M, Baltuch G, Goetz CG, Herzog C, Kordower JH, Alterman R, Lozano AM, Lang AE. Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial. Ann Neurol. 2015 Aug; 78(2):248-57. PMID: 26061140.
      View in: PubMed
    46. Bigley AB, Simpson RJ. NK cells and exercise: implications for cancer immunotherapy and survivorship. Discov Med. 2015 Jun; 19(107):433-45. PMID: 26175401.
      View in: PubMed
    47. Gopal SK, Greening DW, Mathias RA, Ji H, Rai A, Chen M, Zhu HJ, Simpson RJ. YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment. Oncotarget. 2015 May 30; 6(15):13718-30. PMID: 25980435; PMCID: PMC4537044.
      View in: PubMed, PubMed Central
    48. Simpson RJ. Fitness deficits in long-term ALL survivors. Blood. 2015 May 28; 125(22):3366-8. PMID: 26022049.
      View in: PubMed
    49. Yoshikawa H, Ishikawa H, Izumikawa K, Miura Y, Hayano T, Isobe T, Simpson RJ, Takahashi N. Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis. Nucleic Acids Res. 2015 Jun 23; 43(11):5524-36. PMID: 25969445; PMCID: PMC4477673.
      View in: PubMed, PubMed Central
    50. Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M. Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):E2979. PMID: 25956176; PMCID: PMC4460436.
      View in: PubMed, PubMed Central
    51. Xu R, Greening DW, Rai A, Ji H, Simpson RJ. Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct. Methods. 2015 Oct 01; 87:11-25. PMID: 25890246.
      View in: PubMed
    52. Simpson RJ. Editorial: Extracellular vesicles: a paradigm shift in how we think about cell-cell communication. Semin Cell Dev Biol. 2015 Apr; 40:1-3. PMID: 25976596.
      View in: PubMed
    53. LaVoy EC, Bollard CM, Hanley PJ, O'Connor DP, Lowder TW, Bosch JA, Simpson RJ. A single bout of dynamic exercise by healthy adults enhances the generation of monocyte-derived-dendritic cells. Cell Immunol. 2015 May; 295(1):52-9. PMID: 25749006.
      View in: PubMed
    54. Greening DW, Gopal SK, Xu R, Simpson RJ, Chen W. Exosomes and their roles in immune regulation and cancer. Semin Cell Dev Biol. 2015 Apr; 40:72-81. PMID: 25724562.
      View in: PubMed
    55. Greening DW, Gopal SK, Mathias RA, Liu L, Sheng J, Zhu HJ, Simpson RJ. Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression. Semin Cell Dev Biol. 2015 Apr; 40:60-71. PMID: 25721809.
      View in: PubMed
    56. Luwor RB, Hakmana D, Iaria J, Nheu TV, Simpson RJ, Zhu HJ. Single live cell TGF-ß signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-ß-Smad3 activity. Mol Cancer. 2015 Feb 22; 14:50. PMID: 25744371; PMCID: PMC4343191.
      View in: PubMed, PubMed Central
    57. Kim DK, Lee J, Simpson RJ, Lötvall J, Gho YS. EVpedia: A community web resource for prokaryotic and eukaryotic extracellular vesicles research. Semin Cell Dev Biol. 2015 Apr; 40:4-7. PMID: 25704310.
      View in: PubMed
    58. Bigley AB, Rezvani K, Pistillo M, Reed J, Agha N, Kunz H, O'Connor DP, Sekine T, Bollard CM, Simpson RJ. Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Part II: impact of latent cytomegalovirus infection and catecholamine sensitivity. Brain Behav Immun. 2015 Oct; 49:59-65. PMID: 25578514.
      View in: PubMed
    59. Ingram LA, Simpson RJ, Malone E, Florida-James GD. Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise. Brain Behav Immun. 2015 Jul; 47:100-8. PMID: 25582807.
      View in: PubMed
    60. Kunz H, Bishop NC, Spielmann G, Pistillo M, Reed J, Ograjsek T, Park Y, Mehta SK, Pierson DL, Simpson RJ. Fitness level impacts salivary antimicrobial protein responses to a single bout of cycling exercise. Eur J Appl Physiol. 2015 May; 115(5):1015-27. PMID: 25557386.
      View in: PubMed
    61. LaVoy EC, Bollard CM, Hanley PJ, Blaney JW, O'Connor DP, Bosch JA, Simpson RJ. A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults. Exerc Immunol Rev. 2015; 21:144-53. PMID: 25826370.
      View in: PubMed
    62. Greening DW, Xu R, Ji H, Tauro BJ, Simpson RJ. A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. Methods Mol Biol. 2015; 1295:179-209. PMID: 25820723.
      View in: PubMed
    63. Fiuza-Luces C, Garatachea N, Simpson RJ, Berger NA, Ramírez M, Lucia A. Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients. Exerc Immunol Rev. 2015; 21:80-112. PMID: 25826127.
      View in: PubMed
    64. Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stepien E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15; 31(6):933-9. PMID: 25388151; PMCID: PMC4375401.
      View in: PubMed, PubMed Central
    65. Ji H, Chen M, Greening DW, He W, Rai A, Zhang W, Simpson RJ. Deep sequencing of RNA from three different extracellular vesicle (EV) subtypes released from the human LIM1863 colon cancer cell line uncovers distinct miRNA-enrichment signatures. PLoS One. 2014; 9(10):e110314. PMID: 25330373; PMCID: PMC4201526.
      View in: PubMed, PubMed Central
    66. Feng J, He W, Song Y, Wang Y, Simpson RJ, Zhang X, Luo G, Wu J, Huang C. Platelet-derived growth factor receptor beta: a novel urinary biomarker for recurrence of non-muscle-invasive bladder cancer. PLoS One. 2014; 9(5):e96671. PMID: 24801713; PMCID: PMC4011858.
      View in: PubMed, PubMed Central
    67. He W, Kuang Y, Xing X, Simpson RJ, Huang H, Yang T, Chen J, Yang L, Liu E, He W, Gu J. Proteomic comparison of 3D and 2D glioma models reveals increased HLA-E expression in 3D models is associated with resistance to NK cell-mediated cytotoxicity. J Proteome Res. 2014 May 02; 13(5):2272-81. PMID: 24742303.
      View in: PubMed
    68. Simpson RJ, Bosch JA. Special issue on exercise immunology: current perspectives on aging, health and extreme performance. Brain Behav Immun. 2014 Jul; 39:1-7. PMID: 24681210.
      View in: PubMed
    69. Hosseini AA, Simpson RJ, Altaf N, Auer DP. Carotid plaque hemorrhage on magnetic resonance imaging and recurrent cerebrovascular events. J Am Coll Cardiol. 2014 May 27; 63(20):2172-3. PMID: 24613325.
      View in: PubMed
    70. Lavoy EC, Bigley AB, Spielmann G, Rector JL, Morrison MR, O'Connor DP, Simpson RJ. CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus. Med Sci Sports Exerc. 2014 Feb; 46(2):257-67. PMID: 23877375.
      View in: PubMed
    71. Crucian B, Simpson RJ, Mehta S, Stowe R, Chouker A, Hwang SA, Actor JK, Salam AP, Pierson D, Sams C. Terrestrial stress analogs for spaceflight associated immune system dysregulation. Brain Behav Immun. 2014 Jul; 39:23-32. PMID: 24462949.
      View in: PubMed
    72. Nanjappa V, Thomas JK, Marimuthu A, Muthusamy B, Radhakrishnan A, Sharma R, Ahmad Khan A, Balakrishnan L, Sahasrabuddhe NA, Kumar S, Jhaveri BN, Sheth KV, Kumar Khatana R, Shaw PG, Srikanth SM, Mathur PP, Shankar S, Nagaraja D, Christopher R, Mathivanan S, Raju R, Sirdeshmukh R, Chatterjee A, Simpson RJ, Harsha HC, Pandey A, Prasad TS. Plasma Proteome Database as a resource for proteomics research: 2014 update. Nucleic Acids Res. 2014 Jan; 42(Database issue):D959-65. PMID: 24304897; PMCID: PMC3965042.
      View in: PubMed, PubMed Central
    73. Bigley AB, Rezvani K, Chew C, Sekine T, Pistillo M, Crucian B, Bollard CM, Simpson RJ. Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Brain Behav Immun. 2014 Jul; 39:160-71. PMID: 24200514.
      View in: PubMed
    74. Brown FF, Bigley AB, Sherry C, Neal CM, Witard OC, Simpson RJ, Galloway SD. Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise. Brain Behav Immun. 2014 Jul; 39:152-9. PMID: 24200513.
      View in: PubMed
    75. Kalra H, Adda CG, Liem M, Ang CS, Mechler A, Simpson RJ, Hulett MD, Mathivanan S. Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. Proteomics. 2013 Nov; 13(22):3354-64. PMID: 24115447.
      View in: PubMed
    76. Mercier SK, Donaghy H, Botting RA, Turville SG, Harman AN, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson RJ, Moritz RL, Cunningham AL. The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes. PLoS Pathog. 2013 Oct; 9(10):e1003700. PMID: 24204260; PMCID: PMC3798598.
      View in: PubMed, PubMed Central
    77. Lee ST, Ji H, Greening DW, Speirs RW, Rigopoulos A, Pillay V, Murone C, Vitali A, Stühler K, Johns TG, Corner GA, Mariadason JM, Simpson RJ, Scott AM. Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts. Growth Factors. 2013 Oct; 31(5):154-64. PMID: 23957735.
      View in: PubMed
    78. LaVoy EC, Nieman DC, Henson DA, Shanely RA, Knab AM, Cialdella-Kam L, Simpson RJ. Latent cytomegalovirus infection and innate immune function following a 75 km cycling time trial. Eur J Appl Physiol. 2013 Oct; 113(10):2629-35. PMID: 23929537.
      View in: PubMed
    79. Pistillo M, Bigley AB, Spielmann G, LaVoy EC, Morrison MR, Kunz H, Simpson RJ. The effects of age and viral serology on ?d T-cell numbers and exercise responsiveness in humans. Cell Immunol. 2013 Jul-Aug; 284(1-2):91-7. PMID: 23954795.
      View in: PubMed
    80. Greening DW, Ji H, Kapp EA, Simpson RJ. Sulindac modulates secreted protein expression from LIM1215 colon carcinoma cells prior to apoptosis. Biochim Biophys Acta. 2013 Nov; 1834(11):2293-307. PMID: 23899461.
      View in: PubMed
    81. Bigley AB, Spielmann G, LaVoy EC, Simpson RJ. Can exercise-related improvements in immunity influence cancer prevention and prognosis in the elderly? Maturitas. 2013 Sep; 76(1):51-6. PMID: 23870832.
      View in: PubMed
    82. Koester H, Simpson R, Mankowski J. Software wizards to adjust keyboard and mouse settings for people with physical impairments. J Spinal Cord Med. 2013 Jul; 36(4):300-12. PMID: 23820146; PMCID: PMC3758527.
      View in: PubMed, PubMed Central
    83. Greening DW, Simpson RJ. An updated secretome. Biochim Biophys Acta. 2013 Nov; 1834(11):2225. PMID: 23707915.
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    84. Greening DW, Kapp EA, Ji H, Speed TP, Simpson RJ. Colon tumour secretopeptidome: insights into endogenous proteolytic cleavage events in the colon tumour microenvironment. Biochim Biophys Acta. 2013 Nov; 1834(11):2396-407. PMID: 23684732.
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    85. Spielmann G, Bollard CM, Bigley AB, Hanley PJ, Blaney JW, LaVoy EC, Pircher H, Simpson RJ. The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans. Brain Behav Immun. 2014 Jul; 39:142-51. PMID: 23684819.
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    86. Tauro BJ, Mathias RA, Greening DW, Gopal SK, Ji H, Kapp EA, Coleman BM, Hill AF, Kusebauch U, Hallows JL, Shteynberg D, Moritz RL, Zhu HJ, Simpson RJ. Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition. Mol Cell Proteomics. 2013 Aug; 12(8):2148-59. PMID: 23645497; PMCID: PMC3734576.
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    87. Ji H, Greening DW, Barnes TW, Lim JW, Tauro BJ, Rai A, Xu R, Adda C, Mathivanan S, Zhao W, Xue Y, Xu T, Zhu HJ, Simpson RJ. Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. Proteomics. 2013 May; 13(10-11):1672-86. PMID: 23585443.
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    88. Bernhard OK, Greening DW, Barnes TW, Ji H, Simpson RJ. Detection of cadherin-17 in human colon cancer LIM1215 cell secretome and tumour xenograft-derived interstitial fluid and plasma. Biochim Biophys Acta. 2013 Nov; 1834(11):2372-9. PMID: 23557862.
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    89. Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012; 10(12):e1001450. PMID: 23271954; PMCID: PMC3525526.
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    90. Fanayan S, Smith JT, Sethi MK, Cantor D, Goode R, Simpson RJ, Baker MS, Hancock WS, Nice E. Chromosome 7-centric analysis of proteomics data from a panel of human colon carcinoma cell lines. J Proteome Res. 2013 Jan 04; 12(1):89-96. PMID: 23244008.
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    91. Tauro BJ, Greening DW, Mathias RA, Mathivanan S, Ji H, Simpson RJ. Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. Mol Cell Proteomics. 2013 Mar; 12(3):587-98. PMID: 23230278; PMCID: PMC3591653.
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    92. Mathias RA, Gopal SK, Simpson RJ. Contribution of cells undergoing epithelial-mesenchymal transition to the tumour microenvironment. J Proteomics. 2013 Jan 14; 78:545-57. PMID: 23099347.
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    93. Fhaner CJ, Liu S, Ji H, Simpson RJ, Reid GE. Comprehensive lipidome profiling of isogenic primary and metastatic colon adenocarcinoma cell lines. Anal Chem. 2012 Nov 06; 84(21):8917-26. PMID: 23039336; PMCID: PMC3491142.
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    94. LaVoy EC, Bosch JA, Lowder TW, Simpson RJ. Acute aerobic exercise in humans increases cytokine expression in CD27(-) but not CD27(+) CD8(+) T-cells. Brain Behav Immun. 2013 Jan; 27(1):54-62. PMID: 23017234.
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    95. Ondo WG, Jankovic J, Simpson R, Jimenez-Shahed J. Globus pallidus deep brain stimulation for refractory idiopathic restless legs syndrome. Sleep Med. 2012 Oct; 13(9):1202-4. PMID: 22995627.
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    96. Nicholls C, Pinto AR, Li H, Li L, Wang L, Simpson R, Liu JP. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13308-13. PMID: 22847419; PMCID: PMC3421169.
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    97. Mathivanan S, Ji H, Tauro BJ, Chen YS, Simpson RJ. Identifying mutated proteins secreted by colon cancer cell lines using mass spectrometry. J Proteomics. 2012 Dec 05; 76 Spec No.:141-9. PMID: 22796352.
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    98. Baizabal Carvallo JF, Mostile G, Almaguer M, Davidson A, Simpson R, Jankovic J. Deep brain stimulation hardware complications in patients with movement disorders: risk factors and clinical correlations. Stereotact Funct Neurosurg. 2012; 90(5):300-6. PMID: 22797749.
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    99. Layton MJ, Church NL, Faux MC, Ji H, Goode RJ, Kapp EA, Burgess AW, Simpson RJ. Solubilisation of the armadillo-repeat protein ß-catenin using a zwitterionic detergent allows resolution of phosphorylated forms by 2DE. Electrophoresis. 2012 Jul; 33(12):1804-13. PMID: 22740469.
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    100. Lim JW, Mathias RA, Kapp EA, Layton MJ, Faux MC, Burgess AW, Ji H, Simpson RJ. Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4. Electrophoresis. 2012 Jul; 33(12):1873-80. PMID: 22740476.
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    101. Xu Z, He Y, Ju J, Rank G, Cerruti L, Ma C, Simpson RJ, Moritz RL, Jane SM, Zhao Q. The role of WDR5 in silencing human fetal globin gene expression. Haematologica. 2012 Nov; 97(11):1632-40. PMID: 22689669; PMCID: PMC3487434.
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    102. Simpson RJ, Kalra H, Mathivanan S. ExoCarta as a resource for exosomal research. J Extracell Vesicles. 2012; 1. PMID: 24009883; PMCID: PMC3760644.
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    103. Layton MJ, Faux MC, Church NL, Catimel B, Kershaw NJ, Kapp EA, Nowell C, Coates JL, Burgess AW, Simpson RJ. Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of ß-catenin. Biochim Biophys Acta. 2012 Jul; 1824(7):925-37. PMID: 22469663.
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    104. Simpson RJ, Lowder TW, Spielmann G, Bigley AB, LaVoy EC, Kunz H. Exercise and the aging immune system. Ageing Res Rev. 2012 Jul; 11(3):404-20. PMID: 22465452.
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    105. Tauro BJ, Greening DW, Mathias RA, Ji H, Mathivanan S, Scott AM, Simpson RJ. Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods. 2012 Feb; 56(2):293-304. PMID: 22285593.
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    106. Okun MS, Gallo BV, Mandybur G, Jagid J, Foote KD, Revilla FJ, Alterman R, Jankovic J, Simpson R, Junn F, Verhagen L, Arle JE, Ford B, Goodman RR, Stewart RM, Horn S, Baltuch GH, Kopell BH, Marshall F, Peichel D, Pahwa R, Lyons KE, Tröster AI, Vitek JL, Tagliati M. Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial. Lancet Neurol. 2012 Feb; 11(2):140-9. PMID: 22239915.
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    107. Mathias RA, Ji H, Simpson RJ. Proteomic profiling of the epithelial-mesenchymal transition using 2D DIGE. Methods Mol Biol. 2012; 854:269-86. PMID: 22311767.
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    108. Pollonini L, Re R, Simpson RJ, Dacso CC. Integrated device for the measurement of systemic and local oxygen transport during physical exercise. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:3760-3. PMID: 23366746.
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    109. Cosgrove C, Galloway SD, Neal C, Hunter AM, McFarlin BK, Spielmann G, Simpson RJ. The impact of 6-month training preparation for an Ironman triathlon on the proportions of naïve, memory and senescent T cells in resting blood. Eur J Appl Physiol. 2012 Aug; 112(8):2989-98. PMID: 22170013.
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    110. Kinsinger CR, Apffel J, Baker M, Bian X, Borchers CH, Bradshaw R, Brusniak MY, Chan DW, Deutsch EW, Domon B, Gorman J, Grimm R, Hancock W, Hermjakob H, Horn D, Hunter C, Kolar P, Kraus HJ, Langen H, Linding R, Moritz RL, Omenn GS, Orlando R, Pandey A, Ping P, Rahbar A, Rivers R, Seymour SL, Simpson RJ, Slotta D, Smith RD, Stein SE, Tabb DL, Tagle D, Yates JR, Rodriguez H. Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles). Proteomics. 2012 Jan; 12(1):11-20. PMID: 22069307.
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    111. Kinsinger CR, Apffel J, Baker M, Bian X, Borchers CH, Bradshaw R, Brusniak MY, Chan DW, Deutsch EW, Domon B, Gorman J, Grimm R, Hancock W, Hermjakob H, Horn D, Hunter C, Kolar P, Kraus HJ, Langen H, Linding R, Moritz RL, Omenn GS, Orlando R, Pandey A, Ping P, Rahbar A, Rivers R, Seymour SL, Simpson RJ, Slotta D, Smith RD, Stein SE, Tabb DL, Tagle D, Yates JR, Rodriguez H. Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam Principles). J Proteome Res. 2012 Feb 03; 11(2):1412-9. PMID: 22053864; PMCID: PMC3272102.
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    112. Kinsinger CR, Apffel J, Baker M, Bian X, Borchers CH, Bradshaw R, Brusniak MY, Chan DW, Deutsch EW, Domon B, Gorman J, Grimm R, Hancock W, Hermjakob H, Horn D, Hunter C, Kolar P, Kraus HJ, Langen H, Linding R, Moritz RL, Omenn GS, Orlando R, Pandey A, Ping P, Rahbar A, Rivers R, Seymour SL, Simpson RJ, Slotta D, Smith RD, Stein SE, Tabb DL, Tagle D, Yates JR, Rodriguez H. Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles). Proteomics Clin Appl. 2011 Dec; 5(11-12):580-9. PMID: 22213554.
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    113. Kinsinger CR, Apffel J, Baker M, Bian X, Borchers CH, Bradshaw R, Brusniak MY, Chan DW, Deutsch EW, Domon B, Gorman J, Grimm R, Hancock W, Hermjakob H, Horn D, Hunter C, Kolar P, Kraus HJ, Langen H, Linding R, Moritz RL, Omenn GS, Orlando R, Pandey A, Ping P, Rahbar A, Rivers R, Seymour SL, Simpson RJ, Slotta D, Smith RD, Stein SE, Tabb DL, Tagle D, Yates JR, Rodriguez H. Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam Principles). Mol Cell Proteomics. 2011 Dec; 10(12):O111.015446. PMID: 22052993; PMCID: PMC3237091.
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    114. Mathivanan S, Fahner CJ, Reid GE, Simpson RJ. ExoCarta 2012: database of exosomal proteins, RNA and lipids. Nucleic Acids Res. 2012 Jan; 40(Database issue):D1241-4. PMID: 21989406; PMCID: PMC3245025.
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    115. LaVoy EC, McFarlin BK, Simpson RJ. Immune responses to exercising in a cold environment. Wilderness Environ Med. 2011 Dec; 22(4):343-51. PMID: 21982757.
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    116. Bigley AB, Lowder TW, Spielmann G, Rector JL, Pircher H, Woods JA, Simpson RJ. NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection. Brain Behav Immun. 2012 Jan; 26(1):177-86. PMID: 21933704.
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    117. Ji H, Goode RJ, Vaillant F, Mathivanan S, Kapp EA, Mathias RA, Lindeman GJ, Visvader JE, Simpson RJ. Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations. Proteomics. 2011 Oct; 11(20):4029-39. PMID: 21834135.
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    118. Breakefield XO, Frederickson RM, Simpson RJ. Gesicles: Microvesicle "cookies" for transient information transfer between cells. Mol Ther. 2011 Sep; 19(9):1574-6. PMID: 21886114; PMCID: PMC3182359.
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    119. Spielmann G, McFarlin BK, O'Connor DP, Smith PJ, Pircher H, Simpson RJ. Aerobic fitness is associated with lower proportions of senescent blood T-cells in man. Brain Behav Immun. 2011 Nov; 25(8):1521-9. PMID: 21784146.
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    120. Richardson AE, Simpson RJ. Soil microorganisms mediating phosphorus availability update on microbial phosphorus. Plant Physiol. 2011 Jul; 156(3):989-96. PMID: 21606316; PMCID: PMC3135950.
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    121. Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer Res. 2011 May 15; 71(10):3709-19. PMID: 21558389.
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    122. Gorman MA, Uboldi AD, Walsh PJ, Tan KS, Hansen G, Huyton T, Ji H, Curtis J, Kedzierski L, Papenfuss AT, Dogovski C, Perugini MA, Simpson RJ, Handman E, Parker MW. Crystal structure of the Leishmania major MIX protein: a scaffold protein that mediates protein-protein interactions. Protein Sci. 2011 Jun; 20(6):1060-8. PMID: 21465610; PMCID: PMC3104235.
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    123. Navalta J, McFarlin B, Simpson R, Fedor E, Kell H, Lyons S, Arnett S, Schafer M. Finger-stick blood sampling methodology for the determination of exercise-induced lymphocyte apoptosis. J Vis Exp. 2011 Feb 24; (48). PMID: 21403625; PMCID: PMC3197417.
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    124. Mathias RA, Chen YS, Goode RJ, Kapp EA, Mathivanan S, Moritz RL, Zhu HJ, Simpson RJ. Tandem application of cationic colloidal silica and Triton X-114 for plasma membrane protein isolation and purification: towards developing an MDCK protein database. Proteomics. 2011 Apr; 11(7):1238-53. PMID: 21337516.
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    125. Williams AE, Arzola GM, Strutt AM, Simpson R, Jankovic J, York MK. Cognitive outcome and reliable change indices two years following bilateral subthalamic nucleus deep brain stimulation. Parkinsonism Relat Disord. 2011 Jun; 17(5):321-7. PMID: 21316292; PMCID: PMC3109216.
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    126. Mathias RA, Chen YS, Kapp EA, Greening DW, Mathivanan S, Simpson RJ. Triton X-114 phase separation in the isolation and purification of mouse liver microsomal membrane proteins. Methods. 2011 Aug; 54(4):396-406. PMID: 21272644.
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    127. Sparrow RL, Greening DW, Simpson RJ. A protocol for the preparation of cryoprecipitate and cryodepleted plasma. Methods Mol Biol. 2011; 728:259-65. PMID: 21468954.
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    128. Simpson RJ. Aging, persistent viral infections, and immunosenescence: can exercise "make space"? Exerc Sport Sci Rev. 2011 Jan; 39(1):23-33. PMID: 21088603.
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    129. Simpson RJ. Preparation of extracts from yeast. Cold Spring Harb Protoc. 2011 Jan 01; 2011(1):pdb.prot5545. PMID: 21205845.
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    130. Greening DW, Simpson RJ. Low-molecular weight plasma proteome analysis using centrifugal ultrafiltration. Methods Mol Biol. 2011; 728:109-24. PMID: 21468943.
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    131. Bernhard OK, Mathias RA, Barnes TW, Simpson RJ. A fluorescent microsphere-based method for assay of multiple analytes in plasma. Methods Mol Biol. 2011; 728:195-206. PMID: 21468949.
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    132. Greening DW, Sparrow RL, Simpson RJ. Preparation of platelet concentrates. Methods Mol Biol. 2011; 728:267-78. PMID: 21468955.
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    133. Haling RE, Simpson RJ, Culvenor RA, Lambers H, Richardson AE. Effect of soil acidity, soil strength and macropores on root growth and morphology of perennial grass species differing in acid-soil resistance. Plant Cell Environ. 2011 Mar; 34(3):444-56. PMID: 21062319.
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    134. Simpson RJ. Disruption of cultured cells by nitrogen cavitation. Cold Spring Harb Protoc. 2010 Nov 01; 2010(11):pdb.prot5513. PMID: 21041386.
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    135. Peng L, Kapp EA, Fenyö D, Kwon MS, Jiang P, Wu S, Jiang Y, Aguilar MI, Ahmed N, Baker MS, Cai Z, Chen YJ, Van Chi P, Chung MC, He F, Len AC, Liao PC, Nakamura K, Ngai SM, Paik YK, Pan TL, Poon TC, Salekdeh GH, Simpson RJ, Sirdeshmukh R, Srisomsap C, Svasti J, Tyan YC, Dreyer FS, McLauchlan D, Rawson P, Jordan TW. The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterisation of the carbonate-washed membrane standard. Proteomics. 2010 Nov; 10(22):4142-8. PMID: 20486120; PMCID: PMC3891941.
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    136. Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 2010 Dec; 9(12):1164-1172. PMID: 20970382.
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    137. Simpson RJ, Graham SM, Florida-James GD, Connaboy C, Clement R, Jackson AS. Perceived exertion and heart rate models for estimating metabolic workload in elite British soldiers performing a backpack load-carriage task. Appl Physiol Nutr Metab. 2010 Oct; 35(5):650-6. PMID: 20962921.
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    138. Rabilloud T, Hochstrasser D, Simpson RJ. Is a gene-centric human proteome project the best way for proteomics to serve biology? Proteomics. 2010 Sep; 10(17):3067-72. PMID: 20648483.
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    139. Simpson RJ. Small-scale extraction of recombinant proteins from bacteria. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.prot5483. PMID: 20810630.
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    140. Simpson RJ. Large-scale extraction of recombinant proteins from bacteria. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.prot5484. PMID: 20810631.
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    141. Simpson RJ. Solubilization of Escherichia coli recombinant proteins from inclusion bodies. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.prot5485. PMID: 20810632.
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    142. Booth S, Florida-James GD, McFarlin BK, Spielmann G, O'Connor DP, Simpson RJ. The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum. Eur J Appl Physiol. 2010 Dec; 110(6):1259-68. PMID: 20799043.
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    143. Esposito LM, Simpson RJ, Strohacker K, Carpenter KC, McFarlin BK. Defining a longitudinal survival model to examine forced treadmill running as a countermeasure for diet-induced weight gain. Lab Anim. 2010 Oct; 44(4):305-11. PMID: 20696788.
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    144. Strohacker K, Simpson RJ, Carpenter KC, Breslin WL, McFarlin BK. Longitudinal, Diet-induced Weight Gain is Associated with Increased Blood Monocytes and Reduced TLR4 Expression. Int J Exerc Sci. 2010; 3(3):134-142. PMID: 27182339.
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    145. Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010 Sep 10; 73(10):1907-20. PMID: 20601276.
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    146. Simpson RJ. Homogenization of mammalian tissue. Cold Spring Harb Protoc. 2010 Jul 01; 2010(7):pdb.prot5455. PMID: 20647359.
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    147. Chen YS, Mathias RA, Mathivanan S, Kapp EA, Moritz RL, Zhu HJ, Simpson RJ. Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition. Mol Cell Proteomics. 2011 Feb; 10(2):M110.001131. PMID: 20511395; PMCID: PMC3033669.
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    148. Rank G, Cerruti L, Simpson RJ, Moritz RL, Jane SM, Zhao Q. Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood. 2010 Sep 02; 116(9):1585-92. PMID: 20495075; PMCID: PMC2938845.
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    149. Simpson RJ. Stabilization of proteins for storage. Cold Spring Harb Protoc. 2010 May; 2010(5):pdb.top79. PMID: 20439424.
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    150. Simpson RJ. Rapid coomassie blue staining of protein gels. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5413. PMID: 20360367.
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    151. Simpson RJ. CTAB-PAGE. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5412. PMID: 20360366.
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    152. Simpson RJ. Pouring linear gradient gels with a gradient former. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5411. PMID: 20360365.
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    153. Simpson RJ. SYPRO Orange fluorescent staining of protein gels. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5414. PMID: 20360368.
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    154. Ahn SM, Simpson R, Lee B. Genomics and proteomics in stem cell research: the road ahead. Anat Cell Biol. 2010 Mar; 43(1):1-14. PMID: 21190000; PMCID: PMC2998774.
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    155. Segura E, Kapp E, Gupta N, Wong J, Lim J, Ji H, Heath WR, Simpson R, Villadangos JA. Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysis. Mol Immunol. 2010 May; 47(9):1765-73. PMID: 20347150.
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    156. Mathias RA, Chen YS, Wang B, Ji H, Kapp EA, Moritz RL, Zhu HJ, Simpson RJ. Extracellular remodelling during oncogenic Ras-induced epithelial-mesenchymal transition facilitates MDCK cell migration. J Proteome Res. 2010 Feb 05; 9(2):1007-19. PMID: 19954229.
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    157. Boddey JA, Hodder AN, Günther S, Gilson PR, Patsiouras H, Kapp EA, Pearce JA, de Koning-Ward TF, Simpson RJ, Crabb BS, Cowman AF. An aspartyl protease directs malaria effector proteins to the host cell. Nature. 2010 Feb 04; 463(7281):627-31. PMID: 20130643; PMCID: PMC2818761.
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    158. Simpson R, Koester HH, Lopresti E. Research in computer access assessment and intervention. Phys Med Rehabil Clin N Am. 2010 Feb; 21(1):15-32. PMID: 19951775; PMCID: PMC2788505.
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    159. Simpson RJ, Cosgrove C, Chee MM, McFarlin BK, Bartlett DB, Spielmann G, O'Connor DP, Pircher H, Shiels PG. Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. Exerc Immunol Rev. 2010; 16:40-55. PMID: 20839490.
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    160. Simpson RJ, Guy K. Coupling aging immunity with a sedentary lifestyle: has the damage already been done?--a mini-review. Gerontology. 2010; 56(5):449-58. PMID: 20029165.
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    161. Mathivanan S, Simpson RJ. ExoCarta: A compendium of exosomal proteins and RNA. Proteomics. 2009 Nov; 9(21):4997-5000. PMID: 19810033.
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    162. Mathivanan S, Lim JW, Tauro BJ, Ji H, Moritz RL, Simpson RJ. Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol Cell Proteomics. 2010 Feb; 9(2):197-208. PMID: 19837982; PMCID: PMC2830834.
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    163. Greening DW, Simpson RJ. A centrifugal ultrafiltration strategy for isolating the low-molecular weight (
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    164. York MK, Wilde EA, Simpson R, Jankovic J. Relationship between neuropsychological outcome and DBS surgical trajectory and electrode location. J Neurol Sci. 2009 Dec 15; 287(1-2):159-71. PMID: 19767016; PMCID: PMC2783787.
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    165. Greening DW, Glenister KM, Sparrow RL, Simpson RJ. International blood collection and storage: clinical use of blood products. J Proteomics. 2010 Jan 03; 73(3):386-95. PMID: 19664733.
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    166. Simpson RJ, Lim JW, Moritz RL, Mathivanan S. Exosomes: proteomic insights and diagnostic potential. Expert Rev Proteomics. 2009 Jun; 6(3):267-83. PMID: 19489699.
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    167. Delhaize E, Taylor P, Hocking PJ, Simpson RJ, Ryan PR, Richardson AE. Transgenic barley (Hordeum vulgare L.) expressing the wheat aluminium resistance gene (TaALMT1) shows enhanced phosphorus nutrition and grain production when grown on an acid soil. Plant Biotechnol J. 2009 Jun; 7(5):391-400. PMID: 19490502.
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    168. Mathias RA, Wang B, Ji H, Kapp EA, Moritz RL, Zhu HJ, Simpson RJ. Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition. J Proteome Res. 2009 Jun; 8(6):2827-37. PMID: 19296674.
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    169. Mathias RA, Simpson RJ. Towards understanding epithelial-mesenchymal transition: a proteomics perspective. Biochim Biophys Acta. 2009 Sep; 1794(9):1325-31. PMID: 19439204.
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    170. Ji H, Greening DW, Kapp EA, Moritz RL, Simpson RJ. Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells. Proteomics Clin Appl. 2009 Apr; 3(4):433-51. PMID: 21136970.
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    171. Greening DW, Glenister KM, Sparrow RL, Simpson RJ. Enrichment of human platelet membranes for proteomic analysis. Methods Mol Biol. 2009; 528:245-58. PMID: 19153697.
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    172. Goode RJ, Simpson RJ. Purification of basolateral integral membrane proteins by cationic colloidal silica-based apical membrane subtraction. Methods Mol Biol. 2009; 528:177-87. PMID: 19153693.
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    173. Mathias RA, Lim JW, Ji H, Simpson RJ. Isolation of extracellular membranous vesicles for proteomic analysis. Methods Mol Biol. 2009; 528:227-42. PMID: 19153696.
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    174. Ahn SM, Byun K, Kim D, Lee K, Yoo JS, Kim SU, Jho EH, Simpson RJ, Lee B. Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS One. 2008; 3(12):e3917. PMID: 19093005; PMCID: PMC2602983.
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    175. Boddey JA, Moritz RL, Simpson RJ, Cowman AF. Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic. 2009 Mar; 10(3):285-99. PMID: 19055692; PMCID: PMC2682620.
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    176. Ahn SM, Goode RJ, Simpson RJ. Stem cell markers: insights from membrane proteomics? Proteomics. 2008 Dec; 8(23-24):4946-57. PMID: 19016515.
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    177. Cooper RA, Dicianno BE, Brewer B, LoPresti E, Ding D, Simpson R, Grindle G, Wang H. A perspective on intelligent devices and environments in medical rehabilitation. Med Eng Phys. 2008 Dec; 30(10):1387-98. PMID: 18993108.
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    178. Simpson RJ, McFarlin BK, McSporran C, Spielmann G, ó Hartaigh B, Guy K. Toll-like receptor expression on classic and pro-inflammatory blood monocytes after acute exercise in humans. Brain Behav Immun. 2009 Feb; 23(2):232-9. PMID: 18930806.
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    179. Simpson RJ, Jensen SS, Lim JW. Proteomic profiling of exosomes: current perspectives. Proteomics. 2008 Oct; 8(19):4083-99. PMID: 18780348.
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    180. Simpson RJ. Estimation of Free Thiols and Disulfide Bonds Using Ellman's Reagent. CSH Protoc. 2008 Sep 01; 2008:pdb.prot4699. PMID: 21356901.
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    181. Simpson RJ. Quantifying protein by bicinchoninic Acid. CSH Protoc. 2008 Aug 01; 2008:pdb.prot4722. PMID: 21356880.
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    182. Ahn SM, Byun K, Cho K, Kim JY, Yoo JS, Kim D, Paek SH, Kim SU, Simpson RJ, Lee B. Human microglial cells synthesize albumin in brain. PLoS One. 2008 Jul 30; 3(7):e2829. PMID: 18665237; PMCID: PMC2483733.
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    183. Simpson RJ. In-gel s-pyridylethylation of gel-resolved proteins: whole gel method. CSH Protoc. 2008 Jun 01; 2008:pdb.prot4604. PMID: 21356843.
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    184. Simpson RJ. In-gel s-pyridylethylation of gel-resolved proteins: individual spot method. CSH Protoc. 2008 Jun 01; 2008:pdb.prot4605. PMID: 21356844.
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    185. Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ. Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes. Electrophoresis. 2008 Jun; 29(12):2660-71. PMID: 18494037.
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    186. Simpson RJ, Bernhard OK, Greening DW, Moritz RL. Proteomics-driven cancer biomarker discovery: looking to the future. Curr Opin Chem Biol. 2008 Feb; 12(1):72-7. PMID: 18295612.
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    187. Simpson RJ, Cosgrove C, Ingram LA, Florida-James GD, Whyte GP, Pircher H, Guy K. Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain Behav Immun. 2008 May; 22(4):544-51. PMID: 18164586.
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    188. Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008 Feb; 26(2):164-7. PMID: 18259167.
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    189. Rentschler AJ, Simpson R, Cooper RA, Boninger ML. Clinical evaluation of Guido robotic walker. J Rehabil Res Dev. 2008; 45(9):1281-93. PMID: 19319753.
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    190. Nguyen TT, Wang JJ, Islam FM, Mitchell P, Tapp RJ, Zimmet PZ, Simpson R, Shaw J, Wong TY. Retinal arteriolar narrowing predicts incidence of diabetes: the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. Diabetes. 2008 Mar; 57(3):536-9. PMID: 18086902.
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    191. Greening DW, Glenister KM, Kapp EA, Moritz RL, Sparrow RL, Lynch GW, Simpson RJ. Comparison of human platelet membrane-cytoskeletal proteins with the plasma proteome: Towards understanding the platelet-plasma nexus. Proteomics Clin Appl. 2008 Jan; 2(1):63-77. PMID: 21136780.
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    192. Campbell JP, Guy K, Cosgrove C, Florida-James GD, Simpson RJ. Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise. Brain Behav Immun. 2008 Mar; 22(3):375-80. PMID: 17949944.
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    193. Ahn SM, Simpson RJ. Body fluid proteomics: Prospects for biomarker discovery. Proteomics Clin Appl. 2007 Sep; 1(9):1004-15. PMID: 21136753.
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    194. Wilson MR, Foucaud L, Barlow PG, Hutchison GR, Sales J, Simpson RJ, Stone V. Nanoparticle interactions with zinc and iron: implications for toxicology and inflammation. Toxicol Appl Pharmacol. 2007 Nov 15; 225(1):80-9. PMID: 17900645.
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    195. Simpson RJ, Florida-James GD, Whyte GP, Black JR, Ross JA, Guy K. Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. Res Sports Med. 2007 Jul-Sep; 15(3):157-74. PMID: 17987505.
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    196. Simpson RJ. Staining proteins in gels with silver nitrate. CSH Protoc. 2007 Jul 01; 2007:pdb.prot4727. PMID: 21357115.
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    197. Ji H, Moritz RL, Kim YS, Zhu HJ, Simpson RJ. Analysis of Ras-induced oncogenic transformation of NIH-3T3 cells using differential-display 2-DE proteomics. Electrophoresis. 2007 Jun; 28(12):1997-2008. PMID: 17526045.
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    198. Oh S, Kang D, Ahn SM, Simpson RJ, Lee BH, Moon MH. Miniaturized asymmetrical flow field-flow fractionation: application to biological vesicles. J Sep Sci. 2007 May; 30(7):1082-7. PMID: 17566344.
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    199. Simpson RJ. Nomenclature on proteases, proteinases, and peptidases. CSH Protoc. 2007 Apr 01; 2007:pdb.ip13. PMID: 21357051.
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    200. Simpson RJ. Zinc/Imidazole procedure for visualization of proteins in gels by negative staining. CSH Protoc. 2007 Apr 01; 2007:pdb.prot4701. PMID: 21357060.
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    201. Simpson RJ. Staining proteins in gels with coomassie blue. CSH Protoc. 2007 Apr 01; 2007:pdb.prot4719. PMID: 21357065.
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    202. Simpson RJ, Florida-James GD, Cosgrove C, Whyte GP, Macrae S, Pircher H, Guy K. High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. J Appl Physiol (1985). 2007 Jul; 103(1):396-401. PMID: 17379755.
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    203. Bernhard OK, Kapp EA, Simpson RJ. Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. J Proteome Res. 2007 Mar; 6(3):987-95. PMID: 17330941.
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    204. Simpson RJ. Fabricating protein arrays. CSH Protoc. 2007 Mar 01; 2007:pdb.ip24. PMID: 21357028.
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    205. Simpson RJ. Performic Acid oxidation of proteins. CSH Protoc. 2007 Mar 01; 2007:pdb.prot4698. PMID: 21357039.
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    206. Simpson RJ. Cleavage at Tryptophan by o-Iodosobenzoic Acid. CSH Protoc. 2007 Mar 01; 2007:pdb.prot4700. PMID: 21357040.
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    207. Simpson RJ. Cleavage at met-x bonds by cyanogen bromide. CSH Protoc. 2007 Mar 01; 2007:pdb.prot4704. PMID: 21357041.
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    208. Simpson RJ. Cleavage of asn-gly bonds by hydroxylamine. CSH Protoc. 2007 Mar 01; 2007:pdb.prot4697. PMID: 21357038.
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    209. Simpson RJ. Assays with protein arrays. CSH Protoc. 2007 Mar 01; 2007:pdb.top2. PMID: 21357048.
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    210. Simpson RJ. Reduction and s-carboxymethylation of proteins: microscale method. CSH Protoc. 2007 Feb 01; 2007:pdb.prot4568. PMID: 21357010.
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    211. Simpson RJ. Reduction and s-carboxymethylation of proteins: large-scale method. CSH Protoc. 2007 Feb 01; 2007:pdb.prot4569. PMID: 21357011.
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    212. Simpson RJ. In Situ SDS-PAGE Peptide-Mapping Procedure (Cleveland Method). CSH Protoc. 2007 Feb 01; 2007:pdb.prot4570. PMID: 21357012.
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    213. Simpson RJ. SDS-PAGE Peptide-Mapping Procedure (Cleveland Method). CSH Protoc. 2007 Feb 01; 2007:pdb.prot4591. PMID: 21357014.
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    214. Middleton N, Shave R, George K, Whyte G, Simpson R, Florida-James G, Gaze D. Impact of repeated prolonged exercise bouts on cardiac function and biomarkers. Med Sci Sports Exerc. 2007 Jan; 39(1):83-90. PMID: 17218888.
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    215. Simpson R, Koester H, LoPresti E. Selecting an appropriate scan rate: the ".65 rule". Assist Technol. 2007; 19(2):51-8; quiz 59-60. PMID: 17727073.
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    216. Simpson R. Mental Health Act: why not learn from devolution? BMJ. 2006 Dec 09; 333(7580):1221. PMID: 17158399; PMCID: PMC1693580.
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    217. Debrincat MA, Zhang JG, Willson TA, Silke J, Connolly LM, Simpson RJ, Alexander WS, Nicola NA, Kile BT, Hilton DJ. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. J Biol Chem. 2007 Feb 16; 282(7):4728-37. PMID: 17148442.
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    218. Simpson RJ, Florida-James GD, Whyte GP, Middleton N, Shave R, George K, Guy K. The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells. Eur J Appl Physiol. 2007 Jan; 99(2):201-4. PMID: 17089158.
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    219. Simpson RJ. Modification of lysyl side chains using citraconic anhydride. CSH Protoc. 2006 Oct 01; 2006(5). PMID: 22485947.
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    220. Simpson RJ. Fluorescent Staining of Proteins with SYPRO Ruby. CSH Protoc. 2006 Oct 01; 2006(5). PMID: 22485954.
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    221. Simpson RJ. Fragmentation of protein using trypsin. CSH Protoc. 2006 Oct 01; 2006(5). PMID: 22485945.
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    222. Simpson RJ. Modification of lysyl side chains using succinic anhydride. CSH Protoc. 2006 Oct 01; 2006(5). PMID: 22485946.
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    223. Simpson RJ. Concentrating acrylamide gel spots. CSH Protoc. 2006 Oct 01; 2006(5). PMID: 22485966.
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    224. Catimel B, Layton M, Church N, Ross J, Condron M, Faux M, Simpson RJ, Burgess AW, Nice EC. In situ phosphorylation of immobilized receptors on biosensor surfaces: application to E-cadherin/beta-catenin interactions. Anal Biochem. 2006 Oct 15; 357(2):277-88. PMID: 16945320.
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    225. Simpson RJ, O'Farrell PA. Separation of proteins using hydrophobic interaction chromatography. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485602.
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    226. Simpson RJ. Chromatography using a crystalline powder form of hydroxyapatite. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485620.
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    227. Simpson RJ. Bulk precipitation of proteins by ammonium sulfate. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485684.
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    228. Simpson RJ. Fractional precipitation of proteins by ammonium sulfate. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485685.
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    229. Simpson RJ. Precipitation of proteins by organic solvents. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485686.
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    230. Simpson RJ. Precipitation of proteins by polyethylene glycol. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485687.
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    231. Simpson RJ. The tap-fill method for dry packing columns of rigid solids. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485588.
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    232. Simpson RJ. Protein separation on ceramic hydroxyapatite using high-performance liquid chromatography. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485665.
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    233. Simpson RJ, Gray SC, Florida-James GD. Physiological variables and performance markers of serving soldiers from two "elite" units of the British Army. J Sports Sci. 2006 Jun; 24(6):597-604. PMID: 16611570.
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    234. Simpson RJ. Packing ceramic hydroxyapatite columns for high-performance liquid chromatography. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485664.
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    235. Simpson RJ. Electrophoresis of Peptides (Tricine-SDS-PAGE). CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485690.
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    236. Simpson RJ. Precipitation of proteins by polyethylenimine. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485688.
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    237. Simpson RJ. SDS-PAGE of Proteins. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485689.
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    238. Simpson RJ, Florida-James GD, Whyte GP, Guy K. The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53. Eur J Appl Physiol. 2006 May; 97(1):109-21. PMID: 16506060.
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    239. Park JW, Kim S, Lim KJ, Simpson RJ, Kim YS, Bahk YY. A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells. Proteomics. 2006 Feb; 6(4):1175-86. PMID: 16402364.
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    240. Wilkins MR, Appel RD, Van Eyk JE, Chung MC, Görg A, Hecker M, Huber LA, Langen H, Link AJ, Paik YK, Patterson SD, Pennington SR, Rabilloud T, Simpson RJ, Weiss W, Dunn MJ. Guidelines for the next 10 years of proteomics. Proteomics. 2006 Jan; 6(1):4-8. PMID: 16400714.
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    241. Moritz RL, Simpson RJ. Liquid-based free-flow electrophoresis-reversed-phase HPLC: a proteomic tool. Nat Methods. 2005 Nov; 2(11):863-73. PMID: 16278658.
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    242. Skandarajah AR, Moritz RL, Tjandra JJ, Simpson RJ. Proteomic analysis of colorectal cancer: discovering novel biomarkers. Expert Rev Proteomics. 2005 Oct; 2(5):681-92. PMID: 16209648.
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    243. Nam HW, Simpson R, Kim YS. N-terminal isotope tagging with propionic anhydride: proteomic analysis of myogenic differentiation of C2C12 cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 05; 826(1-2):91-107. PMID: 16165407.
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    244. Omenn GS, States DJ, Adamski M, Blackwell TW, Menon R, Hermjakob H, Apweiler R, Haab BB, Simpson RJ, Eddes JS, Kapp EA, Moritz RL, Chan DW, Rai AJ, Admon A, Aebersold R, Eng J, Hancock WS, Hefta SA, Meyer H, Paik YK, Yoo JS, Ping P, Pounds J, Adkins J, Qian X, Wang R, Wasinger V, Wu CY, Zhao X, Zeng R, Archakov A, Tsugita A, Beer I, Pandey A, Pisano M, Andrews P, Tammen H, Speicher DW, Hanash SM. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics. 2005 Aug; 5(13):3226-45. PMID: 16104056.
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    245. Kapp EA, Schütz F, Connolly LM, Chakel JA, Meza JE, Miller CA, Fenyo D, Eng JK, Adkins JN, Omenn GS, Simpson RJ. An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms: sensitivity and specificity analysis. Proteomics. 2005 Aug; 5(13):3475-90. PMID: 16047398.
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    246. Moritz RL, Clippingdale AB, Kapp EA, Eddes JS, Ji H, Gilbert S, Connolly LM, Simpson RJ. Application of 2-D free-flow electrophoresis/RP-HPLC for proteomic analysis of human plasma depleted of multi high-abundance proteins. Proteomics. 2005 Aug; 5(13):3402-13. PMID: 16052629.
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    247. Reid GE, Roberts KD, Simpson RJ, O'Hair RA. Selective identification and quantitative analysis of methionine containing peptides by charge derivatization and tandem mass spectrometry. J Am Soc Mass Spectrom. 2005 Jul; 16(7):1131-50. PMID: 15923125.
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    248. Simpson RJ, Wilson MR, Black JR, Ross JA, Whyte GP, Guy K, Florida-James GD. Immune alterations, lipid peroxidation, and muscle damage following a hill race. Can J Appl Physiol. 2005 Apr; 30(2):196-211. PMID: 15981788.
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    249. Hoffmann P, Olayioye MA, Moritz RL, Lindeman GJ, Visvader JE, Simpson RJ, Kemp BE. Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Electrophoresis. 2005 Mar; 26(6):1029-37. PMID: 15704244.
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    250. George TS, Simpson RJ, Hadobas PA, Richardson AE. Expression of a fungal phytase gene in Nicotiana tabacum improves phosphorus nutrition of plants grown in amended soils. Plant Biotechnol J. 2005 Jan; 3(1):129-40. PMID: 17168905.
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    251. Moritz RL, Skandarajah AR, Ji H, Simpson RJ. Proteomic analysis of colorectal cancer: prefractionation strategies using two-dimensional free-flow electrophoresis. Comp Funct Genomics. 2005; 6(4):236-43. PMID: 18629191; PMCID: PMC2447484.
      View in: PubMed, PubMed Central
    252. Cooper RA, Ding D, Simpson R, Fitzgerald SG, Spaeth DM, Guo S, Koontz AM, Cooper R, Kim J, Boninger ML. Virtual reality and computer-enhanced training applied to wheeled mobility: an overview of work in Pittsburgh. Assist Technol. 2005; 17(2):159-70. PMID: 16392719.
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    253. Pedrioli PG, Eng JK, Hubley R, Vogelzang M, Deutsch EW, Raught B, Pratt B, Nilsson E, Angeletti RH, Apweiler R, Cheung K, Costello CE, Hermjakob H, Huang S, Julian RK, Kapp E, McComb ME, Oliver SG, Omenn G, Paton NW, Simpson R, Smith R, Taylor CF, Zhu W, Aebersold R. A common open representation of mass spectrometry data and its application to proteomics research. Nat Biotechnol. 2004 Nov; 22(11):1459-66. PMID: 15529173.
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    254. Whitehead JP, Simpson F, Hill MM, Thomas EC, Connolly LM, Collart F, Simpson RJ, James DE. Insulin and oleate promote translocation of inosine-5' monophosphate dehydrogenase to lipid bodies. Traffic. 2004 Oct; 5(10):739-49. PMID: 15355510.
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    255. Nakamura K, Aebersold R, Bairoch A, Dunn M, Celis J, Hanash S, Hochstrasser D, Humphrey-Smith I, James P, Klose J, LaBaer J, Langen H, Mann M, Parekh R, Patterson S, Pearce C, Poepstorff P, Simpson RJ, Tomlinson I, Tsugita A, Yates J. [From genome to proteome--aim of human proteomics]. Seikagaku. 2004 Oct; 76(10):1271-4. PMID: 15580857.
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    256. Moritz RL, Ji H, Schütz F, Connolly LM, Kapp EA, Speed TP, Simpson RJ. A proteome strategy for fractionating proteins and peptides using continuous free-flow electrophoresis coupled off-line to reversed-phase high-performance liquid chromatography. Anal Chem. 2004 Aug 15; 76(16):4811-24. PMID: 15307793.
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    257. Olayioye MA, Hoffmann P, Pomorski T, Armes J, Simpson RJ, Kemp BE, Lindeman GJ, Visvader JE. The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Res. 2004 May 15; 64(10):3538-44. PMID: 15150109.
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    258. Faux MC, Ross JL, Meeker C, Johns T, Ji H, Simpson RJ, Layton MJ, Burgess AW. Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. J Cell Sci. 2004 Jan 26; 117(Pt 3):427-39. PMID: 14679305.
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    259. Kapp EA, Schütz F, Reid GE, Eddes JS, Moritz RL, O'Hair RA, Speed TP, Simpson RJ. Mining a tandem mass spectrometry database to determine the trends and global factors influencing peptide fragmentation. Anal Chem. 2003 Nov 15; 75(22):6251-64. PMID: 14616009.
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    260. Simpson RJ. Task imposed on prisons is impossible. BMJ. 2003 Oct 25; 327(7421):989. PMID: 14576263; PMCID: PMC259199.
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    261. Hodder AN, Drew DR, Epa VC, Delorenzi M, Bourgon R, Miller SK, Moritz RL, Frecklington DF, Simpson RJ, Speed TP, Pike RN, Crabb BS. Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5. J Biol Chem. 2003 Nov 28; 278(48):48169-77. PMID: 13679369.
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    262. McColl BK, Baldwin ME, Roufail S, Freeman C, Moritz RL, Simpson RJ, Alitalo K, Stacker SA, Achen MG. Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D. J Exp Med. 2003 Sep 15; 198(6):863-8. PMID: 12963694; PMCID: PMC2194198.
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    263. Taverner T, Hall NE, O'Hair RA, Simpson RJ. Characterization of an antagonist interleukin-6 dimer by stable isotope labeling, cross-linking, and mass spectrometry. J Biol Chem. 2002 Nov 29; 277(48):46487-92. PMID: 12235153.
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    264. Elso C, Toohey B, Reid GE, Poetter K, Simpson RJ, Foote SJ. Mutation detection using mass spectrometric separation of tiny oligonucleotide fragments. Genome Res. 2002 Sep; 12(9):1428-33. PMID: 12213780; PMCID: PMC186647.
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    265. Eddes JS, Kapp EA, Frecklington DF, Connolly LM, Layton MJ, Moritz RL, Simpson RJ. CHOMPER: a bioinformatic tool for rapid validation of tandem mass spectrometry search results associated with high-throughput proteomic strategies. Proteomics. 2002 Sep; 2(9):1097-103. PMID: 12362328.
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    266. Akbarzadeh S, Ji H, Frecklington D, Marmy-Conus N, Mok YF, Bowes L, Devereux L, Linsenmeyer M, Simpson RJ, Dorow DS. Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking. J Biol Chem. 2002 Sep 27; 277(39):36280-7. PMID: 12105200.
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    267. Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol. 2002 Jul; 22(13):4567-78. PMID: 12052866; PMCID: PMC133908.
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    268. Mathaba LT, Pope CH, Lenzo J, Hartofillis M, Peake H, Moritz RL, Simpson RJ, Bubert A, Thompson PJ, Stewart GA. Isolation and characterisation of a 13.8-kDa bacteriolytic enzyme from house dust mite extracts: homology with prokaryotic proteins suggests that the enzyme could be bacterially derived. FEMS Immunol Med Microbiol. 2002 Jun 03; 33(2):77-88. PMID: 12052562.
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    269. Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem. 2002 Jan 04; 277(1):445-54. PMID: 11604410.
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    270. Simpson RJ, Cascio WE, Crow RS, Schreiner PJ, Rautaharju PM, Heiss G. Association of ventricular premature complexes with electrocardiographic-estimated left ventricular mass in a population of African-American and white men and women (The Atherosclerosis Risk in Communities. Am J Cardiol. 2001 Jan 01; 87(1):49-53. PMID: 11137833.
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    271. Evenson KR, Welch VL, Cascio WE, Simpson RJ. Validation of a short rhythm strip compared to ambulatory ECG monitoring for ventricular ectopy. J Clin Epidemiol. 2000 May; 53(5):491-7. PMID: 10812321.
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    272. Guzzo JA, Simpson RJ. Echocardiography in Staphylococcus aureus bacteremia. J Am Coll Cardiol. 1998 May; 31(6):1443-5. PMID: 9581750.
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    273. Simpson RJ. Tell me what ails you, and I'll tell you why it's your fault. J Am Coll Cardiol. 1995 Apr; 25(5):1010-2. PMID: 7897109.
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    274. Holzman TG, Griffith A, Hunter WG, Allen T, Simpson RJ. Computer-assisted trauma care prototype. Medinfo. 1995; 8 Pt 2:1685. PMID: 8591545.
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    275. Curtis JL, Foster JR, Gettes LS, Simpson RJ, Woelfel A. Initial presentation of sustained ventricular tachycardia after resection of left ventricular aneurysm. Am J Cardiol. 1986 Sep 01; 58(6):560-1. PMID: 3751922.
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    276. Woelfel AK, Simpson RJ, Gettes LS, Foster JR. Exercise-induced distal atrioventricular block. J Am Coll Cardiol. 1983 Sep; 2(3):578-81. PMID: 6875122.
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