 Dactinomycin
"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
| Descriptor ID |
D003609
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| MeSH Number(s) |
D03.494.200 D04.345.566.252 D12.644.641.252
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| Concept/Terms |
Cosmegen- Cosmegen
- Lyovac-Cosmegen
- MSD Brand of Dactinomycin
- Merck Frosst Brand of Dactinomycin
- Merck Sharp & Dohme Brand of Dactinomycin
- Cosmegen Lyovac
- Lyovac, Cosmegen
- Merck Brand of Dactinomycin
Ac-De- Ac-De
- Lemery Brand of Dactinomycin
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Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
This graph shows the total number of publications written about "Dactinomycin" by people in this website by year, and whether "Dactinomycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dactinomycin" by people in Profiles.
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Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 1997 Aug 22; 90(4):809-19.
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O'Malley BW, Schwartz RJ, Schrader WT. A review of regulation of gene expression by steroid hormone receptors. J Steroid Biochem. 1976 Nov-Dec; 7(11-12):1151-9.
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Buller RE, Schwartz RJ, O'Malley BW. Steroid hormone receptor fraction stimulation of RNA synthesis: a caution. Biochem Biophys Res Commun. 1976 Mar 08; 69(1):106-13.
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Schwartz RJ, Wilde CE. Changes in protein synthesis in the morphogenesis of Fundulus heteroclitus. Nature. 1973 Oct 19; 245(5425):376-9.
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Schwartz RJ. Control of glutamine synthetase synthesis in the embryonic chick neural retina. A caution in the use of actinomycin D. J Biol Chem. 1973 Sep 25; 248(18):6426-35.
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JURTSHUK P, SEKUZU I, GREEN DE. STUDIES ON THE ELECTRON TRANSFER SYSTEM. LVI. ON THE FORMATION OF AN ACTIVE COMPLEX BETWEEN THE APO-D(--)-BETA-HYDROXYBUTYRIC DEHYDROGENASE AND MICELLAR LECITHIN. J Biol Chem. 1963 Nov; 238:3595-605.
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