 Rats, Zucker
"Rats, Zucker" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.
| Descriptor ID |
D011924
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| MeSH Number(s) |
B01.050.150.900.649.865.635.505.700.550.700
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Rats, Zucker".
Below are MeSH descriptors whose meaning is more specific than "Rats, Zucker".
This graph shows the total number of publications written about "Rats, Zucker" by people in this website by year, and whether "Rats, Zucker" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1993 | 0 | 3 | 3 | | 1994 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1996 | 1 | 1 | 2 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 5 | 5 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 4 | 4 | | 2005 | 0 | 3 | 3 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 3 | 3 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Rats, Zucker" by people in Profiles.
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Tomassoni D, Nwankwo IE, Gabrielli MG, Bhatt S, Muhammad AB, Lokhandwala MF, Tayebati SK, Amenta F. Astrogliosis in the brain of obese Zucker rat: a model of metabolic syndrome. Neurosci Lett. 2013 May 24; 543:136-41.
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Muhammad AB, Lokhandwala MF, Banday AA. Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1 receptor dysfunction in obese rats. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F98-104.
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Alzoubi KH, Aleisa AM, Alkadhi KA. Expression of gLTP in sympathetic ganglia of obese Zucker rats in vivo: molecular evidence. J Mol Neurosci. 2008 Jul; 35(3):297-306.
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Alkadhi K, Alzoubi K. Role of long-term potentiation of sympathetic ganglia (gLTP) in hypertension. Clin Exp Hypertens. 2007 Jul; 29(5):267-86.
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Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem. 2007 Oct; 304(1-2):93-9.
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Banday AA, Lokhandwala MF. Oxidative stress reduces renal dopamine D1 receptor-Gq/11alpha G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2. Am J Physiol Renal Physiol. 2007 Jul; 293(1):F306-15.
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Banday AA, Fazili FR, Marwaha A, Lokhandwala MF. Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats. Kidney Int. 2007 Mar; 71(5):397-406.
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Banday AA, Marwaha A, Tallam LS, Lokhandwala MF. Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes. 2005 Jul; 54(7):2219-26.
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Trivedi M, Lokhandwala MF. Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats. Am J Physiol Renal Physiol. 2005 Aug; 289(2):F298-304.
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Alzoubi KH, Aleisa AM, Alkadhi KA. Impairment of long-term potentiation in the CA1, but not dentate gyrus, of the hippocampus in Obese Zucker rats: role of calcineurin and phosphorylated CaMKII. J Mol Neurosci. 2005; 27(3):337-46.
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