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Brian Knoll

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentPharmacological & Pharmaceutic
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-1299
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    Collapse Research 
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    R01CA039792     (KNOLL, BRIAN J)Apr 1, 1985 - Mar 31, 1988
    NIH/NCI
    GENE EXPRESSION IN LIVER CARCINOGENESIS
    Role: Principal Investigator
    R01CA046763     (KNOLL, BRIAN J)Feb 1, 1988 - Aug 31, 1991
    NIH/NCI
    TISSUE SPECIFIC AND NEOPLASTIC GENE EXPRESSION
    Role: Principal Investigator
    R01HL050047     (KNOLL, BRIAN J)Jul 10, 1994 - May 31, 2004
    NIH/NHLBI
    SMALL GTPASES AND LUNG BETA RECEPTOR REGULATION
    Role: Principal Investigator
    R01HL057445     (KNOLL, BRIAN J)Dec 7, 1998 - Nov 30, 2001
    NIH/NHLBI
    ENDOCYTOSIS AND REGULATION OF BETA-ADRENERGIC RECEPTORS
    Role: Principal Investigator
    R56AI079236     (BOND, RICHARD AGUSTIN)Apr 15, 2012 - Sep 30, 2014
    NIH/NIAID
    Mechanisms of Beta-blocker Induced Improvements in Asthma
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Joshi R, Valdez D, Kim H, Eikenburg DC, Knoll BJ, Bond RA. Effects of ß-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype. Pulm Pharmacol Ther. 2017 Oct; 46:30-40. PMID: 28729042.
      View in: PubMed
    2. Al-Sawalha NA, Knoll BJ. Statins in Asthma: A Closer Look into the Pharmacological Mechanism of Action. Pharmacology. 2016; 98(5-6):279-283. PMID: 27603525.
      View in: PubMed
    3. Forkuo GS, Kim H, Thanawala VJ, Al-Sawalha N, Valdez D, Joshi R, Parra S, Pera T, Gonnella PA, Knoll BJ, Walker JK, Penn RB, Bond RA. Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by ß2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice. Am J Respir Cell Mol Biol. 2016 Aug; 55(2):234-42. PMID: 26909542; PMCID: PMC4979368 [Available on 08/01/17].
      View in: PubMed, PubMed Central
    4. Thanawala VJ, Valdez DJ, Joshi R, Forkuo GS, Parra S, Knoll BJ, Bouvier M, Leff P, Bond RA. ß-Blockers have differential effects on the murine asthma phenotype. Br J Pharmacol. 2015 Oct; 172(20):4833-46. PMID: 26211486; PMCID: PMC4621987 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    5. Al-Sawalha N, Pokkunuri I, Omoluabi O, Kim H, Thanawala VJ, Hernandez A, Bond RA, Knoll BJ. Epinephrine Activation of the ß2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells. PLoS One. 2015; 10(7):e0132559. PMID: 26161982; PMCID: PMC4498766.
      View in: PubMed, PubMed Central
    6. Thanawala VJ, Forkuo GS, Al-Sawalha N, Azzegagh Z, Nguyen LP, Eriksen JL, Tuvim MJ, Lowder TW, Dickey BF, Knoll BJ, Walker JK, Bond RA. ß2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):220-9. PMID: 23204390; PMCID: PMC3604060.
      View in: PubMed, PubMed Central
    7. Peng H, Bond RA, Knoll BJ. The effects of acute and chronic nadolol treatment on ß2AR signaling in HEK293 cells. Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb; 383(2):209-16. PMID: 21225244.
      View in: PubMed
    8. Awwad HO, Millman EE, Alpizar-Foster E, Moore RH, Knoll BJ. Mutating the dileucine motif of the human beta(2)-adrenoceptor reduces the high initial rate of receptor phosphorylation by GRK without affecting postendocytic sorting. Eur J Pharmacol. 2010 Jun 10; 635(1-3):9-15. PMID: 20193676; PMCID: PMC3132186.
      View in: PubMed, PubMed Central
    9. Nguyen LP, Lin R, Parra S, Omoluabi O, Hanania NA, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2435-40. PMID: 19171883; PMCID: PMC2650174.
      View in: PubMed, PubMed Central
    10. Millman EE, Zhang H, Zhang H, Godines V, Bean AJ, Knoll BJ, Moore RH. Rapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb. Traffic. 2008 Nov; 9(11):1958-71. PMID: 18785920; PMCID: PMC2684784.
      View in: PubMed, PubMed Central
    11. Nguyen LP, Omoluabi O, Parra S, Frieske JM, Clement C, Ammar-Aouchiche Z, Ho SB, Ehre C, Kesimer M, Knoll BJ, Tuvim MJ, Dickey BF, Bond RA. Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):256-62. PMID: 18096872; PMCID: PMC2258446.
      View in: PubMed, PubMed Central
    12. Lin R, Peng H, Nguyen LP, Dudekula NB, Shardonofsky F, Knoll BJ, Parra S, Bond RA. Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulm Pharmacol Ther. 2008; 21(1):115-24. PMID: 17689122; PMCID: PMC2775056.
      View in: PubMed, PubMed Central
    13. Awwad HO, Iyer V, Rosenfeld JL, Millman EE, Foster E, Moore RH, Knoll BJ. Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of beta2-adrenergic receptors. Exp Cell Res. 2007 Jul 15; 313(12):2586-96. PMID: 17553490; PMCID: PMC2034330.
      View in: PubMed, PubMed Central
    14. Tran TM, Friedman J, Baameur F, Knoll BJ, Moore RH, Clark RB. Characterization of beta2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization. Mol Pharmacol. 2007 Jan; 71(1):47-60. PMID: 17012621.
      View in: PubMed
    15. Moore RH, Millman EE, Godines V, Hanania NA, Tran TM, Peng H, Dickey BF, Knoll BJ, Clark RB. Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):254-61. PMID: 16980556; PMCID: PMC1899312.
      View in: PubMed, PubMed Central
    16. Iyer V, Tran TM, Foster E, Dai W, Clark RB, Knoll BJ. Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol. 2006 Feb; 147(3):249-59. PMID: 16331289; PMCID: PMC1751300.
      View in: PubMed, PubMed Central
    17. Vaughan DJ, Millman EE, Godines V, Friedman J, Tran TM, Dai W, Knoll BJ, Clark RB, Moore RH. Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. J Biol Chem. 2006 Mar 17; 281(11):7684-92. PMID: 16407241.
      View in: PubMed
    18. Moore RH, Millman EE, Alpizar-Foster E, Dai W, Knoll BJ. Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. J Cell Sci. 2004 Jul 01; 117(Pt 15):3107-17. PMID: 15190120.
      View in: PubMed
    19. Callaerts-Vegh Z, Evans KL, Dudekula N, Cuba D, Knoll BJ, Callaerts PF, Giles H, Shardonofsky FR, Bond RA. Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4948-53. PMID: 15069206; PMCID: PMC387354.
      View in: PubMed, PubMed Central
    20. Millman EE, Rosenfeld JL, Vaughan DJ, Nguyen J, Dai W, Alpizar-Foster E, Clark RB, Knoll BJ, Moore RH. Endosome sorting of beta 2-adrenoceptors is GRK5 independent. Br J Pharmacol. 2004 Jan; 141(2):277-84. PMID: 14691047; PMCID: PMC1574185.
      View in: PubMed, PubMed Central
    21. Liu Q, Reubi JC, Wang Y, Knoll BJ, Schonbrunn A. In vivo phosphorylation of the somatostatin 2A receptor in human tumors. J Clin Endocrinol Metab. 2003 Dec; 88(12):6073-9. PMID: 14671213.
      View in: PubMed
    22. Rosenfeld JL, Knoll BJ, Moore RH. Regulation of G-protein-coupled receptor activity by rab GTPases. Receptors Channels. 2002; 8(2):87-97. PMID: 12448790.
      View in: PubMed
    23. Clark RB, Knoll BJ. Measurement of receptor desensitization and internalization in intact cells. Methods Enzymol. 2002; 343:506-29. PMID: 11665589.
      View in: PubMed
    24. Rosenfeld JL, Moore RH, Zimmer KP, Alpizar-Foster E, Dai W, Zarka MN, Knoll BJ. Lysosome proteins are redistributed during expression of a GTP-hydrolysis-defective rab5a. J Cell Sci. 2001 Dec; 114(Pt 24):4499-508. PMID: 11792815.
      View in: PubMed
    25. Seibold A, Williams B, Huang ZF, Friedman J, Moore RH, Knoll BJ, Clark RB. Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway. Mol Pharmacol. 2000 Nov; 58(5):1162-73. PMID: 11040066.
      View in: PubMed
    26. Hoffenberg S, Liu X, Nikolova L, Hall HS, Dai W, Baughn RE, Dickey BF, Barbieri MA, Aballay A, Stahl PD, Knoll BJ. A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. J Biol Chem. 2000 Aug 11; 275(32):24661-9. PMID: 10818110.
      View in: PubMed
    27. Clark RB, Knoll BJ, Barber R. Partial agonists and G protein-coupled receptor desensitization. Trends Pharmacol Sci. 1999 Jul; 20(7):279-86. PMID: 10390646.
      View in: PubMed
    28. Moore RH, Hall HS, Rosenfeld JL, Dai W, Knoll BJ. Specific changes in beta2-adrenoceptor trafficking kinetics and intracellular sorting during downregulation. Eur J Pharmacol. 1999 Mar 12; 369(1):113-23. PMID: 10204689.
      View in: PubMed
    29. Moore RH, Tuffaha A, Millman EE, Dai W, Hall HS, Dickey BF, Knoll BJ. Agonist-induced sorting of human beta2-adrenergic receptors to lysosomes during downregulation. J Cell Sci. 1999 Feb; 112 ( Pt 3):329-38. PMID: 9885286.
      View in: PubMed
    30. Tuvim MJ, Adachi R, Chocano JF, Moore RH, Lampert RM, Zera E, Romero E, Knoll BJ, Dickey BF. Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis. Am J Respir Cell Mol Biol. 1999 Jan; 20(1):79-89. PMID: 9870920.
      View in: PubMed
    31. January B, Seibold A, Allal C, Whaley BS, Knoll BJ, Moore RH, Dickey BF, Barber R, Clark RB. Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor. Br J Pharmacol. 1998 Feb; 123(4):701-11. PMID: 9517390; PMCID: PMC1565216.
      View in: PubMed, PubMed Central
    32. Morrison KJ, Moore RH, Carsrud ND, Trial J, Millman EE, Tuvim M, Clark RB, Barber R, Dickey BF, Knoll BJ. Repetitive endocytosis and recycling of the beta 2-adrenergic receptor during agonist-induced steady state redistribution. Mol Pharmacol. 1996 Sep; 50(3):692-9. PMID: 8794912.
      View in: PubMed
    33. Hoffenberg S, Nikolova L, Pan JY, Daniel DS, Wessling-Resnick M, Knoll BJ, Dickey BF. Functional and structural interactions of the Rab5 D136N mutant with xanthine nucleotides. Biochem Biophys Res Commun. 1995 Oct 04; 215(1):241-9. PMID: 7575598.
      View in: PubMed
    34. Moore RH, Sadovnikoff N, Hoffenberg S, Liu S, Woodford P, Angelides K, Trial JA, Carsrud ND, Dickey BF, Knoll BJ. Ligand-stimulated beta 2-adrenergic receptor internalization via the constitutive endocytic pathway into rab5-containing endosomes. J Cell Sci. 1995 Sep; 108 ( Pt 9):2983-91. PMID: 8537438.
      View in: PubMed
    35. Ghebranious N, Knoll BJ, Yavorkovsky L, Ilic Z, Papaconstantinou J, Lozano G, Sell S. Developmental control of transcription of the CAT reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice. Mol Reprod Dev. 1995 Sep; 42(1):1-6. PMID: 8562043.
      View in: PubMed
    36. Ghebranious N, Knoll BJ, Wu H, Lozano G, Sell S. Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Mol Carcinog. 1995 Jun; 13(2):104-11. PMID: 7605578.
      View in: PubMed
    37. Hoffenberg S, Sanford JC, Liu S, Daniel DS, Tuvin M, Knoll BJ, Wessling-Resnick M, Dickey BF. Biochemical and functional characterization of a recombinant GTPase, Rab5, and two of its mutants. J Biol Chem. 1995 Mar 10; 270(10):5048-56. PMID: 7890612.
      View in: PubMed
    38. Knoll BJ. Gene expression in the human placental trophoblast: a model for developmental gene regulation. Placenta. 1992 Jul-Aug; 13(4):311-27. PMID: 1332019.
      View in: PubMed
    39. Povinelli CM, Stewart JM, Knoll BJ. Differential and coordinate responses of the human genes encoding the heat stable alkaline phosphatases to cAMP and sodium butyrate in the choriocarcinoma line JEG-3. Biochim Biophys Acta. 1992 Jan 23; 1115(3):243-51. PMID: 1739739.
      View in: PubMed
    40. Povinelli CM, Knoll BJ. Trace expression of the germ-cell alkaline phosphatase gene in human placenta. Placenta. 1991 Nov-Dec; 12(6):663-8. PMID: 1725215.
      View in: PubMed
    41. Knoll BJ, Rothblum KN, Longley M. Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution. J Biol Chem. 1988 Aug 25; 263(24):12020-7. PMID: 3042787.
      View in: PubMed
    42. Knoll BJ, Rothblum KN, Longley M. Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. Gene. 1987; 60(2-3):267-76. PMID: 3443302.
      View in: PubMed
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