 Cimetidine
"Cimetidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
| Descriptor ID |
D002927
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| MeSH Number(s) |
D02.078.370.200 D03.383.129.308.130
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| Concept/Terms |
Cimetidine- Cimetidine
- N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine
SK&F-92334- SK&F-92334
- SK&F 92334
- SK&F92334
- SKF-92334
- SKF 92334
- SKF92334
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Below are MeSH descriptors whose meaning is more general than "Cimetidine".
Below are MeSH descriptors whose meaning is more specific than "Cimetidine".
This graph shows the total number of publications written about "Cimetidine" by people in this website by year, and whether "Cimetidine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1985 | 0 | 2 | 2 | | 1989 | 1 | 0 | 1 | | 1990 | 0 | 2 | 2 | | 1991 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cimetidine" by people in Profiles.
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Clark EA, Hill SJ. Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin. Eur J Pharmacol. 1996 Jan 25; 296(2):223-5.
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Iredale PA, Ruck A, Martin KF, Kendall DA, Hill SJ. Histamine-induced changes in intracellular calcium in undifferentiated N1E-115 cells. Biochem Soc Trans. 1991 Feb; 19(1):6S.
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Ottosson A, Hill SJ, Edvinsson L. Histamine receptors in brain vessels of guinea-pig: in-vitro pharmacology and ligand binding. Acta Physiol Scand. 1990 Sep; 140(1):135-41.
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Alkadhi KA, Bassey EI, Hogan YH. A comparative study of the actions of histamine H2 receptor antagonists on transmission in the isolated superior cervical ganglion of the rat. Neuropharmacology. 1990 Mar; 29(3):285-90.
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Furr MO, Murray MJ. Treatment of gastric ulcers in horses with histamine type 2 receptor antagonists. Equine Vet J Suppl. 1989 Jun; (7):77-9.
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Al-Gadi M, Hill SJ. Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices. Br J Pharmacol. 1985 Aug; 85(4):877-88.
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Donaldson J, Hill SJ. Histamine-induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea-pig ileum. Br J Pharmacol. 1985 Jun; 85(2):499-512.
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