 Insulysin
"Insulysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
| Descriptor ID |
D007339
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| MeSH Number(s) |
D08.811.277.656.300.480.300 D08.811.277.656.675.374.300
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| Concept/Terms |
Insulysin- Insulysin
- Insulin-Degrading Enzyme
- Enzyme, Insulin-Degrading
- Insulin Degrading Enzyme
- Insulin Protease
- Protease, Insulin
- Insulin Proteinase
- Proteinase, Insulin
- Insulinase
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Below are MeSH descriptors whose meaning is more general than "Insulysin".
Below are MeSH descriptors whose meaning is more specific than "Insulysin".
This graph shows the total number of publications written about "Insulysin" by people in this website by year, and whether "Insulysin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Insulysin" by people in Profiles.
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Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One. 2010 May 07; 5(5):e10504.
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Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. PLoS One. 2009; 4(4):e5274.
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