 Keratins
"Keratins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
| Descriptor ID |
D007633
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| MeSH Number(s) |
D05.750.078.593.450 D12.776.220.475.450 D12.776.860.607
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Keratins".
Below are MeSH descriptors whose meaning is more specific than "Keratins".
This graph shows the total number of publications written about "Keratins" by people in this website by year, and whether "Keratins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1997 | 0 | 3 | 3 | | 2000 | 0 | 2 | 2 | | 2001 | 1 | 4 | 5 | | 2003 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2011 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Keratins" by people in Profiles.
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Hampel U, Schröder A, Mitchell T, Brown S, Snikeris P, Garreis F, Kunnen C, Willcox M, Paulsen F. Serum-induced keratinization processes in an immortalized human meibomian gland epithelial cell line. PLoS One. 2015; 10(6):e0128096.
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Al-Kofahi Y, Lassoued W, Grama K, Nath SK, Zhu J, Oueslati R, Feldman M, Lee WM, Roysam B. Cell-based quantification of molecular biomarkers in histopathology specimens. Histopathology. 2011 Jul; 59(1):40-54.
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Rufini A, Weil M, McKeon F, Barlattani A, Melino G, Candi E. p63 protein is essential for the embryonic development of vibrissae and teeth. Biochem Biophys Res Commun. 2006 Feb 17; 340(3):737-41.
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Renshaw AA, Prey MU, Hodes L, Weisson M, Haja J, Moriarty AT. Cytologic features of high-grade squamous intraepithelial lesion in conventional slides: what is the difference between cases that perform well and those that perform poorly? Arch Pathol Lab Med. 2005 Jun; 129(6):733-5.
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Parwani AV, Taylor DC, Burger PC, Erozan YS, Olivi A, Ali SZ. Keratinized squamous cells in fine needle aspiration of the brain. Cytopathologic correlates and differential diagnosis. Acta Cytol. 2003 May-Jun; 47(3):325-31.
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Glickman JN, Yang A, Shahsafaei A, McKeon F, Odze RD. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol. 2001 Nov; 32(11):1157-65.
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McGrath JA, Duijf PH, Doetsch V, Irvine AD, de Waal R, Vanmolkot KR, Wessagowit V, Kelly A, Atherton DJ, Griffiths WA, Orlow SJ, van Haeringen A, Ausems MG, Yang A, McKeon F, Bamshad MA, Brunner HG, Hamel BC, van Bokhoven H. Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Hum Mol Genet. 2001 Feb 01; 10(3):221-9.
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Faquin WC, Brown FM, Krane JF, Renshaw AA, Cibas ES. Extensively keratinized squamous intraepithelial lesions of the cervix are difficult to grade. Am J Clin Pathol. 2001 Jan; 115(1):80-4.
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O'Connell JT, Mutter GL, Cviko A, Nucci M, Quade BJ, Kozakewich HP, Neffen E, Sun D, Yang A, McKeon FD, Crum CP. Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63. Gynecol Oncol. 2001 Jan; 80(1):30-6.
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Quade BJ, Yang A, Wang Y, Sun D, Park J, Sheets EE, Cviko A, Federschneider JM, Peters R, McKeon FD, Crum CP. Expression of the p53 homologue p63 in early cervical neoplasia. Gynecol Oncol. 2001 Jan; 80(1):24-9.
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