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Gregory Cuny

TitleAssistant Professor
InstitutionUniversity of Houston
DepartmentPharmacological & Pharmaceutic
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-1274
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    Collapse Research 
    Collapse research activities and funding
    U24NS049339     (CUNY, GREGORY D)Jun 15, 2005 - May 31, 2011
    NIH/NINDS
    National Center for Drug Discovery in Neurodegeneration
    Role: Principal Investigator
    R21NS067497     (GLICKSMAN, MARCIE A)Sep 30, 2009 - Aug 31, 2012
    NIH/NINDS
    Small molecule probes for elucidating necrotic cell death mechanisms
    Role: Co-Principal Investigator
    U01NS074601     (GLICKSMAN, MARCIE A)Jul 1, 2011 - Jun 30, 2016
    NIH/NINDS
    Small Molecule Modulators of the Glutamate Transporter for Treatment of ALS
    Role: Co-Principal Investigator
    R41AG042205     (PERRELLA, YUKARI)Sep 1, 2012 - Aug 31, 2013
    NIH/NIA
    CSF Tau Biomarker-guided Development of Hsp90 Inhibitors for Alzheimer's Disease
    Role: Co-Principal Investigator
    R56AI106743     (CUNY, GREGORY D)Sep 1, 2014 - Aug 31, 2015
    NIH/NIAID
    Optimizing IMPDH inhibitors for the treatment of cryptosporidiosis
    Role: Principal Investigator
    R01AI125362     (CUNY, GREGORY D)Jul 1, 2016 - Jun 30, 2021
    NIH/NIAID
    IMPDH inhibitors for the treatment of Cryptosporidium infections
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gorla SK, Zhang Y, Rabideau MM, Qin A, Chacko S, House AL, Johnson CR, Mandapati K, Bernstein HM, McKenney ES, Boshoff H, Zhang M, Glomski IJ, Goldberg JB, Cuny GD, Mann BJ, Hedstrom L. Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis. Antimicrob Agents Chemother. 2017 Oct; 61(10). PMID: 28739786.
      View in: PubMed
    2. Rietz A, Li H, Quist KM, Cherry JJ, Lorson CL, Burnett BG, Kern NL, Calder AN, Fritsche M, Lusic H, Boaler PJ, Choi S, Xing X, Glicksman MA, Cuny GD, Androphy EJ, Hodgetts KJ. Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2017 Jun 08; 60(11):4594-4610. PMID: 28481536.
      View in: PubMed
    3. Cuny GD, Suebsuwong C, Ray SS. Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016). Expert Opin Ther Pat. 2017 Jun; 27(6):677-690. PMID: 28074661.
      View in: PubMed
    4. Ku AF, Cuny GD. Access to 6a-Alkyl Aporphines: Synthesis of (±)-N-Methylguattescidine. J Org Chem. 2016 Oct 21; 81(20):10062-10070. PMID: 27689544.
      View in: PubMed
    5. Vippila MR, Nikhar S, Gracia AP, Cuny GD. Divergent Approach for the Synthesis of Gombamide A and Derivatives. Org Lett. 2016 Sep 16; 18(18):4726-9. PMID: 27603447.
      View in: PubMed
    6. Vippila MR, Ly PK, Cuny GD. Synthesis and Antiproliferative Activity Evaluation of the Disulfide-Containing Cyclic Peptide Thiochondrilline C and Derivatives. J Nat Prod. 2015 Oct 23; 78(10):2398-404. PMID: 26444379.
      View in: PubMed
    7. Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. PLoS One. 2015; 10(10):e0138976. PMID: 26440283; PMCID: PMC4594927.
      View in: PubMed, PubMed Central
    8. Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chem Biol. 2015 Sep 17; 22(9):1174-84. PMID: 26320862; PMCID: PMC4579271.
      View in: PubMed, PubMed Central
    9. Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):531-8. PMID: 25945705; PMCID: PMC4427161.
      View in: PubMed, PubMed Central
    10. Lang CA, Ray SS, Liu M, Singh AK, Cuny GD. Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking. Bioorg Med Chem Lett. 2015 Jul 01; 25(13):2713-9. PMID: 25998502.
      View in: PubMed
    11. Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Rep. 2015 Mar 24; 10(11):1850-60. PMID: 25801024; PMCID: PMC4494889.
      View in: PubMed, PubMed Central
    12. Ku AF, Cuny GD. Synthetic studies of 7-oxygenated aporphine alkaloids: preparation of (-)-oliveroline, (-)-nornuciferidine, and derivatives. Org Lett. 2015 Mar 06; 17(5):1134-7. PMID: 25710592.
      View in: PubMed
    13. Takahashi K, Kong Q, Lin Y, Stouffer N, Schulte DA, Lai L, Liu Q, Chang LC, Dominguez S, Xing X, Cuny GD, Hodgetts KJ, Glicksman MA, Lin CL. Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease. J Exp Med. 2015 Mar 09; 212(3):319-32. PMID: 25711212; PMCID: PMC4354363.
      View in: PubMed, PubMed Central
    14. Sun Z, Khan J, Makowska-Grzyska M, Zhang M, Cho JH, Suebsuwong C, Vo P, Gollapalli DR, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. J Med Chem. 2014 Dec 26; 57(24):10544-50. PMID: 25474504; PMCID: PMC4281095.
      View in: PubMed, PubMed Central
    15. Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 09; 57(19):7900-15. PMID: 25101911; PMCID: PMC4191596.
      View in: PubMed, PubMed Central
    16. Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ. Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. PLoS Biol. 2014 Aug; 12(8):e1001923. PMID: 25093460; PMCID: PMC4122355.
      View in: PubMed, PubMed Central
    17. Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. ACS Med Chem Lett. 2014 Aug 14; 5(8):846-50. PMID: 25147601; PMCID: PMC4137380.
      View in: PubMed, PubMed Central
    18. Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. J Biomol Screen. 2014 Aug; 19(7):1024-34. PMID: 24598103; PMCID: PMC4570879.
      View in: PubMed, PubMed Central
    19. Kong Q, Chang LC, Takahashi K, Liu Q, Schulte DA, Lai L, Ibabao B, Lin Y, Stouffer N, Das Mukhopadhyay C, Xing X, Seyb KI, Cuny GD, Glicksman MA, Lin CL. Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J Clin Invest. 2014 Mar; 124(3):1255-67. PMID: 24569372; PMCID: PMC3938250.
      View in: PubMed, PubMed Central
    20. Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L. Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrob Agents Chemother. 2014; 58(3):1603-14. PMID: 24366728; PMCID: PMC3957894.
      View in: PubMed, PubMed Central
    21. Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD, Parmar K. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther. 2013 Dec; 12(12):2651-62. PMID: 24130053; PMCID: PMC4089878.
      View in: PubMed, PubMed Central
    22. Wang X, Cuny GD, Noël T. A mild, one-pot Stadler-Ziegler synthesis of arylsulfides facilitated by photoredox catalysis in batch and continuous-flow. Angew Chem Int Ed Engl. 2013 Jul 22; 52(30):7860-4. PMID: 23784666.
      View in: PubMed
    23. Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. EMBO Mol Med. 2013 Jul; 5(7):1103-18. PMID: 23740718; PMCID: PMC3721476.
      View in: PubMed, PubMed Central
    24. Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS. Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. J Biol Chem. 2013 Jul 26; 288(30):22042-56. PMID: 23737518; PMCID: PMC3724657.
      View in: PubMed, PubMed Central
    25. Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2013 May 23; 56(10):4028-43. PMID: 23668331; PMCID: PMC3756936.
      View in: PubMed, PubMed Central
    26. Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013; 8(4):e62721. PMID: 23646137; PMCID: PMC3639963.
      View in: PubMed, PubMed Central
    27. Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PB. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013; 8(6):1291-302. PMID: 23547776; PMCID: PMC3901569.
      View in: PubMed, PubMed Central
    28. Maki JL, Tres Brazell J, Teng X, Cuny GD, Degterev A. Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system. Protein Expr Purif. 2013 Jun; 89(2):156-61. PMID: 23523699; PMCID: PMC3653991.
      View in: PubMed, PubMed Central
    29. Liu M, Bender SA, Cuny GD, Sherman W, Glicksman M, Ray SS. Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S. Biochemistry. 2013 Mar 12; 52(10):1725-36. PMID: 23379419; PMCID: PMC3966205.
      View in: PubMed, PubMed Central
    30. McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis. PLoS One. 2013; 8(3):e56576. PMID: 23469174; PMCID: PMC3585731.
      View in: PubMed, PubMed Central
    31. Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L. Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett. 2013 Feb 15; 23(4):1004-7. PMID: 23324406; PMCID: PMC3557747.
      View in: PubMed, PubMed Central
    32. Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD. Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2012 Sep 13; 55(17):7759-71. PMID: 22950983; PMCID: PMC3635066.
      View in: PubMed, PubMed Central
    33. Cuny GD. Foreword: neurodegenerative diseases: challenges and opportunities. Future Med Chem. 2012 Sep; 4(13):1647-9. PMID: 22924500.
      View in: PubMed
    34. Lin CL, Kong Q, Cuny GD, Glicksman MA. Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem. 2012 Sep; 4(13):1689-700. PMID: 22924507; PMCID: PMC3580837.
      View in: PubMed, PubMed Central
    35. Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E. Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem. 2012 Sep; 4(13):1671-9. PMID: 22924505; PMCID: PMC3564652.
      View in: PubMed, PubMed Central
    36. Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD. Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorg Med Chem Lett. 2012 Sep 01; 22(17):5685-8. PMID: 22832318; PMCID: PMC3434878.
      View in: PubMed, PubMed Central
    37. Wright PD, Wightman N, Huang M, Weiss A, Sapp PC, Cuny GD, Ivinson AJ, Glicksman MA, Ferrante RJ, Matson W, Matson S, Brown RH. A high-throughput screen to identify inhibitors of SOD1 transcription. Front Biosci (Elite Ed). 2012 06 01; 4:2701-8. PMID: 22652679; PMCID: PMC4083181.
      View in: PubMed, PubMed Central
    38. Maki JL, Smith EE, Teng X, Ray SS, Cuny GD, Degterev A. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15; 427(2):164-74. PMID: 22658960; PMCID: PMC3398245.
      View in: PubMed, PubMed Central
    39. Hellal M, Singh S, Cuny GD. Synthesis of tetracyclic indoles via intramolecular a-arylation of ketones. J Org Chem. 2012 Apr 20; 77(8):4123-30. PMID: 22480284.
      View in: PubMed
    40. Ezgimen M, Lai H, Mueller NH, Lee K, Cuny G, Ostrov DA, Padmanabhan R. Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Res. 2012 Apr; 94(1):18-24. PMID: 22343093; PMCID: PMC3331929.
      View in: PubMed, PubMed Central
    41. Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):2015-9. PMID: 22335895; PMCID: PMC3288743.
      View in: PubMed, PubMed Central
    42. Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD. Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):1985-8. PMID: 22310229; PMCID: PMC3289519.
      View in: PubMed, PubMed Central
    43. Cherry JJ, Evans MC, Ni J, Cuny GD, Glicksman MA, Androphy EJ. Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay. J Biomol Screen. 2012 Apr; 17(4):481-95. PMID: 22233647; PMCID: PMC3870337.
      View in: PubMed, PubMed Central
    44. So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-ß precursor protein dimerization. Am J Neurodegener Dis. 2012; 1(1):75-87. PMID: 22822474; PMCID: PMC3560454.
      View in: PubMed, PubMed Central
    45. King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules that elevate Klotho expression. Biochem J. 2012 Jan 01; 441(1):453-61. PMID: 21939436; PMCID: PMC3677209.
      View in: PubMed, PubMed Central
    46. Hart MJ, Glicksman M, Liu M, Sharma MK, Cuny G, Galvan V. Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein. Anal Biochem. 2012 Feb 15; 421(2):467-76. PMID: 22178911.
      View in: PubMed
    47. Liu M, Kang S, Ray S, Jackson J, Zaitsev AD, Gerber SA, Cuny GD, Glicksman MA. Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant. Biochemistry. 2011 Nov 01; 50(43):9399-408. PMID: 21961647; PMCID: PMC3205922.
      View in: PubMed, PubMed Central
    48. Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE. In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesth Analg. 2012 Aug; 115(2):297-304. PMID: 21965364; PMCID: PMC3252484.
      View in: PubMed, PubMed Central
    49. Laha JK, Cuny GD. Synthesis of fused imidazoles, pyrroles, and indoles with a defined stereocenter a to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. J Org Chem. 2011 Oct 21; 76(20):8477-82. PMID: 21913645.
      View in: PubMed
    50. Xing X, Chang LC, Kong Q, Colton CK, Lai L, Glicksman MA, Lin CL, Cuny GD. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011 Oct 01; 21(19):5774-7. PMID: 21875806; PMCID: PMC3172717.
      View in: PubMed, PubMed Central
    51. Laha JK, Barolo SM, Rossi RA, Cuny GD. Synthesis of carbolines by photostimulated cyclization of anilinohalopyridines. J Org Chem. 2011 Aug 05; 76(15):6421-5. PMID: 21739958.
      View in: PubMed
    52. Shishova EY, Stoll JM, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman MA, Gutierrez-Juarez R, Cuny GD, Cohen DE. Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology. 2011 Aug; 54(2):664-74. PMID: 21538437; PMCID: PMC3144994.
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    53. Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011 May 05; 117(18):4915-23. PMID: 21393479; PMCID: PMC3100698.
      View in: PubMed, PubMed Central
    54. Laha JK, Zhang X, Qiao L, Liu M, Chatterjee S, Robinson S, Kosik KS, Cuny GD. Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors. Bioorg Med Chem Lett. 2011 Apr 01; 21(7):2098-101. PMID: 21353545; PMCID: PMC3062192.
      View in: PubMed, PubMed Central
    55. Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19; 18(4):382-95. PMID: 20951947; PMCID: PMC2957475.
      View in: PubMed, PubMed Central
    56. Hellal M, Cuny GD. Synthesis of the indolizino[7,6-c]quinoline alkaloid isaindigotidione. Org Lett. 2010 Oct 15; 12(20):4628-31. PMID: 20845915.
      View in: PubMed
    57. Cuny GD, Robin M, Ulyanova NP, Patnaik D, Pique V, Casano G, Liu JF, Lin X, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3491-4. PMID: 20836251; PMCID: PMC3118465.
      View in: PubMed, PubMed Central
    58. Liu M, Poulose S, Schuman E, Zaitsev AD, Dobson B, Auerbach K, Seyb K, Cuny GD, Glicksman MA, Stein RL, Yue Z. Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors. Anal Biochem. 2010 Sep 15; 404(2):186-92. PMID: 20566370; PMCID: PMC2921631.
      View in: PubMed, PubMed Central
    59. Colton CK, Kong Q, Lai L, Zhu MX, Seyb KI, Cuny GD, Xian J, Glicksman MA, Lin CL. Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. J Biomol Screen. 2010 Jul; 15(6):653-62. PMID: 20508255; PMCID: PMC3016154.
      View in: PubMed, PubMed Central
    60. Hellal M, Cuny GD. Intramolecular Aldol reaction of N-acylated (2-aminophenyl)-alpha-oxoacetic acids: rapid access to tri- and tetracyclic 1,2-dihydroquinolin-2(1H)-ones. J Org Chem. 2010 May 21; 75(10):3465-8. PMID: 20394404.
      View in: PubMed
    61. Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res. 2010 May 15; 88(7):1569-76. PMID: 20025059.
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    62. Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One. 2010 May 07; 5(5):e10504. PMID: 20498699; PMCID: PMC2866327.
      View in: PubMed, PubMed Central
    63. Nowak RJ, Cuny GD, Choi S, Lansbury PT, Ray SS. Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods. J Med Chem. 2010 Apr 08; 53(7):2709-18. PMID: 20232802; PMCID: PMC2881568.
      View in: PubMed, PubMed Central
    64. Ouertatani-Sakouhi H, Liu M, El-Turk F, Cuny GD, Glicksman MA, Lashuel HA. Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. J Biomol Screen. 2010 Apr; 15(4):347-58. PMID: 20231420.
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    65. Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE. Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44. PMID: 20179500; PMCID: PMC2830733.
      View in: PubMed, PubMed Central
    66. Macpherson IS, Kirubakaran S, Gorla SK, Riera TV, D'Aquino JA, Zhang M, Cuny GD, Hedstrom L. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. J Am Chem Soc. 2010 Feb 03; 132(4):1230-1. PMID: 20052976; PMCID: PMC2819028.
      View in: PubMed, PubMed Central
    67. Lee K, Campbell J, Swoboda JG, Cuny GD, Walker S. Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorg Med Chem Lett. 2010 Mar 01; 20(5):1767-70. PMID: 20138521; PMCID: PMC2844852.
      View in: PubMed, PubMed Central
    68. Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6122-6. PMID: 19783434; PMCID: PMC2785710.
      View in: PubMed, PubMed Central
    69. Maurya SK, Gollapalli DR, Kirubakaran S, Zhang M, Johnson CR, Benjamin NN, Hedstrom L, Cuny GD. Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2009 Aug 13; 52(15):4623-30. PMID: 19624136; PMCID: PMC2810100.
      View in: PubMed, PubMed Central
    70. Cuny GD. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466. Expert Opin Ther Pat. 2009 Jun; 19(6):893-9. PMID: 19473108.
      View in: PubMed
    71. Call MJ, Xing X, Cuny GD, Seth NP, Altmann DM, Fugger L, Krogsgaard M, Stein RL, Wucherpfennig KW. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol. 2009 May 15; 182(10):6342-52. PMID: 19414787; PMCID: PMC2695398.
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    72. Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. PLoS One. 2009; 4(4):e5274. PMID: 19384407; PMCID: PMC2668070.
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    73. Laha JK, Petrou P, Cuny GD. One-pot synthesis of alpha-carbolines via sequential palladium-catalyzed aryl amination and intramolecular arylation. J Org Chem. 2009 Apr 17; 74(8):3152-5. PMID: 19323545.
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    74. Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec; 14(12):1363-9. PMID: 19029982; PMCID: PMC2846458.
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    75. Patnaik D, Glicksman MA, Cuny GD, Stein RL, Higgins JM. Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay. J Biomol Screen. 2008 Dec; 13(10):1025-34. PMID: 18978305; PMCID: PMC2615828.
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    76. Wagle N, Xian J, Shishova EY, Wei J, Glicksman MA, Cuny GD, Stein RL, Cohen DE. Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal Biochem. 2008 Dec 01; 383(1):85-92. PMID: 18762160; PMCID: PMC2783649.
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    77. Liu M, Choi S, Cuny GD, Ding K, Dobson BC, Glicksman MA, Auerbach K, Stein RL. Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. Biochemistry. 2008 Aug 12; 47(32):8367-77. PMID: 18636751.
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    78. Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008 Aug 01; 18(15):4388-92. PMID: 18621530; PMCID: PMC2570262.
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    79. You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1564-73. PMID: 18493258; PMCID: PMC2831087.
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    80. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May; 4(5):313-21. PMID: 18408713.
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    81. Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorg Med Chem Lett. 2008 Jun 01; 18(11):3219-23. PMID: 18467094; PMCID: PMC2519155.
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    82. Glicksman MA, Cuny GD, Liu M, Dobson B, Auerbach K, Stein RL, Kosik KS. New approaches to the discovery of cdk5 inhibitors. Curr Alzheimer Res. 2007 Dec; 4(5):547-9. PMID: 18220519.
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    83. Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6836-40. PMID: 17964153; PMCID: PMC2169518.
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    84. Mermerian AH, Case A, Stein RL, Cuny GD. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 01; 17(13):3729-32. PMID: 17449248.
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    85. Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19; 50(8):1886-95. PMID: 17361994.
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    86. Barolo SM, Teng X, Cuny GD, Rossi RA. Syntheses of aporphine and homoaporphine alkaloids by intramolecular ortho-arylation of phenols with aryl halides via SRN1 reactions in liquid ammonia. J Org Chem. 2006 Oct 27; 71(22):8493-9. PMID: 17064025.
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    87. Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Curr Alzheimer Res. 2006 Jul; 3(3):221-7. PMID: 16842099.
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    88. Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW. Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol. 2006 Apr 01; 176(7):4208-20. PMID: 16547258; PMCID: PMC3412064.
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    89. Zhang D, Xing X, Cuny GD. Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization. J Org Chem. 2006 Feb 17; 71(4):1750-3. PMID: 16468841.
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    90. Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15; 15(22):5039-44. PMID: 16153840.
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    91. Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol. 2005 Jul; 12(7):811-23. PMID: 16039528.
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    92. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul; 1(2):112-9. PMID: 16408008.
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    93. Duval E, Case A, Stein RL, Cuny GD. Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg Med Chem Lett. 2005 Apr 01; 15(7):1885-9. PMID: 15780627.
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    94. Yeh LA, Padmanaban D, Ho P, Xing X, Rowley P, Morse LJ, Jensen RV, Cuny GD. Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression. Bioorg Med Chem Lett. 2005 Feb 15; 15(4):1193-6. PMID: 15686940.
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    95. Choi S, Haggart D, Toll L, Cuny GD. Synthesis, receptor binding and functional studies of mesoridazine stereoisomers. Bioorg Med Chem Lett. 2004 Sep 06; 14(17):4379-82. PMID: 15357957.
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    96. Morse LJ, Payton SM, Cuny GD, Rogers JT. FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein. J Mol Neurosci. 2004; 24(1):129-36. PMID: 15314261.
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    97. Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003 Sep; 10(9):837-46. PMID: 14522054.
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    98. Oliva B, Miller K, Caggiano N, O'Neill AJ, Cuny GD, Hoemann MZ, Hauske JR, Chopra I. Biological properties of novel antistaphylococcal quinoline-indole agents. Antimicrob Agents Chemother. 2003 Feb; 47(2):458-66. PMID: 12543644; PMCID: PMC151732.
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    99. Hoemann MZ, Xie RL, Rossi RF, Meyer S, Sidhu A, Cuny GD, Hauske JR. Potent in vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)tetrahydroquinoline derivatives. Bioorg Med Chem Lett. 2002 Jan 21; 12(2):129-32. PMID: 11755337.
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    100. Sereno D, Holzmuller P, Mangot I, Cuny G, Ouaissi A, Lemesre JL. Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes. Antimicrob Agents Chemother. 2001 Jul; 45(7):2064-9. PMID: 11408224; PMCID: PMC90601.
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    101. Hoemann MZ, Kumaravel G, Xie RL, Rossi RF, Meyer S, Sidhu A, Cuny GD, Hauske JR. Potent in vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)quinoline derivatives. Bioorg Med Chem Lett. 2000 Dec 04; 10(23):2675-8. PMID: 11128649.
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    102. Cuny GD, Landgrebe KD, Smith TP, Fehr MJ, Petrich JW, Carpenter S. Photoactivated virucidal properties of tridentate 2,2'-dihydroxyazobenzene and 2-salicylideneaminophenol platinum pyridine complexes. Bioorg Med Chem Lett. 1999 Jan 18; 9(2):237-40. PMID: 10021936.
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    103. Cao J, Cuny GD, Hauske JR. Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes. Mol Divers. 1997-1998; 3(3):173-9. PMID: 9680648.
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    104. Jubier-Maurin V, Cuny G, Laurent AM, Paquereau L, Roizes G. A new 5' sequence associated with mouse L1 elements is representative of a major class of L1 termini. Mol Biol Evol. 1992 Jan; 9(1):41-55. PMID: 1552840.
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    105. Cuny G, Veas F, Roizès G. "Pocket blotting": a method for transferring nucleic acids onto nylon membranes. Anal Biochem. 1991 Feb 15; 193(1):45-8. PMID: 2042741.
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