 Endothelins
"Endothelins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
| Descriptor ID |
D016232
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| MeSH Number(s) |
D12.644.276.400 D12.776.467.400 D23.529.400
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| Concept/Terms |
Endothelins- Endothelins
- Endothelium-Derived Vasoconstrictor Factors
- Vasoconstrictor Factors, Endothelium-Derived
- Endothelin
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Below are MeSH descriptors whose meaning is more general than "Endothelins".
Below are MeSH descriptors whose meaning is more specific than "Endothelins".
This graph shows the total number of publications written about "Endothelins" by people in this website by year, and whether "Endothelins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 2 | 0 | 2 | | 1992 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 |
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Below are the most recent publications written about "Endothelins" by people in Profiles.
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Hamilton BD, Chow GK, Inman SR, Stowe NT, Winfield HN. Increased intra-abdominal pressure during pneumoperitoneum stimulates endothelin release in a canine model. J Endourol. 1998 Apr; 12(2):193-7.
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Kanyicska B, Freeman ME, Dryer SE. Endothelin activates large-conductance K+ channels in rat lactotrophs: reversal by long-term exposure to dopamine agonist. Endocrinology. 1997 Aug; 138(8):3141-53.
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Shah J, Jandhyala BS. Physiological significance of Na+/K(+)-ATPase activity in the central nervous system and endogenous sodium-pump inhibitors in the neural regulation of arterial blood pressure. J Cardiovasc Pharmacol. 1993; 22 Suppl 2:S13-5.
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Shah J, Jandhyala BS. Antagonism by endothelin of centrally mediated cardiovascular effects of potassium in anaesthetized rats. Clin Exp Pharmacol Physiol. 1992 Feb; 19(2):89-94.
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Landan G, Bdolah A, Wollberg Z, Kochva E, Graur D. Evolution of the sarafotoxin/endothelin superfamily of proteins. Toxicon. 1991; 29(2):237-44.
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Landan G, Bdolah A, Wollberg Z, Kochva E, Graur D. The evolutionary history of the sarafotoxin/endothelin/endothelin-like superfamily. J Cardiovasc Pharmacol. 1991; 17 Suppl 7:S517-9.
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