 Cocaine
"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
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| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.869.388 D04.075.080.875.099.722.388
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 0 | 3 | 3 | | 1984 | 0 | 1 | 1 | | 1985 | 0 | 1 | 1 | | 1988 | 2 | 0 | 2 | | 1989 | 1 | 0 | 1 | | 1990 | 4 | 2 | 6 | | 1991 | 3 | 1 | 4 | | 1992 | 4 | 1 | 5 | | 1993 | 4 | 1 | 5 | | 1994 | 3 | 0 | 3 | | 1995 | 2 | 0 | 2 | | 1996 | 2 | 0 | 2 | | 1997 | 4 | 0 | 4 | | 1998 | 2 | 2 | 4 | | 1999 | 1 | 1 | 2 | | 2000 | 2 | 2 | 4 | | 2001 | 4 | 0 | 4 | | 2003 | 2 | 0 | 2 | | 2004 | 3 | 1 | 4 | | 2005 | 5 | 0 | 5 | | 2006 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2013 | 2 | 1 | 3 | | 2014 | 2 | 1 | 3 | | 2015 | 1 | 1 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Mahoney JJ, Haile CN, De La Garza R, Thakkar H, Newton TF. Electrocardiographic characteristics in individuals with cocaine use disorder. Am J Addict. 2017 Apr; 26(3):221-227.
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Koffarnus MN, Johnson MW, Thompson-Lake DG, Wesley MJ, Lohrenz T, Montague PR, Bickel WK. Cocaine-dependent adults and recreational cocaine users are more likely than controls to choose immediate unsafe sex over delayed safer sex. Exp Clin Psychopharmacol. 2016 Aug; 24(4):297-304.
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Newton TF, Haile CN, Mahoney JJ, Shah R, Verrico CD, De La Garza R, Kosten TR. Dopamine D3 receptor-preferring agonist enhances the subjective effects of cocaine in humans. Psychiatry Res. 2015 Nov 30; 230(1):44-9.
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Johnson MW, Johnson PS, Herrmann ES, Sweeney MM. Delay and probability discounting of sexual and monetary outcomes in individuals with cocaine use disorders and matched controls. PLoS One. 2015; 10(5):e0128641.
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Kosten TA, Shen XY, Kinsey BM, Kosten TR, Orson FM. Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization. Am J Addict. 2014 Nov-Dec; 23(6):604-7.
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Stotts AL, Vujanovic A, Heads A, Suchting R, Green CE, Schmitz JM. The role of avoidance and inflexibility in characterizing response to contingency management for cocaine use disorders: A secondary profile analysis. Psychol Addict Behav. 2015 Jun; 29(2):408-13.
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Verrico CD, Haile CN, Mahoney JJ, Thompson-Lake DG, Newton TF, De La Garza R. Treatment with modafinil and escitalopram, alone and in combination, on cocaine-induced effects: a randomized, double blind, placebo-controlled human laboratory study. Drug Alcohol Depend. 2014 Aug 01; 141:72-8.
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De La Garza R, Galloway GP, Newton TF, Mendelson J, Haile CN, Dib E, Hawkins RY, Chen CY, Mahoney JJ, Mojsiak J, Lao G, Anderson A, Kahn R. Assessment of safety, cardiovascular and subjective effects after intravenous cocaine and lofexidine. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 03; 50:44-52.
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Bruner NR, Johnson MW. Demand curves for hypothetical cocaine in cocaine-dependent individuals. Psychopharmacology (Berl). 2014 Mar; 231(5):889-97.
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Meisch RA, Gomez TH. Drug self-administration studies: a novel reinforcement schedule enhances choice. Behav Pharmacol. 2013 Jun; 24(3):155-63.
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