 Dextromethorphan
"Dextromethorphan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
| Descriptor ID |
D003915
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| MeSH Number(s) |
D03.132.577.249.200 D03.549.686.212 D03.605.497.212 D04.615.723.795.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dextromethorphan".
Below are MeSH descriptors whose meaning is more specific than "Dextromethorphan".
This graph shows the total number of publications written about "Dextromethorphan" by people in this website by year, and whether "Dextromethorphan" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 2 | 0 | 2 |
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Below are the most recent publications written about "Dextromethorphan" by people in Profiles.
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Carter LP, Reissig CJ, Johnson MW, Klinedinst MA, Griffiths RR, Mintzer MZ. Acute cognitive effects of high doses of dextromethorphan relative to triazolam in humans. Drug Alcohol Depend. 2013 Mar 01; 128(3):206-13.
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Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR. High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens. Psychopharmacology (Berl). 2012 Sep; 223(1):1-15.
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