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Shiao-Chun Tu

TitleProfessor Emeritus
InstitutionUniversity of Houston
DepartmentBiology
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-8359
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    Collapse Research 
    Collapse research activities and funding
    R01GM025953     (TU, SHIAO-CHUN)Apr 1, 1979 - Jun 30, 2006
    NIH/NIGMS
    STRUCTURE AND MECHANISM OF FLAVOPROTEIN HYDROXYLASES
    Role: Principal Investigator

    K04ES000088     (TU, SHIAO-CHUN)Sep 15, 1981 - Aug 31, 1986
    NIH/NIEHS
    MECHANISMS AND INTERMEDIATES OF FLAVO-HYDROXYLASES
    Role: Principal Investigator

    S15DK044680     (TU, SHIAO-CHUN)Aug 1, 1991 - Jul 31, 1992
    NIH/NIDDK
    SMALL INSTRUMENTATION GRANT
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chung HW, Tu SC. Structure-function relationship of Vibrio harveyi NADPH-flavin oxidoreductase FRP: essential residues Lys167 and Arg15 for NADPH binding. Biochemistry. 2012 Jun 19; 51(24):4880-7. PMID: 22650604.
      View in: PubMed
    2. Ke D, Tu SC. Activities, kinetics and emission spectra of bacterial luciferase-fluorescent protein fusion enzymes. Photochem Photobiol. 2011 Nov-Dec; 87(6):1346-53. PMID: 21913926.
      View in: PubMed
    3. Jawanda N, Ebalunode J, Gribenko A, Briggs J, Lee JC, Tu SC. A single-residue mutation destabilizes Vibrio harveyi flavin reductase FRP dimer. Arch Biochem Biophys. 2008 Apr 01; 472(1):51-7. PMID: 18294448.
      View in: PubMed
    4. Tu SC. Activity coupling and complex formation between bacterial luciferase and flavin reductases. Photochem Photobiol Sci. 2008 Feb; 7(2):183-8. PMID: 18264585.
      View in: PubMed
    5. Jawanda N, Ahmed K, Tu SC. Vibrio harveyi flavin reductase--luciferase fusion protein mimics a single-component bifunctional monooxygenase. Biochemistry. 2008 Jan 08; 47(1):368-77. PMID: 18067321.
      View in: PubMed
    6. Ortego BC, Whittenton JJ, Li H, Tu SC, Willson RC. In vivo translational inaccuracy in Escherichia coli: missense reporting using extremely low activity mutants of Vibrio harveyi luciferase. Biochemistry. 2007 Dec 04; 46(48):13864-73. PMID: 17985929.
      View in: PubMed
    7. Li X, Chow DC, Tu SC. Thermodynamic analysis of the binding of oxidized and reduced FMN cofactor to Vibrio harveyi NADPH-FMN oxidoreductase FRP apoenzyme. Biochemistry. 2006 Dec 12; 45(49):14781-7. PMID: 17144671.
      View in: PubMed
    8. Li X, Tu SC. Activity coupling of Vibrio harveyi luciferase and flavin reductase (FRP): oxygen as a probe. Arch Biochem Biophys. 2006 Oct 01; 454(1):26-31. PMID: 16949542.
      View in: PubMed
    9. Li CH, Tu SC. Probing the functionalities of alphaGlu328 and alphaAla74 of Vibrio harveyi luciferase by site-directed mutagenesis and chemical rescue. Biochemistry. 2005 Oct 25; 44(42):13866-73. PMID: 16229475.
      View in: PubMed
    10. Li CH, Tu SC. Active site hydrophobicity is critical to the bioluminescence activity of Vibrio harveyi luciferase. Biochemistry. 2005 Oct 04; 44(39):12970-7. PMID: 16185065.
      View in: PubMed
    11. Huang S, Tu SC. Effects of iodide on the fluorescence and activity of the hydroperoxyflavin intermediate of Vibrio harveyi luciferase. Photochem Photobiol. 2005 Mar-Apr; 81(2):425-30. PMID: 15588123.
      View in: PubMed
    12. Lei B, Wang H, Yu Y, Tu SC. Redox potential and equilibria in the reductive half-reaction of Vibrio harveyi NADPH-FMN oxidoreductase. Biochemistry. 2005 Jan 11; 44(1):261-7. PMID: 15628867.
      View in: PubMed
    13. Lei B, Ding Q, Tu SC. Identity of the emitter in the bacterial luciferase luminescence reaction: binding and fluorescence quantum yield studies of 5-decyl-4a-hydroxy-4a,5-dihydroriboflavin-5'-phosphate as a model. Biochemistry. 2004 Dec 21; 43(50):15975-82. PMID: 15595854.
      View in: PubMed
    14. Russell TR, Tu SC. Aminobacter aminovorans NADH:flavin oxidoreductase His140: a highly conserved residue critical for NADH binding and utilization. Biochemistry. 2004 Oct 12; 43(40):12887-93. PMID: 15461461.
      View in: PubMed
    15. Russell TR, Demeler B, Tu SC. Kinetic mechanism and quaternary structure of Aminobacter aminovorans NADH:flavin oxidoreductase: an unusual flavin reductase with bound flavin. Biochemistry. 2004 Feb 17; 43(6):1580-90. PMID: 14769034.
      View in: PubMed
    16. Low JC, Tu SC. Energy transfer evidence for in vitro and in vivo complexes of Vibrio harveyi flavin reductase P and luciferase. Photochem Photobiol. 2003 Apr; 77(4):446-52. PMID: 12733657.
      View in: PubMed
    17. Kremer L, Dover LG, Morbidoni HR, Vilchèze C, Maughan WN, Baulard A, Tu SC, Honoré N, Deretic V, Sacchettini JC, Locht C, Jacobs WR, Besra GS. Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria. J Biol Chem. 2003 Jun 06; 278(23):20547-54. PMID: 12654922.
      View in: PubMed
    18. Wei CJ, Lei B, Musser JM, Tu SC. Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production. Antimicrob Agents Chemother. 2003 Feb; 47(2):670-5. PMID: 12543676; PMCID: PMC151726.
    19. Jeffers CE, Nichols JC, Tu SC. Complex formation between Vibrio harveyi luciferase and monomeric NADPH:FMN oxidoreductase. Biochemistry. 2003 Jan 21; 42(2):529-34. PMID: 12525181.
      View in: PubMed
    20. Low JC, Tu SC. Functional roles of conserved residues in the unstructured loop of Vibrio harveyi bacterial luciferase. Biochemistry. 2002 Feb 12; 41(6):1724-31. PMID: 11827516.
      View in: PubMed
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