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Stephen Hill

TitleTemporary Faculty
InstitutionUniversity of Houston
DepartmentEarth & Atmospheric Sciences
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-3399
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Baker JG, Gardiner SM, Woolard J, Fromont C, Jadhav GP, Mistry SN, Thompson KSJ, Kellam B, Hill SJ, Fischer PM. Novel selective ß1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB J. 2017 Jul; 31(7):3150-3166. PMID: 28400472.
      View in: PubMed
    2. Kilpatrick LE, Friedman-Ohana R, Alcobia DC, Riching K, Peach CJ, Wheal AJ, Briddon SJ, Robers MB, Zimmerman K, Machleidt T, Wood KV, Woolard J, Hill SJ. Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes. Biochem Pharmacol. 2017 Jul 15; 136:62-75. PMID: 28392095.
      View in: PubMed
    3. Schwehm C, Kellam B, Garces AE, Hill SJ, Kindon ND, Bradshaw TD, Li J, Macdonald SJ, Rowedder JE, Stoddart LA, Stocks MJ. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase d (PI3Kd) Inhibitors. J Med Chem. 2017 Feb 23; 60(4):1534-1554. PMID: 28128944.
      View in: PubMed
    4. Hothersall JD, Guo D, Sarda S, Sheppard RJ, Chen H, Keur W, Waring MJ, IJzerman AP, Hill SJ, Dale IL, Rawlins PB. Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics. Mol Pharmacol. 2017 Jan; 91(1):25-38. PMID: 27803241.
      View in: PubMed
    5. Soave M, Stoddart LA, Brown A, Woolard J, Hill SJ. Use of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human ß1-adrenoceptor expressed in HEK-293 cells. Pharmacol Res Perspect. 2016 Oct; 4(5):e00250. PMID: 27588207.
      View in: PubMed
    6. Prince RC, Nash GW, Hill SJ. The biodegradation of crude oil in the deep ocean. Mar Pollut Bull. 2016 Oct 15; 111(1-2):354-357. PMID: 27402500.
      View in: PubMed
    7. Murray HM, Hill SJ, Ang KP. The external morphology of adult female Egrasilus labracis as shown using hexamethyldisilazane treated, uncoated specimens for scanning electron microscopy. Microsc Res Tech. 2016 Jul; 79(7):657-63. PMID: 27151371.
      View in: PubMed
    8. Kilpatrick LE, Hill SJ. The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors. Biochem Soc Trans. 2016 Apr 15; 44(2):624-9. PMID: 27068980.
      View in: PubMed
    9. Luli S, Di Paolo D, Perri P, Brignole C, Hill SJ, Brown H, Leslie J, Marshall HL, Wright MC, Mann DA, Ponzoni M, Oakley F. A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. J Hepatol. 2016 Jul; 65(1):75-83. PMID: 27067455; PMCID: PMC4914605.
      View in: PubMed, PubMed Central
    10. Ranganathan A, Stoddart LA, Hill SJ, Carlsson J. Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. J Med Chem. 2015 Dec 24; 58(24):9578-90. PMID: 26592528.
      View in: PubMed
    11. Stoddart LA, White CW, Nguyen K, Hill SJ, Pfleger KD. Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding. Br J Pharmacol. 2016 Oct; 173(20):3028-37. PMID: 26317175.
      View in: PubMed
    12. Hoffmann C, Castro M, Rinken A, Leurs R, Hill SJ, Vischer HF. Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It. Mol Pharmacol. 2015 Sep; 88(3):552-60. PMID: 26152198.
      View in: PubMed
    13. Stoddart LA, Johnstone EKM, Wheal AJ, Goulding J, Robers MB, Machleidt T, Wood KV, Hill SJ, Pfleger KDG. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015 Jul; 12(7):661-663. PMID: 26030448; PMCID: PMC4488387.
      View in: PubMed, PubMed Central
    14. Stoddart LA, Kilpatrick LE, Briddon SJ, Hill SJ. Probing the pharmacology of G protein-coupled receptors with fluorescent ligands. Neuropharmacology. 2015 Nov; 98:48-57. PMID: 25979488.
      View in: PubMed
    15. van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR, Bouvier M, Adjobo-Hermans MJ. A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms. Mol Pharmacol. 2015 Sep; 88(3):589-95. PMID: 25972446; PMCID: PMC4551049.
      View in: PubMed, PubMed Central
    16. Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology. 2015 Nov; 98:68-77. PMID: 25937210.
      View in: PubMed
    17. Carter JJ, Wheal AJ, Hill SJ, Woolard J. Effects of receptor tyrosine kinase inhibitors on VEGF165 a- and VEGF165 b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2. Br J Pharmacol. 2015 Jun; 172(12):3141-50. PMID: 25684635; PMCID: PMC4459029.
      View in: PubMed, PubMed Central
    18. Gherbi K, May LT, Baker JG, Briddon SJ, Hill SJ. Negative cooperativity across ß1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 ß1-adrenoceptor binding conformation. FASEB J. 2015 Jul; 29(7):2859-71. PMID: 25837585; PMCID: PMC4478806.
      View in: PubMed, PubMed Central
    19. Gherbi K, Briddon SJ, Hill SJ. Detection of the secondary, low-affinity ß1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. Br J Pharmacol. 2014 Dec; 171(23):5431-45. PMID: 25052258; PMCID: PMC4261997.
      View in: PubMed, PubMed Central
    20. Page A, Paoli PP, Hill SJ, Howarth R, Wu R, Kweon SM, French J, White S, Tsukamoto H, Mann DA, Mann J. Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. J Hepatol. 2015 Feb; 62(2):388-97. PMID: 25457206; PMCID: PMC4629846.
      View in: PubMed, PubMed Central
    21. Baker JG, Proudman RG, Hill SJ. Salmeterol's extreme ß2 selectivity is due to residues in both extracellular loops and transmembrane domains. Mol Pharmacol. 2015 Jan; 87(1):103-20. PMID: 25324048.
      View in: PubMed
    22. Stoddart LA, Kellam B, Briddon SJ, Hill SJ. Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. Br J Pharmacol. 2014 Aug; 171(16):3827-44. PMID: 24750014; PMCID: PMC4128046.
      View in: PubMed, PubMed Central
    23. Corriden R, Kilpatrick LE, Kellam B, Briddon SJ, Hill SJ. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB J. 2014 Oct; 28(10):4211-22. PMID: 24970394; PMCID: PMC4202110.
      View in: PubMed, PubMed Central
    24. Baker JG, Proudman RG, Hill SJ. Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human ß1-adrenoceptor. Mol Pharmacol. 2014 May; 85(5):811-29. PMID: 24608857; PMCID: PMC4132118.
      View in: PubMed, PubMed Central
    25. Jaeger WC, Armstrong SP, Hill SJ, Pfleger KD. Biophysical Detection of Diversity and Bias in GPCR Function. Front Endocrinol (Lausanne). 2014; 5:26. PMID: 24634666; PMCID: PMC3943086.
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    26. Vernall AJ, Hill SJ, Kellam B. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs. Br J Pharmacol. 2014 Mar; 171(5):1073-84. PMID: 23734587; PMCID: PMC3952789.
      View in: PubMed, PubMed Central
    27. Hill SJ, May LT, Kellam B, Woolard J. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization. Br J Pharmacol. 2014 Mar; 171(5):1102-13. PMID: 24024783; PMCID: PMC3952791.
      View in: PubMed, PubMed Central
    28. Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Schünemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Devereaux PJ, Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N, Yusuf S, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA, Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes HP, Jacka MJ, Graham M, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, Gerstein H, McDonald S, O'Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Villar JC, Cortés OL, Chaparro MS, Vásquez S, Castañeda A, Ferreira S, Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Chan MT, Choi GY, Gin T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Abraham V, Afzal L, George P, Mala S, Schünemann H, Muti P, Vizza E, Wang CY, Ong GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santaló M, Gonzalez R, Font A, Martínez C, Pelaez X, De Antonio M, Villamor JM, García JA, Ferré MJ, Popova E, Alonso-Coello P, Garutti I, Cruz P, Fernández C, Palencia M, Díaz S, Del Castillo T, Varela A, de Miguel A, Muñoz M, Piñeiro P, Cusati G, Del Barrio M, Membrillo MJ, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood J, Kalin M, Gibson D, Wildes T. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology. 2014 Mar; 120(3):564-78. PMID: 24534856.
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    29. Hutchings CJ, Cseke G, Osborne G, Woolard J, Zhukov A, Koglin M, Jazayeri A, Pandya-Pathak J, Langmead CJ, Hill SJ, Weir M, Marshall FH. Monoclonal anti-ß1-adrenergic receptor antibodies activate G protein signaling in the absence of ß-arrestin recruitment. MAbs. 2014 Jan-Feb; 6(1):246-61. PMID: 24253107; PMCID: PMC3929447.
      View in: PubMed, PubMed Central
    30. Baker JG, Proudman RG, Hill SJ. Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human ß1-adrenoceptor. PLoS One. 2013; 8(11):e77582. PMID: 24250787; PMCID: PMC3826719.
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    31. Vernall AJ, Stoddart LA, Briddon SJ, Ng HW, Laughton CA, Doughty SW, Hill SJ, Kellam B. Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Org Biomol Chem. 2013 Sep 14; 11(34):5673-82. PMID: 23881285.
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    32. Stoddart LA, Briddon SJ, Hill SJ. Fluorescent ligands for G protein-coupled receptors: illuminating receptor-ligand interactions for drug discovery. Future Med Chem. 2013 Aug; 5(12):1367-9. PMID: 23919546.
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    33. Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon SJ, Hill SJ. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Rep. 2013 Aug; 14(8):726-32. PMID: 23817552; PMCID: PMC3736131.
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    34. Mistry SN, Baker JG, Fischer PM, Hill SJ, Gardiner SM, Kellam B. Synthesis and in vitro and in vivo characterization of highly ß1-selective ß-adrenoceptor partial agonists. J Med Chem. 2013 May 23; 56(10):3852-65. PMID: 23614528; PMCID: PMC3694353.
      View in: PubMed, PubMed Central
    35. Stoddart LA, Vernall AJ, Denman JL, Briddon SJ, Kellam B, Hill SJ. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 2012 Sep 21; 19(9):1105-15. PMID: 22999879; PMCID: PMC3456874.
      View in: PubMed, PubMed Central
    36. Rose RH, Briddon SJ, Hill SJ. A novel fluorescent histamine H(1) receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands. Br J Pharmacol. 2012 Mar; 165(6):1789-1800. PMID: 21880035; PMCID: PMC3372830.
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    37. Ayling LJ, Briddon SJ, Halls ML, Hammond GR, Vaca L, Pacheco J, Hill SJ, Cooper DM. Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu. J Cell Sci. 2012 Feb 15; 125(Pt 4):869-86. PMID: 22399809; PMCID: PMC3311928.
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    38. Vernall AJ, Stoddart LA, Briddon SJ, Hill SJ, Kellam B. Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold. J Med Chem. 2012 Feb 23; 55(4):1771-82. PMID: 22277057.
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    39. Baker JG, Adams LA, Salchow K, Mistry SN, Middleton RJ, Hill SJ, Kellam B. Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human ß-adrenoceptors. J Med Chem. 2011 Oct 13; 54(19):6874-87. PMID: 21870877; PMCID: PMC3188295.
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    40. Baker JG, Kemp P, March J, Fretwell L, Hill SJ, Gardiner SM. Predicting in vivo cardiovascular properties of ß-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J. 2011 Dec; 25(12):4486-97. PMID: 21865315; PMCID: PMC3371235.
      View in: PubMed, PubMed Central
    41. May LT, Bridge LJ, Stoddart LA, Briddon SJ, Hill SJ. Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics. FASEB J. 2011 Oct; 25(10):3465-76. PMID: 21715680; PMCID: PMC3177574.
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    42. Connolly S, Alcaraz L, Bailey A, Cadogan E, Christie J, Cook AR, Fisher AJ, Hill S, Humphries A, Ingall AH, Kane Z, Paine S, Pairaudeau G, Stocks MJ, Young A. Design-driven LO: the discovery of new ultra long acting dibasic ß2-adrenoceptor agonists. Bioorg Med Chem Lett. 2011 Aug 01; 21(15):4612-6. PMID: 21723724.
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    43. Stocks MJ, Alcaraz L, Bailey A, Bonnert R, Cadogan E, Christie J, Connolly S, Cook A, Fisher A, Flaherty A, Hill S, Humphries A, Ingall A, Jordan S, Lawson M, Mullen A, Nicholls D, Paine S, Pairaudeau G, St-Gallay S, Young A. Design driven HtL: The discovery and synthesis of new high efficacy ß2-agonists. Bioorg Med Chem Lett. 2011 Jul 01; 21(13):4027-31. PMID: 21652207.
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    44. Baker JG, Hill SJ, Summers RJ. Evolution of ß-blockers: from anti-anginal drugs to ligand-directed signalling. Trends Pharmacol Sci. 2011 Apr; 32(4):227-34. PMID: 21429598; PMCID: PMC3081074.
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    45. Briddon SJ, Kellam B, Hill SJ. Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. Methods Mol Biol. 2011; 746:211-36. PMID: 21607859.
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    46. Alcock J, Warren AY, Goodson YJ, Hill SJ, Khan RN, Lymn JS. Inhibition of tissue transglutaminase 2 attenuates contractility of pregnant human myometrium. Biol Reprod. 2011 Apr; 84(4):646-53. PMID: 21123816.
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    47. Hill SJ, Williams C, May LT. Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies. Br J Pharmacol. 2010 Nov; 161(6):1266-75. PMID: 21049583; PMCID: PMC3000652.
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    48. May LT, Self TJ, Briddon SJ, Hill SJ. The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells. Mol Pharmacol. 2010 Sep; 78(3):511-23. PMID: 20571079; PMCID: PMC2939483.
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    49. Kilpatrick LE, Briddon SJ, Hill SJ, Holliday ND. Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation. Br J Pharmacol. 2010 Jun; 160(4):892-906. PMID: 20438572; PMCID: PMC2901518.
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    50. Wallace K, Cowie DE, Konstantinou DK, Hill SJ, Tjelle TE, Axon A, Koruth M, White SA, Carlsen H, Mann DA, Wright MC. The PXR is a drug target for chronic inflammatory liver disease. J Steroid Biochem Mol Biol. 2010 May 31; 120(2-3):137-48. PMID: 20416375; PMCID: PMC2937210.
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    51. Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. Br J Pharmacol. 2010 Feb; 159(4):772-86. PMID: 20105183; PMCID: PMC2829203.
      View in: PubMed, PubMed Central
    52. May LT, Briddon SJ, Hill SJ. Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. Mol Pharmacol. 2010 Apr; 77(4):678-86. PMID: 20086038; PMCID: PMC2845936.
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    53. Bridge LJ, King JR, Hill SJ, Owen MR. Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition. Math Biosci. 2010 Feb; 223(2):115-32. PMID: 19932126.
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    54. Woodroffe PJ, Bridge LJ, King JR, Chen CY, Hill SJ. Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity. J Math Biol. 2010 Mar; 60(3):313-46. PMID: 19347339.
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    55. Woodroffe PJ, Bridge LJ, King JR, Hill SJ. Modelling the activation of G-protein coupled receptors by a single drug. Math Biosci. 2009 May; 219(1):32-55. PMID: 19249318.
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    56. Williams C, Hill SJ. GPCR signaling: understanding the pathway to successful drug discovery. Methods Mol Biol. 2009; 552:39-50. PMID: 19513640.
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    57. Baker JG, Proudman RG, Hawley NC, Fischer PM, Hill SJ. Role of key transmembrane residues in agonist and antagonist actions at the two conformations of the human beta1-adrenoceptor. Mol Pharmacol. 2008 Nov; 74(5):1246-60. PMID: 18687809.
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    58. Briddon SJ, Gandía J, Amaral OB, Ferré S, Lluís C, Franco R, Hill SJ, Ciruela F. Plasma membrane diffusion of G protein-coupled receptor oligomers. Biochim Biophys Acta. 2008 Dec; 1783(12):2262-8. PMID: 18691614.
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    59. Cordell RL, Hill SJ, Ortori CA, Barrett DA. Quantitative profiling of nucleotides and related phosphate-containing metabolites in cultured mammalian cells by liquid chromatography tandem electrospray mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 01; 871(1):115-24. PMID: 18650133.
      View in: PubMed
    60. May LT, Hill SJ. ERK phosphorylation: spatial and temporal regulation by G protein-coupled receptors. Int J Biochem Cell Biol. 2008; 40(10):2013-7. PMID: 18502166.
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    61. Longden J, Cooke EL, Hill SJ. Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO-K1 cells. Br J Pharmacol. 2008 Apr; 153(7):1513-27. PMID: 18223665; PMCID: PMC2437898.
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    62. Briddon SJ, Hill SJ. Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes. Trends Pharmacol Sci. 2007 Dec; 28(12):637-45. PMID: 18001848; PMCID: PMC2148440.
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    63. Cordeaux Y, Briddon SJ, Alexander SP, Kellam B, Hill SJ. Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells. FASEB J. 2008 Mar; 22(3):850-60. PMID: 17959910.
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    64. Anderson D, Self T, Mellor IR, Goh G, Hill SJ, Denning C. Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Mol Ther. 2007 Nov; 15(11):2027-36. PMID: 17895862.
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    65. Baker JG, Hill SJ. Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates. Trends Pharmacol Sci. 2007 Aug; 28(8):374-81. PMID: 17629959; PMCID: PMC2169386.
      View in: PubMed, PubMed Central
    66. Middleton RJ, Briddon SJ, Cordeaux Y, Yates AS, Dale CL, George MW, Baker JG, Hill SJ, Kellam B. New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells. J Med Chem. 2007 Feb 22; 50(4):782-93. PMID: 17249651.
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    67. Baker JG, Hill SJ. A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor. J Pharmacol Exp Ther. 2007 Jan; 320(1):218-28. PMID: 17018691.
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    68. Birkinshaw TN, Teague SJ, Beech C, Bonnert RV, Hill S, Patel A, Reakes S, Sanganee H, Dougall IG, Phillips TT, Salter S, Schmidt J, Arrowsmith EC, Carrillo JJ, Bell FM, Paine SW, Weaver R. Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorg Med Chem Lett. 2006 Aug 15; 16(16):4287-90. PMID: 16753296.
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    69. Hill SJ. G-protein-coupled receptors: past, present and future. Br J Pharmacol. 2006 Jan; 147 Suppl 1:S27-37. PMID: 16402114; PMCID: PMC1760739.
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    70. Self TJ, Oakley SM, Hill SJ. Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells. Br J Pharmacol. 2005 Oct; 146(4):612-24. PMID: 16086035; PMCID: PMC1751180.
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    71. Carter AA, Hill SJ. Characterization of isoprenaline- and salmeterol-stimulated interactions between beta2-adrenoceptors and beta-arrestin 2 using beta-galactosidase complementation in C2C12 cells. J Pharmacol Exp Ther. 2005 Nov; 315(2):839-48. PMID: 16051698.
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    72. Myatt A, Hill SJ. Trypsin stimulates the phosphorylation of p42,44 mitogen-activated protein kinases via the proteinase-activated receptor-2 and protein kinase C epsilon in human cultured prostate stromal cells. Prostate. 2005 Jul 01; 64(2):175-85. PMID: 15678497.
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    73. Liu B, Hill SJ, Khan RN. Oxytocin inhibits T-type calcium current of human decidual stromal cells. J Clin Endocrinol Metab. 2005 Jul; 90(7):4191-7. PMID: 15855255.
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    74. Cordeaux Y, Ijzerman AP, Hill SJ. Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation. Br J Pharmacol. 2004 Nov; 143(6):705-14. PMID: 15302686; PMCID: PMC1575922.
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    75. Baker JG, Hall IP, Hill SJ. Temporal characteristics of cAMP response element-mediated gene transcription: requirement for sustained cAMP production. Mol Pharmacol. 2004 Apr; 65(4):986-98. PMID: 15044629.
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    76. Briddon SJ, Middleton RJ, Cordeaux Y, Flavin FM, Weinstein JA, George MW, Kellam B, Hill SJ. Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4673-8. PMID: 15070776; PMCID: PMC384805.
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    77. Briddon SJ, Middleton RJ, Yates AS, George MW, Kellam B, Hill SJ. Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level. Faraday Discuss. 2004; 126:197-207; discussion 245-54. PMID: 14992407.
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    78. Baker JG, Hall IP, Hill SJ. Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling. Mol Pharmacol. 2003 Dec; 64(6):1357-69. PMID: 14645666.
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    79. Chen CY, Cordeaux Y, Hill SJ, King JR. Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy. Bull Math Biol. 2003 Sep; 65(5):933-58. PMID: 12909256.
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    80. Baker JG, Hall IP, Hill SJ. Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses. Mol Pharmacol. 2003 Sep; 64(3):679-88. PMID: 12920204.
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    81. Baker JG, Hall IP, Hill SJ. Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor. Mol Pharmacol. 2003 Jun; 63(6):1312-21. PMID: 12761341.
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    82. Hill KJ, Webber AC, Hill SJ. A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus. Br J Pharmacol. 2003 Jun; 139(4):721-32. PMID: 12812995; PMCID: PMC1573890.
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    83. Baker JG, Hall IP, Hill SJ. Pharmacology and direct visualisation of BODIPY-TMR-CGP: a long-acting fluorescent beta2-adrenoceptor agonist. Br J Pharmacol. 2003 May; 139(2):232-42. PMID: 12770928; PMCID: PMC1573863.
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    84. Hill SJ, Baker JG. The ups and downs of Gs- to Gi-protein switching. Br J Pharmacol. 2003 Apr; 138(7):1188-9. PMID: 12711616; PMCID: PMC1573788.
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    85. Liu B, Arulkumaran S, Hill SJ, Khan RN. Comparison of potassium currents in human decidua before and after the onset of labor. Biol Reprod. 2003 Jun; 68(6):2281-8. PMID: 12606323.
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    86. Burton CL, Chhabra SR, Swift S, Baldwin TJ, Withers H, Hill SJ, Williams P. The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system. Infect Immun. 2002 Nov; 70(11):5913-23. PMID: 12379665; PMCID: PMC130287.
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    87. Baker JG, Hall IP, Hill SJ. Pharmacological characterization of CGP 12177 at the human beta(2)-adrenoceptor. Br J Pharmacol. 2002 Oct; 137(3):400-8. PMID: 12237261; PMCID: PMC1573492.
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    88. Hagger JA, Fisher AS, Hill SJ, Depledge MH, Jha AN. Genotoxic, cytotoxic and ontogenetic effects of tri-n-butyltin on the marine worm, Platynereis dumerilii (Polychaeta: Nereidae). Aquat Toxicol. 2002 Jun; 57(4):243-55. PMID: 11932004.
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    89. Cordeaux Y, Hill SJ. Mechanisms of cross-talk between G-protein-coupled receptors. Neurosignals. 2002 Jan-Feb; 11(1):45-57. PMID: 11943882.
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    90. Hill SJ, Baker JG, Rees S. Reporter-gene systems for the study of G-protein-coupled receptors. Curr Opin Pharmacol. 2001 Oct; 1(5):526-32. PMID: 11764780.
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    91. Moreda-Piñeiro A, Marcos A, Fisher A, Hill SJ. Evaluation of the effect of data pre-treatment procedures on classical pattern recognition and principal components analysis: a case study for the geographical classification of tea. J Environ Monit. 2001 Aug; 3(4):352-60. PMID: 11523433.
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    92. Middleton A, Nury D, Willington SJ, Latif L, Hill SJ, Middleton B. Modulation by cellular cholesterol of gene transcription via the cyclic AMP response element. Biochem Pharmacol. 2001 Jul 15; 62(2):171-81. PMID: 11389875.
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    93. Megson AC, Walker EM, Hill SJ. Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus. Mol Pharmacol. 2001 May; 59(5):1012-21. PMID: 11306682.
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    94. Cordeaux Y, Briddon SJ, Megson AE, McDonnell J, Dickenson JM, Hill SJ. Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity. Mol Pharmacol. 2000 Nov; 58(5):1075-84. PMID: 11040056.
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    95. Hopkinson HE, Latif ML, Hill SJ. Non-competitive antagonism of beta(2)-agonist-mediated cyclic AMP accumulation by ICI 118551 in BC3H1 cells endogenously expressing constitutively active beta(2)-adrenoceptors. Br J Pharmacol. 2000 Sep; 131(1):124-30. PMID: 10960078; PMCID: PMC1572294.
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    96. Jha AN, Hagger JA, Hill SJ, Depledge MH. Genotoxic, cytotoxic and developmental effects of tributyltin oxide (TBTO): an integrated approach to the evaluation of the relative sensitivities of two marine species. Mar Environ Res. 2000 Jul-Dec; 50(1-5):565-73. PMID: 11460750.
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    97. Shaw MJ, Hill SJ, Jones P, Nesterenko PN. Determination of beryllium in a stream sediment by high-performance chelation ion chromatography. J Chromatogr A. 2000 Apr 21; 876(1-2):127-33. PMID: 10823508.
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    98. Nash MJ, Maskall JE, Hill SJ. Methodologies for determination of antimony in terrestrial environmental samples. J Environ Monit. 2000 Apr; 2(2):97-109. PMID: 11253048.
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    99. Jha AN, Cheung VV, Foulkes ME, Hill SJ, Depledge MH. Detection of genotoxins in the marine environment: adoption and evaluation of an integrated approach using the embryo-larval stages of the marine mussel, Mytilus edulis. Mutat Res. 2000 Jan 24; 464(2):213-28. PMID: 10648908.
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    100. Jha AN, Hagger JA, Hill SJ. Tributyltin induces cytogenetic damage in the early life stages of the marine mussel, Mytilus edulis. Environ Mol Mutagen. 2000; 35(4):343-50. PMID: 10861953.
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    101. Haynes JM, Selbie LA, Hill SJ. Gi-Protein alpha-subunit mRNA antisense oligonucleotide inhibition of Gi-coupled receptor contractile activity in the epididymis of the guinea-pig. Br J Pharmacol. 1999 May; 127(1):85-90. PMID: 10369459; PMCID: PMC1565995.
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    102. Walker EM, Bispham JR, Hill SJ. Nonselective effects of the putative phospholipase C inhibitor, U73122, on adenosine A1 receptor-mediated signal transduction events in Chinese hamster ovary cells. Biochem Pharmacol. 1998 Dec 01; 56(11):1455-62. PMID: 9827577.
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    103. Dickenson JM, Hill SJ. Potentiation of adenosine A1 receptor-mediated inositol phospholipid hydrolysis by tyrosine kinase inhibitors in CHO cells. Br J Pharmacol. 1998 Nov; 125(5):1049-57. PMID: 9846644; PMCID: PMC1565676.
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    104. Haynes JM, Alexander SP, Hill SJ. A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig. Br J Pharmacol. 1998 Oct; 125(3):570-6. PMID: 9806342; PMCID: PMC1565646.
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    105. McDonnell J, Latif ML, Rees ES, Bevan NJ, Hill SJ. Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor. Br J Pharmacol. 1998 Oct; 125(4):717-26. PMID: 9831907; PMCID: PMC1571039.
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    106. Dickenson JM, Hill SJ. Involvement of G-protein betagamma subunits in coupling the adenosine A1 receptor to phospholipase C in transfected CHO cells. Eur J Pharmacol. 1998 Aug 14; 355(1):85-93. PMID: 9754942.
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    107. Dickenson JM, Blank JL, Hill SJ. Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells. Br J Pharmacol. 1998 Aug; 124(7):1491-9. PMID: 9723963; PMCID: PMC1565535.
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    108. Haynes JM, Alexander SP, Hill SJ. A1 adenosine receptor modulation of electrically-evoked contractions in the bisected vas deferens and cauda epididymis of the guinea-pig. Br J Pharmacol. 1998 Jul; 124(5):964-70. PMID: 9692782; PMCID: PMC1565464.
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    109. Dickenson JM, Hill SJ. Human 5-HT1B receptor stimulated inositol phospholipid hydrolysis in CHO cells: synergy with Gq-coupled receptors. Eur J Pharmacol. 1998 May 08; 348(2-3):279-85. PMID: 9652344.
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    110. Selbie LA, Hill SJ. G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol Sci. 1998 Mar; 19(3):87-93. PMID: 9584624.
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    111. Marsh KA, Draper LM, Rubin PC, Hill SJ. Receptor-stimulated phospholipase C activity in human umbilical artery cultured endothelial cells grown in a low oxygen environment. Biochem Pharmacol. 1997 Dec 15; 54(12):1351-9. PMID: 9393678.
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    112. Haynes JM, Hill SJ, Selbie LA. Neuropeptide Y (NPY) and peptide YY (PYY) effects in the epididymis of the guinea-pig: evidence of a pre-junctional PYY-selective receptor. Br J Pharmacol. 1997 Dec; 122(7):1530-6. PMID: 9421306; PMCID: PMC1565098.
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    113. Selbie LA, King NV, Dickenson JM, Hill SJ. Role of G-protein beta gamma subunits in the augmentation of P2Y2 (P2U)receptor-stimulated responses by neuropeptide Y Y1 Gi/o-coupled receptors. Biochem J. 1997 Nov 15; 328 ( Pt 1):153-8. PMID: 9359846; PMCID: PMC1218899.
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    114. Haynes JM, Hill SJ. Beta-adrenoceptor-mediated inhibition of alpha 1-adrenoceptor-mediated and field stimulation-induced contractile responses in the prostate of the guinea pig. Br J Pharmacol. 1997 Nov; 122(6):1067-74. PMID: 9401771; PMCID: PMC1565050.
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    115. Cooper J, Hill SJ, Alexander SP. An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells. Br J Pharmacol. 1997 Oct; 122(3):546-50. PMID: 9351513; PMCID: PMC1564960.
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    116. Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL. International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacol Rev. 1997 Sep; 49(3):253-78. PMID: 9311023.
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    117. Dickenson JM, Hill SJ. Transfected adenosine A1 receptor-mediated modulation of thrombin-stimulated phospholipase C and phospholipase A2 activity in CHO cells. Eur J Pharmacol. 1997 Feb 19; 321(1):77-86. PMID: 9083789.
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    118. Haynes JM, Hill SJ. Alpha-adrenoceptor mediated responses of the cauda epididymis of the guinea-pig. Br J Pharmacol. 1996 Nov; 119(6):1203-10. PMID: 8937724; PMCID: PMC1915889.
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    119. Alexander SP, Cooper J, Shine J, Hill SJ. Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells. Br J Pharmacol. 1996 Nov; 119(6):1286-90. PMID: 8937736; PMCID: PMC1915903.
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    120. Peakman MC, Hill SJ. Adenosine A1 receptor-mediated inhibition of cyclic AMP accumulation in type-2 but not type-1 rat astrocytes. Eur J Pharmacol. 1996 Jun 13; 306(1-3):281-9. PMID: 8813642.
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    121. Cairns WR, Ebdon L, Hill SJ. A high performance liquid chromatography - inductively coupled plasma-mass spectrometry interface employing desolvation for speciation studies of platinum in chemotherapy drugs. Anal Bioanal Chem. 1996 Jun; 355(3-4):202-8. PMID: 15045365.
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    122. McCrea KE, Hill SJ. Comparison of duration of agonist action at beta 1- and beta 2- adrenoceptors in C6 glioma cells: evidence that the long duration of action of salmeterol is specific to the beta 2-adrenoceptor. Mol Pharmacol. 1996 May; 49(5):927-37. PMID: 8622643.
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    123. Dickenson JM, Hill SJ. Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells. Eur J Pharmacol. 1996 Apr 29; 302(1-3):141-51. PMID: 8791002.
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    124. Marsh KA, Harrisss DR, Hill SJ. Desensitization of muscarinic receptor-coupled inositol phospholipid hydrolysis in human detrusor cultured smooth cells. J Urol. 1996 Apr; 155(4):1439-43. PMID: 8632607.
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    125. Clark EA, Hill SJ. Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin. Eur J Pharmacol. 1996 Jan 25; 296(2):223-5. PMID: 8838460.
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    126. Dickenson JM, Hill SJ. Coupling of an endogenous 5-HT1B-like receptor to increases in intracellular calcium through a pertussis toxin-sensitive mechanism in CHO-K1 cells. Br J Pharmacol. 1995 Dec; 116(7):2889-96. PMID: 8680721; PMCID: PMC1909226.
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    127. Harriss DR, Marsh KA, Birmingham AT, Hill SJ. Expression of muscarinic M3-receptors coupled to inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells. J Urol. 1995 Sep; 154(3):1241-5. PMID: 7637095.
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    128. Megson AC, Dickenson JM, Townsend-Nicholson A, Hill SJ. Synergy between the inositol phosphate responses to transfected human adenosine A1-receptors and constitutive P2-purinoceptors in CHO-K1 cells. Br J Pharmacol. 1995 Aug; 115(8):1415-24. PMID: 8564200; PMCID: PMC1908880.
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    129. Peakman MC, Hill SJ. Adenosine A1 receptor-mediated changes in basal and histamine-stimulated levels of intracellular calcium in primary rat astrocytes. Br J Pharmacol. 1995 Jul; 115(5):801-10. PMID: 8548180; PMCID: PMC1908518.
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    130. Cooper JA, Hill SJ, Alexander SP, Rubin PC, Horn EH. Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets. Br J Clin Pharmacol. 1995 Jul; 40(1):43-50. PMID: 8527267; PMCID: PMC1365026.
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    131. Hawley J, Rubin PC, Hill SJ. Distribution of receptors mediating phosphoinositide hydrolysis in cultured human umbilical artery smooth muscle and endothelial cells. Biochem Pharmacol. 1995 Mar 30; 49(7):1005-11. PMID: 7741756.
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    132. Dickenson JM, Camps M, Gierschik P, Hill SJ. Activation of phospholipase C by G-protein beta gamma subunits in DDT1MF-2 cells. Eur J Pharmacol. 1995 Feb 15; 288(3):393-8. PMID: 7774686.
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    133. Dickenson JM, Hill SJ. Activation of phospholipase C by G-protein beta gamma subunits in DDT1MF-2 cells. Biochem Soc Trans. 1995 Feb; 23(1):17S. PMID: 7758722.
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    134. Clark EA, Hill SJ. Differential effect of sodium ions and guanine nucleotides on the binding of thioperamide and clobenpropit to histamine H3-receptors in rat cerebral cortical membranes. Br J Pharmacol. 1995 Jan; 114(2):357-62. PMID: 7881735; PMCID: PMC1510245.
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    135. Peakman MC, Hill SJ. Endogenous expression of histamine H1 receptors functionally coupled to phosphoinositide hydrolysis in C6 glioma cells: regulation by cyclic AMP. Br J Pharmacol. 1994 Dec; 113(4):1554-60. PMID: 7889313; PMCID: PMC1510483.
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    136. Alexander SP, Curtis AR, Kendall DA, Hill SJ. A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortex. Br J Pharmacol. 1994 Dec; 113(4):1501-7. PMID: 7889308; PMCID: PMC1510515.
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    137. Dickenson JM, Hill SJ. Selective potentiation of histamine H1-receptor stimulated calcium responses by 1,4-dithiothreitol in DDT1MF-2 cells. Biochem Pharmacol. 1994 Nov 01; 48(9):1721-8. PMID: 7980641.
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    138. McCreath G, Hall IP, Hill SJ. Agonist-induced desensitization of histamine H1 receptor-mediated inositol phospholipid hydrolysis in human umbilical vein endothelial cells. Br J Pharmacol. 1994 Nov; 113(3):823-30. PMID: 7858873; PMCID: PMC1510454.
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    139. Dickenson JM, Hill SJ. Interactions between adenosine A1- and histamine H1-receptors. Int J Biochem. 1994 Aug; 26(8):959-69. PMID: 8088416.
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    140. Dickenson JM, Hill SJ. Characteristics of [3H]mepyramine binding in DDT1MF-2 cells: evidence for high affinity binding to a functional histamine H1 receptor. Eur J Pharmacol. 1994 Jul 15; 268(2):257-62. PMID: 7957647.
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    141. Marsh KA, Hill SJ. Des-Arg9-bradykinin-induced increases in intracellular calcium ion concentration in single bovine tracheal smooth muscle cells. Br J Pharmacol. 1994 Jul; 112(3):934-8. PMID: 7921623; PMCID: PMC1910220.
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    142. Iredale PA, Alexander SP, Hill SJ. Coupling of a transfected human brain A1 adenosine receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. Br J Pharmacol. 1994 Apr; 111(4):1252-6. PMID: 8032613; PMCID: PMC1910148.
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    143. Dickenson JM, Bulmer S, Whittaker A, Salwey M, Hawley J, Hill SJ. Bradykinin B2- and 5-hydroxytryptamine (5-HT2)-receptor stimulated increases in intracellular calcium in cultured guinea-pig aortic smooth muscle cells. Biochem Pharmacol. 1994 Mar 15; 47(6):947-52. PMID: 8147914.
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    144. Peakman MC, Hill SJ. Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. Br J Pharmacol. 1994 Jan; 111(1):191-8. PMID: 8012696; PMCID: PMC1910019.
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    145. Alexander SP, Losinski A, Kendall DA, Hill SJ. A comparison of A2 adenosine receptor-induced cyclic AMP generation in cerebral cortex and relaxation of pre-contracted aorta. Br J Pharmacol. 1994 Jan; 111(1):185-90. PMID: 8012695; PMCID: PMC1910056.
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    146. Dickenson JM, Hill SJ. Homologous and heterologous desensitization of histamine H1- and ATP-receptors in the smooth muscle cell line, DDT1MF-2: the role of protein kinase C. Br J Pharmacol. 1993 Dec; 110(4):1449-56. PMID: 8306086; PMCID: PMC2175898.
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    147. Iredale PA, Hill SJ. Increases in intracellular calcium via activation of an endogenous P2-purinoceptor in cultured CHO-K1 cells. Br J Pharmacol. 1993 Dec; 110(4):1305-10. PMID: 8306069; PMCID: PMC2175888.
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    148. Dickenson JM, Hill SJ. Coupling of histamine H1 and adenosine A1 receptors to phospholipase C in DDT1MF-2 cells: synergistic interactions and regulation by cyclic AMP. Biochem Soc Trans. 1993 Nov; 21(4):1124-9. PMID: 8131910.
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    149. McCrea KE, Hill SJ. Salmeterol, a long-acting beta 2-adrenoceptor agonist mediating cyclic AMP accumulation in a neuronal cell line. Br J Pharmacol. 1993 Oct; 110(2):619-26. PMID: 7902176; PMCID: PMC2175908.
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    150. Iredale PA, Fukui H, Hill SJ. High, stable expression of the bovine histamine H1-receptor coupled to [Ca2+]i mobilisation in CHO-K1 cells. Biochem Biophys Res Commun. 1993 Sep 30; 195(3):1294-300. PMID: 8216261.
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    151. Marsh KA, Hill SJ. Characteristics of the bradykinin-induced changes in intracellular calcium ion concentration of single bovine tracheal smooth muscle cells. Br J Pharmacol. 1993 Sep; 110(1):29-35. PMID: 8220891; PMCID: PMC2176018.
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    152. Dickenson JM, Hill SJ. Intracellular cross-talk between receptors coupled to phospholipase C via pertussis toxin sensitive and insensitive G-proteins. Biochem Soc Trans. 1993 Aug; 21 ( Pt 3)(3):296S. PMID: 8224444.
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    153. White TE, Hill SJ. Differential responses to histamine and cyclo-pentyladenosine in subclones of the DDT1MF-2 cell line. Biochem Soc Trans. 1993 Aug; 21 ( Pt 3)(3):293S. PMID: 8224441.
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    154. Dickenson JM, Hill SJ. Intracellular cross-talk between receptors coupled to phospholipase C via pertussis toxin-sensitive and insensitive G-proteins in DDT1MF-2 cells. Br J Pharmacol. 1993 Jul; 109(3):719-24. PMID: 8358567; PMCID: PMC2175649.
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    155. Dickenson JM, White TE, Hill SJ. The effects of elevated cyclic AMP levels on histamine-H1-receptor-stimulated inositol phospholipid hydrolysis and calcium mobilization in the smooth-muscle cell line DDT1MF-2. Biochem J. 1993 Jun 01; 292 ( Pt 2):409-17. PMID: 8389134; PMCID: PMC1134224.
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    156. James MJ, Birmingham AT, Hill SJ. Partial mediation by nitric oxide of the relaxation of human isolated detrusor strips in response to electrical field stimulation. Br J Clin Pharmacol. 1993 Apr; 35(4):366-72. PMID: 8485016; PMCID: PMC1381546.
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    157. Iredale PA, Martin KF, Hill SJ, Kendall DA. The effects of beta-phorbol-12,13 dibutyrate on agonist-induced increases in [Ca2+]i in N1E-115 cells. Differential modulation of responses to angiotensin II and bradykinin. Biochem Pharmacol. 1993 Feb 09; 45(3):611-7. PMID: 8442761.
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    158. Iredale PA, Martin KF, Hill SJ, Kendall DA. The control of intracellular calcium and neurotransmitter release in guinea pig-derived cerebral cortical synaptoneurosomes. Biochem Pharmacol. 1993 Jan 26; 45(2):407-14. PMID: 8094616.
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    159. White TE, Dickenson JM, Hill SJ. Histamine H1-receptor-mediated inositol phospholipid hydrolysis in DDT1MF-2 cells: agonist and antagonist properties. Br J Pharmacol. 1993 Jan; 108(1):196-203. PMID: 8381320; PMCID: PMC1907695.
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    160. Dickenson JM, Hill SJ. Adenosine A1-receptor stimulated increases in intracellular calcium in the smooth muscle cell line, DDT1MF-2. Br J Pharmacol. 1993 Jan; 108(1):85-92. PMID: 8428218; PMCID: PMC1907699.
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    161. Iredale PA, Martin KF, Alexander SP, Hill SJ, Kendall DA. Inositol 1,4,5-trisphosphate generation and calcium mobilisation via activation of an atypical P2 receptor in the neuronal cell line, N1E-115. Br J Pharmacol. 1992 Dec; 107(4):1083-7. PMID: 1467830; PMCID: PMC1907950.
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    162. Alexander SP, Curtis AR, Hill SJ, Kendall DA. Activation of a metabotropic excitatory amino acid receptor potentiates A2b adenosine receptor-stimulated cyclic AMP accumulation. Neurosci Lett. 1992 Nov 09; 146(2):231-3. PMID: 1283452.
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    163. Iredale PA, Martin KF, Alexander SP, Hill SJ, Kendall DA. Qualitative differences in [Ca2+]i increases and InsP3 generation following stimulation of N1E-115 cells with micromolar and millimolar ATP. Biochem Pharmacol. 1992 Oct 20; 44(8):1479-87. PMID: 1417971.
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    164. Marsh KA, Hill SJ. Bradykinin B2 receptor-mediated phosphoinositide hydrolysis in bovine cultured tracheal smooth muscle cells. Br J Pharmacol. 1992 Oct; 107(2):443-7. PMID: 1330177; PMCID: PMC1907848.
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    165. Alexander SP, Kendall DA, Hill SJ. Excitatory amino acid-induced phosphoinositide turnover in guinea pig cerebral cortical slices: selective enhancement by spermine of the response to DL-1-aminocyclopentane-trans-1,3-dicarboxylate. J Neurochem. 1992 Aug; 59(2):610-5. PMID: 1352801.
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    166. Iredale PA, Martin KF, Hill SJ, Kendall DA. Agonist-induced changes in [Ca2+]i in N1E-115 cells: differential effects of bradykinin and carbachol. Eur J Pharmacol. 1992 Jun 05; 226(2):163-8. PMID: 1639111.
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    167. Dickenson JM, Hill SJ. Histamine H1-receptor-mediated calcium influx in DDT1MF-2 cells. Biochem J. 1992 Jun 01; 284 ( Pt 2):425-31. PMID: 1599428; PMCID: PMC1132656.
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    168. Cartmell J, Kemp JA, Alexander SP, Hill SJ, Kendall DA. Inhibition of forskolin-stimulated cyclic AMP formation by 1-aminocyclopentane-trans-1,3-dicarboxylate in guinea-pig cerebral cortical slices. J Neurochem. 1992 May; 58(5):1964-6. PMID: 1313857.
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    169. White TE, Dickenson JM, Alexander SP, Hill SJ. Adenosine A1-receptor stimulation of inositol phospholipid hydrolysis and calcium mobilisation in DDT1 MF-2 cells. Br J Pharmacol. 1992 May; 106(1):215-21. PMID: 1324066; PMCID: PMC1907459.
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    170. Hawley J, Rubin PC, Hill SJ. Expression of 5-HT2- and bradykinin B2-receptors coupled to phosphoinositide hydrolysis in cultured guinea-pig aortic smooth muscle cells. Biochem Soc Trans. 1992 Feb; 20(1):21S. PMID: 1321753.
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    171. Alexander SP, Kendall DA, Hill SJ. Spermine enhances calcium- and GTP analogue-stimulated particulate phosphoinositidase. Biochem Soc Trans. 1992 Feb; 20(1):20S. PMID: 1321751.
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    172. Hill SJ. Multiple histamine receptors: properties and functional characteristics. Biochem Soc Trans. 1992 Feb; 20(1):122-5. PMID: 1321744.
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    173. Dickenson JM, Hill SJ. Intracellular calcium measurements in response to histamine stimulation in DDT1 MF-2 cells. Biochem Soc Trans. 1992 Feb; 20(1):19S. PMID: 1633944.
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    174. Hall IP, Hill SJ. Effects of isozyme selective phosphodiesterase inhibitors on bovine tracheal smooth muscle tone. Biochem Pharmacol. 1992 Jan 09; 43(1):15-7. PMID: 1734897.
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    175. Alexander SP, Hill SJ, Kendall DA. Do polyamines regulate the NMDA inhibition of muscarinic receptor-induced phosphoinositide turnover in guinea pig brain? Neurosci Lett. 1991 Oct 14; 131(2):167-70. PMID: 1662340.
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    176. Dickenson JM, Hill SJ. Histamine-stimulated increases in intracellular calcium in the smooth muscle cell line, DDT1MF-2. Biochem Pharmacol. 1991 Sep 27; 42(8):1545-50. PMID: 1930281.
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    177. Ruck A, Kendall DA, Hill SJ. Alpha- and beta-adrenoceptor regulation of cyclic AMP accumulation in cultured rat astrocytes. A comparison of primary protoplasmic and mixed fibrous/protoplasmic astroglial cultures. Biochem Pharmacol. 1991 Jun 21; 42(1):59-69. PMID: 1648923.
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    178. Ebdon L, Hill SJ, Jones P. HPLC Coupled with in-line photolysis, hydride generation and flame atomic-absorption spectrometry for the speciation of tin in natural waters. Talanta. 1991 Jun; 38(6):607-11. PMID: 18965192.
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    179. Iredale PA, Ruck A, Martin KF, Kendall DA, Hill SJ. Histamine-induced changes in intracellular calcium in undifferentiated N1E-115 cells. Biochem Soc Trans. 1991 Feb; 19(1):6S. PMID: 2037190.
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    180. Hill SJ. Histamine receptors and interactions between second messenger transduction systems. Agents Actions Suppl. 1991; 33:145-59. PMID: 1647127.
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    181. Corns WT, Ebdon LC, Hill SJ, Stockwell PB. Automated cold vapour flow-injection analysis of mercury at high concentrations. J Automat Chem. 1991; 13(6):267-71. PMID: 18924913; PMCID: PMC2547935.
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    182. Ebdon L, Fisher AS, Hill SJ, Worsfold PJ. On-line analyte preconcentration with atomic spectrometric detection. J Automat Chem. 1991; 13(6):281-6. PMID: 18924915; PMCID: PMC2547940.
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    183. Ruck A, Millns P, Kendall DA, Hill SJ. Expression of beta 2-adrenoceptors mediating cyclic AMP accumulation in astroglial and neuronal cell lines derived from the rat CNS. Biochem Pharmacol. 1990 Nov 15; 40(10):2371-5. PMID: 2173929.
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    184. Hew RW, Hodgkinson CR, Hill SJ. Characterization of histamine H3-receptors in guinea-pig ileum with H3-selective ligands. Br J Pharmacol. 1990 Nov; 101(3):621-4. PMID: 1963802; PMCID: PMC1917754.
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    185. Alexander SP, Hill SJ, Kendall DA. Differential effects of elevated calcium ion concentrations on inositol phospholipid responses in mouse and rat cerebral cortical slices. Biochem Pharmacol. 1990 Oct 15; 40(8):1793-9. PMID: 2173588.
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    186. Alexander SP, Hill SJ, Kendall DA. Is the adenosine receptor modulation of histamine-induced accumulation of inositol phosphates in cerebral cortical slices mediated by effects on calcium ion fluxes? J Neurochem. 1990 Oct; 55(4):1138-41. PMID: 2118942.
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    187. Alexander SP, Hill SJ, Kendall DA. Excitatory amino acid-induced formation of inositol phosphates in guinea-pig cerebral cortical slices: involvement of ionotropic or metabotropic receptors? J Neurochem. 1990 Oct; 55(4):1439-41. PMID: 1975837.
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    188. Iacovou JW, Hill SJ, Birmingham AT. Agonist-induced contraction and accumulation of inositol phosphates in the guinea-pig detrusor: evidence that muscarinic and purinergic receptors raise intracellular calcium by different mechanisms. J Urol. 1990 Sep; 144(3):775-9. PMID: 2167391.
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    189. Ottosson A, Hill SJ, Edvinsson L. Histamine receptors in brain vessels of guinea-pig: in-vitro pharmacology and ligand binding. Acta Physiol Scand. 1990 Sep; 140(1):135-41. PMID: 2177313.
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    190. Hall IP, Donaldson J, Hill SJ. Modulation of fluoroaluminate-induced inositol phosphate formation by increases in tissue cyclic AMP content in bovine tracheal smooth muscle. Br J Pharmacol. 1990 Jul; 100(3):646-50. PMID: 1697201; PMCID: PMC1917793.
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    191. Donaldson J, Kendall DA, Hill SJ. Discriminatory effects of forskolin and EGTA on the indirect cyclic AMP responses to histamine, noradrenaline, 5-hydroxytryptamine, and glutamate in guinea-pig cerebral cortical slices. J Neurochem. 1990 May; 54(5):1484-91. PMID: 1969933.
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    192. Hall IP, Donaldson J, Hill SJ. Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors. Biochem Pharmacol. 1990 Apr 15; 39(8):1357-63. PMID: 1690998.
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    193. Hill SJ. Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol Rev. 1990 Mar; 42(1):45-83. PMID: 2164693.
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    194. Alexander SP, Kendall DA, Hill SJ. Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex. Br J Pharmacol. 1989 Dec; 98(4):1241-8. PMID: 2482102; PMCID: PMC1854823.
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    195. Donaldson J, Brown AM, Hill SJ. Temporal changes in the calcium-dependence of the histamine H1-receptor-stimulation of cyclic AMP accumulation in guinea-pig cerebral cortex. Br J Pharmacol. 1989 Dec; 98(4):1365-75. PMID: 2558762; PMCID: PMC1854819.
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    196. Hall IP, Hill SJ. Inhibition by salbutamol, forskolin and IBMX of AlF4-induced inositol phosphate formation in bovine airway smooth muscle. Br J Pharmacol. 1989 Dec; 98 Suppl:788P. PMID: 2482107.
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    197. Alexander SP, Hill SJ, Kendall DA. The 2-chloroadenosine inhibition of histamine-induced inositol phosphates accumulation in mouse brain and calcium ions. Br J Pharmacol. 1989 Dec; 98 Suppl:832P. PMID: 2611535.
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    198. Hall IP, Donaldson J, Hill SJ. Inhibition of histamine-stimulated inositol phospholipid hydrolysis by agents which increase cyclic AMP levels in bovine tracheal smooth muscle. Br J Pharmacol. 1989 Jun; 97(2):603-13. PMID: 2547479; PMCID: PMC1854535.
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    199. Stanley C, Brown AM, Hill SJ. Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus. J Neurochem. 1989 Mar; 52(3):671-6. PMID: 2465375.
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    200. Hill SJ, Kendall DA. Cross-talk between different receptor-effector systems in the mammalian CNS. Cell Signal. 1989; 1(2):135-41. PMID: 2561981.
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    201. Hill SJ, Straw RM. Alpha 2-adrenoceptor-mediated inhibition of histamine release from rat cerebral cortical slices. Br J Pharmacol. 1988 Dec; 95(4):1213-9. PMID: 2464390; PMCID: PMC1854251.
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    202. Hall IP, Hill SJ. Beta-adrenoceptor stimulation inhibits histamine-stimulated inositol phospholipid hydrolysis in bovine tracheal smooth muscle. Br J Pharmacol. 1988 Dec; 95(4):1204-12. PMID: 2905910; PMCID: PMC1854273.
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    203. Young CS, Mason R, Hill SJ. Studies on the mechanism of histamine-induced release of noradrenaline and 5-hydroxytryptamine from slices of rat cerebral cortex. Biochem Pharmacol. 1988 Jul 15; 37(14):2799-805. PMID: 3260780.
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    204. Donaldson J, Hill SJ, Brown AM. Kinetic studies on the mechanism by which histamine H1 receptors potentiate cyclic AMP accumulation in guinea pig cerebral cortical slices. Mol Pharmacol. 1988 Jun; 33(6):626-33. PMID: 2837636.
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    205. Young CS, Mason R, Hill SJ. Inhibition by H1-antihistamines of the uptake of noradrenaline and 5-HT into rat brain synaptosomes. Biochem Pharmacol. 1988 Mar 01; 37(5):976-8. PMID: 2894209.
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    206. Donaldson J, Brown AM, Hill SJ. Influence of rolipram on the cyclic 3',5'-adenosine monophosphate response to histamine and adenosine in slices of guinea-pig cerebral cortex. Biochem Pharmacol. 1988 Feb 15; 37(4):715-23. PMID: 2829922.
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    207. Kendall DA, Hill SJ. Adenosine inhibition of histamine-stimulated inositol phospholipid hydrolysis in mouse cerebral cortex. J Neurochem. 1988 Feb; 50(2):497-502. PMID: 3335859.
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    208. Hill SJ, Kendall DA. Studies on the adenosine-receptor mediating the augmentation of histamine-induced inositol phospholipid hydrolysis in guinea-pig cerebral cortex. Br J Pharmacol. 1987 Jul; 91(3):661-9. PMID: 3038249; PMCID: PMC1853563.
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    209. Al-Gadi M, Hill SJ. The role of calcium in the cyclic AMP response to histamine in rabbit cerebral cortical slices. Br J Pharmacol. 1987 May; 91(1):213-22. PMID: 3036288; PMCID: PMC1853485.
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    210. Donaldson J, Hill SJ. 1,4-Dithiothreitol-induced changes in histamine H1-agonist efficacy and affinity in the longitudinal smooth muscle of guinea-pig ileum. Br J Pharmacol. 1987 Jan; 90(1):263-71. PMID: 2880626; PMCID: PMC1917291.
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    211. Ebdon L, Alonso JI, Hill SJ, Hopkins A. A simple and versatile interface to feed analogue data from the output of analytical instruments to a BBC microcomputer. J Automat Chem. 1987; 9(3):132-4. PMID: 18925168; PMCID: PMC2547710.
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    212. Donaldson J, Hill SJ. Enhancement of histamine H1-receptor agonist activity by 1,4-dithiothreitol in guinea-pig cerebellum and cerebral cortex. J Neurochem. 1986 Nov; 47(5):1476-82. PMID: 3020176.
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    213. Donaldson J, Hill SJ. 1,4-Dithiothreitol-induced alteration in histamine H1-agonist binding in guinea-pig cerebellum and cerebral cortex. Eur J Pharmacol. 1986 Sep 23; 129(1-2):25-31. PMID: 3770075.
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    214. Donaldson J, Hill SJ. Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol. Br J Pharmacol. 1986 Jan; 87(1):191-9. PMID: 2937501; PMCID: PMC1916903.
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    215. Al-Gadi M, Hill SJ. Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices. Br J Pharmacol. 1985 Aug; 85(4):877-88. PMID: 2994788; PMCID: PMC1916657.
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    216. Donaldson J, Hill SJ. Histamine-induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea-pig ileum. Br J Pharmacol. 1985 Jun; 85(2):499-512. PMID: 2992666; PMCID: PMC1916608.
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    217. Hadfield AJ, Robinson NR, Hill SJ. The nature of the binding of [3H]mepyramine to homogenates of guinea-pig cerebral cortex at different [3H]ligand concentrations. Biochem Pharmacol. 1983 Aug 15; 32(16):2449-51. PMID: 6615545.
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    218. Daum PR, Hill SJ, Young JM. Histamine H1-agonist potentiation of adenosine-stimulated cyclic AMP accumulation in slices of guinea-pig cerebral cortex: comparison of response and binding parameters. Br J Pharmacol. 1982 Oct; 77(2):347-57. PMID: 6291688; PMCID: PMC2044606.
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    219. Hill SJ, Daum P, Young JM. Affinities of histamine H1-antagonists in guinea pig brain: similarity of values determined from [3H]mepyramine binding and from inhibition of a functional response. J Neurochem. 1981 Nov; 37(5):1357-60. PMID: 6117608.
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    220. Hill SJ, Hiley CR, Young JM. Extended mepyramine treatment and histamine H1-receptors in guinea-pig brain. Eur J Pharmacol. 1981 May 22; 71(4):421-8. PMID: 7250197.
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    221. Hill SJ, Young JM. Characterization of [3H]mepyramine binding to the longitudinal muscle of guinea pig small intestine. Mol Pharmacol. 1981 May; 19(3):379-87. PMID: 6115306.
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    222. Hill SJ, Young JM. Histamine H1-receptors in the brain of the guinea-pig and the rat: differences in ligand binding properties and regional distribution. Br J Pharmacol. 1980 Apr; 68(4):687-96. PMID: 7378642; PMCID: PMC2044245.
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    223. Hill SJ, Young JM. The binding properties of [3H]-mepyramine in the brain of the guinea-pig and the rat [proceedings]. Br J Pharmacol. 1979 May; 66(1):93P. PMID: 454974; PMCID: PMC2043801.
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    224. Hill SJ, Young M. Antagonism of central histamine H1 receptors by antipsychotic drugs. Eur J Pharmacol. 1978 Dec 01; 52(3-4):397-9. PMID: 32056.
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    225. Hill SJ, Emson PC, Young JM. The binding of [3H]mepyramine to histamine H1 receptors in guinea-pig brain. J Neurochem. 1978 Oct; 31(4):997-1004. PMID: 702161.
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    226. Hill SJ, Young JM. Evidence for the presence of histamine H1-receptors in guinea-pig brain [proceedings]. Br J Pharmacol. 1978 Jun; 63(2):394P. PMID: 667469; PMCID: PMC1668340.
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    227. Hill SJ, Young JM, Marrian DH. Specific binding of 3H-mepyramine to histamine H1 receptors in intestinal smooth muscle. Nature. 1977 Nov 24; 270(5635):361-3. PMID: 593357.
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