Guanethidine
"Guanethidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
| Descriptor ID |
D006145
|
| MeSH Number(s) |
D02.078.370.460
|
| Concept/Terms |
Guanethidine- Guanethidine
- Oktadin
- ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine
- Octadine
|
Below are MeSH descriptors whose meaning is more general than "Guanethidine".
Below are MeSH descriptors whose meaning is more specific than "Guanethidine".
This graph shows the total number of publications written about "Guanethidine" by people in this website by year, and whether "Guanethidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 0 | 1 | 1 |
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Below are the most recent publications written about "Guanethidine" by people in Profiles.
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Nath RG, Lokhandwala MF, McCalden TA. Evidence for presynaptic dopaminergic inhibition of noradrenergic transmission in the rat portal vein. Proc West Pharmacol Soc. 1983; 26:377-9.
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Jandhyala BS, Cavero I, Buckley JP. Time-course effects of oral guanethidine administration on cardiovascular and autonomic effects on dogs. Eur J Pharmacol. 1976 Mar; 36(1):21-32.
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Jandhyala BS, Cavero I, Buckley JP. Effects of chronic guanethidine administration on cardiovascular function of dogs. Res Commun Chem Pathol Pharmacol. 1975 Aug; 11(4):523-32.
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Jandhyala BS, Clarke DE, Buckley JP. Effects of prolonged administration of certain antihypertensive agents. J Pharm Sci. 1974 Oct; 63(10):1497-513.
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Clarke DE, Jandhyala BS, Cavero I, Dixit BN, Buckley JP. A differential effect of chronically administered guanethidine on sympathetic neurotransmission to the dog heart and mesenteric arterial blood vessels. Can J Physiol Pharmacol. 1974 Jun; 52(3):641-8.