 Cyclosporine
"Cyclosporine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
| Descriptor ID |
D016572
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| MeSH Number(s) |
D04.345.566.235.300 D12.644.641.235.300
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| Concept/Terms |
Cyclosporine- Cyclosporine
- Cyclosporin
- Cyclosporine A
- Ciclosporin
- Cyclosporin A
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Below are MeSH descriptors whose meaning is more general than "Cyclosporine".
Below are MeSH descriptors whose meaning is more specific than "Cyclosporine".
This graph shows the total number of publications written about "Cyclosporine" by people in this website by year, and whether "Cyclosporine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1994 | 2 | 0 | 2 | | 1999 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 0 | 2 | 2 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclosporine" by people in Profiles.
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Kim EY, Anderson M, Dryer SE. Sustained activation of N-methyl-D-aspartate receptors in podoctyes leads to oxidative stress, mobilization of transient receptor potential canonical 6 channels, nuclear factor of activated T cells activation, and apoptotic cell death. Mol Pharmacol. 2012 Oct; 82(4):728-37.
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Wallace K, Cowie DE, Konstantinou DK, Hill SJ, Tjelle TE, Axon A, Koruth M, White SA, Carlsen H, Mann DA, Wright MC. The PXR is a drug target for chronic inflammatory liver disease. J Steroid Biochem Mol Biol. 2010 May 31; 120(2-3):137-48.
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Dreyfuss JL, Veiga SS, Coulson-Thomas VJ, Santos IA, Toma L, Coletta RD, Nader HB. Differences in the expression of glycosaminoglycans in human fibroblasts derived from gingival overgrowths is related to TGF-beta up-regulation. Growth Factors. 2010 Feb; 28(1):24-33.
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Bobbala D, Koka S, Lang C, Boini KM, Huber SM, Lang F. Effect of cyclosporine on parasitemia and survival of Plasmodium berghei infected mice. Biochem Biophys Res Commun. 2008 Nov 21; 376(3):494-8.
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Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8969-74.
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Takami A, Nakao S, Tatsumi Y, Wang H, Weihua Z, Yamazaki H, Yasue S, Shiobara S, Matsuda T, Mizoguchi H. High inducibility of heat shock protein 72 (hsp72) in peripheral blood mononuclear cells of aplastic anaemia patients: a reliable marker of immune-mediated aplastic anaemia responsive to cyclosporine therapy. Br J Haematol. 1999 Aug; 106(2):377-84.
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Milan D, Griffith J, Su M, Price ER, McKeon F. The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. Cell. 1994 Nov 04; 79(3):437-47.
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Price ER, Jin M, Lim D, Pati S, Walsh CT, McKeon FD. Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3931-5.
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Walsh CT, Zydowsky LD, McKeon FD. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem. 1992 Jul 05; 267(19):13115-8.
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