 Amiloride
"Amiloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
| Descriptor ID |
D000584
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| MeSH Number(s) |
D03.383.679.149
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| Concept/Terms |
Amiduret Trom- Amiduret Trom
- Trom, Amiduret
- Trommsdorff Brand of Amiloride Hydrochloride
Amiloberag- Amiloberag
- Berolina Brand of Amiloride Hydrochloride
Midoride- Midoride
- Amrad Brand of Amiloride Hydrochloride
Kaluril- Kaluril
- Alphapharm Brand of Amiloride Hydrochloride
Midamor- Midamor
- Modamide
- Merck Sharp & Dohme Brand of Amiloride Hydrochloride
- Cahill May Roberts Brand of Amiloride Hydrochloride
- Merck Brand of Amiloride Hydrochloride
Amidal- Amidal
- Douglas Brand of Amiloride Hydrochloride
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Below are MeSH descriptors whose meaning is more general than "Amiloride".
Below are MeSH descriptors whose meaning is more specific than "Amiloride".
This graph shows the total number of publications written about "Amiloride" by people in this website by year, and whether "Amiloride" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 0 | 1 | 1 | | 1987 | 0 | 1 | 1 | | 1988 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1991 | 0 | 2 | 2 | | 1992 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amiloride" by people in Profiles.
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Morris RG, Schafer JA. cAMP increases density of ENaC subunits in the apical membrane of MDCK cells in direct proportion to amiloride-sensitive Na(+) transport. J Gen Physiol. 2002 Jul; 120(1):71-85.
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Beheray SA, Hussain T, Lokhandwala MF. Dopamine inhibits na,h-exchanger via D1-like receptor-mediated stimulation of protein kinase a in renal proximal tubules. Clin Exp Hypertens. 2000 Aug; 22(6):635-44.
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Kudo LH, Hawk CT, Schafer JA. Sodium and water transport in cortical collecting duct of Dahl salt-resistant rat. Am J Physiol. 1994 Oct; 267(4 Pt 2):F583-91.
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Canessa CM, Schafer JA. AVP stimulates Na+ transport in primary cultures of rabbit cortical collecting duct cells. Am J Physiol. 1992 Mar; 262(3 Pt 2):F454-61.
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Hawk CT, Schafer JA. Effects of AVP and deoxycorticosterone on Na+ and water transport in the Dahl salt-sensitive rat CCD. Am J Physiol. 1991 Apr; 260(4 Pt 2):F471-8.
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Rouch AJ, Chen L, Troutman SL, Schafer JA. Na+ transport in isolated rat CCD: effects of bradykinin, ANP, clonidine, and hydrochlorothiazide. Am J Physiol. 1991 Jan; 260(1 Pt 2):F86-95.
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Schafer JA, Troutman SL, Schlatter E. Vasopressin and mineralocorticoid increase apical membrane driving force for K+ secretion in rat CCD. Am J Physiol. 1990 Jan; 258(1 Pt 2):F199-210.
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Bindels RJ, Schafer JA, Reif MC. Stimulation of sodium transport by aldosterone and arginine vasotocin in A6 cells. Biochim Biophys Acta. 1988 Dec 09; 972(3):320-30.
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Schlatter E, Schafer JA. Electrophysiological studies in principal cells of rat cortical collecting tubules. ADH increases the apical membrane Na+-conductance. Pflugers Arch. 1987 Jun; 409(1-2):81-92.
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Reif MC, Troutman SL, Schafer JA. Sodium transport by rat cortical collecting tubule. Effects of vasopressin and desoxycorticosterone. J Clin Invest. 1986 Apr; 77(4):1291-8.
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