 Antigens, CD40
"Antigens, CD40" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
| Descriptor ID |
D019013
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| MeSH Number(s) |
D12.776.543.750.705.852.760.097 D23.050.301.264.035.140 D23.050.301.264.051.140 D23.101.100.110.140 D23.101.100.150.140
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| Concept/Terms |
Antigens, CD40- Antigens, CD40
- CD40 Antigens
- TNFRSF5 Receptor
- Receptor, TNFRSF5
- Tumor Necrosis Factor Receptor Superfamily, Member 5
- CD40 Antigen
- Antigen, CD40
- CDw40 Antigen
- Antigen, CDw40
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Below are MeSH descriptors whose meaning is more general than "Antigens, CD40".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, Tumor Necrosis Factor [D12.776.543.750.705.852.760]
- Antigens, CD40 [D12.776.543.750.705.852.760.097]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, CD [D23.050.301.264.035]
- Antigens, CD40 [D23.050.301.264.035.140]
- Antigens, Differentiation, B-Lymphocyte [D23.050.301.264.051]
- Antigens, CD40 [D23.050.301.264.051.140]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, CD [D23.101.100.110]
- Antigens, CD40 [D23.101.100.110.140]
- Antigens, Differentiation, B-Lymphocyte [D23.101.100.150]
- Antigens, CD40 [D23.101.100.150.140]
Below are MeSH descriptors whose meaning is more specific than "Antigens, CD40".
This graph shows the total number of publications written about "Antigens, CD40" by people in this website by year, and whether "Antigens, CD40" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 3 | 0 | 3 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2012 | 3 | 0 | 3 | | 2013 | 2 | 0 | 2 | | 2014 | 2 | 1 | 3 | | 2016 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Antigens, CD40" by people in Profiles.
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Wagner DH. Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?). Clin Exp Immunol. 2016 Sep; 185(3):271-80.
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Vaitaitis GM, Olmstead MH, Waid DM, Carter JR, Wagner DH. A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice. Diabetologia. 2014 Nov; 57(11):2366-73.
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Deng G, Carter J, Traystman RJ, Wagner DH, Herson PS. Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation. J Neuroimmunol. 2014 Sep 15; 274(1-2):132-40.
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Waid DM, Schreiner T, Vaitaitis G, Carter JR, Corboy JR, Wagner DH. Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells. J Neuroimmunol. 2014 May 15; 270(1-2):75-85.
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Vaitaitis GM, Wagner DH. CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression. Cell Mol Immunol. 2013 Nov; 10(6):483-9.
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Vaitaitis GM, Carter JR, Waid DM, Olmstead MH, Wagner DH. An alternative role for Foxp3 as an effector T cell regulator controlled through CD40. J Immunol. 2013 Jul 15; 191(2):717-25.
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Vaitaitis GM, Wagner DH. Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity. PLoS One. 2012; 7(6):e38708.
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Shigeta A, Tada Y, Wang JY, Ishizaki S, Tsuyusaki J, Yamauchi K, Kasahara Y, Iesato K, Tanabe N, Takiguchi Y, Sakamoto A, Tokuhisa T, Shibuya K, Hiroshima K, West J, Tatsumi K. CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema. Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L141-51.
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Carter J, Vaitaitis GM, Waid DM, Wagner DH. CD40 engagement of CD4+ CD40+ T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance. Eur J Immunol. 2012 Feb; 42(2):424-35.
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Vaitaitis GM, Wagner DH. CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity. Mol Immunol. 2010 Aug; 47(14):2303-13.
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