 Valproic Acid
"Valproic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
| Descriptor ID |
D014635
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| MeSH Number(s) |
D02.241.081.944.509.900 D10.251.400.895.593.900
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| Concept/Terms |
Valproic Acid- Valproic Acid
- Acid, Valproic
- Divalproex
- Propylisopropylacetic Acid
- Acid, Propylisopropylacetic
- 2-Propylpentanoic Acid
- 2 Propylpentanoic Acid
Divalproex Sodium- Divalproex Sodium
- Sodium, Divalproex
- Valproic Acid, Sodium Salt (2:1)
- Semisodium Valproate
- Valproate, Semisodium
Valproate Sodium- Valproate Sodium
- Sodium, Valproate
- Sodium Valproate
- Valproate, Sodium
Calcium Valproate- Calcium Valproate
- Valproate, Calcium
- Valproate Calcium
- Calcium, Valproate
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Below are MeSH descriptors whose meaning is more general than "Valproic Acid".
Below are MeSH descriptors whose meaning is more specific than "Valproic Acid".
This graph shows the total number of publications written about "Valproic Acid" by people in this website by year, and whether "Valproic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Valproic Acid" by people in Profiles.
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Wong GK, Poon WS. Use of phenytoin and other anticonvulsant prophylaxis in patients with aneurysmal subarachnoid hemorrhage. Stroke. 2005 Dec; 36(12):2532; author reply 2532.
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Otoom SA, Alkadhi KA. Epileptiform activity of veratridine model in rat brain slices: effects of antiepileptic drugs. Epilepsy Res. 2000 Feb; 38(2-3):161-70.
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Otoom SA, Alkadhi KA. Valproic acid intensifies epileptiform activity in the hippocampal pyramidal neurons. Neurosci Res. 1999 Dec 30; 35(4):299-307.
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Otoom S, Tian LM, Alkadhi KA. Veratridine-treated brain slices: a cellular model for epileptiform activity. Brain Res. 1998 Apr 06; 789(1):150-6.
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Tian LM, Alkadhi KA. Valproic acid inhibits the depolarizing rectification in neurons of rat amygdala. Neuropharmacology. 1994 Oct; 33(10):1131-8.
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Alkadhi KA, Banks FW. Pre- and postsynaptic actions of valproic acid at the frog neuromuscular junction. Brain Res. 1984 Jul 23; 306(1-2):388-90.
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