Loading...
Header Logo
Keywords
Last Name
Institution

Frank McKeon

TitleProfessor
InstitutionUniversity of Houston
DepartmentBiology
Address4800 Calhoun Rd
Houston TX 77004
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01GM038556     (MCKEON, FRANK D.)Jul 1, 1987 - Mar 31, 1998
    NIH/NIGMS
    NUCLEAR ENVELOPE AND NUCLEAR TRANSPORT
    Role: Principal Investigator
    R01GM037977     (MCKEON, FRANK D.)Feb 1, 1988 - Jan 31, 1993
    NIH/NIGMS
    FUNCTION DOMAINS IN THE NUCLEAR LAMIN PROTEINS
    Role: Principal Investigator
    R01GM052027     (MCKEON, FRANK D.)Sep 1, 1995 - Aug 31, 2000
    NIH/NIGMS
    FUNCTIONAL COMPONENTS OF THE MAMMALIAN KINETOCHORE
    Role: Principal Investigator
    R01CA075340     (MCKEON, FRANK D.)Jun 15, 1998 - Apr 30, 2009
    NIH/NCI
    Murine p73 in Tumorigenesis
    Role: Principal Investigator
    R01CA083944     (MCKEON, FRANK D.)Feb 9, 2000 - Jan 31, 2005
    NIH/NCI
    P63 IN EPITHELIAL CELL PROLIFERATION AND DIFFERENTIATION
    Role: Principal Investigator
    R01GM063668     (MCKEON, FRANK D.)Apr 1, 2002 - Oct 31, 2006
    NIH/NIGMS
    Control of NF-AT Signaling Through Nuclear Import
    Role: Principal Investigator
    R01CA095632     (MCKEON, FRANK D.)Jul 18, 2002 - Jun 30, 2008
    NIH/NCI
    Mitotic Checkpoint Proteins in Tumorigenesis
    Role: Principal Investigator
    R01GM083348     (MCKEON, FRANK D.)Aug 1, 2008 - Mar 31, 2013
    NIH/NIGMS
    Epithelial Stem Cell Programs
    Role: Principal Investigator
    R01HD058342     (MCKEON, FRANK D.)Aug 1, 2009 - Jul 31, 2012
    NIH/NICHD
    p63-Dependent Checkpoints in Oocytes
    Role: Principal Investigator
    RC1HL100767     (MCKEON, FRANK D.)Sep 30, 2009 - Aug 31, 2012
    NIH/NHLBI
    Monoclonal Antibodies and Genetic Elements for Airway Disease
    Role: Principal Investigator
    R21CA173190     (CRUM, CHRISTOPHER PAUL)Feb 5, 2013 - Jan 31, 2015
    NIH/NCI
    The squamocolumnar junction and cervical cancer
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Srivastava S, Kern F, Sharma N, McKeon F, Xian W, Yeoh KG, Ho KY, Teh M. FABP1 and Hepar expression levels in Barrett's esophagus and associated neoplasia in an Asian population. Dig Liver Dis. 2017 Jul 27. PMID: 28807490.
      View in: PubMed
    2. Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA. A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology. 2017 Jul; 153(1):e6-e13. PMID: 28583825.
      View in: PubMed
    3. Xian W, McKeon F. Barrett's Stem Cells as a Unique and Targetable Entity. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):161-164. PMID: 28593188.
      View in: PubMed
    4. Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV. Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene. 2017 Jul 20; 36(29):4089-4099. PMID: 28319068.
      View in: PubMed
    5. Yamamoto Y, Wang X, Bertrand D, Kern F, Zhang T, Duleba M, Srivastava S, Khor CC, Hu Y, Wilson LH, Blaszyk H, Rolshud D, Teh M, Liu J, Howitt BE, Vincent M, Crum CP, Nagarajan N, Ho KY, McKeon F, Xian W. Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion. Nat Commun. 2016 Jan 19; 7:10380. PMID: 26783136; PMCID: PMC4735693.
      View in: PubMed, PubMed Central
    6. Sharma N, Srivastava S, Kern F, Xian W, Ming T, McKeon F, Ho KY. Endoscopic modalities for the diagnosis of Barrett's oesophagus. United European Gastroenterol J. 2016 Dec; 4(6):733-740. PMID: 28408990.
      View in: PubMed
    7. Sharma P, Katzka DA, Gupta N, Ajani J, Buttar N, Chak A, Corley D, El-Serag H, Falk GW, Fitzgerald R, Goldblum J, Gress F, Ilson DH, Inadomi JM, Kuipers EJ, Lynch JP, McKeon F, Metz D, Pasricha PJ, Pech O, Peek R, Peters JH, Repici A, Seewald S, Shaheen NJ, Souza RF, Spechler SJ, Vennalaganti P, Wang K. Quality indicators for the management of Barrett's esophagus, dysplasia, and esophageal adenocarcinoma: international consensus recommendations from the American Gastroenterological Association Symposium. Gastroenterology. 2015 Nov; 149(6):1599-606. PMID: 26296479; PMCID: PMC4820399.
      View in: PubMed, PubMed Central
    8. Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W. Cloning and variation of ground state intestinal stem cells. Nature. 2015 Jun 11; 522(7555):173-8. PMID: 26040716; PMCID: PMC4853906.
      View in: PubMed, PubMed Central
    9. Yang EJ, Quick MC, Hanamornroongruang S, Lai K, Doyle LA, McKeon FD, Xian W, Crum CP, Herfs M. Microanatomy of the cervical and anorectal squamocolumnar junctions: a proposed model for anatomical differences in HPV-related cancer risk. Mod Pathol. 2015 Jul; 28(7):994-1000. PMID: 25975286; PMCID: PMC4490106.
      View in: PubMed, PubMed Central
    10. Mirkovic J, Howitt BE, Roncarati P, Demoulin S, Suarez-Carmona M, Hubert P, McKeon FD, Xian W, Li A, Delvenne P, Crum CP, Herfs M. Carcinogenic HPV infection in the cervical squamo-columnar junction. J Pathol. 2015 Jul; 236(3):265-71. PMID: 25782708; PMCID: PMC4457596.
      View in: PubMed, PubMed Central
    11. Dulloo I, Phang BH, Othman R, Tan SY, Vijayaraghavan A, Goh LK, Martin-Lopez M, Marques MM, Li CW, Wang de Y, Marín MC, Xian W, McKeon F, Sabapathy K. Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome. Nat Cell Biol. 2015 Apr; 17(4):511-23. PMID: 25774835.
      View in: PubMed
    12. Zuo W, Zhang T, Wu DZ, Guan SP, Liew AA, Yamamoto Y, Wang X, Lim SJ, Vincent M, Lessard M, Crum CP, Xian W, McKeon F. p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration. Nature. 2015 Jan 29; 517(7536):616-20. PMID: 25383540.
      View in: PubMed
    13. Ning G, Bijron JG, Yamamoto Y, Wang X, Howitt BE, Herfs M, Yang E, Hong Y, Cornille M, Wu L, Hanamornroongruang S, McKeon FD, Crum CP, Xian W. The PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium. J Pathol. 2014 Dec; 234(4):478-87. PMID: 25130537; PMCID: PMC4229427.
      View in: PubMed, PubMed Central
    14. Crum CP, Herfs M, Ning G, Bijron JG, Howitt BE, Jimenez CA, Hanamornroongruang S, McKeon FD, Xian W. Through the glass darkly: intraepithelial neoplasia, top-down differentiation, and the road to ovarian cancer. J Pathol. 2013 Dec; 231(4):402-12. PMID: 24030860; PMCID: PMC3947463.
      View in: PubMed, PubMed Central
    15. Srivastava S, Liew MS, McKeon F, Xian W, Yeoh KG, Ho KY, Teh M. Immunohistochemical analysis of metaplastic non-goblet columnar lined oesophagus shows phenotypic similarities to Barrett's oesophagus: a study in an Asian population. Dig Liver Dis. 2014 Feb; 46(2):170-5. PMID: 24290871.
      View in: PubMed
    16. Tordella L, Koch S, Salter V, Pagotto A, Doondeea JB, Feller SM, Ratnayaka I, Zhong S, Goldin RD, Lozano G, McKeon FD, Tavassoli M, Fritzsche F, Huber GF, Rössle M, Moch H, Lu X. ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17969-74. PMID: 24127607; PMCID: PMC3816480.
      View in: PubMed, PubMed Central
    17. Herfs M, Parra-Herran C, Howitt BE, Laury AR, Nucci MR, Feldman S, Jimenez CA, McKeon FD, Xian W, Crum CP. Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions. Am J Surg Pathol. 2013 Sep; 37(9):1311-8. PMID: 24076771; PMCID: PMC3905241.
      View in: PubMed, PubMed Central
    18. Xian W, McKeon F, Ho KY. Biomarkers and molecular imaging in gastrointestinal cancers. Clin Gastroenterol Hepatol. 2014 Jan; 12(1):126-9. PMID: 23978343.
      View in: PubMed
    19. Ning G, Bijron JG, Yuan J, Hirsch MS, McKeon FD, Nucci MR, Crum CP, Xian W. Differential expression of p-ERM, a marker of cell polarity, in benign and neoplastic oviductal epithelium. Int J Gynecol Pathol. 2013 Jul; 32(4):345-52. PMID: 23722506.
      View in: PubMed
    20. Herfs M, Vargas SO, Yamamoto Y, Howitt BE, Nucci MR, Hornick JL, McKeon FD, Xian W, Crum CP. A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia. J Pathol. 2013 Feb; 229(3):460-8. PMID: 23007879.
      View in: PubMed
    21. Soh BS, Zheng D, Li Yeo JS, Yang HH, Ng SY, Wong LH, Zhang W, Li P, Nichane M, Asmat A, Wong PS, Wong PC, Su LL, Mantalaris SA, Lu J, Xian W, McKeon F, Chen J, Lim EH, Lim B. CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury. Mol Ther. 2012 Dec; 20(12):2335-46. PMID: 22968480; PMCID: PMC3519990.
      View in: PubMed, PubMed Central
    22. Bijron JG, Ning G, Laury AR, Quick CM, Betensky RA, Monte NM, King E, McKeon FD, Xian W, Crum CP. Digital quantification of precursor frequency in the fallopian tube and its significance. Mod Pathol. 2012 Dec; 25(12):1654-61. PMID: 22766793.
      View in: PubMed
    23. Herfs M, Yamamoto Y, Laury A, Wang X, Nucci MR, McLaughlin-Drubin ME, Münger K, Feldman S, McKeon FD, Xian W, Crum CP. A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10516-21. PMID: 22689991; PMCID: PMC3387104.
      View in: PubMed, PubMed Central
    24. Crum CP, McKeon FD, Xian W. BRCA, the oviduct, and the space and time continuum of pelvic serous carcinogenesis. Int J Gynecol Cancer. 2012 May; 22 Suppl 1:S29-34. PMID: 22543918.
      View in: PubMed
    25. Xian W, Ho KY, Crum CP, McKeon F. Cellular origin of Barrett's esophagus: controversy and therapeutic implications. Gastroenterology. 2012 Jun; 142(7):1424-30. PMID: 22537611.
      View in: PubMed
    26. Zhan Q, Korngold R, Lezcano C, McKeon F, Murphy GF. Graft-versus-host disease-related cytokine-driven apoptosis depends on p73 in cytokeratin 15-positive target cells. Biol Blood Marrow Transplant. 2012 Jun; 18(6):841-51. PMID: 22469882; PMCID: PMC3352968.
      View in: PubMed, PubMed Central
    27. Xian W, McKeon F. Adult stem cells underlying lung regeneration. Cell Cycle. 2012 Mar 01; 11(5):887-94. PMID: 22333577; PMCID: PMC3323794.
      View in: PubMed, PubMed Central
    28. Crum CP, McKeon FD, Xian W. The oviduct and ovarian cancer: causality, clinical implications, and "targeted prevention". Clin Obstet Gynecol. 2012 Mar; 55(1):24-35. PMID: 22343226; PMCID: PMC3319355.
      View in: PubMed, PubMed Central
    29. Agostini M, Tucci P, Killick R, Candi E, Sayan BS, Rivetti di Val Cervo P, Nicotera P, McKeon F, Knight RA, Mak TW, Melino G. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21093-8. PMID: 22160687; PMCID: PMC3248477.
      View in: PubMed, PubMed Central
    30. Laury AR, Ning G, Quick CM, Bijron J, Parast MM, Betensky RA, Vargas SO, McKeon FD, Xian W, Nucci MR, Crum CP. Fallopian tube correlates of ovarian serous borderline tumors. Am J Surg Pathol. 2011 Dec; 35(12):1759-65. PMID: 22089527; PMCID: PMC3219906.
      View in: PubMed, PubMed Central
    31. Quick CM, Ning G, Bijron J, Laury A, Wei TS, Chen EY, Vargas SO, Betensky RA, McKeon FD, Xian W, Crum CP. PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancer. Mod Pathol. 2012 Mar; 25(3):449-55. PMID: 22080059.
      View in: PubMed
    32. Kumar PA, Hu Y, Yamamoto Y, Hoe NB, Wei TS, Mu D, Sun Y, Joo LS, Dagher R, Zielonka EM, Wang de Y, Lim B, Chow VT, Crum CP, Xian W, McKeon F. Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell. 2011 Oct 28; 147(3):525-38. PMID: 22036562; PMCID: PMC4040224.
      View in: PubMed, PubMed Central
    33. Wang X, Ouyang H, Yamamoto Y, Kumar PA, Wei TS, Dagher R, Vincent M, Lu X, Bellizzi AM, Ho KY, Crum CP, Xian W, McKeon F. Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell. 2011 Jun 24; 145(7):1023-35. PMID: 21703447; PMCID: PMC3125107.
      View in: PubMed, PubMed Central
    34. Xian W, McKeon F. The challenges and hopes of personalized cancer medicine. Genome Med. 2011 Apr 19; 3(4):22. PMID: 21542874; PMCID: PMC3129638.
      View in: PubMed, PubMed Central
    35. Levine AJ, Tomasini R, McKeon FD, Mak TW, Melino G. The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol. 2011 04; 12(4):259-65. PMID: 21427767.
      View in: PubMed
    36. Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Schäfer B, Hannewald J, Luh LM, Durst FG, Ibrahim M, Hoffmann J, Niesen FH, Sentürk A, Kunkel H, Brutschy B, Schleiff E, Knapp S, Acker-Palmer A, Grez M, McKeon F, Dötsch V. DNA damage in oocytes induces a switch of the quality control factor TAp63a from dimer to tetramer. Cell. 2011 Feb 18; 144(4):566-76. PMID: 21335238; PMCID: PMC3087504.
      View in: PubMed, PubMed Central
    37. Li CW, Shi L, Zhang KK, Li TY, Lin ZB, Lim MK, McKeon F, Xian W, Wang de Y. Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis. J Allergy Clin Immunol. 2011 Mar; 127(3):765-72.e1-2. PMID: 21269671.
      View in: PubMed
    38. Mehra K, Mehrad M, Ning G, Drapkin R, McKeon FD, Xian W, Crum CP. STICS, SCOUTs and p53 signatures; a new language for pelvic serous carcinogenesis. Front Biosci (Elite Ed). 2011 Jan 01; 3:625-34. PMID: 21196340.
      View in: PubMed
    39. Agostini M, Tucci P, Chen H, Knight RA, Bano D, Nicotera P, McKeon F, Melino G. p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun. 2010 Dec 03; 403(1):13-7. PMID: 20977890; PMCID: PMC3041924.
      View in: PubMed, PubMed Central
    40. Chen EY, Mehra K, Mehrad M, Ning G, Miron A, Mutter GL, Monte N, Quade BJ, McKeon FD, Yassin Y, Xian W, Crum CP. Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube. J Pathol. 2010 Sep; 222(1):110-6. PMID: 20597068; PMCID: PMC2914810.
      View in: PubMed, PubMed Central
    41. Yang A, Zhu Z, Kettenbach A, Kapranov P, McKeon F, Gingeras TR, Struhl K. Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo. PLoS One. 2010 Jul 14; 5(7):e11572. PMID: 20644729; PMCID: PMC2904373.
      View in: PubMed, PubMed Central
    42. Roh MH, Yassin Y, Miron A, Mehra KK, Mehrad M, Monte NM, Mutter GL, Nucci MR, Ning G, Mckeon FD, Hirsch MS, Wa X, Crum CP. High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression. Mod Pathol. 2010 Oct; 23(10):1316-24. PMID: 20562848.
      View in: PubMed
    43. Crum CP, McKeon FD. p63 in epithelial survival, germ cell surveillance, and neoplasia. Annu Rev Pathol. 2010; 5:349-71. PMID: 20078223.
      View in: PubMed
    44. Coutandin D, Löhr F, Niesen FH, Ikeya T, Weber TA, Schäfer B, Zielonka EM, Bullock AN, Yang A, Güntert P, Knapp S, McKeon F, Ou HD, Dötsch V. Conformational stability and activity of p73 require a second helix in the tetramerization domain. Cell Death Differ. 2009 Dec; 16(12):1582-9. PMID: 19763140.
      View in: PubMed
    45. Fete M, vanBokhoven H, Clements SE, McKeon F, Roop DR, Koster MI, Missero C, Attardi LD, Lombillo VA, Ratovitski E, Julapalli M, Ruths D, Sybert VP, Siegfried EC, Bree AF. International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome. Am J Med Genet A. 2009 Sep; 149A(9):1885-93. PMID: 19353643; PMCID: PMC2736474.
      View in: PubMed, PubMed Central
    46. Wei L, McKeon F, Russo JW, Lemire J, Castellot J. Domain-and species-specific monoclonal antibodies recognize the Von Willebrand Factor-C domain of CCN5. J Cell Commun Signal. 2009 Mar; 3(1):65-77. PMID: 19401828; PMCID: PMC2686757.
      View in: PubMed, PubMed Central
    47. Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F. Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth. Cancer Cell. 2008 May; 13(5):420-31. PMID: 18455125.
      View in: PubMed
    48. Ha GH, Baek KH, Kim HS, Jeong SJ, Kim CM, McKeon F, Lee CW. p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. Cancer Res. 2007 Aug 01; 67(15):7155-64. PMID: 17671183.
      View in: PubMed
    49. Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007 Oct; 21(12):3023-8. PMID: 17595344.
      View in: PubMed
    50. Senoo M, Pinto F, Crum CP, McKeon F. p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell. 2007 May 04; 129(3):523-36. PMID: 17482546.
      View in: PubMed
    51. Lee Y, Kim KR, McKeon F, Yang A, Boyd TK, Crum CP, Parast MM. A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression. Hum Pathol. 2007 Jul; 38(7):1003-13. PMID: 17397906.
      View in: PubMed
    52. McKeon F, Melino G. Fog of war: the emerging p53 family. Cell Cycle. 2007 Feb 01; 6(3):229-32. PMID: 17297295.
      View in: PubMed
    53. Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, Cramer DW, McKeon FD, Crum CP. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol. 2007 Jan; 211(1):26-35. PMID: 17117391.
      View in: PubMed
    54. Suh EK, Yang A, Kettenbach A, Bamberger C, Michaelis AH, Zhu Z, Elvin JA, Bronson RT, Crum CP, McKeon F. p63 protects the female germ line during meiotic arrest. Nature. 2006 Nov 30; 444(7119):624-8. PMID: 17122775.
      View in: PubMed
    55. Yang A, Zhu Z, Kapranov P, McKeon F, Church GM, Gingeras TR, Struhl K. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell. 2006 Nov 17; 24(4):593-602. PMID: 17188034.
      View in: PubMed
    56. Rufini A, Weil M, McKeon F, Barlattani A, Melino G, Candi E. p63 protein is essential for the embryonic development of vibrissae and teeth. Biochem Biophys Res Commun. 2006 Feb 17; 340(3):737-41. PMID: 16410075.
      View in: PubMed
    57. Chan B, Greenan G, McKeon F, Ellenberger T. Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13075-80. PMID: 16131541; PMCID: PMC1201586.
      View in: PubMed, PubMed Central
    58. Signoretti S, Pires MM, Lindauer M, Horner JW, Grisanzio C, Dhar S, Majumder P, McKeon F, Kantoff PW, Sellers WR, Loda M. p63 regulates commitment to the prostate cell lineage. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11355-60. PMID: 16051706; PMCID: PMC1183537.
      View in: PubMed, PubMed Central
    59. Ying H, Chang DL, Zheng H, McKeon F, Xiao ZX. DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol Cell Biol. 2005 Jul; 25(14):6154-64. PMID: 15988026; PMCID: PMC1168832.
      View in: PubMed, PubMed Central
    60. Flores ER, Sengupta S, Miller JB, Newman JJ, Bronson R, Crowley D, Yang A, McKeon F, Jacks T. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell. 2005 Apr; 7(4):363-73. PMID: 15837625.
      View in: PubMed
    61. Witkiewicz AK, Hecht JL, Cviko A, McKeon FD, Ince TA, Crum CP. Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells. Hum Pathol. 2005 Feb; 36(2):154-61. PMID: 15754292.
      View in: PubMed
    62. Baek KH, Shin HJ, Jeong SJ, Park JW, McKeon F, Lee CW, Kim CM. Caspases-dependent cleavage of mitotic checkpoint proteins in response to microtubule inhibitor. Oncol Res. 2005; 15(3):161-8. PMID: 16050137.
      View in: PubMed
    63. Senoo M, Manis JP, Alt FW, McKeon F. p63 and p73 are not required for the development and p53-dependent apoptosis of T cells. Cancer Cell. 2004 Jul; 6(1):85-9. PMID: 15261144.
      View in: PubMed
    64. Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8969-74. PMID: 15184684; PMCID: PMC428456.
      View in: PubMed, PubMed Central
    65. Terui Y, Saad N, Jia S, McKeon F, Yuan J. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J Biol Chem. 2004 Jul 02; 279(27):28257-65. PMID: 15117942.
      View in: PubMed
    66. McKeon F. p63 and the epithelial stem cell: more than status quo? Genes Dev. 2004 Mar 01; 18(5):465-9. PMID: 15037544.
      View in: PubMed
    67. McKeon FD. p63 and p73 in tumor suppression and promotion. Cancer Res Treat. 2004 Feb; 36(1):6-12. PMID: 20396560; PMCID: PMC2855112.
      View in: PubMed, PubMed Central
    68. Shin HJ, Baek KH, Jeon AH, Park MT, Lee SJ, Kang CM, Lee HS, Yoo SH, Chung DH, Sung YC, McKeon F, Lee CW. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell. 2003 Dec; 4(6):483-97. PMID: 14706340.
      View in: PubMed
    69. Ryeom S, Greenwald RJ, Sharpe AH, McKeon F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol. 2003 Sep; 4(9):874-81. PMID: 12925851.
      View in: PubMed
    70. Baek KH, Shin HJ, Yoo JK, Cho JH, Choi YH, Sung YC, McKeon F, Lee CW. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J Leukoc Biol. 2003 Jun; 73(6):850-61. PMID: 12773518.
      View in: PubMed
    71. Whitman M, McKeon F. p53 and TGF-beta in development: prelude to tumor suppression? Cell. 2003 May 02; 113(3):275-6. PMID: 12732134.
      View in: PubMed
    72. Serber Z, Lai HC, Yang A, Ou HD, Sigal MS, Kelly AE, Darimont BD, Duijf PH, Van Bokhoven H, McKeon F, Dötsch V. A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol Cell Biol. 2002 Dec; 22(24):8601-11. PMID: 12446779; PMCID: PMC139862.
      View in: PubMed, PubMed Central
    73. Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, Oliner JD, McKeon F, Haber DA. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell. 2002 Nov; 10(5):995-1005. PMID: 12453409.
      View in: PubMed
    74. Ince TA, Cviko AP, Quade BJ, Yang A, McKeon FD, Mutter GL, Crum CP. p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract. Am J Pathol. 2002 Oct; 161(4):1111-7. PMID: 12368184; PMCID: PMC1867285.
      View in: PubMed, PubMed Central
    75. Urist MJ, Di Como CJ, Lu ML, Charytonowicz E, Verbel D, Crum CP, Ince TA, McKeon FD, Cordon-Cardo C. Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol. 2002 Oct; 161(4):1199-206. PMID: 12368193; PMCID: PMC1867279.
      View in: PubMed, PubMed Central
    76. Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature. 2002 Apr 04; 416(6880):560-4. PMID: 11932750.
      View in: PubMed
    77. Duijf PH, Vanmolkot KR, Propping P, Friedl W, Krieger E, McKeon F, Dötsch V, Brunner HG, van Bokhoven H. Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63. Hum Mol Genet. 2002 Apr 01; 11(7):799-804. PMID: 11929852.
      View in: PubMed
    78. van Bokhoven H, McKeon F. Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans. Trends Mol Med. 2002 Mar; 8(3):133-9. PMID: 11879774.
      View in: PubMed
    79. Yang A, Kaghad M, Caput D, McKeon F. On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet. 2002 Feb; 18(2):90-5. PMID: 11818141.
      View in: PubMed
    80. Glickman JN, Yang A, Shahsafaei A, McKeon F, Odze RD. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol. 2001 Nov; 32(11):1157-65. PMID: 11727253.
      View in: PubMed
    81. Wang TY, Chen BF, Yang YC, Chen H, Wang Y, Cviko A, Quade BJ, Sun D, Yang A, McKeon FD, Crum CP. Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases. Hum Pathol. 2001 May; 32(5):479-86. PMID: 11381365.
      View in: PubMed
    82. Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, Ponzin D, McKeon F, De Luca M. p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3156-61. PMID: 11248048; PMCID: PMC30623.
      View in: PubMed, PubMed Central
    83. McGrath JA, Duijf PH, Doetsch V, Irvine AD, de Waal R, Vanmolkot KR, Wessagowit V, Kelly A, Atherton DJ, Griffiths WA, Orlow SJ, van Haeringen A, Ausems MG, Yang A, McKeon F, Bamshad MA, Brunner HG, Hamel BC, van Bokhoven H. Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Hum Mol Genet. 2001 Feb 01; 10(3):221-9. PMID: 11159940.
      View in: PubMed
    84. Ichimiya S, Nimura Y, Kageyama H, Takada N, Sunahara M, Shishikura T, Nakamura Y, Sakiyama S, Seki N, Ohira M, Kaneko Y, McKeon F, Caput D, Nakagawara A. Genetic analysis of p73 localized at chromosome 1p36.3 in primary neuroblastomas. Med Pediatr Oncol. 2001 Jan; 36(1):42-4. PMID: 11464902.
      View in: PubMed
    85. Quade BJ, Yang A, Wang Y, Sun D, Park J, Sheets EE, Cviko A, Federschneider JM, Peters R, McKeon FD, Crum CP. Expression of the p53 homologue p63 in early cervical neoplasia. Gynecol Oncol. 2001 Jan; 80(1):24-9. PMID: 11136565.
      View in: PubMed
    86. O'Connell JT, Mutter GL, Cviko A, Nucci M, Quade BJ, Kozakewich HP, Neffen E, Sun D, Yang A, McKeon FD, Crum CP. Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63. Gynecol Oncol. 2001 Jan; 80(1):30-6. PMID: 11136566.
      View in: PubMed
    87. Yang A, McKeon F. P63 and P73: P53 mimics, menaces and more. Nat Rev Mol Cell Biol. 2000 Dec; 1(3):199-207. PMID: 11252895.
      View in: PubMed
    88. Signoretti S, Waltregny D, Dilks J, Isaac B, Lin D, Garraway L, Yang A, Montironi R, McKeon F, Loda M. p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol. 2000 Dec; 157(6):1769-75. PMID: 11106548; PMCID: PMC1885786.
      View in: PubMed, PubMed Central
    89. Park JJ, Sun D, Quade BJ, Flynn C, Sheets EE, Yang A, McKeon F, Crum CP. Stratified mucin-producing intraepithelial lesions of the cervix: adenosquamous or columnar cell neoplasia? Am J Surg Pathol. 2000 Oct; 24(10):1414-9. PMID: 11023104.
      View in: PubMed
    90. Liefer KM, Koster MI, Wang XJ, Yang A, McKeon F, Roop DR. Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res. 2000 Aug 01; 60(15):4016-20. PMID: 10945600.
      View in: PubMed
    91. Pozniak CD, Radinovic S, Yang A, McKeon F, Kaplan DR, Miller FD. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science. 2000 Jul 14; 289(5477):304-6. PMID: 10894779.
      View in: PubMed
    92. Cviko A, Briem B, Granter SR, Pinto AP, Wang TY, Yang YC, Chen BF, Yang A, Sheets EE, McKeon FD, Crum CP. Adenoid basal carcinomas of the cervix: a unique morphological evolution with cell cycle correlates. Hum Pathol. 2000 Jun; 31(6):740-4. PMID: 10872669.
      View in: PubMed
    93. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, McKeon F, Caput D. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 2000 Mar 02; 404(6773):99-103. PMID: 10716451.
      View in: PubMed
    94. Zhu J, McKeon F. Nucleocytoplasmic shuttling and the control of NF-AT signaling. Cell Mol Life Sci. 2000 Mar; 57(3):411-20. PMID: 10823242.
      View in: PubMed
    95. Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol. 1999 Dec; 113(6):1099-105. PMID: 10594758.
      View in: PubMed
    96. Celli J, Duijf P, Hamel BC, Bamshad M, Kramer B, Smits AP, Newbury-Ecob R, Hennekam RC, Van Buggenhout G, van Haeringen A, Woods CG, van Essen AJ, de Waal R, Vriend G, Haber DA, Yang A, McKeon F, Brunner HG, van Bokhoven H. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell. 1999 Oct 15; 99(2):143-53. PMID: 10535733.
      View in: PubMed
    97. McKeon F. Killing the umpire: cooperative defects in mitotic checkpoint and BRCA2 genes on the road to transformation. Breast Cancer Res. 1999; 1(1):8-10. PMID: 11250674; PMCID: PMC138502.
      View in: PubMed, PubMed Central
    98. Wolf DA, McKeon F, Jackson PK. Budding yeast Cdc6p induces re-replication in fission yeast by inhibition of SCF(Pop)-mediated proteolysis. Mol Gen Genet. 1999 Oct; 262(3):473-80. PMID: 10589835.
      View in: PubMed
    99. Rolls MM, Stein PA, Taylor SS, Ha E, McKeon F, Rapoport TA. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. J Cell Biol. 1999 Jul 12; 146(1):29-44. PMID: 10402458; PMCID: PMC2199743.
      View in: PubMed, PubMed Central
    100. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C, McKeon F. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999 Apr 22; 398(6729):714-8. PMID: 10227294.
      View in: PubMed
    101. Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science. 1999 Apr 09; 284(5412):339-43. PMID: 10195903.
      View in: PubMed
    102. Wolf DA, McKeon F, Jackson PK. F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p. Curr Biol. 1999 Apr 08; 9(7):373-6. PMID: 10209119.
      View in: PubMed
    103. Zhu J, McKeon F. NF-AT activation requires suppression of Crm1-dependent export by calcineurin. Nature. 1999 Mar 18; 398(6724):256-60. PMID: 10094050.
      View in: PubMed
    104. Ichimiya S, Nimura Y, Kageyama H, Takada N, Sunahara M, Shishikura T, Nakamura Y, Sakiyama S, Seki N, Ohira M, Kaneko Y, McKeon F, Caput D, Nakagawara A. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. Oncogene. 1999 Jan 28; 18(4):1061-6. PMID: 10023682.
      View in: PubMed
    105. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998 Sep; 2(3):305-16. PMID: 9774969.
      View in: PubMed
    106. Taylor SS, Ha E, McKeon F. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. J Cell Biol. 1998 Jul 13; 142(1):1-11. PMID: 9660858; PMCID: PMC2133037.
      View in: PubMed, PubMed Central
    107. Zhu J, Shibasaki F, Price R, Guillemot JC, Yano T, Dötsch V, Wagner G, Ferrara P, McKeon F. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell. 1998 May 29; 93(5):851-61. PMID: 9630228.
      View in: PubMed
    108. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 1997 Aug 22; 90(4):809-19. PMID: 9288759.
      View in: PubMed
    109. Taylor SS, McKeon F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell. 1997 May 30; 89(5):727-35. PMID: 9182760.
      View in: PubMed
    110. Shibasaki F, Kondo E, Akagi T, McKeon F. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature. 1997 Apr 17; 386(6626):728-31. PMID: 9109491.
      View in: PubMed
    111. Wolf DA, Wu D, McKeon F. Disruption of re-replication control by overexpression of human ORC1 in fission yeast. J Biol Chem. 1996 Dec 20; 271(51):32503-6. PMID: 8955071.
      View in: PubMed
    112. Shibasaki F, Price ER, Milan D, McKeon F. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature. 1996 Jul 25; 382(6589):370-3. PMID: 8684469.
      View in: PubMed
    113. Tourret J, McKeon F. Tyrosine kinases wee1 and mik1 as effectors of DNA replication checkpoint control. Prog Cell Cycle Res. 1996; 2:91-7. PMID: 9552386.
      View in: PubMed
    114. Shibasaki F, McKeon F. Calcineurin functions in Ca(2+)-activated cell death in mammalian cells. J Cell Biol. 1995 Nov; 131(3):735-43. PMID: 7593193; PMCID: PMC2120616.
      View in: PubMed, PubMed Central
    115. Lanini L, McKeon F. Domains required for CENP-C assembly at the kinetochore. Mol Biol Cell. 1995 Aug; 6(8):1049-59. PMID: 7579707; PMCID: PMC301262.
      View in: PubMed, PubMed Central
    116. Milan D, Griffith J, Su M, Price ER, McKeon F. The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. Cell. 1994 Nov 04; 79(3):437-47. PMID: 7525078.
      View in: PubMed
    117. Eichbaum Q, Clerc P, Bruns G, McKeon F, Ezekowitz RA. Assignment of the human macrophage mannose receptor gene (MRC1) to 10p13 by in situ hybridization and PCR-based somatic cell hybrid mapping. Genomics. 1994 Aug; 22(3):656-8. PMID: 8001982.
      View in: PubMed
    118. Price ER, Jin M, Lim D, Pati S, Walsh CT, McKeon FD. Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3931-5. PMID: 7909608; PMCID: PMC43696.
      View in: PubMed, PubMed Central
    119. Heald R, McLoughlin M, McKeon F. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell. 1993 Aug 13; 74(3):463-74. PMID: 8348613.
      View in: PubMed
    120. Walsh CT, Zydowsky LD, McKeon FD. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem. 1992 Jul 05; 267(19):13115-8. PMID: 1618811.
      View in: PubMed
    121. McKeon F. When worlds collide: immunosuppressants meet protein phosphatases. Cell. 1991 Sep 06; 66(5):823-6. PMID: 1716181.
      View in: PubMed
    122. Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD, Walsh CT. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):1903-7. PMID: 2000394; PMCID: PMC51134.
      View in: PubMed, PubMed Central
    123. McKeon F. Nuclear lamin proteins: domains required for nuclear targeting, assembly, and cell-cycle-regulated dynamics. Curr Opin Cell Biol. 1991 Feb; 3(1):82-6. PMID: 1854488.
      View in: PubMed
    124. Heald R, McKeon F. Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. Cell. 1990 May 18; 61(4):579-89. PMID: 2344612.
      View in: PubMed
    125. Holtz D, Tanaka RA, Hartwig J, McKeon F. The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope. Cell. 1989 Dec 22; 59(6):969-77. PMID: 2557160.
      View in: PubMed
    126. Loewinger L, McKeon F. Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm. EMBO J. 1988 Aug; 7(8):2301-9. PMID: 3056713; PMCID: PMC457094.
      View in: PubMed, PubMed Central
    127. Krohne G, Wolin SL, McKeon FD, Franke WW, Kirschner MW. Nuclear lamin LI of Xenopus laevis: cDNA cloning, amino acid sequence and binding specificity of a member of the lamin B subfamily. EMBO J. 1987 Dec 01; 6(12):3801-8. PMID: 3428276; PMCID: PMC553852.
      View in: PubMed, PubMed Central
    128. McKeon FD. Nuclear lamin proteins and the structure of the nuclear envelope: where is the function? Bioessays. 1987 Oct; 7(4):169-73. PMID: 3318823.
      View in: PubMed
    129. McKeon FD, Kirschner MW, Caput D. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 1986 Feb 6-12; 319(6053):463-8. PMID: 3453101.
      View in: PubMed
    130. McKeon FD, Tuffanelli DL, Kobayashi S, Kirschner MW. The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation. Cell. 1984 Jan; 36(1):83-92. PMID: 6420073.
      View in: PubMed
    131. Tuffanelli DL, McKeon F, Kleinsmith DM, Burnham TK, Kirschner M. Anticentromere and anticentriole antibodies in the scleroderma spectrum. Arch Dermatol. 1983 Jul; 119(7):560-6. PMID: 6859899.
      View in: PubMed
    132. McKeon FD, Tuffanelli DL, Fukuyama K, Kirschner MW. Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma. Proc Natl Acad Sci U S A. 1983 Jul; 80(14):4374-8. PMID: 6192431; PMCID: PMC384040.
      View in: PubMed, PubMed Central
    133. McGuire J, Moellmann G, McKeon F. Cytochalasin B and pigment granule translocation. Cytochalasin B reverses and prevents pigment granule dispersion caused by dibutyryl cyclic AMP and theophylline in Rana pipiens Melanocytes. J Cell Biol. 1972 Mar; 52(3):754-8. PMID: 4333212; PMCID: PMC2108657.
      View in: PubMed, PubMed Central
    McKeon's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (609) concept(s)
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department
    Physical Neighbors Expand Description
    _