 Focal Adhesion Kinase 1
"Focal Adhesion Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
| Descriptor ID |
D051417
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| MeSH Number(s) |
D08.811.913.696.620.682.725.049.500 D12.776.744.493
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| Concept/Terms |
Focal Adhesion Kinase 1- Focal Adhesion Kinase 1
- p125FAK Protein
- Endogenous Substrate pp120
- Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
- Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
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Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 1".
This graph shows the total number of publications written about "Focal Adhesion Kinase 1" by people in this website by year, and whether "Focal Adhesion Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Focal Adhesion Kinase 1" by people in Profiles.
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Haemmerle M, Bottsford-Miller J, Pradeep S, Taylor ML, Choi HJ, Hansen JM, Dalton HJ, Stone RL, Cho MS, Nick AM, Nagaraja AS, Gutschner T, Gharpure KM, Mangala LS, Rupaimoole R, Han HD, Zand B, Armaiz-Pena GN, Wu SY, Pecot CV, Burns AR, Lopez-Berestein G, Afshar-Kharghan V, Sood AK. FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. J Clin Invest. 2016 May 02; 126(5):1885-96.
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Wei L, Wang L, Carson JA, Agan JE, Imanaka-Yoshida K, Schwartz RJ. beta1 integrin and organized actin filaments facilitate cardiomyocyte-specific RhoA-dependent activation of the skeletal alpha-actin promoter. FASEB J. 2001 Mar; 15(3):785-96.
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Wei L, Zhou W, Wang L, Schwartz RJ. beta(1)-integrin and PI 3-kinase regulate RhoA-dependent activation of skeletal alpha-actin promoter in myoblasts. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H1736-43.
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