Protein Kinase C-alpha
"Protein Kinase C-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
| Descriptor ID |
D051571
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.100
|
| Concept/Terms |
Protein Kinase C-alpha- Protein Kinase C-alpha
- Protein Kinase C(alpha)
- PKC-alpha Serine-Threonine Kinase
- PKC alpha Serine Threonine Kinase
- Serine-Threonine Kinase, PKC-alpha
- Protein Kinase C alpha
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-alpha".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-alpha".
This graph shows the total number of publications written about "Protein Kinase C-alpha" by people in this website by year, and whether "Protein Kinase C-alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C-alpha" by people in Profiles.
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Iyer D, Chang D, Marx J, Wei L, Olson EN, Parmacek MS, Balasubramanyam A, Schwartz RJ. Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4516-21.
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Megson AC, Walker EM, Hill SJ. Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus. Mol Pharmacol. 2001 May; 59(5):1012-21.