Loading...
Header Logo
Keywords
Last Name
Institution

David Wagner

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentMathematics
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-3460
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01DK075013     (WAGNER, DAVID H.)Aug 1, 2007 - Apr 30, 2013
    NIH/NIDDK
    CD40-Induced TCR Revision: A Mechanism for Autoimmunity
    Role: Principal Investigator
    R21AI106011     (WAGNER, DAVID H.)Aug 7, 2013 - Jul 31, 2015
    NIH/NIAID
    A unique approach to control the CD40/CD154 inflammatory axis in type 1 diabetes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wagner DH. Overlooked Mechanisms in Type 1 Diabetes Etiology: How Unique Costimulatory Molecules Contribute to Diabetogenesis. Front Endocrinol (Lausanne). 2017; 8:208. PMID: 28878738.
      View in: PubMed
    2. Vaitaitis GM, Waid DM, Yussman MG, Wagner DH. CD40-mediated signalling influences trafficking, T-cell receptor expression, and T-cell pathogenesis, in the NOD model of type 1 diabetes. Immunology. 2017 Oct; 152(2):243-254. PMID: 28542921.
      View in: PubMed
    3. Wagner DH. Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?). Clin Exp Immunol. 2016 Sep; 185(3):271-80. PMID: 27271348; PMCID: PMC4991519 [Available on 09/01/17].
      View in: PubMed, PubMed Central
    4. Vaitaitis GM, Olmstead MH, Waid DM, Carter JR, Wagner DH. A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice. Diabetologia. 2014 Nov; 57(11):2366-73. PMID: 25104468; PMCID: PMC4183717.
      View in: PubMed, PubMed Central
    5. Deng G, Carter J, Traystman RJ, Wagner DH, Herson PS. Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation. J Neuroimmunol. 2014 Sep 15; 274(1-2):132-40. PMID: 25084739; PMCID: PMC4152553.
      View in: PubMed, PubMed Central
    6. Waid DM, Schreiner T, Vaitaitis G, Carter JR, Corboy JR, Wagner DH. Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells. J Neuroimmunol. 2014 May 15; 270(1-2):75-85. PMID: 24690203; PMCID: PMC4038952.
      View in: PubMed, PubMed Central
    7. Vaitaitis GM, Wagner DH. CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression. Cell Mol Immunol. 2013 Nov; 10(6):483-9. PMID: 24037181; PMCID: PMC3818448.
      View in: PubMed, PubMed Central
    8. Vaitaitis GM, Carter JR, Waid DM, Olmstead MH, Wagner DH. An alternative role for Foxp3 as an effector T cell regulator controlled through CD40. J Immunol. 2013 Jul 15; 191(2):717-25. PMID: 23776180; PMCID: PMC3712636.
      View in: PubMed, PubMed Central
    9. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173; PMCID: PMC3641738.
      View in: PubMed, PubMed Central
    10. Wagner DH. The specific antigen approach in multiple sclerosis: can it ever be enough? Clin Immunol. 2012 Aug; 144(2):139-41. PMID: 22729132.
      View in: PubMed
    11. Vaitaitis GM, Wagner DH. Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity. PLoS One. 2012; 7(6):e38708. PMID: 22685601; PMCID: PMC3369903.
      View in: PubMed, PubMed Central
    12. Carter J, Vaitaitis GM, Waid DM, Wagner DH. CD40 engagement of CD4+ CD40+ T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance. Eur J Immunol. 2012 Feb; 42(2):424-35. PMID: 22105491.
      View in: PubMed
    13. Chow KS, Jun D, Helm KM, Wagner DH, Majka SM. Isolation & characterization of Hoechst(low) CD45(negative) mouse lung mesenchymal stem cells. J Vis Exp. 2011 Oct 26; (56):e3159. PMID: 22064472; PMCID: PMC3227187.
      View in: PubMed, PubMed Central
    14. Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH, Majka SM. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells. 2011 Apr; 29(4):725-35. PMID: 21312316; PMCID: PMC3322548.
      View in: PubMed, PubMed Central
    15. Vaitaitis GM, Wagner DH. CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity. Mol Immunol. 2010 Aug; 47(14):2303-13. PMID: 20646763; PMCID: PMC2918662.
      View in: PubMed, PubMed Central
    16. Wagner DH. The co-evolution of our understanding of CD40 and inflammation. Diabetologia. 2009 Jun; 52(6):997-9. PMID: 19360393.
      View in: PubMed
    17. Baker RL, Wagner DH, Haskins K. CD40 on NOD CD4 T cells contributes to their activation and pathogenicity. J Autoimmun. 2008 Dec; 31(4):385-92. PMID: 18951762.
      View in: PubMed
    18. Waid DM, Vaitaitis GM, Pennock ND, Wagner DH. Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes. J Leukoc Biol. 2008 Aug; 84(2):431-9. PMID: 18469093; PMCID: PMC2493071.
      View in: PubMed, PubMed Central
    19. Vaitaitis GM, Wagner DH. High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity. PLoS One. 2008 Apr 30; 3(4):e2076. PMID: 18446238; PMCID: PMC2324204.
      View in: PubMed, PubMed Central
    20. Siebert JC, Inokuma M, Waid DM, Pennock ND, Vaitaitis GM, Disis ML, Dunne JF, Wagner DH, Maecker HT. An analytical workflow for investigating cytokine profiles. Cytometry A. 2008 Apr; 73(4):289-98. PMID: 18163472.
      View in: PubMed
    21. Waid DM, Wagner RJ, Putnam A, Vaitaitis GM, Pennock ND, Calverley DC, Gottlieb P, Wagner DH. A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes. Clin Immunol. 2007 Aug; 124(2):138-48. PMID: 17560173.
      View in: PubMed
    22. Wagner DH. Re-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad. Clin Immunol. 2007 Apr; 123(1):1-6. PMID: 16990051.
      View in: PubMed
    23. Waid DM, Vaitaitis GM, Wagner DH. Peripheral CD4loCD40+ auto-aggressive T cell expansion during insulin-dependent diabetes mellitus. Eur J Immunol. 2004 May; 34(5):1488-97. PMID: 15114683.
      View in: PubMed
    24. Vaitaitis GM, Poulin M, Sanderson RJ, Haskins K, Wagner DH. Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery. J Immunol. 2003 Apr 01; 170(7):3455-9. PMID: 12646605.
      View in: PubMed
    25. Wagner DH, Vaitaitis G, Sanderson R, Poulin M, Dobbs C, Haskins K. Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3782-7. PMID: 11891296; PMCID: PMC122601.
      View in: PubMed, PubMed Central
    26. Wagner DH, Newell E, Sanderson RJ, Freed JH, Newell MK. Increased expression of CD40 on thymocytes and peripheral T cells in autoimmunity: a mechanism for acquiring changes in the peripheral T cell receptor repertoire. Int J Mol Med. 1999 Sep; 4(3):231-42. PMID: 10425271.
      View in: PubMed
    27. Huber SA, Stone JE, Wagner DH, Kupperman J, Pfeiffer L, David C, O'Brien RL, Davis GS, Newell MK. gamma delta+ T cells regulate major histocompatibility complex class II(IA and IE)-dependent susceptibility to coxsackievirus B3-induced autoimmune myocarditis. J Virol. 1999 Jul; 73(7):5630-6. PMID: 10364312; PMCID: PMC112621.
      View in: PubMed, PubMed Central
    28. Poe JC, Wagner DH, Miller RW, Stout RD, Suttles J. IL-4 and IL-10 modulation of CD40-mediated signaling of monocyte IL-1beta synthesis and rescue from apoptosis. J Immunol. 1997 Jul 15; 159(2):846-52. PMID: 9218603.
      View in: PubMed
    29. Wagner DH, Hagman J, Linsley PS, Hodsdon W, Freed JH, Newell MK. Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2. J Exp Med. 1996 Nov 01; 184(5):1631-8. PMID: 8920853; PMCID: PMC2192898.
      View in: PubMed, PubMed Central
    30. Wagner DH, Stout RD, Suttles J. Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis. Eur J Immunol. 1994 Dec; 24(12):3148-54. PMID: 7528671.
      View in: PubMed
    Wagner's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (169) concept(s)
    _
    Co-Authors Expand Description
    See all (1) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department
    Physical Neighbors Expand Description
    _