 Thienamycins
"Thienamycins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
| Descriptor ID |
D013845
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| MeSH Number(s) |
D02.065.589.099.124.300 D04.075.080.875.099.221.124.300
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| Concept/Terms |
Thienamycins- Thienamycins
- Antibiotics, Thienamycin
- Thienamycin Antibiotics
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Below are MeSH descriptors whose meaning is more general than "Thienamycins".
Below are MeSH descriptors whose meaning is more specific than "Thienamycins".
This graph shows the total number of publications written about "Thienamycins" by people in this website by year, and whether "Thienamycins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 | | 2005 | 2 | 1 | 3 | | 2007 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thienamycins" by people in Profiles.
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Singh V, Arora V, Alam MJ, Garey KW. Inhibition of biofilm formation by esomeprazole in Pseudomonas aeruginosa and Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug; 56(8):4360-4.
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Tam VH, Ledesma KR, Schilling AN, Lim TP, Yuan Z, Ghose R, Lewis RE. In vivo dynamics of carbapenem-resistant Pseudomonas aeruginosa selection after suboptimal dosing. Diagn Microbiol Infect Dis. 2009 Aug; 64(4):427-33.
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Tam VH, Schilling AN, Poole K, Nikolaou M. Mathematical modelling response of Pseudomonas aeruginosa to meropenem. J Antimicrob Chemother. 2007 Dec; 60(6):1302-9.
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Tam VH, Schilling AN, Neshat S, Poole K, Melnick DA, Coyle EA. Optimization of meropenem minimum concentration/MIC ratio to suppress in vitro resistance of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2005 Dec; 49(12):4920-7.
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Nikolaou M, Tam VH. A new modeling approach to the effect of antimicrobial agents on heterogeneous microbial populations. J Math Biol. 2006 Feb; 52(2):154-82.
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Tam VH, Schilling AN, Nikolaou M. Modelling time-kill studies to discern the pharmacodynamics of meropenem. J Antimicrob Chemother. 2005 May; 55(5):699-706.
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Tam VH, Schilling AN, Lewis RE, Melnick DA, Boucher AN. Novel approach to characterization of combined pharmacodynamic effects of antimicrobial agents. Antimicrob Agents Chemother. 2004 Nov; 48(11):4315-21.
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