Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
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MeSH Number(s) |
E05.393.620.500
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Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
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Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1990 | 1 | 0 | 1 | 1991 | 0 | 1 | 1 | 1992 | 0 | 1 | 1 | 1993 | 0 | 2 | 2 | 1994 | 0 | 1 | 1 | 1995 | 0 | 2 | 2 | 1996 | 0 | 6 | 6 | 1997 | 0 | 5 | 5 | 1998 | 0 | 7 | 7 | 1999 | 0 | 3 | 3 | 2001 | 0 | 4 | 4 | 2002 | 0 | 3 | 3 | 2003 | 1 | 6 | 7 | 2004 | 0 | 2 | 2 | 2005 | 0 | 2 | 2 | 2006 | 0 | 5 | 5 | 2007 | 1 | 5 | 6 | 2008 | 0 | 3 | 3 | 2009 | 1 | 1 | 2 | 2010 | 1 | 7 | 8 | 2011 | 2 | 9 | 11 | 2012 | 1 | 9 | 10 | 2013 | 0 | 1 | 1 | 2014 | 0 | 2 | 2 | 2015 | 1 | 2 | 3 | 2016 | 0 | 3 | 3 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Albayrak L, Khanipov K, Pimenova M, Golovko G, Rojas M, Pavlidis I, Chumakov S, Aguilar G, Chávez A, Widger WR, Fofanov Y. The ability of human nuclear DNA to cause false positive low-abundance heteroplasmy calls varies across the mitochondrial genome. BMC Genomics. 2016 Dec 12; 17(1):1017.
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Ha Y, Liu H, Zhu S, Yi P, Liu W, Nathanson J, Kayed R, Loucas B, Sun J, Frishman LJ, Motamedi M, Zhang W. Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush. Am J Pathol. 2017 Feb; 187(2):352-365.
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Moogk D, Zhong S, Yu Z, Liadi I, Rittase W, Fang V, Dougherty J, Perez-Garcia A, Osman I, Zhu C, Varadarajan N, Restifo NP, Frey AB, Krogsgaard M. Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. J Immunol. 2016 Jul 15; 197(2):644-54.
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Nesher L, Hadi CM, Salazar L, Wootton SH, Garey KW, Lasco T, Luce AM, Hasbun R. Epidemiology of meningitis with a negative CSF Gram stain: under-utilization of available diagnostic tests. Epidemiol Infect. 2016 Jan; 144(1):189-97.
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Banday AA, Lokhandwala MF. Transcriptional regulation of renal dopamine D1 receptor function during oxidative stress. Hypertension. 2015 May; 65(5):1064-72.
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Martinson JN, Broadaway S, Lohman E, Johnson C, Alam MJ, Khaleduzzaman M, Garey KW, Schlackman J, Young VB, Santhosh K, Rao K, Lyons RH, Walk ST. Evaluation of portability and cost of a fluorescent PCR ribotyping protocol for Clostridium difficile epidemiology. J Clin Microbiol. 2015 Apr; 53(4):1192-7.
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Page A, Paoli PP, Hill SJ, Howarth R, Wu R, Kweon SM, French J, White S, Tsukamoto H, Mann DA, Mann J. Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. J Hepatol. 2015 Feb; 62(2):388-97.
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Tuomi PA, Murray MJ, Garner MM, Goertz CE, Nordhausen RW, Burek-Huntington KA, Getzy DM, Nielsen O, Archer LL, Maness HT, Wellehan JF, Waltzek TB. Novel poxvirus infection in northern and southern sea otters (Enhydra lutris kenyoni and Enhydra lutris neiris), Alaska and California, USA. J Wildl Dis. 2014 Jul; 50(3):607-15.
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Drummond MJ, Timmerman KL, Markofski MM, Walker DK, Dickinson JM, Jamaluddin M, Brasier AR, Rasmussen BB, Volpi E. Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 01; 305(3):R216-23.
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Koo OK, Mertz AW, Akins EL, Sirsat SA, Neal JA, Morawicki R, Crandall PG, Ricke SC. Analysis of microbial diversity on deli slicers using polymerase chain reaction and denaturing gradient gel electrophoresis technologies. Lett Appl Microbiol. 2013 Feb; 56(2):111-9.
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