 Dizocilpine Maleate
"Dizocilpine Maleate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
| Descriptor ID |
D016291
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| MeSH Number(s) |
D02.455.426.559.847.181.384.380 D04.615.181.384.380
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dizocilpine Maleate".
Below are MeSH descriptors whose meaning is more specific than "Dizocilpine Maleate".
This graph shows the total number of publications written about "Dizocilpine Maleate" by people in this website by year, and whether "Dizocilpine Maleate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 2001 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 0 | 2 | 2 | | 2013 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dizocilpine Maleate" by people in Profiles.
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Roshanravan H, Kim EY, Dryer SE. NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801. Diabetes. 2016 Oct; 65(10):3139-50.
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Moy SS, Riddick NV, Nikolova VD, Teng BL, Agster KL, Nonneman RJ, Young NB, Baker LK, Nadler JJ, Bodfish JW. Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism. Behav Brain Res. 2014 Feb 01; 259:200-14.
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Zhang C, Yi F, Xia M, Boini KM, Zhu Q, Laperle LA, Abais JM, Brimson CA, Li PL. NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. Antioxid Redox Signal. 2010 Oct 01; 13(7):975-86.
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Anderson M, Suh JM, Kim EY, Dryer SE. Functional NMDA receptors with atypical properties are expressed in podocytes. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C22-32.
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Elhardt M, Martinez L, Tejada-Simon MV. Neurochemical, behavioral and architectural changes after chronic inactivation of NMDA receptors in mice. Neurosci Lett. 2010 Jan 04; 468(2):166-71.
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Kosten TA, Bombace JC. Ethanol enhances naloxone sensitization and disrupts morphine discrimination--comparison to dizocilpine and pentobarbital: explanation of enhancing acute and attenuating chronic effects. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Aug; 25(6):1283-306.
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Vosler PS, Bombace JC, Kosten TA. A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior. Life Sci. 2001 Jun 22; 69(5):591-8.
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Kosten TA, Bombace JC. Prior and delayed applications of dizocilpine or ethanol alter locomotor sensitization to morphine. Brain Res. 2000 Sep 29; 878(1-2):20-31.
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Carlezon WA, Kosten TA, Nestler EJ. Behavioral interactions caused by combined administration of morphine and MK-801 in rats. Psychopharmacology (Berl). 2000 Aug; 151(2-3):261-72.
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Shoemaker WJ, Kosten TA, Muly SM. Ethanol attenuation of morphine dependence: comparison to dizocilpine. Psychopharmacology (Berl). 1997 Nov; 134(1):83-7.
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