Alkylating Agents
"Alkylating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Descriptor ID |
D000477
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MeSH Number(s) |
D27.505.519.124 D27.888.569.035
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Alkylating Agents".
Below are MeSH descriptors whose meaning is more specific than "Alkylating Agents".
This graph shows the total number of publications written about "Alkylating Agents" by people in this website by year, and whether "Alkylating Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1981 | 0 | 1 | 1 | 1999 | 1 | 0 | 1 | 2006 | 0 | 1 | 1 | 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alkylating Agents" by people in Profiles.
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Margison GP, Butt A, Pearson SJ, Wharton S, Watson AJ, Marriott A, Caetano CM, Hollins JJ, Rukazenkova N, Begum G, Santibáñez-Koref MF. Alkyltransferase-like proteins. DNA Repair (Amst). 2007 Aug 01; 6(8):1222-8.
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Pearson SJ, Wharton S, Watson AJ, Begum G, Butt A, Glynn N, Williams DM, Shibata T, Santibáñez-Koref MF, Margison GP. A novel DNA damage recognition protein in Schizosaccharomyces pombe. Nucleic Acids Res. 2006; 34(8):2347-54.
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El-Harazi SM, Feldman RM, Villanueva G, Carter-Dawson L, Mietz H, Chuang AZ. Low-dose postoperative transconjunctival application of mitomycin C in rabbit trabeculectomy. J Glaucoma. 1999 Dec; 8(6):374-9.
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Fuks JZ, Egorin MJ, Aisner J, Ostrow SS, Klein ME, Bachur NR, Colvin M, Wiernik PH. Cyclophosphamide and dimethylsulfoxide in the treatment of squamous carcinoma of the lung. Therapeutic efficacy, toxicity, and pharmacokinetics. Cancer Chemother Pharmacol. 1981; 6(2):117-20.
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