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Amanda Watson

TitleNew Summer Appointment
InstitutionUniversity of Houston
DepartmentDean, Law
Address4800 Calhoun Rd
Houston TX 77004
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Watson AJ, Hopkins GV, Hitchin S, Begum H, Jones S, Jordan A, Holt S, March HN, Newton R, Small H, Stowell A, Waddell ID, Waszkowycz B, Ogilvie DJ. Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade. F1000Res. 2016; 5:1005. PMID: 27429741; PMCID: PMC4937820.
      View in: PubMed, PubMed Central
    2. Jordan AM, Begum H, Fairweather E, Fritzl S, Goldberg K, Hopkins GV, Hamilton NM, Lyons AJ, March HN, Newton R, Small HF, Vishwanath S, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position. Bioorg Med Chem Lett. 2016 Jun 01; 26(11):2724-9. PMID: 27086121; PMCID: PMC4896930.
      View in: PubMed, PubMed Central
    3. Newton R, Bowler KA, Burns EM, Chapman PJ, Fairweather EE, Fritzl SJR, Goldberg KM, Hamilton NM, Holt SV, Hopkins GV, Jones SD, Jordan AM, Lyons AJ, Nikki March H, McDonald NQ, Maguire LA, Mould DP, Purkiss AG, Small HF, Stowell AIJ, Thomson GJ, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity. Eur J Med Chem. 2016 Apr 13; 112:20-32. PMID: 26874741; PMCID: PMC4896931.
      View in: PubMed, PubMed Central
    4. Ramcharan R, Aleksic T, Kamdoum WP, Gao S, Pfister SX, Tanner J, Bridges E, Asher R, Watson AJ, Margison GP, Woodcock M, Repapi E, Li JL, Middleton MR, Macaulay VM. IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. Oncotarget. 2015 Nov 24; 6(37):39877-90. PMID: 26497996; PMCID: PMC4741867.
      View in: PubMed, PubMed Central
    5. Cuevas K, Deater-Deckard K, Kim-Spoon J, Watson AJ, Morasch KC, Bell MA. What's mom got to do with it? Contributions of maternal executive function and caregiving to the development of executive function across early childhood. Dev Sci. 2014 Mar; 17(2):224-38. PMID: 24410963; PMCID: PMC3947460.
      View in: PubMed, PubMed Central
    6. Nyskohus LS, Watson AJ, Margison GP, Le Leu RK, Kim SW, Lockett TJ, Head RJ, Young GP, Hu Y. Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis. Mutat Res. 2013 Dec 12; 758(1-2):80-6. PMID: 24140386.
      View in: PubMed
    7. Raoof A, Depledge P, Hamilton NM, Hamilton NS, Hitchin JR, Hopkins GV, Jordan AM, Maguire LA, McGonagle AE, Mould DP, Rushbrooke M, Small HF, Smith KM, Thomson GJ, Turlais F, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II. J Med Chem. 2013 Aug 22; 56(16):6352-70. PMID: 23859074.
      View in: PubMed
    8. Thomson GJ, Hamilton NS, Hopkins GV, Waddell ID, Watson AJ, Ogilvie DJ. A fluorescence-based assay for the apurinic/apyrimidinic-site cleavage activity of human tyrosyl-DNA phosphodiesterase 1. Anal Biochem. 2013 Sep 01; 440(1):1-5. PMID: 23688965.
      View in: PubMed
    9. Crosbie PA, Harrison K, Shah R, Watson AJ, Agius R, Barber PV, Margison GP, Povey AC. Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue. Chem Biol Interact. 2013 Jul 05; 204(2):98-104. PMID: 23665414.
      View in: PubMed
    10. Thomson G, Watson A, Caldecott K, Denneny O, Depledge P, Hamilton N, Hopkins G, Jordan A, Morrow C, Raoof A, Waddell I, Ogilvie D. Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase. Anal Biochem. 2013 May 15; 436(2):145-50. PMID: 23416181.
      View in: PubMed
    11. Senthong P, Millington CL, Wilkinson OJ, Marriott AS, Watson AJ, Reamtong O, Eyers CE, Williams DM, Margison GP, Povey AC. The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase. Nucleic Acids Res. 2013 Mar 01; 41(5):3047-55. PMID: 23335782; PMCID: PMC3597670.
      View in: PubMed, PubMed Central
    12. Watson AJ, Bell MA. Individual differences in inhibitory control skills at three years of age. Dev Neuropsychol. 2013; 38(1):1-21. PMID: 23311312; PMCID: PMC3584163.
      View in: PubMed, PubMed Central
    13. Wilkinson OJ, Latypov V, Tubbs JL, Millington CL, Morita R, Blackburn H, Marriott A, McGown G, Thorncroft M, Watson AJ, Connolly BA, Grasby JA, Masui R, Hunter CA, Tainer JA, Margison GP, Williams DM. Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-p interactions. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18755-60. PMID: 23112169; PMCID: PMC3503161.
      View in: PubMed, PubMed Central
    14. Latypov VF, Tubbs JL, Watson AJ, Marriott AS, McGown G, Thorncroft M, Wilkinson OJ, Senthong P, Butt A, Arvai AS, Millington CL, Povey AC, Williams DM, Santibanez-Koref MF, Tainer JA, Margison GP. Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Mol Cell. 2012 Jul 13; 47(1):50-60. PMID: 22658721; PMCID: PMC3398191.
      View in: PubMed, PubMed Central
    15. Millington CL, Watson AJ, Marriott AS, Margison GP, Povey AC, Williams DM. Convenient and efficient syntheses of oligodeoxyribonucleotides containing O(6)-(carboxymethyl)guanine and O(6)-(4-oxo-4-(3-pyridyl)butyl)guanine. Nucleosides Nucleotides Nucleic Acids. 2012 Apr; 31(4):328-38. PMID: 22444194.
      View in: PubMed
    16. Crosbie PA, Watson AJ, Agius R, Barber PV, Margison GP, Povey AC. Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer. Mutat Res. 2012 Apr 01; 732(1-2):43-6. PMID: 22266085.
      View in: PubMed
    17. Zhang H, Xie C, Spencer HJ, Zuo C, Higuchi M, Ranganathan G, Kern PA, Chou MW, Huang Q, Szczesny B, Mitra S, Watson AJ, Margison GP, Fan CY. Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol. 2011 Apr; 178(4):1715-27. PMID: 21435453; PMCID: PMC3078437.
      View in: PubMed, PubMed Central
    18. Watson AJ, Sabharwal A, Thorncroft M, McGown G, Kerr R, Bojanic S, Soonawalla Z, King A, Miller A, Waller S, Leung H, Margison GP, Middleton MR. Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. Clin Cancer Res. 2010 Jan 15; 16(2):743-9. PMID: 20068091; PMCID: PMC2807621.
      View in: PubMed, PubMed Central
    19. Duthie SJ, Grant G, Pirie LP, Watson AJ, Margison GP. Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prev Res (Phila). 2010 Jan; 3(1):92-100. PMID: 20051376; PMCID: PMC2880451.
      View in: PubMed, PubMed Central
    20. Tubbs JL, Latypov V, Kanugula S, Butt A, Melikishvili M, Kraehenbuehl R, Fleck O, Marriott A, Watson AJ, Verbeek B, McGown G, Thorncroft M, Santibanez-Koref MF, Millington C, Arvai AS, Kroeger MD, Peterson LA, Williams DM, Fried MG, Margison GP, Pegg AE, Tainer JA. Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature. 2009 Jun 11; 459(7248):808-13. PMID: 19516334; PMCID: PMC2729916.
      View in: PubMed, PubMed Central
    21. Milsom MD, Jerabek-Willemsen M, Harris CE, Schambach A, Broun E, Bailey J, Jansen M, Schleimer D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison GP, Moritz T, Baum C, Thomale J, Williams DA. Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res. 2008 Aug 01; 68(15):6171-80. PMID: 18676840; PMCID: PMC4337843.
      View in: PubMed, PubMed Central
    22. Ranson M, Hersey P, Thompson D, Beith J, McArthur GA, Haydon A, Davis ID, Kefford RF, Mortimer P, Harris PA, Baka S, Seebaran A, Sabharwal A, Watson AJ, Margison GP, Middleton MR. Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma. J Clin Oncol. 2007 Jun 20; 25(18):2540-5. PMID: 17577032.
      View in: PubMed
    23. Margison GP, Butt A, Pearson SJ, Wharton S, Watson AJ, Marriott A, Caetano CM, Hollins JJ, Rukazenkova N, Begum G, Santibáñez-Koref MF. Alkyltransferase-like proteins. DNA Repair (Amst). 2007 Aug 01; 6(8):1222-8. PMID: 17500045.
      View in: PubMed
    24. Zhang H, Mizumachi T, Carcel-Trullols J, Li L, Naito A, Spencer HJ, Spring PM, Smoller BR, Watson AJ, Margison GP, Higuchi M, Fan CY. Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells. Carcinogenesis. 2007 Aug; 28(8):1629-37. PMID: 17389610.
      View in: PubMed
    25. Pearson SJ, Wharton S, Watson AJ, Begum G, Butt A, Glynn N, Williams DM, Shibata T, Santibáñez-Koref MF, Margison GP. A novel DNA damage recognition protein in Schizosaccharomyces pombe. Nucleic Acids Res. 2006; 34(8):2347-54. PMID: 16679453; PMCID: PMC1458281.
      View in: PubMed, PubMed Central
    26. Browne JE, Watson AJ, Hoskins PR, Elliott AT. Investigation of the effect of subcutaneous fat on image quality performance of 2D conventional imaging and tissue harmonic imaging. Ultrasound Med Biol. 2005 Jul; 31(7):957-64. PMID: 15972201.
      View in: PubMed
    27. Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, Curtin NJ. Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. Clin Cancer Res. 2005 May 01; 11(9):3402-9. PMID: 15867241.
      View in: PubMed
    28. Margison GP, Heighway J, Pearson S, McGown G, Thorncroft MR, Watson AJ, Harrison KL, Lewis SJ, Rohde K, Barber PV, O'Donnell P, Povey AC, Santibáñez-Koref MF. Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells. Carcinogenesis. 2005 Aug; 26(8):1473-80. PMID: 15831531.
      View in: PubMed
    29. Browne JE, Watson AJ, Hoskins PR, Elliott AT. Validation of a sensitivity performance index test protocol and evaluation of colour Doppler sensitivity for a range of ultrasound scanners. Ultrasound Med Biol. 2004 Nov; 30(11):1475-83. PMID: 15588958.
      View in: PubMed
    30. Browne JE, Watson AJ, Gibson NM, Dudley NJ, Elliott AT. Objective measurements of image quality. Ultrasound Med Biol. 2004 Feb; 30(2):229-37. PMID: 14998675.
      View in: PubMed
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