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Sergey Shevkoplyas

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentBiomedical Engineering
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-5696
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    Collapse Research 
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    R01HL117329     (SHEVKOPLYAS, SERGEY S)Sep 30, 2012 - Dec 31, 2017
    NIH/NHLBI
    Eliminating Mediators of Toxicity from Stored Blood
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Torabian K, Lezzar D, Piety NZ, George A, Shevkoplyas SS. Substituting Sodium Hydrosulfite with Sodium Metabisulfite Improves Long-Term Stability of a Distributable Paper-Based Test Kit for Point-of-Care Screening for Sickle Cell Anemia. Biosensors (Basel). 2017 Sep 20; 7(3). PMID: 28930183.
      View in: PubMed
    2. Reinhart WH, Piety NZ, Shevkoplyas SS. Influence of feeding hematocrit and perfusion pressure on hematocrit reduction (Fåhraeus effect) in an artificial microvascular network. Microcirculation. 2017 Aug 12. PMID: 28801994.
      View in: PubMed
    3. Piety NZ, Reinhart WH, Stutz J, Shevkoplyas SS. Optimal hematocrit in an artificial microvascular network. Transfusion. 2017 Sep; 57(9):2257-2266. PMID: 28681482.
      View in: PubMed
    4. Reinhart WH, Piety NZ, Shevkoplyas SS. Influence of red blood cell aggregation on perfusion of an artificial microvascular network. Microcirculation. 2017 Jul; 24(5). PMID: 27647727.
      View in: PubMed
    5. Xia H, Khanal G, Strachan BC, Vörös E, Piety NZ, Gifford SC, Shevkoplyas SS. Washing in hypotonic saline reduces the fraction of irreversibly-damaged cells in stored blood: a proof-of-concept study. Blood Transfus. 2017 Sep; 15(5):463-471. PMID: 28686152.
      View in: PubMed
    6. Piety NZ, Shevkoplyas SS. Paper-Based Diagnostics: Rethinking Conventional Sickle Cell Screening to Improve Access to High-Quality Health Care in Resource-Limited Settings. IEEE Pulse. 2017 May-Jun; 8(3):42-46. PMID: 28534763.
      View in: PubMed
    7. Xia H, Strachan BC, Gifford SC, Shevkoplyas SS. A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma. Sci Rep. 2016 Oct 24; 6:35943. PMID: 27775049.
      View in: PubMed
    8. Khoory J, Estanislau J, Elkhal A, Lazaar A, Melhorn MI, Brodsky A, Illigens B, Hamachi I, Kurishita Y, Ivanov AR, Shevkoplyas S, Shapiro NI, Ghiran IC. Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function. PLoS One. 2016; 11(1):e0141206. PMID: 26784696; PMCID: PMC4718526.
      View in: PubMed, PubMed Central
    9. Piety NZ, Yang X, Kanter J, Vignes SM, George A, Shevkoplyas SS. Validation of a Low-Cost Paper-Based Screening Test for Sickle Cell Anemia. PLoS One. 2016; 11(1):e0144901. PMID: 26735691; PMCID: PMC4703210.
      View in: PubMed, PubMed Central
    10. Piety NZ, Reinhart WH, Pourreau PH, Abidi R, Shevkoplyas SS. Shape matters: the effect of red blood cell shape on perfusion of an artificial microvascular network. Transfusion. 2016 Apr; 56(4):844-51. PMID: 26711854; PMCID: PMC4833558 [Available on 04/01/17].
      View in: PubMed, PubMed Central
    11. Burns JM, Yoshida T, Dumont LJ, Yang X, Piety NZ, Shevkoplyas SS. Deterioration of red blood cell mechanical properties is reduced in anaerobic storage. Blood Transfus. 2016 Jan; 14(1):80-8. PMID: 26674833; PMCID: PMC4731343.
      View in: PubMed, PubMed Central
    12. Piety NZ, Gifford SC, Yang X, Shevkoplyas SS. Quantifying morphological heterogeneity: a study of more than 1 000 000 individual stored red blood cells. Vox Sang. 2015 Oct; 109(3):221-30. PMID: 25900518; PMCID: PMC4669964 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    13. Piety NZ, Yang X, Lezzar D, George A, Shevkoplyas SS. A rapid paper-based test for quantifying sickle hemoglobin in blood samples from patients with sickle cell disease. Am J Hematol. 2015 Jun; 90(6):478-82. PMID: 25689370; PMCID: PMC4439389.
      View in: PubMed, PubMed Central
    14. Reinhart WH, Piety NZ, Deuel JW, Makhro A, Schulzki T, Bogdanov N, Goede JS, Bogdanova A, Abidi R, Shevkoplyas SS. Washing stored red blood cells in an albumin solution improves their morphologic and hemorheologic properties. Transfusion. 2015 Aug; 55(8):1872-81. PMID: 25752902; PMCID: PMC4536109.
      View in: PubMed, PubMed Central
    15. Reinhart WH, Piety NZ, Goede JS, Shevkoplyas SS. Effect of osmolality on erythrocyte rheology and perfusion of an artificial microvascular network. Microvasc Res. 2015 Mar; 98:102-7. PMID: 25660474; PMCID: PMC4361376.
      View in: PubMed, PubMed Central
    16. Gifford SC, Spillane AM, Vignes SM, Shevkoplyas SS. Controlled incremental filtration: a simplified approach to design and fabrication of high-throughput microfluidic devices for selective enrichment of particles. Lab Chip. 2014 Dec 07; 14(23):4496-505. PMID: 25254358; PMCID: PMC4247995.
      View in: PubMed, PubMed Central
    17. Kumar AA, Patton MR, Hennek JW, Lee SY, D'Alesio-Spina G, Yang X, Kanter J, Shevkoplyas SS, Brugnara C, Whitesides GM. Density-based separation in multiphase systems provides a simple method to identify sickle cell disease. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14864-9. PMID: 25197072; PMCID: PMC4205650.
      View in: PubMed, PubMed Central
    18. Muroya T, Kannan L, Ghiran IC, Shevkoplyas SS, Paz Z, Tsokos M, Dalle Lucca JJ, Shapiro NI, Tsokos GC. C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med. 2014 May; 42(5):e364-72. PMID: 24448198; PMCID: PMC4099476.
      View in: PubMed, PubMed Central
    19. Yamaguchi E, Giannetti MJ, Van Houten MJ, Forouzan O, Shevkoplyas SS, Gaver DP. The unusual symmetric reopening effect induced by pulmonary surfactant. J Appl Physiol (1985). 2014 Mar 15; 116(6):635-44. PMID: 24458752; PMCID: PMC3949241.
      View in: PubMed, PubMed Central
    20. Sosa JM, Nielsen ND, Vignes SM, Chen TG, Shevkoplyas SS. The relationship between red blood cell deformability metrics and perfusion of an artificial microvascular network. Clin Hemorheol Microcirc. 2014; 57(3):275-89. PMID: 23603326; PMCID: PMC3766416.
      View in: PubMed, PubMed Central
    21. Ratnayaka SH, Hillburn TE, Forouzan O, Shevkoplyas SS, Khismatullin DB. PDMS well platform for culturing millimeter-size tumor spheroids. Biotechnol Prog. 2013 Sep-Oct; 29(5):1265-9. PMID: 23832880.
      View in: PubMed
    22. Yang X, Piety NZ, Vignes SM, Benton MS, Kanter J, Shevkoplyas SS. Simple paper-based test for measuring blood hemoglobin concentration in resource-limited settings. Clin Chem. 2013 Oct; 59(10):1506-13. PMID: 23788584; PMCID: PMC3880468.
      View in: PubMed, PubMed Central
    23. Yang X, Kanter J, Piety NZ, Benton MS, Vignes SM, Shevkoplyas SS. A simple, rapid, low-cost diagnostic test for sickle cell disease. Lab Chip. 2013 Apr 21; 13(8):1464-7. PMID: 23429713.
      View in: PubMed
    24. Brown TP, Forouzan O, Shevkoplyas SS, Khismatullin DB. Histamine reduces GPIba-mediated adhesion of platelets to TNF-a-activated vascular endothelium. Thromb Res. 2013 Feb; 131(2):150-7. PMID: 23260446.
      View in: PubMed
    25. Forouzan O, Yang X, Sosa JM, Burns JM, Shevkoplyas SS. Spontaneous oscillations of capillary blood flow in artificial microvascular networks. Microvasc Res. 2012 Sep; 84(2):123-32. PMID: 22732344.
      View in: PubMed
    26. Pinan-Lucarre B, Gabel CV, Reina CP, Hulme SE, Shevkoplyas SS, Slone RD, Xue J, Qiao Y, Weisberg S, Roodhouse K, Sun L, Whitesides GM, Samuel A, Driscoll M. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans. PLoS Biol. 2012; 10(5):e1001331. PMID: 22629231; PMCID: PMC3358320.
      View in: PubMed, PubMed Central
    27. Shapiro ND, Mirica KA, Soh S, Phillips ST, Taran O, Mace CR, Shevkoplyas SS, Whitesides GM. Measuring binding of protein to gel-bound ligands using magnetic levitation. J Am Chem Soc. 2012 Mar 28; 134(12):5637-46. PMID: 22364170; PMCID: PMC3319098.
      View in: PubMed, PubMed Central
    28. Yang X, Forouzan O, Brown TP, Shevkoplyas SS. Integrated separation of blood plasma from whole blood for microfluidic paper-based analytical devices. Lab Chip. 2012 Jan 21; 12(2):274-80. PMID: 22094609.
      View in: PubMed
    29. Burns JM, Yang X, Forouzan O, Sosa JM, Shevkoplyas SS. Artificial microvascular network: a new tool for measuring rheologic properties of stored red blood cells. Transfusion. 2012 May; 52(5):1010-23. PMID: 22043858.
      View in: PubMed
    30. Yang X, Forouzan O, Burns JM, Shevkoplyas SS. Traffic of leukocytes in microfluidic channels with rectangular and rounded cross-sections. Lab Chip. 2011 Oct 07; 11(19):3231-40. PMID: 21847500.
      View in: PubMed
    31. Mirica KA, Ilievski F, Ellerbee AK, Shevkoplyas SS, Whitesides GM. Using magnetic levitation for three dimensional self-assembly. Adv Mater. 2011 Sep 22; 23(36):4134-40. PMID: 21830239.
      View in: PubMed
    32. Forouzan O, Burns JM, Robichaux JL, Murfee WL, Shevkoplyas SS. Passive recruitment of circulating leukocytes into capillary sprouts from existing capillaries in a microfluidic system. Lab Chip. 2011 Jun 07; 11(11):1924-32. PMID: 21503282.
      View in: PubMed
    33. Ghiran IC, Zeidel ML, Shevkoplyas SS, Burns JM, Tsokos GC, Kyttaris VC. Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum. 2011 Feb; 63(2):503-12. PMID: 21280005; PMCID: PMC3334350.
      View in: PubMed, PubMed Central
    34. Yoshida T, Shevkoplyas SS. Anaerobic storage of red blood cells. Blood Transfus. 2010 Oct; 8(4):220-36. PMID: 20967163; PMCID: PMC2957487.
      View in: PubMed, PubMed Central
    35. Glodek AM, Mirchev R, Golan DE, Khoory JA, Burns JM, Shevkoplyas SS, Nicholson-Weller A, Ghiran IC. Ligation of complement receptor 1 increases erythrocyte membrane deformability. Blood. 2010 Dec 23; 116(26):6063-71. PMID: 20861458; PMCID: PMC3031392.
      View in: PubMed, PubMed Central
    36. Hulme SE, Shevkoplyas SS, McGuigan AP, Apfeld J, Fontana W, Whitesides GM. Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans. Lab Chip. 2010 Mar 07; 10(5):589-97. PMID: 20162234; PMCID: PMC3060707.
      View in: PubMed, PubMed Central
    37. Mirica KA, Shevkoplyas SS, Phillips ST, Gupta M, Whitesides GM. Measuring densities of solids and liquids using magnetic levitation: fundamentals. J Am Chem Soc. 2009 Jul 29; 131(29):10049-58. PMID: 19621960.
      View in: PubMed
    38. Stan CA, Schneider GF, Shevkoplyas SS, Hashimoto M, Ibanescu M, Wiley BJ, Whitesides GM. A microfluidic apparatus for the study of ice nucleation in supercooled water drops. Lab Chip. 2009 Aug 21; 9(16):2293-305. PMID: 19636459.
      View in: PubMed
    39. Mirica KA, Phillips ST, Shevkoplyas SS, Whitesides GM. Using magnetic levitation to distinguish atomic-level differences in chemical composition of polymers, and to monitor chemical reactions on solid supports. J Am Chem Soc. 2008 Dec 31; 130(52):17678-80. PMID: 19063630.
      View in: PubMed
    40. Hulme SE, Shevkoplyas SS, Whitesides GM. Incorporation of prefabricated screw, pneumatic, and solenoid valves into microfluidic devices. Lab Chip. 2009 Jan 07; 9(1):79-86. PMID: 19209338; PMCID: PMC3065121.
      View in: PubMed, PubMed Central
    41. Wong AP, Gupta M, Shevkoplyas SS, Whitesides GM. Egg beater as centrifuge: isolating human blood plasma from whole blood in resource-poor settings. Lab Chip. 2008 Dec; 8(12):2032-7. PMID: 19023465.
      View in: PubMed
    42. Hashimoto M, Shevkoplyas SS, Zasonska B, Szymborski T, Garstecki P, Whitesides GM. Formation of bubbles and droplets in parallel, coupled flow-focusing geometries. Small. 2008 Oct; 4(10):1795-805. PMID: 18819139.
      View in: PubMed
    43. Elizabeth Hulme S, DiLuzio WR, Shevkoplyas SS, Turner L, Mayer M, Berg HC, Whitesides GM. Using ratchets and sorters to fractionate motile cells of Escherichia coli by length. Lab Chip. 2008 Nov; 8(11):1888-95. PMID: 18941690.
      View in: PubMed
    44. Hulme SE, Shevkoplyas SS, Samuel A. Microfluidics: streamlining discovery in worm biology. Nat Methods. 2008 Jul; 5(7):589-90. PMID: 18587316.
      View in: PubMed
    45. Feinberg AW, Feigel A, Shevkoplyas SS, Sheehy S, Whitesides GM, Parker KK. Muscular thin films for building actuators and powering devices. Science. 2007 Sep 07; 317(5843):1366-70. PMID: 17823347.
      View in: PubMed
    46. Fuerstman MJ, Lai A, Thurlow ME, Shevkoplyas SS, Stone HA, Whitesides GM. The pressure drop along rectangular microchannels containing bubbles. Lab Chip. 2007 Nov; 7(11):1479-89. PMID: 17960275.
      View in: PubMed
    47. Hulme SE, Shevkoplyas SS, Apfeld J, Fontana W, Whitesides GM. A microfabricated array of clamps for immobilizing and imaging C. elegans. Lab Chip. 2007 Nov; 7(11):1515-23. PMID: 17960280.
      View in: PubMed
    48. Shevkoplyas SS, Siegel AC, Westervelt RM, Prentiss MG, Whitesides GM. The force acting on a superparamagnetic bead due to an applied magnetic field. Lab Chip. 2007 Oct; 7(10):1294-302. PMID: 17896013.
      View in: PubMed
    49. Siegel AC, Shevkoplyas SS, Weibel DB, Bruzewicz DA, Martinez AW, Whitesides GM. Cofabrication of electromagnets and microfluidic systems in poly(dimethylsiloxane). Angew Chem Int Ed Engl. 2006 Oct 20; 45(41):6877-82. PMID: 17001718.
      View in: PubMed
    50. Gifford SC, Derganc J, Shevkoplyas SS, Yoshida T, Bitensky MW. A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence. Br J Haematol. 2006 Nov; 135(3):395-404. PMID: 16989660.
      View in: PubMed
    51. Shevkoplyas SS, Yoshida T, Gifford SC, Bitensky MW. Direct measurement of the impact of impaired erythrocyte deformability on microvascular network perfusion in a microfluidic device. Lab Chip. 2006 Jul; 6(7):914-20. PMID: 16804596.
      View in: PubMed
    52. Gifford SC, Yoshida T, Shevkoplyas SS, Bitensky MW. A high-resolution, double-labeling method for the study of in vivo red blood cell aging. Transfusion. 2006 Apr; 46(4):578-88. PMID: 16584434.
      View in: PubMed
    53. Shevkoplyas SS, Yoshida T, Munn LL, Bitensky MW. Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device. Anal Chem. 2005 Feb 01; 77(3):933-7. PMID: 15679363; PMCID: PMC3022340.
      View in: PubMed, PubMed Central
    54. Shevkoplyas SS, Gifford SC, Yoshida T, Bitensky MW. Prototype of an in vitro model of the microcirculation. Microvasc Res. 2003 Mar; 65(2):132-6. PMID: 12686171.
      View in: PubMed
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