 HIV Integrase
"HIV Integrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is a DNA nucleotidyltransferase encoded by the pol gene.
| Descriptor ID |
D019427
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| MeSH Number(s) |
D08.811.739.500.667.500 D08.811.913.696.445.825.500 D12.776.964.775.375.545.500 D12.776.964.775.562.764.500 D12.776.964.970.600.850.375.545.500
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| Concept/Terms |
HIV Integrase- HIV Integrase
- Integrase, HIV
- p31 pol Gene Product, Human Immunodeficiency Virus
- p31 Integrase Protein, Human Immunodeficiency Virus
- p31 pol Gene Product, HIV
- HIV Integration Protein
- Integration Protein, HIV
- p31 Integrase Protein, HIV
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Below are MeSH descriptors whose meaning is more general than "HIV Integrase".
Below are MeSH descriptors whose meaning is more specific than "HIV Integrase".
This graph shows the total number of publications written about "HIV Integrase" by people in this website by year, and whether "HIV Integrase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 3 | 0 | 3 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 5 | 0 | 5 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "HIV Integrase" by people in Profiles.
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Nunthaboot N, Pianwanit S, Parasuk V, Ebalunode JO, Briggs JM, Kokpol S. Hybrid quantum mechanical/molecular mechanical molecular dynamics simulations of HIV-1 integrase/inhibitor complexes. Biophys J. 2007 Nov 15; 93(10):3613-26.
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Deng J, Sanchez T, Neamati N, Briggs JM. Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors. J Med Chem. 2006 Mar 09; 49(5):1684-92.
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Brigo A, Lee KW, Fogolari F, Mustata GI, Briggs JM. Comparative molecular dynamics simulations of HIV-1 integrase and the T66I/M154I mutant: binding modes and drug resistance to a diketo acid inhibitor. Proteins. 2005 Jun 01; 59(4):723-41.
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Brigo A, Mustata GI, Briggs JM, Moro S. Discovery of HIV-1 integrase inhibitors through a novel combination of ligand and structure-based drug design. Med Chem. 2005 May; 1(3):263-75.
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Brigo A, Lee KW, Iurcu Mustata G, Briggs JM. Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/M154I catalytic domain. Biophys J. 2005 May; 88(5):3072-82.
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Deng J, Lee KW, Sanchez T, Cui M, Neamati N, Briggs JM. Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors. J Med Chem. 2005 Mar 10; 48(5):1496-505.
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Lee MC, Deng J, Briggs JM, Duan Y. Large-scale conformational dynamics of the HIV-1 integrase core domain and its catalytic loop mutants. Biophys J. 2005 May; 88(5):3133-46.
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Mustata GI, Brigo A, Briggs JM. HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors. Bioorg Med Chem Lett. 2004 Mar 22; 14(6):1447-54.
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Adesokan AA, Roberts VA, Lee KW, Lins RD, Briggs JM. Prediction of HIV-1 integrase/viral DNA interactions in the catalytic domain by fast molecular docking. J Med Chem. 2004 Feb 12; 47(4):821-8.
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Barreca ML, Lee KW, Chimirri A, Briggs JM. Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistance. Biophys J. 2003 Mar; 84(3):1450-63.
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