 O(6)-Methylguanine-DNA Methyltransferase
"O(6)-Methylguanine-DNA Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.
| Descriptor ID |
D019853
|
| MeSH Number(s) |
D08.811.913.555.500.800.650
|
| Concept/Terms |
O(6)-Methylguanine-DNA Methyltransferase- O(6)-Methylguanine-DNA Methyltransferase
- Methylated-DNA-Protein-Cysteine S-Methyltransferase
- Methylated DNA Protein Cysteine S Methyltransferase
- S-Methyltransferase, Methylated-DNA-Protein-Cysteine
- O(6)-Methylguanine Methyltransferase
- O(6)-Alkylguanine-DNA Alkyltransferase
- O(6)-MeG-DNA Methyltransferase
- O(6)-Methylguanine DNA Transmethylase
- Guanine-O(6)-Alkyltransferase
- O(6)-AGT
|
Below are MeSH descriptors whose meaning is more general than "O(6)-Methylguanine-DNA Methyltransferase".
Below are MeSH descriptors whose meaning is more specific than "O(6)-Methylguanine-DNA Methyltransferase".
This graph shows the total number of publications written about "O(6)-Methylguanine-DNA Methyltransferase" by people in this website by year, and whether "O(6)-Methylguanine-DNA Methyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "O(6)-Methylguanine-DNA Methyltransferase" by people in Profiles.
-
Nyskohus LS, Watson AJ, Margison GP, Le Leu RK, Kim SW, Lockett TJ, Head RJ, Young GP, Hu Y. Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis. Mutat Res. 2013 Dec 12; 758(1-2):80-6.
-
Crosbie PA, Harrison K, Shah R, Watson AJ, Agius R, Barber PV, Margison GP, Povey AC. Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue. Chem Biol Interact. 2013 Jul 05; 204(2):98-104.
-
Chan DT, Ng RY, Siu DY, Tang P, Kam MK, Ma BB, Wong GK, Ng SC, Pang JC, Lau CK, Zhu XL, Ng HK, Poon WS. Pseudoprogression of malignant glioma in Chinese patients receiving concomitant chemoradiotherapy. Hong Kong Med J. 2012 Jun; 18(3):221-5.
-
Watson AJ, Sabharwal A, Thorncroft M, McGown G, Kerr R, Bojanic S, Soonawalla Z, King A, Miller A, Waller S, Leung H, Margison GP, Middleton MR. Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. Clin Cancer Res. 2010 Jan 15; 16(2):743-9.
-
Duthie SJ, Grant G, Pirie LP, Watson AJ, Margison GP. Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prev Res (Phila). 2010 Jan; 3(1):92-100.
-
Milsom MD, Jerabek-Willemsen M, Harris CE, Schambach A, Broun E, Bailey J, Jansen M, Schleimer D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison GP, Moritz T, Baum C, Thomale J, Williams DA. Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res. 2008 Aug 01; 68(15):6171-80.
-
Ranson M, Hersey P, Thompson D, Beith J, McArthur GA, Haydon A, Davis ID, Kefford RF, Mortimer P, Harris PA, Baka S, Seebaran A, Sabharwal A, Watson AJ, Margison GP, Middleton MR. Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma. J Clin Oncol. 2007 Jun 20; 25(18):2540-5.
-
Margison GP, Butt A, Pearson SJ, Wharton S, Watson AJ, Marriott A, Caetano CM, Hollins JJ, Rukazenkova N, Begum G, Santibáñez-Koref MF. Alkyltransferase-like proteins. DNA Repair (Amst). 2007 Aug 01; 6(8):1222-8.
-
Pearson SJ, Wharton S, Watson AJ, Begum G, Butt A, Glynn N, Williams DM, Shibata T, Santibáñez-Koref MF, Margison GP. A novel DNA damage recognition protein in Schizosaccharomyces pombe. Nucleic Acids Res. 2006; 34(8):2347-54.
-
Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, Curtin NJ. Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. Clin Cancer Res. 2005 May 01; 11(9):3402-9.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|