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Navin Varadarajan

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentChemical Engineering
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-1691
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    Collapse Research 
    Collapse research activities and funding
    R01CA174385     (VARADARAJAN, NAVIN)Sep 19, 2012 - Jun 30, 2016
    NIH/NCI
    Quantitative single-cell biomarkers of T-cells to optimize tumor immunotherapy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G. Corrigendum: IgG Fc domains that bind C1q but not effector Fc? receptors delineate the importance of complement-mediated effector functions. Nat Immunol. 2017 Sep 19; 18(10):1173. PMID: 28926542.
      View in: PubMed
    2. An X, Sendra VG, Liadi I, Ramesh B, Romain G, Haymaker C, Martinez-Paniagua M, Lu Y, Radvanyi LG, Roysam B, Varadarajan N. Single-cell profiling of dynamic cytokine secretion and the phenotype of immune cells. PLoS One. 2017; 12(8):e0181904. PMID: 28837583.
      View in: PubMed
    3. Ritthipichai K, Haymaker CL, Martinez M, Aschenbrenner A, Yi X, Zhang M, Kale C, Vence LM, Roszik J, Hailemichael Y, Overwijk WW, Varadarajan N, Nurieva R, Radvanyi LG, Hwu P, Bernatchez C. Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter. Clin Cancer Res. 2017 Jul 28. PMID: 28754817.
      View in: PubMed
    4. Varadarajan N. Unmassked: Single-Cell Profiling of Immune Cell Populations in Tumors. Mol Ther. 2017 Aug 02; 25(8):1745-1747. PMID: 28684257.
      View in: PubMed
    5. Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G. IgG Fc domains that bind C1q but not effector Fc? receptors delineate the importance of complement-mediated effector functions. Nat Immunol. 2017 Aug; 18(8):889-898. PMID: 28604720.
      View in: PubMed
    6. Moogk D, Zhong S, Yu Z, Liadi I, Rittase W, Fang V, Dougherty J, Perez-Garcia A, Osman I, Zhu C, Varadarajan N, Restifo NP, Frey AB, Krogsgaard M. Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. J Immunol. 2016 Jul 15; 197(2):644-54. PMID: 27271569; PMCID: PMC4935560 [Available on 07/15/17].
      View in: PubMed, PubMed Central
    7. Mahendra A, Peyron I, Thaunat O, Dollinger C, Gilardin L, Sharma M, Wootla B, Rao DN, Padiolleau-Lefevre S, Boquet D, More A, Varadarajan N, Kaveri SV, Legendre C, Lacroix-Desmazes S. Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients. J Immunol. 2016 May 15; 196(10):4075-81. PMID: 27067006; PMCID: PMC4868768 [Available on 05/15/17].
      View in: PubMed, PubMed Central
    8. Ramesh B, Frei CS, Cirino PC, Varadarajan N. Functional enrichment by direct plasmid recovery after fluorescence activated cell sorting. Biotechniques. 2015 Sep; 59(3):157-61. PMID: 26345509.
      View in: PubMed
    9. Merouane A, Rey-Villamizar N, Lu Y, Liadi I, Romain G, Lu J, Singh H, Cooper LJ, Varadarajan N, Roysam B. Automated profiling of individual cell-cell interactions from high-throughput time-lapse imaging microscopy in nanowell grids (TIMING). Bioinformatics. 2015 Oct 01; 31(19):3189-97. PMID: 26059718; PMCID: PMC4693004 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    10. Liadi I, Singh H, Romain G, Rey-Villamizar N, Merouane A, Adolacion JR, Kebriaei P, Huls H, Qiu P, Roysam B, Cooper LJ, Varadarajan N. Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells. Cancer Immunol Res. 2015 May; 3(5):473-82. PMID: 25711538; PMCID: PMC4421910.
      View in: PubMed, PubMed Central
    11. Romain G, Senyukov V, Rey-Villamizar N, Merouane A, Kelton W, Liadi I, Mahendra A, Charab W, Georgiou G, Roysam B, Lee DA, Varadarajan N. Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells. Blood. 2014 Nov 20; 124(22):3241-9. PMID: 25232058; PMCID: PMC4239333.
      View in: PubMed, PubMed Central
    12. Ogunniyi AO, Thomas BA, Politano TJ, Varadarajan N, Landais E, Poignard P, Walker BD, Kwon DS, Love JC. Profiling human antibody responses by integrated single-cell analysis. Vaccine. 2014 May 19; 32(24):2866-73. PMID: 24602776; PMCID: PMC4164152.
      View in: PubMed, PubMed Central
    13. Sendra VG, Lie A, Romain G, Agarwal SK, Varadarajan N. Detection and isolation of auto-reactive human antibodies from primary B cells. Methods. 2013 Dec 01; 64(2):153-9. PMID: 23811296; PMCID: PMC3836837.
      View in: PubMed, PubMed Central
    14. Liadi I, Roszik J, Romain G, Cooper LJ, Varadarajan N. Quantitative high-throughput single-cell cytotoxicity assay for T cells. J Vis Exp. 2013 Feb 02; (72):e50058. PMID: 23407457; PMCID: PMC3596999.
      View in: PubMed, PubMed Central
    15. DeKosky BJ, Ippolito GC, Deschner RP, Lavinder JJ, Wine Y, Rawlings BM, Varadarajan N, Giesecke C, Dörner T, Andrews SF, Wilson PC, Hunicke-Smith SP, Willson CG, Ellington AD, Georgiou G. High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat Biotechnol. 2013 Feb; 31(2):166-9. PMID: 23334449; PMCID: PMC3910347.
      View in: PubMed, PubMed Central
    16. Ramesh B, Sendra VG, Cirino PC, Varadarajan N. Single-cell characterization of autotransporter-mediated Escherichia coli surface display of disulfide bond-containing proteins. J Biol Chem. 2012 Nov 09; 287(46):38580-9. PMID: 23019324; PMCID: PMC3493903.
      View in: PubMed, PubMed Central
    17. Skretas G, Makino T, Varadarajan N, Pogson M, Georgiou G. Multi-copy genes that enhance the yield of mammalian G protein-coupled receptors in Escherichia coli. Metab Eng. 2012 Sep; 14(5):591-602. PMID: 22609824; PMCID: PMC3428473.
      View in: PubMed, PubMed Central
    18. Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3885-90. PMID: 22355106; PMCID: PMC3309713.
      View in: PubMed, PubMed Central
    19. Varadarajan N, Julg B, Yamanaka YJ, Chen H, Ogunniyi AO, McAndrew E, Porter LC, Piechocka-Trocha A, Hill BJ, Douek DC, Pereyra F, Walker BD, Love JC. A high-throughput single-cell analysis of human CD8? T cell functions reveals discordance for cytokine secretion and cytolysis. J Clin Invest. 2011 Nov; 121(11):4322-31. PMID: 21965332; PMCID: PMC3204845.
      View in: PubMed, PubMed Central
    20. Varadarajan N, Pogson M, Georgiou G, Iverson BL. Proteases that can distinguish among different post-translational forms of tyrosine engineered using multicolor flow cytometry. J Am Chem Soc. 2009 Dec 23; 131(50):18186-90. PMID: 19924991.
      View in: PubMed
    21. Varadarajan N, Cantor JR, Georgiou G, Iverson BL. Construction and flow cytometric screening of targeted enzyme libraries. Nat Protoc. 2009; 4(6):893-901. PMID: 19478805.
      View in: PubMed
    22. Varadarajan N, Rodriguez S, Hwang BY, Georgiou G, Iverson BL. Highly active and selective endopeptidases with programmed substrate specificities. Nat Chem Biol. 2008 May; 4(5):290-4. PMID: 18391948; PMCID: PMC2654239.
      View in: PubMed, PubMed Central
    23. Varadarajan N, Georgiou G, Iverson BL. An engineered protease that cleaves specifically after sulfated tyrosine. Angew Chem Int Ed Engl. 2008; 47(41):7861-3. PMID: 18780393; PMCID: PMC2671331.
      View in: PubMed, PubMed Central
    24. Hwang BY, Varadarajan N, Li H, Rodriguez S, Iverson BL, Georgiou G. Substrate specificity of the Escherichia coli outer membrane protease OmpP. J Bacteriol. 2007 Jan; 189(2):522-30. PMID: 17085556; PMCID: PMC1797397.
      View in: PubMed, PubMed Central
    25. Varadarajan N, Gam J, Olsen MJ, Georgiou G, Iverson BL. Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6855-60. PMID: 15867160; PMCID: PMC1100772.
      View in: PubMed, PubMed Central
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