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Damith Udugamasooriya

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentPharmacological & Pharmaceutic
Address4800 Calhoun Rd
Houston TX 77004
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    Collapse Research 
    Collapse research activities and funding
    R21EB015602     (UDUGAMASOORIYA, DAMITH GOMIKA)Sep 30, 2012 - Aug 31, 2014
    NIH/NIBIB
    Direct identification of ready-to-use peptoid-DOTA theranostic systems
    Role: Principal Investigator
    R01CA175779     (UDUGAMASOORIYA, DAMITH GOMIKA)Apr 1, 2013 - Mar 31, 2018
    NIH/NCI
    Phosphatidylserine Targeted Tumor Cell Lytic Peptoids
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shukla SP, Manarang JC, Udugamasooriya DG. A unique mid-sequence linker used to multimerize the lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1. Eur J Med Chem. 2017 Sep 08; 137:1-10. PMID: 28551176.
      View in: PubMed
    2. Singh J, Rustagi V, Zhang S, Sherry AD, Udugamasooriya DG. On-bead combinatorial synthesis and imaging of europium(III)-based paraCEST agents aids in identification of chemical features that enhance CEST sensitivity. Magn Reson Chem. 2017 Aug; 55(8):747-753. PMID: 28220538.
      View in: PubMed
    3. Desai TJ, Udugamasooriya DG. A comprehensive lipid binding and activity validation of a cancer-specific peptide-peptoid hybrid PPS1. Biochem Biophys Res Commun. 2017 Apr 29; 486(2):545-550. PMID: 28322795.
      View in: PubMed
    4. Singh J, Shukla SP, Desai TJ, Udugamasooriya DG. Identification of the minimum pharmacophore of lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1D1. Bioorg Med Chem. 2016 Sep 15; 24(18):4470-4477. PMID: 27485601; PMCID: PMC4999298 [Available on 09/15/17].
      View in: PubMed, PubMed Central
    5. Desai TJ, Toombs JE, Minna JD, Brekken RA, Udugamasooriya DG. Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1. Oncotarget. 2016 May 24; 7(21):30678-90. PMID: 27120792.
      View in: PubMed
    6. Matharage JM, Minna JD, Brekken RA, Udugamasooriya DG. Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells. ACS Chem Biol. 2015 Dec 18; 10(12):2891-9. PMID: 26509598; PMCID: PMC4774050 [Available on 12/18/16].
      View in: PubMed, PubMed Central
    7. Udugamasooriya DG, Kodadek T. On-Bead Two-Color (OBTC) Cell Screen for Direct Identification of Highly Selective Cell Surface Receptor Ligands. Curr Protoc Chem Biol. 2012 Mar; 4:35-48. PMID: 22582145.
      View in: PubMed
    8. Napolitano R, Soesbe TC, De León-Rodríguez LM, Sherry AD, Udugamasooriya DG. On-bead combinatorial synthesis and imaging of chemical exchange saturation transfer magnetic resonance imaging agents to identify factors that influence water exchange. J Am Chem Soc. 2011 Aug 24; 133(33):13023-30. PMID: 21793515; PMCID: PMC3180893.
      View in: PubMed, PubMed Central
    9. Hooks JC, Matharage JP, Udugamasooriya DG. Development of homomultimers and heteromultimers of lung cancer-specific peptoids. Biopolymers. 2011; 96(5):567-77. PMID: 22180904; PMCID: PMC4515028.
      View in: PubMed, PubMed Central
    10. De León-Rodríguez LM, Lubag A, Udugamasooriya DG, Proneth B, Brekken RA, Sun X, Kodadek T, Dean Sherry A. MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting. J Am Chem Soc. 2010 Sep 22; 132(37):12829-31. PMID: 20795620; PMCID: PMC2967214.
      View in: PubMed, PubMed Central
    11. Lynn KD, Udugamasooriya DG, Roland CL, Castrillon DH, Kodadek TJ, Brekken RA. GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer. BMC Cancer. 2010 Jul 30; 10:397. PMID: 20673348; PMCID: PMC2920882.
      View in: PubMed, PubMed Central
    12. Lee J, Udugamasooriya DG, Lim HS, Kodadek T. Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates. Nat Chem Biol. 2010 Apr; 6(4):258-60. PMID: 20228793; PMCID: PMC3049443.
      View in: PubMed, PubMed Central
    13. Rubini C, Ruzza P, Spaller MR, Siligardi G, Hussain R, Udugamasooriya DG, Bellanda M, Mammi S, Borgogno A, Calderan A, Cesaro L, Brunati AM, Donella-Deana A. Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies. Biopolymers. 2010; 94(3):298-306. PMID: 19921743.
      View in: PubMed
    14. Gocke AR, Udugamasooriya DG, Archer CT, Lee J, Kodadek T. Isolation of antagonists of antigen-specific autoimmune T cell proliferation. Chem Biol. 2009 Nov 25; 16(11):1133-9. PMID: 19942136; PMCID: PMC2810551.
      View in: PubMed, PubMed Central
    15. Roland CL, Lynn KD, Toombs JE, Dineen SP, Udugamasooriya DG, Brekken RA. Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer. PLoS One. 2009 Nov 03; 4(11):e7669. PMID: 19888452; PMCID: PMC2766251.
      View in: PubMed, PubMed Central
    16. Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, Udugamasooriya DG, Memic A, Rupasinghe CN, Rupashinghe CN, Baretton GB, Aust DE, Langer S, Datta K, Simons M, Spaller MR, Mukhopadhyay D. Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. Clin Cancer Res. 2009 Jun 15; 15(12):4095-103. PMID: 19509165; PMCID: PMC2731998.
      View in: PubMed, PubMed Central
    17. Udugamasooriya DG, Spaller MR. Conformational constraint in protein ligand design and the inconsistency of binding entropy. Biopolymers. 2008 Aug; 89(8):653-67. PMID: 18335423.
      View in: PubMed
    18. Udugamasooriya DG, Dunham G, Ritchie C, Brekken RA, Kodadek T. The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5892-4. PMID: 18653335; PMCID: PMC2593102.
      View in: PubMed, PubMed Central
    19. Udugamasooriya DG, Sharma SC, Spaller MR. A chemical library approach to organic-modified peptide ligands for PDZ domain proteins: a synthetic, thermodynamic and structural investigation. Chembiochem. 2008 Jul 02; 9(10):1587-9. PMID: 18506876; PMCID: PMC3000795.
      View in: PubMed, PubMed Central
    20. Udugamasooriya DG, Ritchie C, Brekken RA, Kodadek T. A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site. Bioorg Med Chem. 2008 Jun 15; 16(12):6338-43. PMID: 18501615; PMCID: PMC2460570.
      View in: PubMed, PubMed Central
    21. Udugamasooriya DG, Dineen SP, Brekken RA, Kodadek T. A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity. J Am Chem Soc. 2008 Apr 30; 130(17):5744-52. PMID: 18386897.
      View in: PubMed
    22. Shores KS, Udugamasooriya DG, Kodadek T, Knapp DR. Use of peptide analogue diversity library beads for increased depth of proteomic analysis: application to cerebrospinal fluid. J Proteome Res. 2008 May; 7(5):1922-31. PMID: 18357977.
      View in: PubMed
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