 Receptor, Epidermal Growth Factor
"Receptor, Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
| Descriptor ID |
D011958
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.009.300 D12.776.543.750.060.009.300 D12.776.543.750.750.360.300 D12.776.543.750.750.400.074.300
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| Concept/Terms |
Receptor, Epidermal Growth Factor- Receptor, Epidermal Growth Factor
- EGF Receptor
- Epidermal Growth Factor Receptor
- Epidermal Growth Factor Receptor Kinase
- Epidermal Growth Factor Receptor Protein-Tyrosine Kinase
- Epidermal Growth Factor Receptor Protein Tyrosine Kinase
- erbB-1 Proto-Oncogene Protein
- Proto-Oncogene Protein, erbB-1
- erbB 1 Proto Oncogene Protein
- Proto-oncogene c-ErbB-1 Protein
- Protein, Proto-oncogene c-ErbB-1
- Proto oncogene c ErbB 1 Protein
- c-ErbB-1 Protein, Proto-oncogene
- Receptor, EGF
- Receptor, ErbB-1
- ErbB-1 Receptor
- Receptor, ErbB 1
- Receptor, TGF-alpha
- Receptor, TGF alpha
- Receptor, Transforming-Growth Factor alpha
- Receptor, Transforming Growth Factor alpha
- Receptor, Urogastrone
- Resceptor Tyrosine-protein Kinase erbB-1
- Resceptor Tyrosine protein Kinase erbB 1
- TGF-alpha Receptor
- Transforming Growth Factor alpha Receptor
- Urogastrone Receptor
- c-erbB-1 Protein
- c erbB 1 Protein
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Below are MeSH descriptors whose meaning is more general than "Receptor, Epidermal Growth Factor".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Transferases [D08.811.913]
- Phosphotransferases [D08.811.913.696]
- Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
- Protein Kinases [D08.811.913.696.620.682]
- Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
- Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
- ErbB Receptors [D08.811.913.696.620.682.725.400.009]
- Receptor, Epidermal Growth Factor [D08.811.913.696.620.682.725.400.009.300]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptor Protein-Tyrosine Kinases [D12.776.543.750.060]
- ErbB Receptors [D12.776.543.750.060.009]
- Receptor, Epidermal Growth Factor [D12.776.543.750.060.009.300]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Gastrointestinal Hormone [D12.776.543.750.750.360]
- Receptor, Epidermal Growth Factor [D12.776.543.750.750.360.300]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- ErbB Receptors [D12.776.543.750.750.400.074]
- Receptor, Epidermal Growth Factor [D12.776.543.750.750.400.074.300]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Epidermal Growth Factor".
This graph shows the total number of publications written about "Receptor, Epidermal Growth Factor" by people in this website by year, and whether "Receptor, Epidermal Growth Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 1997 | 0 | 2 | 2 | | 2001 | 1 | 0 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 2 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2013 | 2 | 2 | 4 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptor, Epidermal Growth Factor" by people in Profiles.
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Yin M, Li X, Tan S, Zhou HJ, Ji W, Bellone S, Xu X, Zhang H, Santin AD, Lou G, Min W. Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. J Clin Invest. 2016 Nov 01; 126(11):4157-4173.
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Bollu LR, Katreddy RR, Blessing AM, Pham N, Zheng B, Wu X, Weihua Z. Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation. Oncotarget. 2015 Oct 27; 6(33):34992-5003.
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Tal TL, McCollum CW, Harris PS, Olin J, Kleinstreuer N, Wood CE, Hans C, Shah S, Merchant FA, Bondesson M, Knudsen TB, Padilla S, Hemmer MJ. Immediate and long-term consequences of vascular toxicity during zebrafish development. Reprod Toxicol. 2014 Sep; 48:51-61.
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Bollu LR, Ren J, Blessing AM, Katreddy RR, Gao G, Xu L, Wang J, Su F, Weihua Z. Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells. Cell Cycle. 2014; 13(15):2415-30.
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Lee ST, Ji H, Greening DW, Speirs RW, Rigopoulos A, Pillay V, Murone C, Vitali A, Stühler K, Johns TG, Corner GA, Mariadason JM, Simpson RJ, Scott AM. Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts. Growth Factors. 2013 Oct; 31(5):154-64.
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Tang L, Wang Y, Strom A, Gustafsson JÅ, Guan X. Lapatinib induces p27(Kip1)-dependent G1 arrest through both transcriptional and post-translational mechanisms. Cell Cycle. 2013 Aug 15; 12(16):2665-74.
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Ren J, Bollu LR, Su F, Gao G, Xu L, Huang WC, Hung MC, Weihua Z. EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors. Prostate. 2013 Sep; 73(13):1453-61.
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Ji H, Greening DW, Barnes TW, Lim JW, Tauro BJ, Rai A, Xu R, Adda C, Mathivanan S, Zhao W, Xue Y, Xu T, Zhu HJ, Simpson RJ. Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. Proteomics. 2013 May; 13(10-11):1672-86.
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Xu S, Weihua Z. Loss of EGFR induced autophagy sensitizes hormone refractory prostate cancer cells to adriamycin. Prostate. 2011 Aug 01; 71(11):1216-24.
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Kokovay E, Goderie S, Wang Y, Lotz S, Lin G, Sun Y, Roysam B, Shen Q, Temple S. Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling. Cell Stem Cell. 2010 Aug 06; 7(2):163-73.
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