 Drug Discovery
"Drug Discovery" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of finding chemicals for potential therapeutic use.
| Descriptor ID |
D055808
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| MeSH Number(s) |
E05.295 H01.158.703.007.675 H01.181.466.675
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Drug Discovery".
Below are MeSH descriptors whose meaning is more specific than "Drug Discovery".
This graph shows the total number of publications written about "Drug Discovery" by people in this website by year, and whether "Drug Discovery" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 | | 2010 | 2 | 1 | 3 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 1 | 2 | | 2014 | 2 | 0 | 2 | | 2015 | 0 | 1 | 1 | | 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "Drug Discovery" by people in Profiles.
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Rietz A, Li H, Quist KM, Cherry JJ, Lorson CL, Burnett BG, Kern NL, Calder AN, Fritsche M, Lusic H, Boaler PJ, Choi S, Xing X, Glicksman MA, Cuny GD, Androphy EJ, Hodgetts KJ. Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2017 Jun 08; 60(11):4594-4610.
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Boga SB, Alhassan AB, Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Yu Y, Anand R, Liu S, Yang C, Wu H, Cai J, Zhu H, Desai J, Maloney K, Gao YD, Fischmann TO, Presland J, Mansueto M, Xu Z, Leccese E, Knemeyer I, Garlisi CG, Bays N, Stivers P, Brandish PE, Hicks A, Cooper A, Kim RM, Kozlowski JA. Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis. Bioorg Med Chem Lett. 2017 Aug 15; 27(16):3939-3943.
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Lang CA, Ray SS, Liu M, Singh AK, Cuny GD. Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking. Bioorg Med Chem Lett. 2015 Jul 01; 25(13):2713-9.
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Michel MC, Seifert R, Bond RA. Dynamic bias and its implications for GPCR drug discovery. Nat Rev Drug Discov. 2014 Nov; 13(11):869.
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Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. J Biomol Screen. 2014 Aug; 19(7):1024-34.
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Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L. Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrob Agents Chemother. 2014; 58(3):1603-14.
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Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. EMBO Mol Med. 2013 Jul; 5(7):1103-18.
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Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E. Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem. 2012 Sep; 4(13):1671-9.
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Cuny GD. Foreword: neurodegenerative diseases: challenges and opportunities. Future Med Chem. 2012 Sep; 4(13):1647-9.
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Charlton SJ, Bond RA. BJP issue on drug discovery. Br J Pharmacol. 2010 Nov; 161(6):1201-2.
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