 Protamines
"Protamines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
| Descriptor ID |
D011479
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| MeSH Number(s) |
D12.776.660.750 D12.776.664.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protamines".
Below are MeSH descriptors whose meaning is more specific than "Protamines".
This graph shows the total number of publications written about "Protamines" by people in this website by year, and whether "Protamines" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protamines" by people in Profiles.
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Hwang BY, Varadarajan N, Li H, Rodriguez S, Iverson BL, Georgiou G. Substrate specificity of the Escherichia coli outer membrane protease OmpP. J Bacteriol. 2007 Jan; 189(2):522-30.
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Nuttall GA, Oliver WC, Beynen FM, Santrach PJ, Strickland RA, Murray MJ. Determination of normal versus abnormal activated partial thromboplastin time and prothrombin time after cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 1995 Aug; 9(4):355-61.
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Nuttall GA, Murray MJ, Bowie EJ. Protamine-heparin-induced pulmonary hypertension in pigs: effects of treatment with a thromboxane receptor antagonist on hemodynamics and coagulation. Anesthesiology. 1991 Jan; 74(1):138-45.
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