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Michihisa Umetani

TitleAssistant Professor
InstitutionUniversity of Houston
DepartmentCtr for Nuclear Rec & Cell Sig
Address4800 Calhoun Rd
Houston TX 77004
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW, Morrison SJ. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. J Clin Invest. 2017 Sep 01; 127(9):3392-3401. PMID: 28783041.
      View in: PubMed
    2. Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW. Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice. Endocrinology. 2016 Oct; 157(10):3731-3741. PMID: 27552247.
      View in: PubMed
    3. Umetani M. Re-adopting classical nuclear receptors by cholesterol metabolites. J Steroid Biochem Mol Biol. 2016 Mar; 157:20-6. PMID: 26563834; PMCID: PMC4724260 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    4. Umetani M, Ghosh P, Ishikawa T, Umetani J, Ahmed M, Mineo C, Shaul PW. The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab. 2014 Jul 01; 20(1):172-82. PMID: 24954418; PMCID: PMC4098728.
      View in: PubMed, PubMed Central
    5. Lee WR, Ishikawa T, Umetani M. The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol. Clin Lipidol. 2014; 9(6):617-624. PMID: 25632306.
      View in: PubMed
    6. Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science. 2013 Nov 29; 342(6162):1094-8. PMID: 24288332; PMCID: PMC3899689.
      View in: PubMed, PubMed Central
    7. Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW. 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. Cell Rep. 2013 Nov 14; 5(3):637-45. PMID: 24210818; PMCID: PMC3950897.
      View in: PubMed, PubMed Central
    8. Ishikawa T, Yuhanna IS, Umetani J, Lee WR, Korach KS, Shaul PW, Umetani M. LXRß/estrogen receptor-a signaling in lipid rafts preserves endothelial integrity. J Clin Invest. 2013 Aug; 123(8):3488-97. PMID: 23867501; PMCID: PMC3726156.
      View in: PubMed, PubMed Central
    9. Sundgren NC, Zhu W, Yuhanna IS, Chambliss KL, Ahmed M, Tanigaki K, Umetani M, Mineo C, Shaul PW. Coupling of Fc? receptor I to Fc? receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function. Circ Res. 2011 Oct 28; 109(10):1132-40. PMID: 21940940; PMCID: PMC3215097.
      View in: PubMed, PubMed Central
    10. Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 2011 Dec; 152(12):4691-705. PMID: 21933863; PMCID: PMC3230052.
      View in: PubMed, PubMed Central
    11. Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ. The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Mol Endocrinol. 2011 Jun; 25(6):1066-71. PMID: 21454404; PMCID: PMC3100601.
      View in: PubMed, PubMed Central
    12. Umetani M, Shaul PW. 27-Hydroxycholesterol: the first identified endogenous SERM. Trends Endocrinol Metab. 2011 Apr; 22(4):130-5. PMID: 21353593; PMCID: PMC3070823.
      View in: PubMed, PubMed Central
    13. Wu Q, Chambliss K, Umetani M, Mineo C, Shaul PW. Non-nuclear estrogen receptor signaling in the endothelium. J Biol Chem. 2011 Apr 29; 286(17):14737-43. PMID: 21343284; PMCID: PMC3083154.
      View in: PubMed, PubMed Central
    14. Chambliss KL, Wu Q, Oltmann S, Konaniah ES, Umetani M, Korach KS, Thomas GD, Mineo C, Yuhanna IS, Kim SH, Madak-Erdogan Z, Maggi A, Dineen SP, Roland CL, Hui DY, Brekken RA, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW. Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest. 2010 Jul; 120(7):2319-30. PMID: 20577047; PMCID: PMC2898582.
      View in: PubMed, PubMed Central
    15. DuSell CD, Nelson ER, Wang X, Abdo J, Mödder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology. 2010 Aug; 151(8):3675-85. PMID: 20501668; PMCID: PMC2940523.
      View in: PubMed, PubMed Central
    16. Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, Mangelsdorf DJ. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med. 2007 Oct; 13(10):1185-92. PMID: 17873880.
      View in: PubMed
    17. DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol. 2008 Jan; 22(1):65-77. PMID: 17872378; PMCID: PMC2194632.
      View in: PubMed, PubMed Central
    18. Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, Kodama T. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17278-83. PMID: 17088532; PMCID: PMC1634838.
      View in: PubMed, PubMed Central
    19. Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, Mangelsdorf DJ, Kliewer SA. Identification of a hormonal basis for gallbladder filling. Nat Med. 2006 Nov; 12(11):1253-5. PMID: 17072310.
      View in: PubMed
    20. Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22; 281(38):27816-26. PMID: 16857673.
      View in: PubMed
    21. Goodwin B, Gauthier KC, Umetani M, Watson MA, Lochansky MI, Collins JL, Leitersdorf E, Mangelsdorf DJ, Kliewer SA, Repa JJ. Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):223-8. PMID: 12509506; PMCID: PMC140933.
      View in: PubMed, PubMed Central
    22. Iwasaki A, Doi T, Umetani M, Watanabe M, Suda M, Hattori Y, Nagoya T. Affinity improvement of the high-affinity immunoglobulin E receptor by phage display. Biochem Biophys Res Commun. 2002 Apr 26; 293(1):542-8. PMID: 12054635.
      View in: PubMed
    23. Saiura A, Mataki C, Murakami T, Umetani M, Wada Y, Kohro T, Aburatani H, Harihara Y, Hamakubo T, Yamaguchi T, Hasegawa G, Naito M, Makuuchi M, Kodama T. A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis. Transplantation. 2001 Jul 27; 72(2):320-9. PMID: 11477360.
      View in: PubMed
    24. Umetani M, Mataki C, Minegishi N, Yamamoto M, Hamakubo T, Kodama T. Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol. 2001 Jun; 21(6):917-22. PMID: 11397697.
      View in: PubMed
    25. Umetani M, Kodama T, Hamakubo T. [Genetic plan for the formation of cardiovascular system]. Tanpakushitsu Kakusan Koso. 2000 Sep; 45(13 Suppl):2235-42. PMID: 11021229.
      View in: PubMed
    26. Umetani M, Nakao H, Doi T, Iwasaki A, Ohtaka M, Nagoya T, Mataki C, Hamakubo T, Kodama T. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 07; 272(2):370-4. PMID: 10833420.
      View in: PubMed
    27. Murakami T, Mataki C, Nagao C, Umetani M, Wada Y, Ishii M, Tsutsumi S, Kohro T, Saiura A, Aburatani H, Hamakubo T, Kodama T. The gene expression profile of human umbilical vein endothelial cells stimulated by tumor necrosis factor alpha using DNA microarray analysis. J Atheroscler Thromb. 2000; 7(1):39-44. PMID: 11425043.
      View in: PubMed
    28. Mataki C, Murakami T, Umetani M, Wada Y, Ishii M, Tsutsumi S, Aburatani H, Hamakubo T, Kodama T. A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha. J Atheroscler Thromb. 2000; 7(2):97-103. PMID: 11426589.
      View in: PubMed
    29. Morikawa S, Umetani M, Nakagawa S, Yamazaki H, Suganami H, Inoue K, Kitahara M, Hamakubo T, Kodama T, Saito Y. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000; 7(3):138-44. PMID: 11480454.
      View in: PubMed
    30. Takaku M, Wada Y, Jinnouchi K, Takeya M, Takahashi K, Usuda H, Naito M, Kurihara H, Yazaki Y, Kumazawa Y, Okimoto Y, Umetani M, Noguchi N, Niki E, Hamakubo T, Kodama T. An in vitro coculture model of transmigrant monocytes and foam cell formation. Arterioscler Thromb Vasc Biol. 1999 Oct; 19(10):2330-9. PMID: 10521361.
      View in: PubMed
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