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Therese Kosten

TitleProfessor
InstitutionUniversity of Houston
DepartmentPsychology
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-3725
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    Collapse Research 
    Collapse research activities and funding
    R01DA009994     (KOSTEN, THERESE A)May 1, 1997 - Mar 31, 2001
    NIH/NIDA
    NEUROBEHAVIORAL STUDIES OF DUAL DRUG ADDICTION
    Role: Principal Investigator
    U01AA013476     (KOSTEN, THERESE A)Sep 27, 2001 - Aug 31, 2016
    NIH/NIAAA
    Target Validation Core Rats
    Role: Principal Investigator
    R21DA020117     (KOSTEN, THERESE A)Jul 1, 2008 - Jun 30, 2012
    NIH/NIDA
    Sex Differences in Vulnerability to Cocaine Addiction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gao Y, Zhou JJ, Zhu Y, Wang L, Kosten TA, Zhang X, Li DP. Neuroadaptations of presynaptic and postsynaptic GABAB receptor function in the paraventricular nucleus in response to chronic unpredictable stress. Br J Pharmacol. 2017 Sep; 174(17):2929-2940. PMID: 28635080.
      View in: PubMed
    2. Haile CN, Kosten TA. The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats. Neuropharmacology. 2017 Apr; 116:364-370. PMID: 28088358.
      View in: PubMed
    3. Zhou JJ, Gao Y, Kosten TA, Zhao Z, Li DP. Acute stress diminishes M-current contributing to elevated activity of hypothalamic-pituitary-adrenal axis. Neuropharmacology. 2017 Mar 01; 114:67-76. PMID: 27908768.
      View in: PubMed
    4. Nieto SJ, Patriquin MA, Nielsen DA, Kosten TA. Don't worry; be informed about the epigenetics of anxiety. Pharmacol Biochem Behav. 2016 Jul-Aug; 146-147:60-72. PMID: 27189589; PMCID: PMC4939112 [Available on 07/01/17].
      View in: PubMed, PubMed Central
    5. Ohia-Nwoko O, Kosten TA, Haile CN. Animal Models and the Development of Vaccines to Treat Substance Use Disorders. Int Rev Neurobiol. 2016; 126:263-91. PMID: 27055616.
      View in: PubMed
    6. Haile CN, Kosten TA, Shen XY, O'Malley PW, Winoske KJ, Kinsey BM, Wu Y, Huang Z, Lykissa ED, Naidu N, Cox JA, Arora R, Kosten TR, Orson FM. Altered methamphetamine place conditioning in mice vaccinated with a succinyl-methamphetamine-tetanus-toxoid vaccine. Am J Addict. 2015 Dec; 24(8):748-55. PMID: 26584468.
      View in: PubMed
    7. Gomez JL, Cunningham CL, Finn DA, Young EA, Helpenstell LK, Schuette LM, Fidler TL, Kosten TA, Ryabinin AE. Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence. Neuropharmacology. 2015 Oct; 97:182-93. PMID: 26051399; PMCID: PMC4537402 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    8. Helms CM, Bell RL, Bennett AJ, Davies DL, Chester JA, Kosten TA, Leeman RF, Panicker S, Platt DM, Weiner JL, Edwards S. The importance of animals in advancing research on alcohol use disorders. Alcohol Clin Exp Res. 2015 Apr; 39(4):575-8. PMID: 25833015.
      View in: PubMed
    9. Krupitsky EM, Blokhina EA, Zvartau EE, Verbitskaya VE, Bushara EM, Tiurina AA, Palatkin VY, Yaroslavtseva TS, Burakov AM, Masalov DV, Romanova TN, Grininko AY, Sinha R, Kosten T. [A double-blind randomized placebo-controlled study of the efficacy of the combined treatment with naltrexone and guanfacine for relapse prevention in opiate dependence]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015; 115(10):39-46. PMID: 26525620.
      View in: PubMed
    10. Kosten TA, Shen XY, Kinsey BM, Kosten TR, Orson FM. Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization. Am J Addict. 2014 Nov-Dec; 23(6):604-7. PMID: 25251469; PMCID: PMC4184912.
      View in: PubMed, PubMed Central
    11. Kosten TA, Nielsen DA. Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon 17 promoter gene in hippocampus and cerebellum. Int J Dev Neurosci. 2014 Aug; 36:5-12. PMID: 24721039; PMCID: PMC4101021.
      View in: PubMed, PubMed Central
    12. Kosten TA, Shen XY, O'Malley PW, Kinsey BM, Lykissa ED, Orson FM, Kosten TR. A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 01; 45:223-9. PMID: 23739535; PMCID: PMC3773503.
      View in: PubMed, PubMed Central
    13. Zhang XY, Chen DC, Xiu MH, Yang FD, Tan Y, Luo X, Zuo L, Kosten TA, Kosten TR. Cognitive function, plasma MnSOD activity, and MnSOD Ala-9Val polymorphism in patients with schizophrenia and normal controls. Schizophr Bull. 2014 May; 40(3):592-601. PMID: 23588476; PMCID: PMC3984504.
      View in: PubMed, PubMed Central
    14. Kosten TA, Huang W, Nielsen DA. Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats. Dev Psychobiol. 2014 Apr; 56(3):392-406. PMID: 23460384.
      View in: PubMed
    15. Kosten TA, Meisch RA. Predicting extinction and reinstatement of alcohol and sucrose self-administration in outbred rats. Exp Clin Psychopharmacol. 2013 Jun; 21(3):245-51. PMID: 23421354; PMCID: PMC4040462.
      View in: PubMed, PubMed Central
    16. Zhang XY, Chen DC, Xiu MH, Luo X, Zuo L, Haile CN, Kosten TA, Kosten TR. BDNF Val66Met variant and smoking in a Chinese population. PLoS One. 2012; 7(12):e53295. PMID: 23285275; PMCID: PMC3532294.
      View in: PubMed, PubMed Central
    17. Zhang XY, Chen DC, Xiu MH, Yang FD, Tan YL, He S, Kosten TA, Kosten TR. Thioredoxin, a novel oxidative stress marker and cognitive performance in chronic and medicated schizophrenia versus healthy controls. Schizophr Res. 2013 Feb; 143(2-3):301-6. PMID: 23238053.
      View in: PubMed
    18. Haile CN, Hao Y, O'Malley PW, Newton TF, Kosten TA. The a1 Antagonist Doxazosin Alters the Behavioral Effects of Cocaine in Rats. Brain Sci. 2012 Nov 13; 2(4):619-33. PMID: 24961263; PMCID: PMC4061810.
      View in: PubMed, PubMed Central
    19. Zhang XY, Chen DC, Xiu MH, Haile CN, He SC, Luo X, Zuo L, Rosenheck R, Kosten TA, Kosten TR. Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study. Psychol Med. 2013 Aug; 43(8):1651-60. PMID: 23149169.
      View in: PubMed
    20. Shen XY, Kosten TA, Lopez AY, Kinsey BM, Kosten TR, Orson FM. A vaccine against methamphetamine attenuates its behavioral effects in mice. Drug Alcohol Depend. 2013 Apr 01; 129(1-2):41-8. PMID: 23022610; PMCID: PMC3563850.
      View in: PubMed, PubMed Central
    21. Zhang XY, Liu L, Liu S, Hong X, Chen DC, Xiu MH, Yang FD, Zhang Z, Zhang X, Kosten TA, Kosten TR. Short-term tropisetron treatment and cognitive and P50 auditory gating deficits in schizophrenia. Am J Psychiatry. 2012 Sep; 169(9):974-81. PMID: 22952075.
      View in: PubMed
    22. Singh RA, Kosten TA, Kinsey BM, Shen X, Lopez AY, Kosten TR, Orson FM. Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: low doses induce hypolocomotion. Pharmacol Biochem Behav. 2012 Dec; 103(2):230-6. PMID: 23010423; PMCID: PMC3494772.
      View in: PubMed, PubMed Central
    23. Zhang XY, Chen DC, Xiu MH, Hui L, Liu H, Luo X, Zuo L, Zhang H, Kosten TA, Kosten TR. Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers. Schizophr Res. 2012 Oct; 141(1):48-53. PMID: 22871345.
      View in: PubMed
    24. Kosten TA, Kim JJ, Lee HJ. Early life manipulations alter learning and memory in rats. Neurosci Biobehav Rev. 2012 Oct; 36(9):1985-2006. PMID: 22819985; PMCID: PMC3463710.
      View in: PubMed, PubMed Central
    25. Zhang XY, Chen DC, Xiu MH, Yang FD, Haile CN, Kosten TA, Kosten TR. Gender differences in never-medicated first-episode schizophrenia and medicated chronic schizophrenia patients. J Clin Psychiatry. 2012 Jul; 73(7):1025-33. PMID: 22901352.
      View in: PubMed
    26. Zhang XY, Zhang WF, Zhou DF, Chen DC, Xiu MH, Wu HR, Haile CN, Kosten TA, Kosten TR. Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to Ginkgo biloba. Biol Psychiatry. 2012 Oct 15; 72(8):700-6. PMID: 22695185.
      View in: PubMed
    27. Zhang XY, Chen DC, Xiu MH, Haile CN, Sun H, Lu L, Kosten TA, Kosten TR. Cigarette smoking and cognitive function in Chinese male schizophrenia: a case-control study. PLoS One. 2012; 7(5):e36563. PMID: 22570726; PMCID: PMC3343009.
      View in: PubMed, PubMed Central
    28. Zhang XY, Chen DC, Xiu MH, Tang W, Zhang F, Liu L, Chen Y, Liu J, Yao JK, Kosten TA, Kosten TR. Plasma total antioxidant status and cognitive impairments in schizophrenia. Schizophr Res. 2012 Aug; 139(1-3):66-72. PMID: 22555016.
      View in: PubMed
    29. Liu H, Kang Y, Liang J, Li C, Xiu M, Chen D, Yang F, Wang F, Wu G, Haile CN, Kosten TA, Kosten TR, Zhang XY. Lower serum interleukin-2 levels in schizophrenic patients with tardive dyskinesia. Psychiatry Res. 2012 Jul 30; 198(2):329-31. PMID: 22417931.
      View in: PubMed
    30. Kosten TA, Miserendino MJ. Stress alters the discriminative stimulus and response rate effects of cocaine differentially in lewis and Fischer inbred rats. Behav Sci (Basel). 2012 Mar; 2(1):23-37. PMID: 25379213; PMCID: PMC4217579.
      View in: PubMed, PubMed Central
    31. Zhang XY, Chen DC, Xiu MH, Haile CN, Luo X, Xu K, Zhang HP, Zuo L, Zhang Z, Zhang X, Kosten TA, Kosten TR. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Hum Genet. 2012 Jul; 131(7):1187-95. PMID: 22362486; PMCID: PMC3671849.
      View in: PubMed, PubMed Central
    32. Zhang XY, Liang J, Chen DC, Xiu MH, He J, Cheng W, Wu Z, Yang FD, Haile CN, Sun H, Lu L, Kosten TA, Kosten TR. Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes. PLoS One. 2012; 7(2):e30937. PMID: 22347412; PMCID: PMC3274516.
      View in: PubMed, PubMed Central
    33. Zhang XY, Liang J, Chen DC, Xiu MH, Yang FD, Kosten TA, Kosten TR. Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia. Psychopharmacology (Berl). 2012 Jul; 222(2):277-84. PMID: 22274000.
      View in: PubMed
    34. Zhang XY, Zhou DF, Shen YC, Zhang PY, Zhang WF, Liang J, Chen DC, Xiu MH, Kosten TA, Kosten TR. Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia. Neuropharmacology. 2012 Apr; 62(5-6):1928-34. PMID: 22227558.
      View in: PubMed
    35. Xiang X, Hao W, Kosten TA. [Sex difference in performance in elevated plus maze and hippocampal GluR1 level]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Aug; 36(8):750-3. PMID: 21937801.
      View in: PubMed
    36. Zhang XY, Yu YQ, Sun S, Zhang X, Li W, Xiu MH, Chen DC, Yang FD, Zhu F, Kosten TA, Kosten TR. Smoking and tardive dyskinesia in male patients with chronic schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15; 35(7):1765-9. PMID: 21723906.
      View in: PubMed
    37. Hao Y, Huang W, Nielsen DA, Kosten TA. Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring. Front Psychiatry. 2011; 2:21. PMID: 21629839; PMCID: PMC3098712.
      View in: PubMed, PubMed Central
    38. Xiang X, Huang W, Haile CN, Kosten TA. Hippocampal GluR1 associates with behavior in the elevated plus maze and shows sex differences. Behav Brain Res. 2011 Sep 23; 222(2):326-31. PMID: 21497621; PMCID: PMC3096704.
      View in: PubMed, PubMed Central
    39. Kosten TA. Pharmacologically targeting the P2rx4 gene on maintenance and reinstatement of alcohol self-administration in rats. Pharmacol Biochem Behav. 2011 Jun; 98(4):533-8. PMID: 21402096; PMCID: PMC3081972.
      View in: PubMed, PubMed Central
    40. Zhang XY, Xiu MH, Chen DC, Yang FD, Wu GY, Lu L, Kosten TA, Kosten TR. Nicotine dependence and serum BDNF levels in male patients with schizophrenia. Psychopharmacology (Berl). 2010 Oct; 212(3):301-7. PMID: 20661552.
      View in: PubMed
    41. Zhang XY, Xiu MH, Song C, Chen DC, Wu GY, Haile CN, Kosten TA, Kosten TR. Increased serum S100B in never-medicated and medicated schizophrenic patients. J Psychiatr Res. 2010 Dec; 44(16):1236-40. PMID: 20510426.
      View in: PubMed
    42. Zhang XY, Xiu MH, Chen DC, Zhu FY, Wu GY, Haile CN, Lu L, Kosten TA, Kosten TR. Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements. J Psychiatr Res. 2010 May; 44(7):429-33. PMID: 19932492.
      View in: PubMed
    43. Kosten TA, Kehoe P. Immediate and enduring effects of neonatal isolation on maternal behavior in rats. Int J Dev Neurosci. 2010 Feb; 28(1):53-61. PMID: 19782745; PMCID: PMC2815133.
      View in: PubMed, PubMed Central
    44. Qiu HT, Meng HQ, Song C, Xiu MH, Chen DC, Zhu FY, Wu GY, Kosten TA, Kosten TR, Zhang XY. Association between monoamine oxidase (MAO)-A gene variants and schizophrenia in a Chinese population. Brain Res. 2009 Sep 01; 1287:67-73. PMID: 19573521.
      View in: PubMed
    45. Zhang XY, Chen DC, Xiu MH, Wang F, Qi LY, Sun HQ, Chen S, He SC, Wu GY, Haile CN, Kosten TA, Lu L, Kosten TR. The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients. Schizophr Res. 2009 Sep; 113(2-3):151-7. PMID: 19540723.
      View in: PubMed
    46. Qi LY, Xiu MH, Chen DC, Wang F, Kosten TA, Kosten TR, Zhang XY. Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics. Neurosci Lett. 2009 Sep 22; 462(2):113-7. PMID: 19539717.
      View in: PubMed
    47. Zhang XY, Chen DC, Qi LY, Wang F, Xiu MH, Chen S, Wu GY, Kosten TA, Kosten TR. Gender differences in the prevalence, risk and clinical correlates of tardive dyskinesia in Chinese schizophrenia. Psychopharmacology (Berl). 2009 Sep; 205(4):647-54. PMID: 19529921.
      View in: PubMed
    48. Zhang XY, Zhou DF, Qi LY, Chen S, Cao LY, Chen DC, Xiu MH, Wang F, Wu GY, Lu L, Kosten TA, Kosten TR. Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics. Psychopharmacology (Berl). 2009 May; 204(1):177-84. PMID: 19139851.
      View in: PubMed
    49. Haile CN, Kosten TR, Kosten TA. Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. Am J Drug Alcohol Abuse. 2009; 35(3):161-77. PMID: 19462300; PMCID: PMC2754046.
      View in: PubMed, PubMed Central
    50. Xiu MH, Chen S, Wang F, Cao LY, Qi LY, Chen DC, Wu GY, Lu L, Kosten TA, Kosten TR, Zhang XY. Altered interleukin-3 serum levels in drug-naïve and neuroleptic-treated schizophrenic patients. Schizophr Res. 2008 Dec; 106(2-3):369-70. PMID: 18838250.
      View in: PubMed
    51. Chen DC, Qi LY, Xiu MH, Cao LY, Wang F, Chen S, Wu GY, Kosten TA, Kosten TR, Zhang XY. Elevated serum levels of tumor necrosis factor-alpha in clozapine-associated obesity in chronic schizophrenia. Schizophr Res. 2008 Dec; 106(2-3):367-8. PMID: 18835132.
      View in: PubMed
    52. Zhang XY, Cao LY, Song C, Wu GY, Chen DC, Qi LY, Wang F, Xiu MH, Chen S, Zhang Y, Lu L, Kosten TA, Kosten TR. Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics. Psychopharmacology (Berl). 2008 Dec; 201(3):383-9. PMID: 18719893.
      View in: PubMed
    53. Sun S, Wang F, Wei J, Cao LY, Qi LY, Xiu MH, Chen S, Li XH, Kosten TA, Kosten TR, Zhang XY. Association between interleukin-6 receptor polymorphism and patients with schizophrenia. Schizophr Res. 2008 Jul; 102(1-3):346-7. PMID: 18508242.
      View in: PubMed
    54. Sun S, Wang F, Wei J, Cao LY, Wu GY, Lu L, Kosten TA, Kosten TR, Zhang XY. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. Neurosci Lett. 2008 Jul 25; 440(1):35-7. PMID: 18547720.
      View in: PubMed
    55. Li YQ, Wang XY, Zhai HF, Zheng YQ, Zhang XY, Kosten T, Lu L. Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats. Psychopharmacology (Berl). 2008 Aug; 199(2):245-53. PMID: 18452033.
      View in: PubMed
    56. Wang F, Xiu MH, Zhou DF, Cao LY, Wu GY, Kosten TA, Kosten TR, Zhang XY. The CCR5 32-bp deletion allele is rare in a Chinese population. Schizophr Res. 2008 Apr; 101(1-3):341-3. PMID: 18295459.
      View in: PubMed
    57. Haile CN, Kosten TA, Kosten TR. Pharmacogenetic treatments for drug addiction: alcohol and opiates. Am J Drug Alcohol Abuse. 2008; 34(4):355-81. PMID: 18584566.
      View in: PubMed
    58. Kosten TA, Zhang XY. Sex differences in non-reinforced responding for cocaine. Am J Drug Alcohol Abuse. 2008; 34(4):473-88. PMID: 18584577.
      View in: PubMed
    59. Zhang XY, Zhou DF, Wu GY, Cao LY, Tan YL, Haile CN, Li J, Lu L, Kosten TA, Kosten TR. BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia. Neuropsychopharmacology. 2008 Aug; 33(9):2200-5. PMID: 17987059.
      View in: PubMed
    60. Wang ZR, Zhou DF, Cao LY, Tan YL, Zhang XY, Li J, Lu L, Wu GY, Kosten TA, Kosten TR. Brain-derived neurotrophic factor polymorphisms and smoking in schizophrenia. Schizophr Res. 2007 Dec; 97(1-3):299-301. PMID: 17869486.
      View in: PubMed
    61. Kosten TA, Galloway MP, Duman RS, Russell DS, D'Sa C. Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures. Neuropsychopharmacology. 2008 Jun; 33(7):1545-58. PMID: 17700647.
      View in: PubMed
    62. Li W, Wei J, Zhou DF, Tan YL, Cao YL, Zhang XY, Wu G, Kosten TA, Kosten TR. Lack of association between the BDNF C270T polymorphism and schizophrenia in a Chinese Han population. Schizophr Res. 2007 Dec; 97(1-3):297-8. PMID: 17669628.
      View in: PubMed
    63. Li YQ, Wang XY, Zhai HF, Zhang XY, Kosten T, Lu L. Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats. Behav Brain Res. 2008 Jan 10; 186(1):138-42. PMID: 17765982.
      View in: PubMed
    64. Zhang XY, Tan YL, Zhou DF, Haile CN, Cao LY, Xu Q, Shen Y, Kosten TA, Kosten TR. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. J Clin Psychopharmacol. 2007 Jun; 27(3):246-51. PMID: 17502770.
      View in: PubMed
    65. Kosten TA, Karanian DA, Yeh J, Haile CN, Kim JJ, Kehoe P, Bahr BA. Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience. Neurobiol Learn Mem. 2007 Sep; 88(2):167-76. PMID: 17543553.
      View in: PubMed
    66. Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Haile CN, Kosten TA, Kosten TR. Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia. J Clin Psychiatry. 2007 May; 68(5):754-60. PMID: 17503985.
      View in: PubMed
    67. Kosten TA, Zhang XY, Haile CN. Strain differences in maintenance of cocaine self-administration and their relationship to novelty activity responses. Behav Neurosci. 2007 Apr; 121(2):380-8. PMID: 17469928.
      View in: PubMed
    68. Kosten TA, Lee HJ, Kim JJ. Neonatal handling alters learning in adult male and female rats in a task-specific manner. Brain Res. 2007 Jun 18; 1154:144-53. PMID: 17475223.
      View in: PubMed
    69. Zhang XY, Tan YL, Zhou DF, Haile CN, Wu GY, Cao LY, Kosten TA, Kosten TR. Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia. Neuropsychopharmacology. 2007 Sep; 32(9):2020-4. PMID: 17228336.
      View in: PubMed
    70. Guo S, Chen DF, Zhou DF, Sun HQ, Wu GY, Haile CN, Kosten TA, Kosten TR, Zhang XY. Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. Psychopharmacology (Berl). 2007 Mar; 190(4):449-56. PMID: 17206495.
      View in: PubMed
    71. Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Xu Q, Shen Y, Haile CN, Kosten TA, Kosten TR. Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. J Psychiatr Res. 2007 Dec; 41(12):997-1004. PMID: 17095017.
      View in: PubMed
    72. Haile CN, Kosten TR, Kosten TA. Genetics of dopamine and its contribution to cocaine addiction. Behav Genet. 2007 Jan; 37(1):119-45. PMID: 17063402.
      View in: PubMed
    73. Zhang XY, Kosten TA. Previous exposure to cocaine enhances cocaine self-administration in an alpha 1-adrenergic receptor dependent manner. Neuropsychopharmacology. 2007 Mar; 32(3):638-45. PMID: 16794571.
      View in: PubMed
    74. Kosten TA, Lee HJ, Kim JJ. Early life stress impairs fear conditioning in adult male and female rats. Brain Res. 2006 May 04; 1087(1):142-50. PMID: 16626646.
      View in: PubMed
    75. Kim JJ, Song EY, Kosten TA. Stress effects in the hippocampus: synaptic plasticity and memory. Stress. 2006 Mar; 9(1):1-11. PMID: 16753928.
      View in: PubMed
    76. Zhang XY, Kehoe P, Kosten TA. Neonatal isolation alters estrous cycle effects on ventral striatal extracellular monoamine levels. Prog Neuropsychopharmacol Biol Psychiatry. 2006 May; 30(3):504-11. PMID: 16412549.
      View in: PubMed
    77. Kosten TA, Zhang XY, Kehoe P. Heightened cocaine and food self-administration in female rats with neonatal isolation experience. Neuropsychopharmacology. 2006 Jan; 31(1):70-6. PMID: 15956993.
      View in: PubMed
    78. Haile CN, Zhang XY, Carroll FI, Kosten TA. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Res. 2005 Sep 07; 1055(1-2):186-95. PMID: 16095575.
      View in: PubMed
    79. Kosten TA, Kehoe P. Neonatal isolation is a relevant model for studying the contributions of early life stress to vulnerability to drug abuse: response to Marmendal et al. (2004). Dev Psychobiol. 2005 Sep; 47(2):108-10. PMID: 16136566.
      View in: PubMed
    80. Karanian DA, Brown QB, Makriyannis A, Kosten TA, Bahr BA. Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. J Neurosci. 2005 Aug 24; 25(34):7813-20. PMID: 16120783.
      View in: PubMed
    81. Zhang XY, Kosten TA. Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking. Biol Psychiatry. 2005 May 15; 57(10):1202-4. PMID: 15866561.
      View in: PubMed
    82. Kosten TA, Zhang XY, Kehoe P. Neurochemical and behavioral responses to cocaine in adult male rats with neonatal isolation experience. J Pharmacol Exp Ther. 2005 Aug; 314(2):661-7. PMID: 15845857.
      View in: PubMed
    83. Kosten TA, Sanchez H, Jatlow PI, Kehoe P. Neonatal isolation alters the estrous cycle interactions on the acute behavioral effects of cocaine. Psychoneuroendocrinology. 2005 Sep; 30(8):753-61. PMID: 15919581.
      View in: PubMed
    84. Kosten TA, Miserendino MJ, Bombace JC, Lee HJ, Kim JJ. Sex-selective effects of neonatal isolation on fear conditioning and foot shock sensitivity. Behav Brain Res. 2005 Feb 28; 157(2):235-44. PMID: 15639174.
      View in: PubMed
    85. Kosten TR, Kosten TA. New medication strategies for comorbid substance use and bipolar affective disorders. Biol Psychiatry. 2004 Nov 15; 56(10):771-7. PMID: 15556122.
      View in: PubMed
    86. Kosten TA, Zhang XY, Kehoe P. Infant rats with chronic neonatal isolation experience show decreased extracellular serotonin levels in ventral striatum at baseline and in response to cocaine. Brain Res Dev Brain Res. 2004 Aug 18; 152(1):19-24. PMID: 15283991.
      View in: PubMed
    87. Zhang XY, Sanchez H, Kehoe P, Kosten TA. Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats. Psychopharmacology (Berl). 2005 Feb; 177(4):391-9. PMID: 15258719.
      View in: PubMed
    88. Kosten TA, Sanchez H, Zhang XY, Kehoe P. Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats. Behav Brain Res. 2004 May 05; 151(1-2):137-49. PMID: 15084429.
      View in: PubMed
    89. Haile CN, During MJ, Jatlow PI, Kosten TR, Kosten TA. Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats. Biol Psychiatry. 2003 Nov 01; 54(9):915-21. PMID: 14573319.
      View in: PubMed
    90. Miserendino MJ, Haile CN, Kosten TA. Strain differences in response to escapable and inescapable novel environments and their ability to predict amphetamine-induced locomotor activity. Psychopharmacology (Berl). 2003 May; 167(3):281-90. PMID: 12664191.
      View in: PubMed
    91. Kosten TA, Zhang XY, Kehoe P. Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups. Brain Res Dev Brain Res. 2003 Mar 14; 141(1-2):109-16. PMID: 12644254.
      View in: PubMed
    92. Kosten TR, George TP, Kosten TA. The potential of dopamine agonists in drug addiction. Expert Opin Investig Drugs. 2002 Apr; 11(4):491-9. PMID: 11922858.
      View in: PubMed
    93. Kosten TA, Ambrosio E. HPA axis function and drug addictive behaviors: insights from studies with Lewis and Fischer 344 inbred rats. Psychoneuroendocrinology. 2002 Jan-Feb; 27(1-2):35-69. PMID: 11750769.
      View in: PubMed
    94. Haile CN, Kosten TA. Differential effects of D1- and D2-like compounds on cocaine self-administration in Lewis and Fischer 344 inbred rats. J Pharmacol Exp Ther. 2001 Nov; 299(2):509-18. PMID: 11602661.
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    95. Haile CN, Hiroi N, Nestler EJ, Kosten TA. Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats. Synapse. 2001 Sep 01; 41(3):179-90. PMID: 11391778.
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    96. Kosten TA, Bombace JC. Ethanol enhances naloxone sensitization and disrupts morphine discrimination--comparison to dizocilpine and pentobarbital: explanation of enhancing acute and attenuating chronic effects. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Aug; 25(6):1283-306. PMID: 11474846.
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    97. Rosenheck R, Kosten T. Buprenorphine for opiate addiction: potential economic impact. Drug Alcohol Depend. 2001 Aug 01; 63(3):253-62. PMID: 11418229.
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    98. Vosler PS, Bombace JC, Kosten TA. A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior. Life Sci. 2001 Jun 22; 69(5):591-8. PMID: 11510953.
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    99. McCance-Katz EF, Kosten TA, Kosten TR. Going from the bedside back to the bench with ecopipam: a new strategy for cocaine pharmacotherapy development. Psychopharmacology (Berl). 2001 Jun; 155(4):327-9. PMID: 11441421.
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    100. Gottschalk C, Beauvais J, Hart R, Kosten T. Cognitive function and cerebral perfusion during cocaine abstinence. Am J Psychiatry. 2001 Apr; 158(4):540-5. PMID: 11282686.
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    101. Haile CN, GrandPre T, Kosten TA. Chronic unpredictable stress, but not chronic predictable stress, enhances the sensitivity to the behavioral effects of cocaine in rats. Psychopharmacology (Berl). 2001 Mar 01; 154(2):213-20. PMID: 11314684.
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    102. Boutros NN, Lisanby SH, Tokuno H, Torello MW, Campbell D, Berman R, Malison R, Krystal JH, Kosten T. Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation. Biol Psychiatry. 2001 Feb 15; 49(4):369-73. PMID: 11239908.
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    103. Boutros N, Campbell D, Petrakis I, Krystal J, Caporale M, Kosten T. Cocaine use and the mid-latency auditory evoked responses. Psychiatry Res. 2000 Oct 30; 96(2):117-26. PMID: 11063784.
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    104. Kosten TA, Bombace JC. Prior and delayed applications of dizocilpine or ethanol alter locomotor sensitization to morphine. Brain Res. 2000 Sep 29; 878(1-2):20-31. PMID: 10996133.
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    105. Kosten TA, Miserendino MJ, Kehoe P. Enhanced acquisition of cocaine self-administration in adult rats with neonatal isolation stress experience. Brain Res. 2000 Sep 01; 875(1-2):44-50. PMID: 10967297.
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    106. Carlezon WA, Kosten TA, Nestler EJ. Behavioral interactions caused by combined administration of morphine and MK-801 in rats. Psychopharmacology (Berl). 2000 Aug; 151(2-3):261-72. PMID: 10972473.
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    107. Kosten TA, Haile CN, Jatlow P. Naltrexone and morphine alter the discrimination and plasma levels of ethanol. Behav Pharmacol. 1999 Feb; 10(1):1-13. PMID: 10780298.
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    108. Brodkin ES, Kosten TA, Haile CN, Heninger GR, Carlezon WA, Jatlow P, Remmers EF, Wilder RL, Nestler EJ. Dark Agouti and Fischer 344 rats: differential behavioral responses to morphine and biochemical differences in the ventral tegmental area. Neuroscience. 1999; 88(4):1307-15. PMID: 10336139.
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    109. Druss BG, Rohrbaugh R, Kosten T, Hoff R, Rosenheck RA. Use of alternative medicine in major depression. Psychiatr Serv. 1998 Nov; 49(11):1397. PMID: 9826237.
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    110. Rosenheck R, Harkness L, Johnson B, Sweeney C, Buck N, Deegan D, Kosten T. Intensive community-focused treatment of veterans with dual diagnoses. Am J Psychiatry. 1998 Oct; 155(10):1429-33. PMID: 9766776.
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    111. Brodkin ES, Carlezon WA, Haile CN, Kosten TA, Heninger GR, Nestler EJ. Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice. Brain Res. 1998 Sep 14; 805(1-2):55-68. PMID: 9733917.
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    112. Kosten TA, Miserendino MJ. Dissociation of novelty- and cocaine-conditioned locomotor activity from cocaine place conditioning. Pharmacol Biochem Behav. 1998 Aug; 60(4):785-91. PMID: 9700959.
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    113. Oliveto AH, Rosen MI, Kosten TA, Hameedi FA, Woods SW, Kosten TR. Hydromorphone-naloxone combinations in opioid-dependent humans under a naloxone novel-response discrimination procedure. Exp Clin Psychopharmacol. 1998 May; 6(2):169-78. PMID: 9608349.
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    114. Petrakis I, Carroll KM, Nich C, Gordon L, Kosten T, Rounsaville B. Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. Drug Alcohol Depend. 1998 May 01; 50(3):221-6. PMID: 9649975.
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    115. Kosten TA, Miserendino MJ, Haile CN, DeCaprio JL, Jatlow PI, Nestler EJ. Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains. Brain Res. 1997 Dec 19; 778(2):418-29. PMID: 9459563.
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    116. Shoemaker WJ, Kosten TA, Muly SM. Ethanol attenuation of morphine dependence: comparison to dizocilpine. Psychopharmacology (Berl). 1997 Nov; 134(1):83-7. PMID: 9399370.
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    117. Kosten TA. Enhanced neurobehavioral effects of cocaine with chronic neuroleptic exposure in rats. Schizophr Bull. 1997; 23(2):203-13. PMID: 9165631.
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    118. Kosten TA, DeCaprio JL, Nestler EJ. Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure. Psychopharmacology (Berl). 1996 Dec; 128(3):304-12. PMID: 8972550.
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    119. Kosten TR, Kosten TA, McDougle CJ, Hameedi FA, McCance EF, Rosen MI, Oliveto AH, Price LH. Gender differences in response to intranasal cocaine administration to humans. Biol Psychiatry. 1996 Jan 15; 39(2):147-8. PMID: 8717615.
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    120. Kosten TA, DeCaprio JL, Rosen MI. The severity of naloxone-precipitated opiate withdrawal is attenuated by felbamate, a possible glycine antagonist. Neuropsychopharmacology. 1995 Dec; 13(4):323-33. PMID: 8747757.
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    121. Ortiz J, DeCaprio JL, Kosten TA, Nestler EJ. Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegmental area. Neuroscience. 1995 Jul; 67(2):383-97. PMID: 7675174.
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    122. Kosten TA, Ball SA, Rounsaville BJ. A sibling study of sensation seeking and opiate addiction. J Nerv Ment Dis. 1994 May; 182(5):284-9. PMID: 10678310.
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    123. Kosten TA, Miserendino MJ, Chi S, Nestler EJ. Fischer and Lewis rat strains show differential cocaine effects in conditioned place preference and behavioral sensitization but not in locomotor activity or conditioned taste aversion. J Pharmacol Exp Ther. 1994 Apr; 269(1):137-44. PMID: 8169817.
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    124. Kosten TA. Clonidine attenuates conditioned aversion produced by naloxone-precipitated opiate withdrawal. Eur J Pharmacol. 1994 Mar 11; 254(1-2):59-63. PMID: 8206117.
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    125. Leal J, Ziedonis D, Kosten T. Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. Drug Alcohol Depend. 1994 Mar; 35(1):31-5. PMID: 8082553.
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    126. Kosten TA, Nestler EJ. Clozapine attenuates cocaine conditioned place preference. Life Sci. 1994; 55(1):PL9-14. PMID: 8015343.
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    127. Oliveto A, Kosten T, Schottenfeld R, Ziedonis D. Cocaine abuse among methadone-maintained patients. Am J Psychiatry. 1993 Nov; 150(11):1755. PMID: 8214197.
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    128. Kosten TA, Gawin FH, Kosten TR, Rounsaville BJ. Gender differences in cocaine use and treatment response. J Subst Abuse Treat. 1993 Jan-Feb; 10(1):63-6. PMID: 8450576.
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    129. Kosten T, Gawin FH, Silverman DG, Fleming J, Compton M, Jatlow P, Byck R. Intravenous cocaine challenges during desipramine maintenance. Neuropsychopharmacology. 1992 Nov; 7(3):169-76. PMID: 1388643.
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    130. Guitart X, Beitner-Johnson D, Marby DW, Kosten TA, Nestler EJ. Fischer and Lewis rat strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine system. Synapse. 1992 Nov; 12(3):242-53. PMID: 1362292.
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    131. Kosten T, Silverman DG, Fleming J, Kosten TA, Gawin FH, Compton M, Jatlow P, Byck R. Intravenous cocaine challenges during naltrexone maintenance: a preliminary study. Biol Psychiatry. 1992 Sep 15; 32(6):543-8. PMID: 1445971.
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    132. Kosten TA, Rounsaville BJ. Sensitivity of psychiatric diagnosis based on the best estimate procedure. Am J Psychiatry. 1992 Sep; 149(9):1225-7. PMID: 1503136.
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    133. Kosten TA, Anton SF, Rounsaville BJ. Ascertaining psychiatric diagnoses with the family history method in a substance abuse population. J Psychiatr Res. 1992 Apr; 26(2):135-47. PMID: 1613680.
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    134. Ziedonis D, Richardson T, Lee E, Petrakis I, Kosten T. Adjunctive desipramine in the treatment of cocaine abusing schizophrenics. Psychopharmacol Bull. 1992; 28(3):309-14. PMID: 1480735.
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    135. Kosten TA, Bianchi MS, Kosten TR. The predictive validity of the dependence syndrome in opiate abusers. Am J Drug Alcohol Abuse. 1992; 18(2):145-56. PMID: 1562012.
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    136. Rosen MI, Kosten T. Cocaine-associated panic attacks in methadone-maintained patients. Am J Drug Alcohol Abuse. 1992; 18(1):57-62. PMID: 1314016.
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    137. Kosten TR, Kosten TA, Rounsaville BJ. Alcoholism and depressive disorders in opioid addicts and their family members. Compr Psychiatry. 1991 Nov-Dec; 32(6):521-7. PMID: 1778079.
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    138. Kosten TA, Kosten TR. Pharmacological blocking agents for treating substance abuse. J Nerv Ment Dis. 1991 Oct; 179(10):583-92. PMID: 1919542.
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    139. Stine SM, Burns B, Kosten T. Methadone dose for cocaine abuse. Am J Psychiatry. 1991 Sep; 148(9):1268. PMID: 1883015.
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    140. Kosten TR, Rounsaville BJ, Kosten TA, Merikangas K. Gender differences in the specificity of alcoholism transmission among the relatives of opioid addicts. J Nerv Ment Dis. 1991 Jul; 179(7):392-400. PMID: 1869867.
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    141. Kosten TA, Marby DW, Nestler EJ. Cocaine conditioned place preference is attenuated by chronic buprenorphine treatment. Life Sci. 1991; 49(24):PL201-6. PMID: 1943479.
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    142. Kosten TA, Kosten TR. The dependence syndrome concept as applied to alcohol and other substances of abuse. Recent Dev Alcohol. 1990; 8:47-68. PMID: 2185524.
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    143. Kosten TA, Kosten TR, Rounsaville BJ. Cocaine symptoms are predicted by familial psychopathology. NIDA Res Monogr. 1990; 105:603-4. PMID: 1876139.
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    144. Kosten TR, Morgan C, Kosten TA. Depressive symptoms during buprenorphine treatment of opioid abusers. J Subst Abuse Treat. 1990; 7(1):51-4. PMID: 2313769.
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    145. Pickett G, Kosten TR, Gawin FH, Byck R, Fleming J, Silverman D, Kosten TA, Jatlow P. Concurrent effects of acute intravenous cocaine in context of chronic desipramine in humans. NIDA Res Monogr. 1990; 105:508-9. PMID: 1876102.
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    146. Kosten TA. Cocaine attenuates the severity of naloxone-precipitated opioid withdrawal. Life Sci. 1990; 47(18):1617-23. PMID: 2250575.
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    147. Kosten T, Contreras RJ. Deficits in conditioned heart rate and taste aversion in area postrema-lesioned rats. Behav Brain Res. 1989 Oct 01; 35(1):9-21. PMID: 2553056.
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    148. Kosten TA, Kosten TR, Rounsaville BJ. Personality disorders in opiate addicts show prognostic specificity. J Subst Abuse Treat. 1989; 6(3):163-8. PMID: 2795705.
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    149. Kosten TA. Cocaine attenuates opiate withdrawal in human and rat. NIDA Res Monogr. 1989; 95:361-2. PMID: 2640996.
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    150. Kosten TA, Jacobsen LK, Kosten TR. Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria. Am J Drug Alcohol Abuse. 1989; 15(3):237-50. PMID: 2763981.
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    151. Morgan C, Kosten T, Gawin F, Kleber H. A pilot trial of amantadine for ambulatory withdrawal for cocaine dependence. NIDA Res Monogr. 1988; 81:81-5. PMID: 3136395.
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    152. Kosten T, Rounsaville B, Kleber H. A 2.5 year follow-up of abstinence and relapse to cocaine abuse in opioid addicts. NIDA Res Monogr. 1988; 81:231-6. PMID: 3136365.
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    153. Kosten T. The symptomatic and prognostic implications of psychiatric diagnoses in treated substance abusers. NIDA Res Monogr. 1988; 81:416-21. PMID: 3136380.
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    154. Kleber HD, Topazian M, Gaspari J, Riordan CE, Kosten T. Clonidine and naltrexone in the outpatient treatment of heroin withdrawal. Am J Drug Alcohol Abuse. 1987; 13(1-2):1-17. PMID: 3687878.
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    155. Kosten T, Contreras RJ. Adrenalectomy reduces peripheral neural responses to gustatory stimuli in the rat. Behav Neurosci. 1985 Aug; 99(4):734-41. PMID: 2441723.
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    156. Contreras RJ, Kosten T. Prenatal and early postnatal sodium chloride intake modifies the solution preferences of adult rats. J Nutr. 1983 May; 113(5):1051-62. PMID: 6842300.
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    157. Marini JL, Sheard MH, Kosten T. Study of the role of serotonin in lithium action using shock-elicited fighting. Commun Psychopharmacol. 1979; 3(4):225-33. PMID: 93531.
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