 Chloramphenicol O-Acetyltransferase
"Chloramphenicol O-Acetyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
| Descriptor ID |
D015500
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| MeSH Number(s) |
D08.811.913.050.134.170
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| Concept/Terms |
Chloramphenicol O-Acetyltransferase- Chloramphenicol O-Acetyltransferase
- Chloramphenicol O Acetyltransferase
- O-Acetyltransferase, Chloramphenicol
- Chloramphenicol Transacetylase
- Transacetylase, Chloramphenicol
- CAT Enzyme
- Enzyme, CAT
- Chloramphenicol Acetyltransferase
- Acetyltransferase, Chloramphenicol
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Below are MeSH descriptors whose meaning is more general than "Chloramphenicol O-Acetyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Chloramphenicol O-Acetyltransferase".
This graph shows the total number of publications written about "Chloramphenicol O-Acetyltransferase" by people in this website by year, and whether "Chloramphenicol O-Acetyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1986 | 0 | 2 | 2 | | 1990 | 0 | 3 | 3 | | 1991 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 1996 | 0 | 3 | 3 |
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Below are the most recent publications written about "Chloramphenicol O-Acetyltransferase" by people in Profiles.
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Seid CA, George JM, Sater AK, Kozlowski MT, Lee H, Govindarajan V, Ramachandran RK, Tomlinson CR. USF in the Lytechinus sea urchin embryo may act as a transcriptional repressor in non-aboral ectoderm cells for the cell lineage-specific expression of the LpS1 genes. J Mol Biol. 1996 Nov 22; 264(1):7-19.
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Seid CA, Sater AK, Falzone RL, Tomlinson CR. A tissue-specific repressor in the sea urchin embryo of Lytechinus pictus binds the distal G-string element in the LpS1-beta promoter. DNA Cell Biol. 1996 Jun; 15(6):511-7.
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Ray MK, Chen CY, Schwartz RJ, DeMayo FJ. Transcriptional regulation of a mouse Clara cell-specific protein (mCC10) gene by the NKx transcription factor family members thyroid transciption factor 1 and cardiac muscle-specific homeobox protein (CSX). Mol Cell Biol. 1996 May; 16(5):2056-64.
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Ghebranious N, Knoll BJ, Yavorkovsky L, Ilic Z, Papaconstantinou J, Lozano G, Sell S. Developmental control of transcription of the CAT reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice. Mol Reprod Dev. 1995 Sep; 42(1):1-6.
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Blank RS, McQuinn TC, Yin KC, Thompson MM, Takeyasu K, Schwartz RJ, Owens GK. Elements of the smooth muscle alpha-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation. J Biol Chem. 1992 Jan 15; 267(2):984-9.
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Sands AT, DeMayo F, Lei X, Schwartz RJ. Targeting of gene expression to skeletal and cardiac muscle of trangenic animals. SAAS Bull Biochem Biotechnol. 1991 Jan; 4:27-33.
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Parker TG, Chow KL, Schwartz RJ, Schneider MD. Differential regulation of skeletal alpha-actin transcription in cardiac muscle by two fibroblast growth factors. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7066-70.
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Liou GI, Geng L, al-Ubaidi MR, Matragoon S, Hanten G, Baehr W, Overbeek PA. Tissue-specific expression in transgenic mice directed by the 5'-flanking sequences of the human gene encoding interphotoreceptor retinoid-binding protein. J Biol Chem. 1990 May 25; 265(15):8373-6.
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French BA, Bergsma DJ, Schwartz RJ. Analysis of a CR1 (chicken repeat) sequence flanking the 5' end of the gene encoding alpha-skeletal actin. Gene. 1990 Apr 16; 88(2):173-80.
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Ingolia DE, Al-Ubaidi MR, Yeung CY, Bigo HA, Wright D, Kellems RE. Molecular cloning of the murine adenosine deaminase gene from a genetically enriched source: identification and characterization of the promoter region. Mol Cell Biol. 1986 Dec; 6(12):4458-66.
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